EnamineStore

Welcome, Guest
Tutorials

Peroxisome proliferator-activated receptor (PPAR)

StructureProduct infoAvailabilityQuantity / Price
BRC0168
Product IDBRC0168
Product classBioreference compound
CAS number89-57-6
MW153.1
Synonyms
5-ASA, Asacol, Asacolitin, Canasa, Claversal, Fisalamine, Iialda, Lixacol, m-Aminosalicylic acid, P-Aminosalicylsaeure, Pentasa, Rowasa, Salofalk
Transport conditionsNormal

Mesalazine

An anti-inflammatory agent, structurally related to the salicylates, which is active in inflammatory bowel disease. It is considered to be the active moiety of sulphasalazine. 

Product Page

In Stock(5 business days)  
BRC0814
Product IDBRC0814
Product classBioreference compound
CAS number15687-27-1
MW206.3
Synonyms
NSC 256857; U-18753;
Transport conditionsNormal

Ibuprofen

Ibuprofen is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. It is a non-selective, reversible COX inhibitor (IC50 for human recombinant COX-1 and COX-2 are 2.6 and 1.53 µM, respectively).

Product Page

In Stock(5 business days)  
BRC0827
Product IDBRC0827
Product classBioreference compound
CAS number51146-56-6
MW206.3
Synonyms
d-ibuproten; S(+)-ibuprofen;
Transport conditionsNormal

Dexibuprofen

Dexibuprofen is a non-steroidal anti-inflammatory drug. It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties.

Product Page

In Stock(5 business days)  
BRC0212
Product IDBRC0212
Product classBioreference compound
CAS number882-09-7
MW214.6
Synonyms
Clofibrin
Transport conditionsNormal

Clofibric acid

Clofibric acid is a compound that reduces cholesterol levels in blood through diminishing the activity of NADPH.

Product Page

In Stock(5 business days)  
BRC0247
Product IDBRC0247
Product classBioreference compound
CAS number882-09-7
MW242.7
Synonyms
ELPI, EPIB, Lipofacton, Liprin, Alufibrate, Atromid-S, Binograc, Clobrate, Clofibrate, Hisunsero, Koliva, Myanlin
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Clofibrate

Clofibrate increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Clofibrate also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL. Also, as a fibrate, Clofibrate is an agonist of the PPAR-α receptor in muscle, liver, and other tissues.

Product Page

In Stock(5 business days)  
BRC0310
Product IDBRC0310
Product classBioreference compound
CAS number22978-25-2
MW276.7
Synonyms
2-chloro-5-nitrobenzanilide
Transport conditionsNormal

GW 9662

Selective PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM. Anticancer, inhibits growth of human mammary tumor cell lines.

Product Page

In Stock(5 business days)  
BRC0479
Product IDBRC0479
Product classBioreference compound
CAS number530-78-9
MW281.2
Synonyms
Arlef, CI 440, CN 27544, INF 1837, NSC 219007, NSC 82699
Transport conditionsNormal

Flufenamic acid

Flufenamic acid is an anthranilic acid-derived nonsteroidal anti-inflammatory drug (NSAID) thought to exert its actions by a prostanoid-independent mechanism.

Product Page

In Stock(5 business days)  
BRC0163
Product IDBRC0163
Product classBioreference compound
CAS number105816-04-4
MW317.4
Synonyms
Starlix, Starsis, Fastic, Senaglinide, A-4166
Transport conditionsNormal

Nateglinide

Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release.

Product Page

In Stock(5 business days)  
BRC0842
Product IDBRC0842
Product classBioreference compound
CAS number80573-04-2
MW357.3
Synonyms
Colazide, Giazo
Transport conditionsNormal

Balsalazide

Balsalazide is a prodrug that produce mesalamine (5-aminosalicylic acid), an anti inflammatory drug.

Product Page

In Stock(5 business days)  
BRC0367
Product IDBRC0367
Product classBioreference compound
CAS number53-86-1
MW357.8
Synonyms
Indocin
Transport conditionsNormal

Indomethacin

Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

Product Page

In Stock(5 business days)  
BRC0862
Product IDBRC0862
Product classBioreference compound
CAS number49562-28-9
MW360.8
Synonyms
NSC 281319, LF 178, FNF
Transport conditionsNormal

Fenofibrate

Fenofibrate is PPARα agonist, lipid regulating drug. It increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression.

Product Page

In Stock(5 business days)  
BRC1060
Product IDBRC1060
Product classBioreference compound
CAS number94875-80-6
MW368.4
Synonyms
E100; INS-100(I); NSC-32982;
Transport conditionsNormal

Curcumin

Curcumin is a yellow-orange dye and possesses a vast number of biological targets. It is an antitumor, anti-inflammatory, and antioxidant agent.

Product Page

In Stock(5 business days)  
BRC0868
Product IDBRC0868
Product classBioreference compound
CAS number112529-15-4
MW392.9
Synonyms
U72107A
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Pioglitazone hydrochloride

Pioglitazone hydrochloride is a selective agonist at peroxisome proliferator activated receptor gamma (PPARγ) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. It is used as an antidiabetic.

Product Page

In Stock(5 business days)  
BRC0702
Product IDBRC0702
Product classBioreference compound
CAS number599-79-1
MW398.4
Synonyms
NSC 203730, NSC 667219, Reupirin, Azulfin, Benzosulfa
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Sulfasalazine

Sulfasalazine is an anti-inflammatory (gastrointestinal). It is inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC).

Product Page

In Stock(5 business days)  
BRC0881
Product IDBRC0881
Product classBioreference compound
CAS number777075-57-7
MW418.3
Synonyms
Transport conditionsNormal

GQ-16

GQ-16 is a novel effective inhibitor of Cdk5-mediated phosphorylation of PPARγ, promotes insulin sensitization without weight gain.

Product Page

In Stock(5 business days)  
BRC0735
Product IDBRC0735
Product classBioreference compound
CAS number29094-61-9
MW445.5
Synonyms
Aldiab, CP 28720, Digrin, K 4024, Melizide
Transport conditionsNormal

Glipizide

Glipizide is an oral hypoglycemic agent which is rapidly absorbed and completely metabolized. It is a second-generation sulfonylurea, is used with diet to lower blood glucose in patients with diabetes mellitus type II.

Product Page

In Stock(5 business days)  
BRC0762
Product IDBRC0762
Product classBioreference compound
CAS number135062-02-1
MW452.6
Synonyms
AG-EE 623ZW, AGEE 623, Eurepa
Transport conditionsNormal

Repaglinide

Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release.

Product Page

In Stock(5 business days)  
BRC0016
Product IDBRC0016
Product classBioreference compound
CAS number155141-29-0
MW473.5
Synonyms
Avandia, Brl-49653, Rosiglizole, BRL49653,
Transport conditionsNormal

Rosiglitazone maleate

Rosiglitazone acts as a highly selective and potent agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin.

Product Page

In Stock(5 business days)  
BRC0679
Product IDBRC0679
Product classBioreference compound
CAS number144701-48-4
MW514.6
Synonyms
BIBR 277, BIBR 277SE, Kinzalmono, Micardis, Pritor, Telday
Transport conditionsNormal

Telmisartan

Telmisartan is a non-peptide AT1 angiotensin receptor antagonist (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Telmisartan also have PPAR-gamma agonistic properties (EC50 = 4 nM) that could potentially confer beneficial metabolic effects.

Product Page

In Stock(5 business days)  
Display records per page

 

x
x