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Toll-like receptor

StructureProduct infoAvailabilityQuantity / Price
BRC0915
Product IDBRC0915
Product classBioreference compound
CAS number803647-40-7
MW265.3
Synonyms
Transport conditionsNormal

NSC 59984

NSC59984 restores wild-​type p53 signaling via p73 activation, specifically in mutant p53-​expressing colorectal cancer cells. It synergizes with CPT11 to induce cell death in mutant p53-​expressing colorectal cancer cells and inhibits mutant p53-​assocd. colon tumor xenograft growth in a p73-​dependent manner in vivo.

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BRC0018
Product IDBRC0018
Product classBioreference compound
CAS number747-36-4
MW434.0
Synonyms
Plaquenil, Oxichloroquine, Oxychlorochin, Oxichlorochinum
Transport conditionsNormal

Hydroxychloroquine sulfate

Hydroxychloroquine possesses antimalarial properties and also exerts a beneficial effect in lupus erythematosus (chronic discoid or systemic) and acute or chronic rheumatoid arthritis.

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BRC0670
Product IDBRC0670
Product classBioreference compound
CAS number1280193-99-8
MW472.0
Synonyms
Transport conditionsNormal

({1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}methyl)[3-(4-ethoxyphenoxy)-2-methoxypropyl]methylamine

The compound is Toll-like receptor 4 inhibitor (IC50 = 19.8 µM). It displays TLR4-mediated inflammation inhibition, potential antiseptic.

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BRC0003
Product IDBRC0003
Product classBioreference compound
CAS number50-63-5
MW515.9
Synonyms
Aralen, Artrichin, Bemaphate, Capquin, Malarex, Nivaquine B, Resoquine, Reumachlor, Sanoquin
Transport conditionsNormal

Chloroquine diphosphate

Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. Chloroquine inhibits the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. It may also interfere with the biosynthesis of nucleic acids.

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