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Receptor protein serine/threonine kinases

StructureProduct infoAvailabilityQuantity / Price
BRC1048
Product IDBRC1048
Product classBioreference compound
CAS number62613-82-5
MW
Synonyms
CGP 21690; CT 848; Hydroxypiracetam; ISF 2522; Neuractiv;
Transport conditionsNormal

Oxiracetam

Oxiracetam, a cyclic derivative of gamma-aminobutyric acid (GABA), is a nootropic drug of the racetam family and very mild stimulant.

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BRC1305
Product IDBRC1305
Product classBioreference compound
CAS number68252-28-8
MW158.2
Synonyms
Transport conditionsNormal

(R)-(+)-Oxiracetam

(R)-(+)-Oxiracetam is enantiomer of Oxiracetam, nootropic drug.

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BRC1041
Product IDBRC1041
Product classBioreference compound
CAS number490-91-5
MW164.2
Synonyms
NSC 2228;
Transport conditionsNormal

Thymoquinone

Thymoquinone is a natural phytochemical with anti-inflammatory effects, blocking the synthesis of leukotrienes. It inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression.

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BRC1044
Product IDBRC1044
Product classBioreference compound
CAS number61-80-3
MW168.6
Synonyms
Flexin; McN-485; NSC 24995; Zoxamin;
Transport conditionsNormal

Zoxazolamine

Zoxazolamine is a potent skeletal muscle relaxant that also has uricosuric activity. It is used as a tool for assessing hepatic cytochrome P-450 activity.

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BRC0628
Product IDBRC0628
Product classBioreference compound
CAS number13721-01-2
MW189.2
Synonyms
Transport conditionsNormal

4-Quinolone-3-carboxylic acid

4-Quinolone-3-carboxylic acidis a novel HIV-1 integrase strand transfer inhibitor.

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BRC1319
Product IDBRC1319
Product classBioreference compound
CAS number515-13-9
MW204.4
Synonyms
Levo-β-elemene;
Transport conditionsNormal

β-Elemen

β-Elemene is a natural sesquiterpene, inhibits the proliferation of a wide range of tumors. It has antioxidant and antimicrobial properties.

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BRC1421
Product IDBRC1421
Product classBioreference compound
CAS number137-26-8
MW240.4
Synonyms
Basultra; Betoxin; ENT 987; NSC 1771; NSC 49512; NSC 59637; NSC 622696; Nobecutan; SQ 1489;
Transport conditionsNormal

Thiram

Thiram is a fungicide, ectoparasiticide, and animal repellent.

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BRC0082
Product IDBRC0082
Product classBioreference compound
CAS number51-30-9
MW247.7
Synonyms
Norisodrine, Novodrin, Isopropydrin, Aludrine
Transport conditionsNormal

Isoproterenol hydrochloride

Isoproterenol is a relatively selective beta2-adrenergic bronchodilator. Isoproterenol is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease.

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BRC1295
Product IDBRC1295
Product classBioreference compound
CAS number51298-62-5
MW269.7
Synonyms
Transport conditionsNormal

L-NAME hydrochloride

L-NAME hydrochloride is a nonselective inhibitor of nitric oxide synthetases.

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BRC0817
Product IDBRC0817
Product classBioreference compound
CAS number133-16-4
MW270.8
Synonyms
Halestyn; Piocaine;
Transport conditionsNormal

Chloroprocaine

Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia. It blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rising of the action potential.

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BRC0503
Product IDBRC0503
Product classBioreference compound
CAS number22816-60-0
MW271.6
Synonyms
Transport conditionsNormal

A 22 hydrochloride

A22 s a cell-permeable isothiourea compound that inhibits MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant.

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BRC0476
Product IDBRC0476
Product classBioreference compound
CAS number315694-89-4
MW276.3
Synonyms
Transport conditionsNormal

TC-DAPK 6

TC-DAPK 6 is potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).

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BRC0514
Product IDBRC0514
Product classBioreference compound
CAS number116970-50-4
MW287.8
Synonyms
Protein kinase inhibitor H-9
Transport conditionsNormal

H-9 hydrochloride

H-9 (hydrochloride), an isoquinolinesulfonamide protein kinase inhibitor, is a competitive inhibitor of PKC, PKG, and PKA with Ki values of 18, 0.87, and 1.9 µM, respectively.

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BRC0556
Product IDBRC0556
Product classBioreference compound
CAS number325979-58-6
MW300.4
Synonyms
Transport conditionsNormal

SB-347804

SB-347804 is a potent and selective inhibitor of JNK3 kinase (IC50 = 3.16 μM).

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BRC1358
Product IDBRC1358
Product classBioreference compound
CAS number1214672-15-7
MW316.3
Synonyms
Transport conditionsNormal

LM11A-31 dihydrochloride

LM11A-31 dihydrochloride is a p75 neurotrophin receptor ligand that inhibits nerve growth factor binding to p75NTR-Fc. It inhibits DNA damage in and promotes survival of hippocampal neuronal cultures in a p75NTR- and concentration-dependent manner.

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BRC0667
Product IDBRC0667
Product classBioreference compound
CAS number125314-13-8
MW317.3
Synonyms
Transport conditionsNormal

CP21R7

CP21R7 is a potent and selective inhibitor of GSK3 beta (IC50 = 1.8 nM).

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BRC0472
Product IDBRC0472
Product classBioreference compound
CAS number380491-32-7
MW330.4
Synonyms
SJ000170251
Transport conditionsNormal

GNF-Pf-2466

GNF-Pf-2466 is kinase inhibitor. Also potential antitubercular agent (TB IC90 = 3.2).

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BRC1047
Product IDBRC1047
Product classBioreference compound
CAS number133039-73-3
MW338.2
Synonyms
LDN 0097519; Lagistase; C.I. 55005; C.I. 75270; Alizarin yellow;
Transport conditionsNormal

Ellagic Acid

Ellagic acid is selective ATP-competitive inhibitor of casein kinase 2. It exhibits antioxidant, antitumor and antiproliferative activity.

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BRC0875
Product IDBRC0875
Product classBioreference compound
CAS number210297-47-5
MW350.3
Synonyms
Transport conditionsNormal

HA-100 dihydrochloride

HA-100 dihydrochloride is an inhibitor of protein kinases, including PKA, PKC, and PKG (IC50 = 8, 12, and 4 ВµM, respectively). It less effectively blocks the activity of myosin light chain kinase (IC50 = 240 ВµM).

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BRC0498
Product IDBRC0498
Product classBioreference compound
CAS number326886-05-9
MW355.2
Synonyms
Sulfonylhydrazone-
Transport conditionsNormal

Shz-1

Shz-1 is an activator of early cardiac genes (including Nkx2.5) in pluripotent stem cells. Induces phenotypic differentiation in human mobilized peripheral blood mononuclear cells. Enhances myocardial regenerative repair by stem cells in a rat myocardial cryoinjury model.

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BRC0793
Product IDBRC0793
Product classBioreference compound
CAS number710323-58-3
MW356.2
Synonyms
GSK 3 Inhibitor IX; MLS 2052; 6-Bromoindirubin-3-oxime;
Transport conditionsNormal

BIO

BIO is a cell-permeable, highly potent, selective, reversible and ATP-competitive glycogen synthase kinase-3 inhibitor. Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro. Also, promotes proliferation and dedifferentiation in cardiomyocytes.

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BRC0064
Product IDBRC0064
Product classBioreference compound
CAS number10540-29-1
MW371.5
Synonyms
Zemide, Ethanamine, ICI 46474
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Tamoxifen

Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ. Tamoxifen is a nonsteroidal agent that binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the expression of estrogen dependent genes. The prolonged binding of tamoxifen to the nuclear chromatin of these results in reduced DNA polymerase activity, impaired thymidine utilization, blockade of estradiol uptake, and decreased estrogen response.

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BRC0740
Product IDBRC0740
Product classBioreference compound
CAS number1351758-81-0
MW377.8
Synonyms
Transport conditionsNormal

HG-10-102-01

HG-10-102-01 is an aminopyrimidine derivative, LRRK2 inhibitor (IC50 is 3 - 29 nM).

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BRC0833
Product IDBRC0833
Product classBioreference compound
CAS number
MW394.9
Synonyms
Transport conditionsNormal

Rhosin hydrochloride

Rhosin hydrochloride is Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF.

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BRC0570
Product IDBRC0570
Product classBioreference compound
CAS number1596413-63-6
MW402.5
Synonyms
Transport conditionsNormal

2-(3-{4-[(1H-indazol-5-yl)imino]-1,4-dihydropyrimidin-2-yl}phenoxy)-N-(propan-2-yl)acetamide

The compound is ROCK1 and ROCK2 inhibitor (IC50 = 0.07 uM and > 3 uM respectively).

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BRC0919
Product IDBRC0919
Product classBioreference compound
CAS number1191951-57-1
MW409.6
Synonyms
Transport conditionsNormal

PHT 427

PHT-427 is a pleckstrin homology domain inhibitor to Akt and PKB Kinase (PDPK1).

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BRC0754
Product IDBRC0754
Product classBioreference compound
CAS number602293-00-5
MW419.5
Synonyms
Transport conditionsNormal

N-(3-Acetylphenyl)-9-amino-2,3-dihydro-1,4-dioxino[2,3-g]thieno[2,3-b]quinoline-8-carboxamide

The compound is a novel disruptor of the PKCε/RACK2 protein-protein interaction.

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BRC0376
Product IDBRC0376
Product classBioreference compound
CAS number1042432-58-5
MW438.9
Synonyms
Transport conditionsNormal

CTx-0152960

CTx-0152960, was reported as a new member of the broad spectrum PKI family and developed as a Sepharose-supported kinase capture reagent in the identification of 235 protein kinases from a digest of human breast adenocarcinoma, MDA-MB-231, cells.

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BRC0442
Product IDBRC0442
Product classBioreference compound
CAS number924198-81-2
MW451.5
Synonyms
A17(SMURF1 inhibitor)
Transport conditionsNormal

A17

A17 is an inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smuf1) that is a major regulator of bone morphogenetic protein (BMP) signaling. A17 strongly inhibits Smad1/5 ubiquitination mediated by Smuf1, increases BMP signal responsiveness and enhances BMP-2 induced osteoblastic activity.

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BRC0553
Product IDBRC0553
Product classBioreference compound
CAS number1400989-38-9
MW453.4
Synonyms
Transport conditionsNormal

N-[3-(3-Amino-4-nitrophenoxy)phenyl]-3-(trifluoromethyl)benzenesulfonamide

The compound is protein tyrosine phosphatase SHP1 agonist.

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BRC0219
Product IDBRC0219
Product classBioreference compound
CAS number284461-73-0
MW464.8
Synonyms
BAY 43-9006, Nexavar,
Transport conditionsNormal

Sorafenib

Sorafenib is a small molecular inhibitor of Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 and 3 kinases and c Kit the receptor for Stem cell factor. A growing number of drugs target most of these pathways. The originality of Sorafenib lays in its simultaneous targeting of the Raf/Mek/Erk pathway.

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BRC0707
Product IDBRC0707
Product classBioreference compound
CAS number1394011-91-6
MW481.8
Synonyms
Transport conditionsNormal

UC 2288

UC 2288 is novel p21 attenuator which is structurally related to sorafenib. Soluble epoxide hydrolase inhibitor (IC50 = 2.9 nM).

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BRC0921
Product IDBRC0921
Product classBioreference compound
CAS number1007647-73-5
MW512.9
Synonyms
Transport conditionsNormal

A01 (Smurf1 inhibitor)

A01 is an inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smuf1) that is a major regulator of bone morphogenetic protein (BMP) signaling. AO1 strongly inhibits Smad1/5 ubiquitination mediated by Smuf1, increases BMP signal responsiveness and enhances BMP-2 induced osteoblastic activity.

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BRC0434
Product IDBRC0434
Product classBioreference compound
CAS number1347797-73-2
MW1005.2
Synonyms
Transport conditionsNormal

calcium (3R,5R)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyheptanoate

Is rosuvastatin enantiomer compound that inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, also has inhibitory activity against human recombinant p38 MAP kinase expressed in Escherichia coli using myelin basic protein (MBP).

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