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Non-classical benzene bioisosteres


Bioisosteric replacement of various groups is an important technique in the Medicinal Chemist’s toolbox. Replacing a phenyl or benzene ring with a non-classical ring system, rather than just a spacer, can improve physiochemical properties such as passive permeability and aqueous solubility. To see examples see below:

Search returned 363 hits.

StructureProduct infoAvailabilityQuantity / Price
Catalog IDEN300-345564
Product class Building Block
Namebicyclo[1.1.1]pentane-1-carbaldehyde
ACD numberMFCD24393552
CAS number117633-03-1
Formula
MW96.1
CLogP0.444
Storage conditions-10
Transport conditionsIce pack
See details
Purity: 95%Global stock:0.7 g(5 business days)  
Catalog IDEN300-1608565
Product class Building Block
Namebicyclo[1.1.1]pentan-1-ylmethanol
ACD numberMFCD28040494
CAS number22287-32-7
Formula
MW98.1
CLogP1.043
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:8.2 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-23294351
Product class Building Block
Name3-methylbicyclo[1.1.1]pentan-1-ol
ACD numberMFCD31537338
CAS number2091012-43-8
Formula
MW98.1
CLogP0.423
Storage conditions+4
Transport conditionsIce pack
See details
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-6763405
Product class Building Block
Namebicyclo[1.1.1]pentane-1-thiol
ACD numberMFCD31915505
CAS number754149-00-3
Formula
MW100.2
CLogP1.314
Storage conditions+4
Transport conditionsIce pack
See details
Purity: 95%Global stock:2.8 g(5 business days)  
Catalog IDEN300-83811
Product class Building Block
Namebicyclo[1.1.1]pentane-1-carboxylic acid
ACD numberMFCD19228106
CAS number22287-28-1
Formula
MW112.1
CLogP0.474
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-27152160
Product class Building Block
Name3-ethylbicyclo[1.1.1]pentan-1-ol
ACD numberMFCD33549847
CAS number2639409-42-8
Formula
MW112.2
CLogP
Storage conditions+4
Transport conditionsIce pack
See details
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-329105
Product class Building Block
Name{2-oxabicyclo[2.1.1]hexan-1-yl}methanol
ACD numberMFCD30486978
CAS number2060007-65-8
Formula
MW114.1
CLogP-0.537
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-1703642
Product class Building Block
Name(3-fluorobicyclo[1.1.1]pentan-1-yl)methanol
ACD numberMFCD29037345
CAS number262852-01-7
Formula
MW116.1
CLogP0.436
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-295395
Product class Building Block
Namebicyclo[1.1.1]pentan-1-amine hydrochloride
ACD numberMFCD19204065
CAS number22287-35-0
Formula
MW119.6
CLogP0.004
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 5x0.25 g, 5x0.5 g, 5x1 g
Catalog IDEN300-173156
Product class Building Block
Name2-{bicyclo[1.1.1]pentan-1-yl}acetic acid
ACD numberMFCD19229645
CAS number131515-31-6
Formula
MW126.2
CLogP1.613
Storage conditions+4
Transport conditionsIce pack
See details
Purity: 95%Global stock:> 10 g(5 business days)   EU Rush delivery : (2 business days)
1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-7433125
Product class Building Block
Namerac-(1R,3R,4S)-3-hydroxybicyclo[2.1.0]pentane-1-carboxylic acid
ACD number
CAS number2410594-78-2
Formula
MW128.1
CLogP-0.529
Storage conditions-10
Transport conditionsIce pack
See details
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x1 g
Catalog IDEN300-1604607
Product class Building Block
Name2-oxabicyclo[2.1.1]hexane-4-carboxylic acid
ACD numberMFCD28650664
CAS number1784145-36-3
Formula
MW128.1
CLogP-0.294
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-6729668
Product class Building Block
Name1-ethynylcubane
ACD numberMFCD28955445
CAS number163332-93-2
Formula
MW128.2
CLogP1.986
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:3.2 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-253473
Product class Building Block
Name3-fluorobicyclo[1.1.1]pentane-1-carboxylic acid
ACD numberMFCD19228680
CAS number146038-53-1
Formula
MW130.1
CLogP0.317
Storage conditions-10
Transport conditionsIce pack
See details
Now available as 94% pureGlobal stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x1 g
Catalog IDEN300-27695481
Product class Building Block
Name3-(difluoromethyl)bicyclo[1.1.1]pentan-1-ol
ACD number
CAS number2694728-58-8
Formula
MW134.1
CLogP
Storage conditions+4
Transport conditionsIce pack
See details
Purity: 95%Global stock:2.5 g(5 business days)  
Catalog IDEN300-113973
Product class Building Block
Name3-cyanobicyclo[1.1.1]pentane-1-carboxylic acid
ACD numberMFCD19229172
CAS number83249-02-9
Formula
MW137.1
CLogP0.161
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-262200
Product class Building Block
Name3-fluorobicyclo[1.1.1]pentan-1-amine hydrochloride
ACD numberMFCD28963742
CAS number1826900-79-1
Formula
MW137.6
CLogP-0.153
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-6489846
Product class Building Block
Name1-(aminomethyl)-2-oxabicyclo[2.1.1]hexane-4-carbonitrile
ACD numberMFCD31736477
CAS number2247107-84-0
Formula
MW138.2
CLogP-1.03
Storage conditions+4
Transport conditionsIce pack
See details
Purity: 95%Global stock:8.5 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-6499583
Product class Building Block
Name1-ethynyl-4-fluorobicyclo[2.2.1]heptane
ACD numberMFCD31794458
CAS number2287310-81-8
Formula
MW138.2
CLogP2.712
Storage conditions-10
Transport conditionsIce pack
See details
Purity: 95%Global stock:0.8 g(5 business days)  
Catalog IDEN300-7178266
Product class Building Block
Name{4-aminobicyclo[2.2.1]heptan-1-yl}methanol
ACD numberMFCD27987298
CAS number1375000-42-2
Formula
MW141.2
CLogP-0.346
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)  
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