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Proline analogues


L-Proline has a unique role in protein structure in particular in the formation of B-turns. It has both a secondary nucleophilic amine and a carboxylic acid group, which can act as a Brønsted acid. Thus close analogues are of particular interest. The EnamineStore offers many proline analogues, some with additional conformational constraints like fused, spiro or aza-bicyclo systems. Furthermore there are examples of oxa-systems like the 2-oxa-7-azaspiro[4.4]nonane. To see selected examples, browse compounds below:

Search returned 244 hits.

StructureProduct infoAvailabilityQuantity / Price
Catalog ID EN300-74879
Product class Building Block
Nameazetidine-3-carboxylic acid
ACD numberMFCD00191763
CAS number36476-78-5
Formula
MW101.1
CLogP-2.664
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g   EU Rush delivery : (2 business days)
1x0.25 g, 1x0.5 g, 1x1 gUSA Rush delivery(2 business days)
available in New Jersey stock : 3x0.25 g, 3x0.5 g, 2x1 g, 1x2.5 g
Catalog ID EN300-6479762
Product class Building Block
Namerac-(2R,4S)-4-methylazetidine-2-carboxylic acid, trans
ACD numberMFCD31700188
CAS number2241129-92-8
Formula
MW115.1
CLogP-2.453
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g  
Catalog ID EN300-1709414
Product class Building Block
Name4-methylazetidine-2-carboxylic acid
ACD numberMFCD24498411
CAS number1779725-63-1
Formula
MW115.1
CLogP-2.453
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g
Catalog ID EN300-68611
Product class Building Block
Name3-methylpyrrolidine-3-carboxylic acid
ACD numberMFCD05663313
CAS number885953-27-5
Formula
MW129.2
CLogP-2.239
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g   USA Rush delivery(2 business days)
available in New Jersey stock : 3x0.25 g, 3x0.5 g, 3x1 g, 1x2.5 g
Catalog ID EN300-174676
Product class Building Block
Name(2S)-2-methylpyrrolidine-2-carboxylic acid
ACD numberMFCD01318647
CAS number42856-71-3
Formula
MW129.2
CLogP0.499
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g   EU Rush delivery : (2 business days)
1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 gUSA Rush delivery(2 business days)
available in New Jersey stock : 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 g
Catalog ID EN300-6477839
Product class Building Block
Namerac-(2R,3S)-3-fluoropyrrolidine-2-carboxylic acid, trans
ACD numberMFCD32066778
CAS number2199280-76-5
Formula
MW133.1
CLogP-2.62
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g   EU Rush delivery : (2 business days)
1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 gUSA Rush delivery(2 business days)
available in New Jersey stock : 5x0.05 g, 5x0.1 g, 5x0.25 g, 4x0.5 g, 4x1 g, 1x2.5 g, 1x5 g
Catalog ID EN300-373686
Product class Building Block
Namerac-(2R,4S,6R)-4,6-dimethylpiperidine-2-carboxylic acid
ACD number
CAS number1807941-47-4
Formula
MW157.2
CLogP-0.816
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:1.4 g  
Catalog ID EN300-1477614
Product class Building Block
Name6-ethylpiperidine-2-carboxylic acid
ACD numberMFCD26045085
CAS number1037471-93-4
Formula
MW157.2
CLogP-0.806
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g
Catalog ID EN300-35220
Product class Building Block
Name2-azabicyclo[2.1.1]hexane-1-carboxylic acid hydrochloride
ACD number
CAS number116129-07-8
Formula
MW163.6
CLogP-0.265
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g   USA Rush delivery(2 business days)
available in New Jersey stock : 3x0.25 g, 3x0.5 g, 2x1 g, 1x2.5 g, 1x5 g
Catalog ID EN300-88447
Product class Building Block
Namerac-(1R,5S,6R)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid hydrochloride
ACD numberMFCD11099877
CAS number1212105-25-3
Formula
MW163.6
CLogP-2.574
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g   USA Rush delivery(2 business days)
available in New Jersey stock : 3x0.25 g, 3x0.5 g, 2x1 g, 2x2.5 g, 1x5 g
Catalog ID EN300-53419
Product class Building Block
Name(1S,5R)-2-azabicyclo[3.1.0]hexane-1-carboxylic acid hydrochloride
ACD numberMFCD08460279
CAS number1212477-19-4
Formula
MW163.6
CLogP-0.265
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g  
Catalog ID EN300-85729
Product class Building Block
Name(1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid hydrochloride
ACD numberMFCD09971683
CAS number1807939-32-7
Formula
MW163.6
CLogP-2.428
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:0.9 g   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g
Catalog ID EN300-45049
Product class Building Block
Name1,1-dioxo-1lambda6,2-thiazolidine-3-carboxylic acid
ACD numberMFCD07369945
CAS number1146957-01-8
Formula
MW165.2
CLogP-1.109
Storage conditions+4
Transport conditionsNormal
See details
Now available as 93% pureGlobal stock:7.3 g   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g
Catalog ID EN300-114790
Product class Building Block
Name2-methylpyrrolidine-2-carboxylic acid hydrochloride
ACD numberMFCD22565928
CAS number1423025-85-7
Formula
MW165.6
CLogP0.499
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:6.0 g   USA Rush delivery(2 business days)
available in New Jersey stock : 2x0.25 g, 2x0.5 g, 2x1 g, 1x2.5 g
Catalog ID EN300-139285
Product class Building Block
Name3-methylpyrrolidine-2-carboxylic acid hydrochloride, Mixture of diastereomers
ACD numberMFCD26936039
CAS number14704-69-9
Formula
MW165.6
CLogP-1.894
Storage conditionsRT
Transport conditionsNormal
See details
Now available as 94% pureGlobal stock:> 10 g   EU Rush delivery : (2 business days)
1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 gUSA Rush delivery(2 business days)
available in New Jersey stock : 2x0.05 g, 2x0.1 g, 2x0.25 g, 2x0.5 g, 1x1 g, 1x2.5 g
Catalog ID EN300-331563
Product class Building Block
Name3,3-dimethylazetidine-2-carboxylic acid hydrochloride
ACD numberMFCD30497784
CAS number2059936-62-6
Formula
MW165.6
CLogP-1.934
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g   EU Rush delivery : (2 business days)
1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 gUSA Rush delivery(2 business days)
available in New Jersey stock : 3x0.05 g, 3x0.1 g, 3x0.25 g, 3x0.5 g, 2x1 g
Catalog ID EN300-105554
Product class Building Block
Name3-methylpyrrolidine-3-carboxylic acid hydrochloride
ACD numberMFCD22369922
CAS number1222503-25-4
Formula
MW165.6
CLogP-2.239
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:2.3 g   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.25 g, 1x0.5 g
Catalog ID EN300-114208
Product class Building Block
Name2-(pyrrolidin-2-yl)acetic acid hydrochloride
ACD numberMFCD11506301
CAS number71985-79-0
Formula
MW165.6
CLogP-2.139
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g   USA Rush delivery(2 business days)
available in New Jersey stock : 2x0.1 g, 2x0.25 g, 2x0.5 g, 2x1 g, 1x2.5 g
Catalog ID EN300-39671450
Product class Building Block
Name3,3-difluoroazetidine-2-carboxylic acid hydrochloride
ACD number
CAS number
Formula
MW173.5
CLogP-1.536
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:6.0 g  
Catalog ID EN300-295593
Product class Building Block
Name2-azabicyclo[2.2.1]heptane-1-carboxylic acid hydrochloride
ACD numberMFCD30180465
CAS number1955494-71-9
Formula
MW177.6
CLogP0.294
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:9.4 g   EU Rush delivery : (2 business days)
1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 gUSA Rush delivery(2 business days)
available in New Jersey stock : 3x0.05 g, 3x0.1 g, 3x0.25 g, 3x0.5 g, 3x1 g, 1x2.5 g
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