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Proline analogues


L-Proline has a unique role in protein structure in particular in the formation of B-turns. It has both a secondary nucleophilic amine and a carboxylic acid group, which can act as a Brønsted acid. Thus close analogues are of particular interest. The EnamineStore offers many proline analogues, some with additional conformational constraints like fused, spiro or aza-bicyclo systems. Furthermore there are examples of oxa-systems like the 2-oxa-7-azaspiro[4.4]nonane. To see selected examples, browse compounds below:

Search returned 235 hits.

StructureProduct infoAvailabilityQuantity / Price
Catalog IDEN300-74879
Product class Building Block
Nameazetidine-3-carboxylic acid
ACD numberMFCD00191763
CAS number36476-78-5
Formula
MW101.1
CLogP-2.664
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)   EU Rush delivery : (2 business days)
1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-6479762
Product class Building Block
Namerac-(2R,4S)-4-methylazetidine-2-carboxylic acid, trans
ACD numberMFCD31700188
CAS number2237226-49-0
Formula
MW115.1
CLogP-2.453
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-1709414
Product class Building Block
Name4-METHYLAZETIDINE-2-CARBOXYLIC ACID
ACD numberMFCD24498411
CAS number1779725-63-1
Formula
MW115.1
CLogP-2.453
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-174676
Product class Building Block
Name(2S)-2-methylpyrrolidine-2-carboxylic acid
ACD numberMFCD01318647
CAS number42856-71-3
Formula
MW129.2
CLogP0.499
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 g
Catalog IDEN300-68611
Product class Building Block
Name3-methylpyrrolidine-3-carboxylic acid
ACD numberMFCD05663313
CAS number885953-27-5
Formula
MW129.2
CLogP-2.239
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 2x0.25 g, 2x0.5 g, 2x1 g
Catalog IDEN300-6477839
Product class Building Block
Namerac-(2R,3S)-3-fluoropyrrolidine-2-carboxylic acid, trans
ACD numberMFCD32066778
CAS number2199280-76-5
Formula
MW133.1
CLogP-2.62
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)   EU Rush delivery : (2 business days)
1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 gUSA Rush delivery(2 business days)
available in New Jersey stock : 3x0.001 g, 3x0.002 g, 3x0.005 g, 3x0.01 g, 3x0.02 g, 3x0.025 g, 3x0.05 g, 3x0.1 g, 3x0.25 g, 3x0.5 g, 3x1 g
Catalog IDEN300-373686
Product class Building Block
Namerac-(2R,4S,6R)-4,6-dimethylpiperidine-2-carboxylic acid
ACD number
CAS number2089245-52-1
Formula
MW157.2
CLogP-0.816
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:2.5 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-1477614
Product class Building Block
Name6-ETHYLPIPERIDINE-2-CARBOXYLIC ACID
ACD numberMFCD26045085
CAS number1037471-93-4
Formula
MW157.2
CLogP-0.806
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-35220
Product class Building Block
Name2-azabicyclo[2.1.1]hexane-1-carboxylic acid hydrochloride
ACD number
CAS number116129-07-8
Formula
MW163.6
CLogP-0.265
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-88447
Product class Building Block
Namerac-(1R,5S,6R)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid hydrochloride
ACD numberMFCD11099877
CAS number1212105-25-3
Formula
MW163.6
CLogP-2.574
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-53419
Product class Building Block
Name(1S,5R)-2-azabicyclo[3.1.0]hexane-1-carboxylic acid hydrochloride
ACD numberMFCD08460279
CAS number1212477-19-4
Formula
MW163.6
CLogP-0.265
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:0.2 g(5 business days)  
Catalog IDEN300-85729
Product class Building Block
Name(1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid hydrochloride
ACD numberMFCD09971683
CAS number1807939-32-7
Formula
MW163.6
CLogP-2.428
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:1.5 g(5 business days)  
Catalog IDEN300-45049
Product class Building Block
Name1,1-dioxo-1lambda6,2-thiazolidine-3-carboxylic acid
ACD numberMFCD07369945
CAS number1146957-01-8
Formula
MW165.2
CLogP-1.109
Storage conditions+4
Transport conditionsNormal
See details
Now available as 92% pureGlobal stock:> 10 g(5 business days)  
Catalog IDEN300-331563
Product class Building Block
Name3,3-dimethylazetidine-2-carboxylic acid hydrochloride
ACD numberMFCD30497784
CAS number2059936-62-6
Formula
MW165.6
CLogP-1.934
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-114790
Product class Building Block
Name2-methylpyrrolidine-2-carboxylic acid hydrochloride
ACD numberMFCD22565928
CAS number1423025-85-7
Formula
MW165.6
CLogP0.499
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:5.0 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-139285
Product class Building Block
Name3-methylpyrrolidine-2-carboxylic acid hydrochloride, Mixture of diastereomers
ACD numberMFCD26936039
CAS number14704-69-9
Formula
MW165.6
CLogP-1.894
Storage conditionsRT
Transport conditionsNormal
See details
Now available as 94% pureGlobal stock:> 10 g(5 business days)   EU Rush delivery : (2 business days)
1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 gUSA Rush delivery(2 business days)
available in New Jersey stock : 1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 g
Catalog IDEN300-105554
Product class Building Block
Name3-methylpyrrolidine-3-carboxylic acid hydrochloride
ACD numberMFCD22369922
CAS number1222503-25-4
Formula
MW165.6
CLogP-2.239
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:2.3 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-114208
Product class Building Block
Name2-(pyrrolidin-2-yl)acetic acid hydrochloride
ACD numberMFCD11506301
CAS number71985-79-0
Formula
MW165.6
CLogP-2.139
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:7.1 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.25 g, 1x0.5 g, 1x1 g
Catalog IDEN300-295593
Product class Building Block
Name2-azabicyclo[2.2.1]heptane-1-carboxylic acid hydrochloride
ACD numberMFCD30180465
CAS number1955494-71-9
Formula
MW177.6
CLogP0.294
Storage conditionsRT
Transport conditionsNormal
See details
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-367074
Product class Building Block
Name(S)-METHYL 4-METHYLENEPYRROLIDINE-2-CARBOXYLATE HCL
ACD numberMFCD24856407
CAS number84348-41-4
Formula
MW177.6
CLogP0.5
Storage conditions+4
Transport conditionsNormal
See details
Purity: 95%Global stock:6.9 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock : 1x0.001 g, 1x0.002 g, 1x0.005 g, 1x0.01 g, 1x0.02 g, 1x0.025 g, 1x0.05 g, 1x0.1 g, 1x0.25 g, 1x0.5 g, 1x1 g, 1x2.5 g, 1x5 g
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