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Proline analogues


L-Proline has a unique role in protein structure in particular in the formation of B-turns. It has both a secondary nucleophilic amine and a carboxylic acid group, which can act as a Brønsted acid. Thus close analogues are of particular interest. The EnamineStore offers many proline analogues, some with additional conformational constraints like fused, spiro or aza-bicyclo systems. Furthermore there are examples of oxa-systems like the 2-oxa-7-azaspiro[4.4]nonane. To see selected examples, browse compounds below:
StructureProduct infoAvailabilityQuantity / Price
Catalog IDEN300-74879
Product class Building Block
Nameazetidine-3-carboxylic acid
ACD numberMFCD00191763
CAS number36476-78-5
Formula
MW101.1
CLogP-2.664
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-6479762
Product class Building Block
Namerac-(2R,4S)-4-methylazetidine-2-carboxylic acid, trans
ACD numberMFCD31700188
CAS number2237226-49-0
Formula
MW115.1
CLogP-2.453
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-1709414
Product class Building Block
Name4-METHYLAZETIDINE-2-CARBOXYLIC ACID
ACD numberMFCD24498411
CAS number1779725-63-1
Formula
MW115.1
CLogP-2.453
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-174676
Product class Building Block
Name(2S)-2-methylpyrrolidine-2-carboxylic acid
ACD numberMFCD01318647
CAS number42856-71-3
Formula
MW129.2
CLogP0.499
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 5 g 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-68611
Product class Building Block
Name3-methylpyrrolidine-3-carboxylic acid
ACD numberMFCD05663313
CAS number885953-27-5
Formula
MW129.2
CLogP-2.239
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-6477839
Product class Building Block
Namerac-(2R,3S)-3-fluoropyrrolidine-2-carboxylic acid, trans
ACD numberMFCD32066778
CAS number2199280-76-5
Formula
MW133.1
CLogP-2.62
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:1.0 g(5 business days)   EU Rush delivery(0.101 g)(2 business days)
1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1USA Rush delivery(2 business days)
available in Ohio stock: 0.25 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25
Catalog IDEN300-1477614
Product class Building Block
Name6-ETHYLPIPERIDINE-2-CARBOXYLIC ACID
ACD numberMFCD26045085
CAS number1037471-93-4
Formula
MW157.2
CLogP-0.806
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-373686
Product class Building Block
Namerac-(2R,4S,6R)-4,6-dimethylpiperidine-2-carboxylic acid
ACD number
CAS number2089245-52-1
Formula
MW157.2
CLogP-0.816
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:2.5 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-35220
Product class Building Block
Name2-azabicyclo[2.1.1]hexane-1-carboxylic acid hydrochloride
ACD number
CAS number116129-07-8
Formula
MW163.6
CLogP-0.265
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-88447
Product class Building Block
Namerac-(1R,5S,6R)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid hydrochloride
ACD numberMFCD11099877
CAS number1212105-25-3
Formula
MW163.6
CLogP-2.574
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-45049
Product class Building Block
Name1,1-dioxo-1,2-thiazolidine-3-carboxylic acid
ACD numberMFCD07369945
CAS number1146957-01-8
Formula
MW165.2
CLogP-1.109
Storage conditions+4
Transport conditionsNormal
Now available as 90% pureGlobal stock:2.9 g(5 business days)  
Catalog IDEN300-331563
Product class Building Block
Name3,3-dimethylazetidine-2-carboxylic acid hydrochloride
ACD numberMFCD30497784
CAS number2059936-62-6
Formula
MW165.6
CLogP-1.934
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-105554
Product class Building Block
Name3-methylpyrrolidine-3-carboxylic acid hydrochloride
ACD numberMFCD22369922
CAS number1222503-25-4
Formula
MW165.6
CLogP-2.239
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:3.3 g(5 business days)  
Catalog IDEN300-114208
Product class Building Block
Name2-(pyrrolidin-2-yl)acetic acid hydrochloride
ACD numberMFCD11506301
CAS number71985-79-0
Formula
MW165.6
CLogP-2.139
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-114790
Product class Building Block
Name2-methylpyrrolidine-2-carboxylic acid hydrochloride
ACD numberMFCD22565928
CAS number1423025-85-7
Formula
MW165.6
CLogP0.499
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-139285
Product class Building Block
Name3-methylpyrrolidine-2-carboxylic acid hydrochloride, Mixture of diastereomers
ACD numberMFCD26936039
CAS number14704-69-9
Formula
MW165.6
CLogP-1.894
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 5 g 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-6740513
Product class Building Block
Name(6S)-5-azaspiro[2.4]heptane-6-carboxylic acid hydrochloride
ACD numberMFCD29918531
CAS number2200278-74-4
Formula
MW177.6
CLogP-2.099
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-295593
Product class Building Block
Name2-azabicyclo[2.2.1]heptane-1-carboxylic acid hydrochloride
ACD numberMFCD30180465
CAS number1955494-71-9
Formula
MW177.6
CLogP0.294
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-367074
Product class Building Block
Name(S)-METHYL 4-METHYLENEPYRROLIDINE-2-CARBOXYLATE HCL
ACD numberMFCD24856407
CAS number84348-41-4
Formula
MW177.6
CLogP0.5
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:6.9 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 5 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-204155
Product class Building Block
Name2-{2-azabicyclo[2.1.1]hexan-1-yl}acetic acid hydrochloride
ACD numberMFCD28348295
CAS number637740-18-2
Formula
MW177.6
CLogP-2.384
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:1.7 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 0.25 g 1x0.25
Catalog IDEN300-1704559
Product class Building Block
Namerac-(1R,5R)-2-azabicyclo[3.2.0]heptane-1-carboxylic acid hydrochloride, cis
ACD numberMFCD31629904
CAS number2173998-87-1
Formula
MW177.6
CLogP0.294
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:8.0 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-39280
Product class Building Block
Name7-azabicyclo[2.2.1]heptane-1-carboxylic acid hydrochloride
ACD number
CAS number182137-43-5
Formula
MW177.6
CLogP0.294
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   EU Rush delivery(1 g)(2 business days)
1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-73242
Product class Building Block
Name2-azaspiro[3.3]heptane-6-carboxylic acid hydrochloride
ACD numberMFCD11858156
CAS number1172252-57-1
Formula
MW177.6
CLogP-3.097
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-301433
Product class Building Block
Name4-methyl-2-azabicyclo[2.1.1]hexane-1-carboxylic acid hydrochloride
ACD numberMFCD30181140
CAS number1955540-92-7
Formula
MW177.6
CLogP0.254
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-705715
Product class Building Block
Namerac-(1R,6S)-2-azabicyclo[4.1.0]heptane-1-carboxylic acid hydrochloride, cis
ACD numberMFCD31542473
CAS number2137717-74-7
Formula
MW177.6
CLogP0.294
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-6735921
Product class Building Block
Namerac-(1R,2S,5S)-3-azabicyclo[3.2.0]heptane-2-carboxylic acid hydrochloride
ACD number
CAS number2287246-58-4
Formula
MW177.6
CLogP-2.099
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-252788
Product class Building Block
Name3,3-dimethylpyrrolidine-2-carboxylic acid hydrochloride
ACD numberMFCD19382435
CAS number61406-78-8
Formula
MW179.6
CLogP-1.375
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-1086669
Product class Building Block
Namemethyl (2R)-2-methylpyrrolidine-2-carboxylate hydrochloride
ACD numberMFCD20685906
CAS number1286768-32-8
Formula
MW179.6
CLogP0.784
Storage conditions+4
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-1212484
Product class Building Block
Name3-ethylpyrrolidine-2-carboxylic acid hydrochloride, Mixture of diastereomers
ACD numberMFCD20640491
CAS number104757-47-3
Formula
MW179.6
CLogP-1.365
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-1605416
Product class Building Block
Name4,4-dimethylpyrrolidine-2-carboxylic acid hydrochloride
ACD numberMFCD31665535
CAS number2197372-53-3
Formula
MW179.6
CLogP-1.375
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-188012
Product class Building Block
Name(2R,3S)-2-methylmorpholine-3-carboxylic acid hydrochloride
ACD numberMFCD28145077
CAS number1808578-40-6
Formula
MW181.6
CLogP-1.032
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-344717
Product class Building Block
Namerac-(3R,6R)-6-methylmorpholine-3-carboxylic acid hydrochloride, trans
ACD numberMFCD28954384
CAS number2059909-93-0
Formula
MW181.6
CLogP-1.032
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:4.6 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 0.25 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25
Catalog IDEN300-1168847
Product class Building Block
Namerac-(3R,5R)-5-methylmorpholine-3-carboxylic acid hydrochloride, cis
ACD numberMFCD28246426
CAS number1807938-48-2
Formula
MW181.6
CLogP-1.032
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-6478515
Product class Building Block
Name(3S,6R)-6-methylmorpholine-3-carboxylic acid hydrochloride
ACD numberMFCD31695967
CAS number2237216-22-5
Formula
MW181.6
CLogP-1.032
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-6764094
Product class Building Block
Namerac-(2R,4R)-4-chloropyrrolidine-2-carboxylic acid hydrochloride, cis
ACD numberMFCD31915836
CAS number2309431-84-1
Formula
MW186.0
CLogP-1.88
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-264302
Product class Building Block
Name3-(piperidin-4-yl)prop-2-ynoic acid hydrochloride
ACD numberMFCD29991443
CAS number1955530-40-1
Formula
MW189.6
CLogP-2.112
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 5 g 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-298246
Product class Building Block
Name3-(piperidin-3-yl)prop-2-ynoic acid hydrochloride
ACD numberMFCD29991818
CAS number1955523-88-2
Formula
MW189.6
CLogP-2.062
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 5 g 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-131172
Product class Building Block
Name3-phenylpyrrolidine-2-carboxylic acid, Mixture of diastereomers
ACD numberMFCD01191420
CAS number3005-68-3
Formula
MW191.2
CLogP-1.555
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:1.6 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-7441792
Product class Building Block
Name6-azaspiro[2.5]octane-5-carboxylic acid hydrochloride
ACD numberMFCD31744411
CAS number2227204-75-1
Formula
MW191.7
CLogP-1.54
Storage conditionsRT
Transport conditionsNormal
USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-26623742
Product class Building Block
Name5-azaspiro[3.4]octane-6-carboxylic acid hydrochloride
ACD number
CAS number2413866-73-4
Formula
MW191.7
CLogP-1.54
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-1272862
Product class Building Block
Namerac-methyl (1R,5R)-2-azabicyclo[3.2.0]heptane-1-carboxylate hydrochloride, cis
ACD numberMFCD31629030
CAS number2155840-01-8
Formula
MW191.7
CLogP0.579
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-7539752
Product class Building Block
Namerac-(1R,6S)-2-azabicyclo[4.2.0]octane-1-carboxylic acid hydrochloride, cis
ACD numberMFCD32269124
CAS number2408937-58-4
Formula
MW191.7
CLogP0.853
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-7894437
Product class Building Block
Namemethyl 2-azabicyclo[2.2.1]heptane-1-carboxylate hydrochloride
ACD numberMFCD24508252
CAS number1824224-77-2
Formula
MW191.7
CLogP0.579
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-26981245
Product class Building Block
Namemethyl 4-methyl-2-azabicyclo[2.1.1]hexane-1-carboxylate hydrochloride
ACD number
CAS number
Formula
MW191.7
CLogP0.539
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)  
Catalog IDEN300-43003
Product class Building Block
Name2-azabicyclo[2.2.2]octane-1-carboxylic acid hydrochloride
ACD number
CAS number1156078-42-0
Formula
MW191.7
CLogP0.853
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.25, 1x0.5, 1x1EU Rush delivery(1 g)(2 business days)
1x0.25, 1x0.5, 1x1
Catalog IDEN300-253656
Product class Building Block
Name6-azaspiro[2.5]octane-1-carboxylic acid hydrochloride
ACD numberMFCD18071370
CAS number1332530-45-6
Formula
MW191.7
CLogP-2.308
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 5 g 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-1266430
Product class Building Block
Namerac-(1R,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid hydrochloride
ACD number
CAS number2220172-17-6
Formula
MW191.7
CLogP-1.54
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 5 g 1x0.25, 1x0.5, 1x1, 1x2.5, 1x5
Catalog IDEN300-26678042
Product class Building Block
Name4-methyl-2-azabicyclo[2.2.1]heptane-1-carboxylic acid hydrochloride
ACD number
CAS number2418706-02-0
Formula
MW191.7
CLogP0.813
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:4.6 g(5 business days)   USA Rush delivery(2 business days)
available in New Jersey stock: 1 g 1x0.002, 1x0.005, 1x0.01, 1x0.02, 1x0.025, 1x0.05, 1x0.1, 1x0.25, 1x0.5, 1x1
Catalog IDEN300-645522
Product class Building Block
Namerac-(3aR,6aR)-hexahydro-2H-furo[3,2-b]pyrrole-5-carboxylic acid hydrochloride
ACD number
CAS number2137432-91-6
Formula
MW193.6
CLogP-2.084
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:> 10 g(5 business days)   USA Rush delivery(2 business days)
available in Ohio stock: 1 g 1x0.25, 1x0.5, 1x1
Catalog IDEN300-181119
Product class Building Block
Name4,4-dimethylpiperidine-2-carboxylic acid hydrochloride
ACD numberMFCD28064046
CAS number1803560-90-8
Formula
MW193.7
CLogP-0.816
Storage conditionsRT
Transport conditionsNormal
Purity: 95%Global stock:6.6 g(5 business days)  
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