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Signal Transducer and Activator of Transcription (STAT) Inhibitors

StructureProduct infoAvailabilityQuantity / Price
BRC0323
Product IDBRC0323
Product classBioreference compound
CAS number19983-44-9
MW211.2
Synonyms
STAT3 Inhibitor V
Transport conditionsNormal

Stattic

Stat3 Inhibitor V, Stattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events.

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BRC0688
Product IDBRC0688
Product classBioreference compound
CAS number1548865-41-3
MW216.6
Synonyms
Transport conditionsNormal

(2S)-2-Amino-N-2H-tetrazol-5-yl-4-pentynamide hydrochloride

The compound is cystathionine-(gamma)-lyase (CSE) inhibitor (IC50 <= 100 μM). Potential means to treat of cutaneous injuries or conditions and sleep-related breathing disorders, pain.

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BRC0300
Product IDBRC0300
Product classBioreference compound
CAS number129-56-6
MW220.2
Synonyms
Nsc75890,
Transport conditionsNormal

SP600125

SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.

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BRC0501
Product IDBRC0501
Product classBioreference compound
CAS number140405-36-3
MW312.4
Synonyms
Transport conditionsNormal

RSVA 405

RSVA 405 is an AMP-activated protein kinase (AMPK) activator (EC50 = 1 μM). Also inhibits LPS-induced STAT3 phosphorylation (IC50 = 0.5 μM). Induces autophagy and promotes Aβ degradation in vitro. Also inhibits adipogenesis in vitro and reduces weight gain in diet-induced obese mice.

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BRC0083
Product IDBRC0083
Product classBioreference compound
CAS number50-65-7
MW327.1
Synonyms
Niclocide, Yomesan, Cestocid, Sagimid
Transport conditionsNormal

Niclosamide

Niclosamide is an antihelminth used against tapeworm infections. It may act by the uncoupling of the electron transport chain to ATP synthase. The disturbance of this crucial metabolic pathway prevents creation of adenosine tri-phosphate (ATP), an essential molecule that supplies energy for metabolism.

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BRC0555
Product IDBRC0555
Product classBioreference compound
CAS number1400989-25-4
MW431.8
Synonyms
Transport conditionsNormal

SC 43

The compound is protein tyrosine phosphatase SHP1 agonist.

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BRC0553
Product IDBRC0553
Product classBioreference compound
CAS number1400989-38-9
MW453.4
Synonyms
Transport conditionsNormal

N-[3-(3-Amino-4-nitrophenoxy)phenyl]-3-(trifluoromethyl)benzenesulfonamide

The compound is protein tyrosine phosphatase SHP1 agonist.

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BRC0742
Product IDBRC0742
Product classBioreference compound
CAS number1334493-07-0
MW626.6
Synonyms
Transport conditionsNormal

BP-1-102

BP-1-102 is a cell-permeable, orally bioavailable amidosalicylic acid compound. It is potent and selective STAT3 inhibitor. BP 1-102 exhibits antitumor activity against Waldenstrom macroglobulinemia, a rare form of B cell non-Hodgkin lymphoma.

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