The comprehensive Drug Collection - CLOUD
Unique collection of FDA-approved drugs that covers all biochemical space of synthetic terapeutic agents.
Search for a suitable collection of approved drugs that covers all drug classes is always a challenging task. To date no commercially available compound collection covered all drug classes.
In collaboration with a group of researchers at CeMM, we collected a condensed screening set of 281 small molecules representing the entire target and chemical space of all FDA-approved drugs.
Database of all to date approved drugs was evaluated by therapeutic application and chemical structure. After careful analysis we found that compounds belonging to the same class are often structurally very similar and can be clustered to significantly reduce the number of compounds in the library. Dedicated computational analysis and extensive literature search resulted in generation of the CeMM Library of Unique Drugs (CLOUD).
CLOUD covers prodrugs and active forms at pharmacologically relevant concentrations and is ideally suited for combinatorial studies.
CLOUD147
Iloprost
pulmonary arterial hypertension
CLOUD019
Clopidogrel
prodrug, an antiplatelet agent
CLOUD014
Norcisapride
metabolite of Cisapride, parasympathomimetic
CLOUD003
Chloroquine
prototype anti-malarial drug
The recent publication [1] provides evidence of successful drug repurposing by pairwise compound screening from CLOUD collection in cancer cell viability assay. The findings highlight that refined chemical library CLOUD is a powerful tool for drug repurposing and evaluation of new substances suitable for all high-content and high- throughput assays.
The main features of CLOUD collection, 281 compounds:
- Covers all therapeutically significant space of approved drugs.
- Contains prodrugs and active metabolites at pharmacologically relevant concentrations.
- Ideally applicable for combinatorial assays to study new drug combinations.
- Most structurally diverse drug library among commercially available collections.
- Immediately accessible in convenient pre-plated formats with carefully prepared detailed documentation.
Available in different formats:
- 281 compounds at pharmacologically relevant concentrations in mM, 50uL DMSO solution, 96-well plates (Matrix Cat. No ), 80 cmpds per plate.
- 275 compounds at 10mM concentration, 50/100uL DMSO solution, 96-well plates (Matrix Cat. No ), 80 cmpds per plate: first and last columns empty.
[1] Nature Chemical Biology 13, 771–778 (2017).