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Receptor Tyrosine Kinase

StructureProduct infoAvailabilityQuantity / Price
BRC1245
Product IDBRC1245
Product classBioreference compound
CAS number98-79-3
MW129.1
Synonyms
NSC 143034; Oxoproline; Glutiminic acid; Pidolidone; Pidolic Acid;
Transport conditionsNormal

L-Pyroglutamic acid

L-Pyroglutamic acid is an amino acid that is used in the synthesis of peptides. It is cyclooxygenase inhibitor.

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BRC0622
Product IDBRC0622
Product classBioreference compound
CAS number73-24-5
MW135.1
Synonyms
Vitamin B4;
Transport conditionsNormal

Adenine

Adenine is a purine base that acts as a precursor, substrate, or cofactor in diverse biochemical pathways. It is a fundamental component of DNA, RNA, and ATP, as well as numerous other natural biochemicals.

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BRC1251
Product IDBRC1251
Product classBioreference compound
CAS number124-04-9
MW146.1
Synonyms
Acifloctin; Acinetten; Adilactetten; Adipinic acid; Asapic; E 355; Inipol DS; NSC 7622; NSC 87836;
Transport conditionsNormal

Adipic acid

Adipic acid is a dicarboxylic acid that is a useful synthetic reagent. Also, it has enzyme inhibitory activity.

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BRC0321
Product IDBRC0321
Product classBioreference compound
CAS number4940-39-0
MW190.2
Synonyms
Atremon, Chromone-2-carboxylic acid,
Transport conditionsNormal

Chromocarb

Chromocarb is a vascular protective agent used in the treatment of venous disorders and microvascular affections.

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BRC0452
Product IDBRC0452
Product classBioreference compound
CAS number1485-00-3
MW193.2
Synonyms
NSC 10120, NSC 105303, NSC 170724, Syk Inhibitor III
Transport conditionsNormal

MNS

MNS is selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation). Exhibits no effects on Ca2+-dependent enzymes, PKC or arachidonic acid metabolism.

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BRC0202
Product IDBRC0202
Product classBioreference compound
CAS number672-87-7
MW195.2
Synonyms
Demser, 357 O, L 588, L 588357-0, MK 781, α-MPT,
Transport conditionsNormal

Metyrosine

Metyrosine inhibits tyrosine hydroxylase, which catalyzes the first transformation in catecholamine biosynthesis, i.e., the conversion of tyrosine to dihydroxyphenylalanine (DOPA).

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BRC0637
Product IDBRC0637
Product classBioreference compound
CAS number2809-21-4
MW206.0
Synonyms
M05BA01; NSC-227995; EHDP; HEDP; Hydroxyethylidene Diphosphonic Acid;
Transport conditionsNormal

Etidronic acid

Etidronate is a first generation, non-nitrogenous diphosphonate analog of endogenous pyrophosphate. It affects on calcium metabolism, inhibits ectopic calcification and slows down bone resorption and bone turnover.

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BRC0609
Product IDBRC0609
Product classBioreference compound
CAS number776-53-4
MW213.3
Synonyms
Transport conditionsNormal

NSC 9310

NSC 9310 is CDK inhibitor.

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BRC0580
Product IDBRC0580
Product classBioreference compound
CAS number773-76-2
MW214.0
Synonyms
Endiaron; NSC 3904; Quesyl; CHQ;
Transport conditionsNormal

Chloroxine

Chloroxine is a synthetic antibacterial compound. It inhibits the growth of gram-positive as well as some gram-negative organisms.

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BRC0630
Product IDBRC0630
Product classBioreference compound
CAS number71897-07-9
MW234.3
Synonyms
AG-1295, NSC 380341
Transport conditionsNormal

Tyrphostin AG-1295

Tyrphostin AG 1295 is a cell-permeable, reversible, ATP-competitive and selective inhibitor of PDGFR (platelet-derived growth factor receptor) protein tyrosine kinase (PDGF-receptor PTK)(IC50 = 500 nM) and PDGF-dependent DNA synthesis (IC50 = 2.5 μM) in Swiss/3T3 cells, and demonstrates about 50% inhibition on neointimal formation after balloon injury in porcine femoral arteries.

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BRC0967
Product IDBRC0967
Product classBioreference compound
CAS number137-58-6
MW234.3
Synonyms
ALGRX-3268; LSM-3165; NSC-40030;
Transport conditionsNormal

Lidocaine

Lidocaine is an anaesthetic agent and class Ib antiarrhythmic agent. It is a selective inverse peripheral histamine H1-receptor agonist. This compound is known to block voltage-gated sodium channels in the inactivated state.

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BRC0760
Product IDBRC0760
Product classBioreference compound
CAS number1018454-97-1
MW242.3
Synonyms
Transport conditionsNormal

Thienopyridone

Thienopyridone is selective phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage.

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BRC0973
Product IDBRC0973
Product classBioreference compound
CAS number66376-36-1
MW249.1
Synonyms
G 704650; GTH 4; L 670; L 670452; MK 217; ABDP;
Transport conditionsNormal

Alendronic acid

Alendronate is a second-generation bisphosphonate. Used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Pagets disease.

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BRC0121
Product IDBRC0121
Product classBioreference compound
CAS number50-35-1
MW258.2
Synonyms
Thalomid, Distaval, Softenon, Talimol,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Thalidomide

Thalidomide is an immunomodulatory agent with a spectrum of activity that is not fully characterized. Thalidomide is racemic — it contains both left and right handed isomers in equal amounts: one enantiomer is effective against morning sickness, and the other is teratogenic.

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BRC0860
Product IDBRC0860
Product classBioreference compound
CAS number63132-39-8
MW263.1
Synonyms
Transport conditionsNormal

Olpadronic acid

Olpadronic Acid is the starting compound for obtaining bisphosphonic acid derivatives as anti-osteoporosis agents.

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BRC1295
Product IDBRC1295
Product classBioreference compound
CAS number51298-62-5
MW269.7
Synonyms
Transport conditionsNormal

L-NAME hydrochloride

L-NAME hydrochloride is a nonselective inhibitor of nitric oxide synthetases.

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BRC0243
Product IDBRC0243
Product classBioreference compound
CAS number75706-12-6
MW270.2
Synonyms
Arava, HW 486, Avara, SU 101
Transport conditionsNormal

Leflunomide

Leflunomide is a pyrimidine synthesis inhibitor indicated in adults for the treatment of active rheumatoid arthritis (RA).

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BRC0476
Product IDBRC0476
Product classBioreference compound
CAS number315694-89-4
MW276.3
Synonyms
Transport conditionsNormal

TC-DAPK 6

TC-DAPK 6 is potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).

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BRC0303
Product IDBRC0303
Product classBioreference compound
CAS number117-39-5
MW302.2
Synonyms
Sophoretin, Meletin, Quercetol, Xanthaurine
Transport conditionsNormal

Quercetin

Quercetin is a type of plant-based chemical. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM.

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BRC1032
Product IDBRC1032
Product classBioreference compound
CAS number521-74-4
MW303.0
Synonyms
Fenilor; Intensopan; NSC 1810; NSC 74937;
Transport conditionsNormal

Broxyquinoline

Broxyquinoline is an antiprotozoal agent.

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BRC0545
Product IDBRC0545
Product classBioreference compound
CAS number330786-24-8
MW303.3
Synonyms
Transport conditionsNormal

3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

The compound is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor (IC50 < 10 µM) and useful synthetic intermediate in the synthesis of Ibrutinib.

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BRC0472
Product IDBRC0472
Product classBioreference compound
CAS number380491-32-7
MW330.4
Synonyms
SJ000170251
Transport conditionsNormal

GNF-Pf-2466

GNF-Pf-2466 is kinase inhibitor. Also potential antitubercular agent (TB IC90 = 3.2).

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BRC0916
Product IDBRC0916
Product classBioreference compound
CAS number518-45-6
MW332.3
Synonyms
Japan Yellow 201, Resorcinolphthalein, Solvent Yellow 94, Yellow fluorescein, CI 45350:1
Transport conditionsNormal

Fluorescein

Fluorescein is a phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma.

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BRC1047
Product IDBRC1047
Product classBioreference compound
CAS number133039-73-3
MW338.2
Synonyms
LDN 0097519; Lagistase; C.I. 55005; C.I. 75270; Alizarin yellow;
Transport conditionsNormal

Ellagic Acid

Ellagic acid is selective ATP-competitive inhibitor of casein kinase 2. It exhibits antioxidant, antitumor and antiproliferative activity.

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BRC0575
Product IDBRC0575
Product classBioreference compound
CAS number218156-96-8
MW349.4
Synonyms
Transport conditionsNormal

SRPIN340

SRPIN 340 is selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM). Inhibits SRPK2 at higher concentrations. SRPIN 340 is competitive with ATP and does not inhibit other SRPKs significantly.

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BRC0574
Product IDBRC0574
Product classBioreference compound
CAS number848057-98-7
MW354.3
Synonyms
MVRL1
Transport conditionsNormal

SPHINX

SPHINX is SRPK1 kinase inhibitor (IC50 = 440 nM).

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BRC0793
Product IDBRC0793
Product classBioreference compound
CAS number710323-58-3
MW356.2
Synonyms
GSK 3 Inhibitor IX; MLS 2052; 6-Bromoindirubin-3-oxime;
Transport conditionsNormal

BIO

BIO is a cell-permeable, highly potent, selective, reversible and ATP-competitive glycogen synthase kinase-3 inhibitor. Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro. Also, promotes proliferation and dedifferentiation in cardiomyocytes.

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BRC0558
Product IDBRC0558
Product classBioreference compound
CAS number301305-73-7
MW360.4
Synonyms
Transport conditionsNormal

TCS 359

TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases.

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BRC0071
Product IDBRC0071
Product classBioreference compound
CAS number557795-19-4
MW398.5
Synonyms
Sutent, SU-11248, sunitinibum
Transport conditionsNormal

Sunitinib

Sunitinib is a small molecule that inhibits multiple RTKs (receptor tyrosine kinase), some of which are implicated in tumor growth, pathologic angiogenesis, and metastatic progression of cancer.

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BRC0853
Product IDBRC0853
Product classBioreference compound
CAS number72956-09-3
MW406.5
Synonyms
BM 14190, SKF 105517
Transport conditionsNormal

Carvedilol

Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity. Indicated for the treatment of hypertension and mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

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BRC1281
Product IDBRC1281
Product classBioreference compound
CAS number335-67-1
MW414.1
Synonyms
A 5717; EF 201; Eftop EF 201; NSC 95114; PFOA;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Perfluorooctanoic acid

Perfluorooctanoic acid is one of the most commonly used perfluorinated compounds, it causes hepatic peroxisome proliferation in rodents. It may have toxic effects on the immune system, liver, development, and endocrine systems through alteration of DNA methylation enzymes.

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BRC0754
Product IDBRC0754
Product classBioreference compound
CAS number602293-00-5
MW419.5
Synonyms
Transport conditionsNormal

N-(3-Acetylphenyl)-9-amino-2,3-dihydro-1,4-dioxino[2,3-g]thieno[2,3-b]quinoline-8-carboxamide

The compound is a novel disruptor of the PKCε/RACK2 protein-protein interaction.

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BRC0331
Product IDBRC0331
Product classBioreference compound
CAS number183319-69-9
MW429.9
Synonyms
CP358774, NSC 718781
Transport conditionsNormal

Erlotinib hydrochloride

Erlotinib inhibits the intracellular phosphorylation of tyrosine kinase associated with the epidermal growth factor receptor (EGFR).

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BRC0555
Product IDBRC0555
Product classBioreference compound
CAS number1400989-25-4
MW431.8
Synonyms
Transport conditionsNormal

SC 43

The compound is protein tyrosine phosphatase SHP1 agonist.

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BRC0234
Product IDBRC0234
Product classBioreference compound
CAS number444731-52-6
MW437.5
Synonyms
GW 78603, GW786034,
Transport conditionsNormal

Pazopanib

Pazopanib is a second-generation multitargeted tyrosine kinase inhibitor against vascular endothelial growth factor receptor-1, -2, and -3, platelet-derived growth factor receptor-alpha, platelet-derived growth factor receptor-beta, and c-kit. These receptor targets are part of the angiogenesis pathway that facilitates the formation of tumour blood vessel for tumour survival and growth.

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BRC0205
Product IDBRC0205
Product classBioreference compound
CAS number184475-35-2
MW446.9
Synonyms
Gefitinib, Iressa, ZD 1839
Transport conditionsNormal

Gefitinib

Gefitinib inhibits the epidermal growth factor receptor (EGFR) tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme. Thus the function of the EGFR tyrosine kinase in activating the Ras signal transduction cascade is inhibited; and malignant cells are inhibited.

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BRC0553
Product IDBRC0553
Product classBioreference compound
CAS number1400989-38-9
MW453.4
Synonyms
Transport conditionsNormal

N-[3-(3-Amino-4-nitrophenoxy)phenyl]-3-(trifluoromethyl)benzenesulfonamide

The compound is protein tyrosine phosphatase SHP1 agonist.

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BRC0219
Product IDBRC0219
Product classBioreference compound
CAS number284461-73-0
MW464.8
Synonyms
BAY 43-9006, Nexavar,
Transport conditionsNormal

Sorafenib

Sorafenib is a small molecular inhibitor of Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 and 3 kinases and c Kit the receptor for Stem cell factor. A growing number of drugs target most of these pathways. The originality of Sorafenib lays in its simultaneous targeting of the Raf/Mek/Erk pathway.

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BRC0457
Product IDBRC0457
Product classBioreference compound
CAS number314291-83-3
MW465.4
Synonyms
Phenylhydrazonopyrazolone sulfonate 1, PTP Inhibitor V
Transport conditionsNormal

PHPS 1

PHPS 1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively).

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BRC0330
Product IDBRC0330
Product classBioreference compound
CAS number302962-49-8
MW488.0
Synonyms
BMS 354825, Sprycel
Transport conditionsNormal

Dasatinib

Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.

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BRC0114
Product IDBRC0114
Product classBioreference compound
CAS number152459-95-5
MW493.6
Synonyms
Glivec, STI 571, CGP057148B
Transport conditionsNormal

Imatinib

Imatinib is an antineoplastic agent used to treat chronic myelogenous leukemia. Imatinib is a 2-phenylaminopyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes.

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BRC0332
Product IDBRC0332
Product classBioreference compound
CAS number388082-78-8
MW581.1
Synonyms
FMM, GW 572016, Tykerb
Transport conditionsNormal

Lapatinib ditosylate

Lapatinib is a 4-anilinoquinazoline kinase inhibitor of the intracellular tyrosine kinase domains of both epidermal growth factor receptor (HER1/EGFR/ERBB1) and human epidermal growth factor receptor type 2 (HER2/ERBB2)with a dissociation half-life of ≥300 minutes. Lapatinib inhibits ERBB-driven tumor cell growth in vitro and in various animal models.

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BRC0454
Product IDBRC0454
Product classBioreference compound
CAS number587841-73-4
MW584.9
Synonyms
Transport conditionsNormal

ZCL 278

ZCL 278 is a selective inhibitor of Cdc42. It inhibits Cdc42-mediated microspike formation and neuronal branching in 3T3 fibroblast and neonatal cortical neurons, respectively. It also exhibits potent antiviral activity by inhibiting cellular entry of Junin virus (JUNV) and other enveloped viruses into cells and inhibiting viral replication in mice.

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