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Nuclear Receptors (nuclear hormone receptors)

StructureProduct infoAvailabilityQuantity / Price
BRC0993
Product IDBRC0993
Product classBioreference compound
CAS number65-45-2
MW137.1
Synonyms
OHB;
Transport conditionsNormal

Salicylamide

Salicylamide is an analgesic and antipyretic agent. Its medicinal uses are similar to those of aspirin.

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BRC0168
Product IDBRC0168
Product classBioreference compound
CAS number89-57-6
MW153.1
Synonyms
5-ASA, Asacol, Asacolitin, Canasa, Claversal, Fisalamine, Iialda, Lixacol, m-Aminosalicylic acid, P-Aminosalicylsaeure, Pentasa, Rowasa, Salofalk
Transport conditionsNormal

Mesalazine

An anti-inflammatory agent, structurally related to the salicylates, which is active in inflammatory bowel disease. It is considered to be the active moiety of sulphasalazine. 

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BRC0969
Product IDBRC0969
Product classBioreference compound
CAS number97-53-0
MW164.2
Synonyms
NSC-209525; NSC-8895; 4-allylguaiacol;
Transport conditionsNormal

Eugenol

Eugenol is an antifungal and antimicrobial agent, TRPV1 receptor agonist. Its exact mechanism of action is unknown, however, it has been shown to interfere with action potential conduction.

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BRC1071
Product IDBRC1071
Product classBioreference compound
CAS number120-47-8
MW166.2
Synonyms
Mycocten; NSC 23514; NSC 8510; E 214; Easeptol;
Transport conditionsNormal

Ethylparaben

Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an anti-microbial agent and food additive. It is a standardized chemical allergen. The physiologic effect of ethylparaben is by means of increased histamine release, and cell-mediated immunity.

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BRC1080
Product IDBRC1080
Product classBioreference compound
CAS number94-25-7
MW193.2
Synonyms
Butylcaine; Hemoride; NSC 128464; Planoform; Scuroform;
Transport conditionsNormal

Butamben

Butamben is a mildly water-soluble, long-duration local anesthetic that is thought to reversibly blocking nerve conduction.

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BRC1077
Product IDBRC1077
Product classBioreference compound
CAS number94-26-8
MW194.2
Synonyms
NSC 13164; NSC 8475; Nipabutyl; SPF;
Transport conditionsNormal

Butylparaben

Butylparaben is an antifungal preservative in cosmetic products.

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BRC0814
Product IDBRC0814
Product classBioreference compound
CAS number15687-27-1
MW206.3
Synonyms
NSC 256857; U-18753;
Transport conditionsNormal

Ibuprofen

Ibuprofen is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. It is a non-selective, reversible COX inhibitor (IC50 for human recombinant COX-1 and COX-2 are 2.6 and 1.53 µM, respectively).

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BRC0827
Product IDBRC0827
Product classBioreference compound
CAS number51146-56-6
MW206.3
Synonyms
d-ibuproten; S(+)-ibuprofen;
Transport conditionsNormal

Dexibuprofen

Dexibuprofen is a non-steroidal anti-inflammatory drug. It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties.

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BRC0212
Product IDBRC0212
Product classBioreference compound
CAS number882-09-7
MW214.6
Synonyms
Clofibrin
Transport conditionsNormal

Clofibric acid

Clofibric acid is a compound that reduces cholesterol levels in blood through diminishing the activity of NADPH.

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BRC0858
Product IDBRC0858
Product classBioreference compound
CAS number131-57-7
MW228.2
Synonyms
NSC-7778; Benzophenone-3;
Transport conditionsNormal

Oxybenzone

Oxybenzone is a derivative of benzophenone. It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays.

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BRC0247
Product IDBRC0247
Product classBioreference compound
CAS number882-09-7
MW242.7
Synonyms
ELPI, EPIB, Lipofacton, Liprin, Alufibrate, Atromid-S, Binograc, Clobrate, Clofibrate, Hisunsero, Koliva, Myanlin
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Clofibrate

Clofibrate increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Clofibrate also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL. Also, as a fibrate, Clofibrate is an agonist of the PPAR-α receptor in muscle, liver, and other tissues.

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BRC0684
Product IDBRC0684
Product classBioreference compound
CAS number56-53-1
MW268.4
Synonyms
NSC 3070, DES
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Diethylstilbestrol

Diethylstilbestrol is a synthetic estrogen with carcinogenic properties (estrogen receptor agonist, EC50 = 0.007 nM). Used in the treatment of prostate cancer to block the production of testosterone.

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BRC0796
Product IDBRC0796
Product classBioreference compound
CAS number53-16-7
MW270.4
Synonyms
NSC 9699, WAY 164397
Transport conditionsNormal

Estrone

Estrone is an estradiol metabolite, estrogen receptor agonist.

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BRC0142
Product IDBRC0142
Product classBioreference compound
CAS number13311-84-7
MW276.2
Synonyms
Eulexin, Niftolide, Drogenil, SCH-13521
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Flutamide

Flutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition Flutamide is a potent inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen.

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BRC0310
Product IDBRC0310
Product classBioreference compound
CAS number22978-25-2
MW276.7
Synonyms
2-chloro-5-nitrobenzanilide
Transport conditionsNormal

GW 9662

Selective PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM. Anticancer, inhibits growth of human mammary tumor cell lines.

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BRC0479
Product IDBRC0479
Product classBioreference compound
CAS number530-78-9
MW281.2
Synonyms
Arlef, CI 440, CN 27544, INF 1837, NSC 219007, NSC 82699
Transport conditionsNormal

Flufenamic acid

Flufenamic acid is an anthranilic acid-derived nonsteroidal anti-inflammatory drug (NSAID) thought to exert its actions by a prostanoid-independent mechanism.

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BRC0136
Product IDBRC0136
Product classBioreference compound
CAS number52806-53-8
MW292.2
Synonyms
Hydroxyniphtholide, Sch 16423
Transport conditionsNormal

Hydroxyflutamide

2-hydroxy Flutamide is the major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4. Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC50 = ~ 300-900), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR.

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BRC0043
Product IDBRC0043
Product classBioreference compound
CAS number797-63-7
MW312.5
Synonyms
Levonorgestrel, Methylnorethindrone, Logynon, Nordette, Eugynon, Microgynon, Ovran, Ovranette, Trinordiol
Transport conditionsNormal
Restrictions Included in DEA controlled list

(-) - Norgestrel

(-) - Norgestrel is a synthetic progesterone analog and the biologically active component of norgestrel, which is a racemic mixture. Levonorgestrel prevents pregnancy by inhibiting ovulation and by causing the cervical mucous to thicken, which makes it harder for sperm to move toward the uterus. Levonorgestrel exhibits approximately three-times higher binding affinity than progesterone for the progesterone receptor.

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BRC0866
Product IDBRC0866
Product classBioreference compound
CAS number57-83-0
MW314.5
Synonyms
BP 14, NSC-64377, NSC-9704, U 3672
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Progesterone

Progesterone is steroid hormone produced by the corpus luteum. It is endogenous progesterone receptor (PR) agonist (EC50 = 0.5 nM).

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BRC0940
Product IDBRC0940
Product classBioreference compound
CAS number63612-50-0
MW317.2
Synonyms
RU-23908;
Transport conditionsNormal

Nilutamide

Nilutamide is an antineoplastic hormonal agent, nonsteroidal anti-androgen with selectivity for androgen receptors.

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BRC0163
Product IDBRC0163
Product classBioreference compound
CAS number105816-04-4
MW317.4
Synonyms
Starlix, Starsis, Fastic, Senaglinide, A-4166
Transport conditionsNormal

Nateglinide

Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release.

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BRC0339
Product IDBRC0339
Product classBioreference compound
CAS number66778-17-4
MW340.3
Synonyms
Aesculin
Transport conditionsNormal

Esculin

The main activities of Esculine focus on capillary protection, as it improves capillary permeability and fragility. It is reported to inhibit catabolic enzymes such as hyaluronidase and collagenase, thus preserving the integrity of the perivascular connective tissue.

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BRC0048
Product IDBRC0048
Product classBioreference compound
CAS number976-71-6
MW340.5
Synonyms
Phanurane, Aldadiene, Luvion, Aldadiene,
Transport conditionsNormal

Canrenone

Mineralocorticoid receptor antagonist. Active metabolite of spironolactone. A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects.

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BRC0842
Product IDBRC0842
Product classBioreference compound
CAS number80573-04-2
MW357.3
Synonyms
Colazide, Giazo
Transport conditionsNormal

Balsalazide

Balsalazide is a prodrug that produce mesalamine (5-aminosalicylic acid), an anti inflammatory drug.

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BRC0367
Product IDBRC0367
Product classBioreference compound
CAS number53-86-1
MW357.8
Synonyms
Indocin
Transport conditionsNormal

Indomethacin

Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

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BRC0106
Product IDBRC0106
Product classBioreference compound
CAS number50-24-8
MW360.4
Synonyms
Meticortelone, Predonine, Metacortandralone, Deltacortril, Hydeltra
Transport conditionsNormal

Prednisolone

Prednisolone is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent.

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BRC0862
Product IDBRC0862
Product classBioreference compound
CAS number49562-28-9
MW360.8
Synonyms
NSC 281319, LF 178, FNF
Transport conditionsNormal

Fenofibrate

Fenofibrate is PPARα agonist, lipid regulating drug. It increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression.

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BRC0836
Product IDBRC0836
Product classBioreference compound
CAS number50-23-7
MW362.5
Synonyms
NSC-10483
Transport conditionsNormal

Hydrocortisone

Hydrocortisone is steroid hormone of the adrenal cortex with anti-inflammatory properties.

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BRC0488
Product IDBRC0488
Product classBioreference compound
CAS number71653-63-9
MW367.3
Synonyms
Foridon, Foridone, PP 1466
Transport conditionsNormal

Riodipine

Riodipine is a calcium channel blocker.

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BRC1060
Product IDBRC1060
Product classBioreference compound
CAS number94875-80-6
MW368.4
Synonyms
E100; INS-100(I); NSC-32982;
Transport conditionsNormal

Curcumin

Curcumin is a yellow-orange dye and possesses a vast number of biological targets. It is an antitumor, anti-inflammatory, and antioxidant agent.

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BRC0844
Product IDBRC0844
Product classBioreference compound
CAS number378-44-9
MW392.5
Synonyms
NSC-39470, SCH 4831
Transport conditionsNormal

Betamethasone

Betamethasone is a glucocorticoid receptor agonist.

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BRC0352
Product IDBRC0352
Product classBioreference compound
CAS number50-02-2
MW392.5
Synonyms
MK 125, NSC 34521
Transport conditionsNormal

Dexamethasone

Dexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein in vitro.

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BRC0868
Product IDBRC0868
Product classBioreference compound
CAS number112529-15-4
MW392.9
Synonyms
U72107A
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Pioglitazone hydrochloride

Pioglitazone hydrochloride is a selective agonist at peroxisome proliferator activated receptor gamma (PPARγ) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. It is used as an antidiabetic.

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BRC0702
Product IDBRC0702
Product classBioreference compound
CAS number599-79-1
MW398.4
Synonyms
NSC 203730, NSC 667219, Reupirin, Azulfin, Benzosulfa
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Sulfasalazine

Sulfasalazine is an anti-inflammatory (gastrointestinal). It is inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC).

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BRC1281
Product IDBRC1281
Product classBioreference compound
CAS number335-67-1
MW414.1
Synonyms
A 5717; EF 201; Eftop EF 201; NSC 95114; PFOA;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Perfluorooctanoic acid

Perfluorooctanoic acid is one of the most commonly used perfluorinated compounds, it causes hepatic peroxisome proliferation in rodents. It may have toxic effects on the immune system, liver, development, and endocrine systems through alteration of DNA methylation enzymes.

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BRC0072
Product IDBRC0072
Product classBioreference compound
CAS number52-01-7
MW416.6
Synonyms
Aldactone, Verospiron, Spiroctan
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Spironolactone

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM. Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics.

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BRC0881
Product IDBRC0881
Product classBioreference compound
CAS number777075-57-7
MW418.3
Synonyms
Transport conditionsNormal

GQ-16

GQ-16 is a novel effective inhibitor of Cdk5-mediated phosphorylation of PPARγ, promotes insulin sensitization without weight gain.

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BRC0296
Product IDBRC0296
Product classBioreference compound
CAS number84371-65-3
MW429.6
Synonyms
RU 486, RU 38486, C-1073
Transport conditionsNormal

Mifepristone

A progestational and glucocorticoid hormone antagonist.

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BRC0735
Product IDBRC0735
Product classBioreference compound
CAS number29094-61-9
MW445.5
Synonyms
Aldiab, CP 28720, Digrin, K 4024, Melizide
Transport conditionsNormal

Glipizide

Glipizide is an oral hypoglycemic agent which is rapidly absorbed and completely metabolized. It is a second-generation sulfonylurea, is used with diet to lower blood glucose in patients with diabetes mellitus type II.

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BRC0762
Product IDBRC0762
Product classBioreference compound
CAS number135062-02-1
MW452.6
Synonyms
AG-EE 623ZW, AGEE 623, Eurepa
Transport conditionsNormal

Repaglinide

Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release.

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BRC0016
Product IDBRC0016
Product classBioreference compound
CAS number155141-29-0
MW473.5
Synonyms
Avandia, Brl-49653, Rosiglizole, BRL49653,
Transport conditionsNormal

Rosiglitazone maleate

Rosiglitazone acts as a highly selective and potent agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin.

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BRC0027
Product IDBRC0027
Product classBioreference compound
CAS number126784-99-4
MW475.6
Synonyms
EllaOne, Ella, CDB 2914,
Transport conditionsNormal

Ulipristal acetate

Ulipristal is a selective, reversible progestin receptor modulator and its tissue targets include the uterus, cervix, ovaries, and hypothalamus. Ulipristal may act as an agonist or antagonist in the presence or absence of progesterone based on the tissue target.

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BRC0646
Product IDBRC0646
Product classBioreference compound
CAS number146-56-5
MW510.4
Synonyms
SQ 10733, Squibb 16144, Moditen, OMCA, Anatensol, Trancin, Valamina
Transport conditionsNormal

Fluphenazine dihydrochloride

Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. Intended for the management of schizophrenia and other psychotic disorders.

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BRC0679
Product IDBRC0679
Product classBioreference compound
CAS number144701-48-4
MW514.6
Synonyms
BIBR 277, BIBR 277SE, Kinzalmono, Micardis, Pritor, Telday
Transport conditionsNormal

Telmisartan

Telmisartan is a non-peptide AT1 angiotensin receptor antagonist (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Telmisartan also have PPAR-gamma agonistic properties (EC50 = 4 nM) that could potentially confer beneficial metabolic effects.

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BRC0901
Product IDBRC0901
Product classBioreference compound
CAS number65277-42-1
MW531.4
Synonyms
Phytorol, R 41400, Tocon
Transport conditionsNormal

Ketoconazole

Ketoconazole is anti-fungal agent with potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. It is an inhibitor of cytochrome P-450 in steroid biosynthesis. Also acts as an inhibitor of 5-lipoxygenase and thromboxane synthase activities.

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