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Reductases

StructureProduct infoAvailabilityQuantity / Price
BRC0179
Product IDBRC0179
Product classBioreference compound
CAS number8029-68-3
MW76.1
Synonyms
Carbamohydroxamic Acid, Hidroxicarbamida, Hydrea, N-Hydroxyurea, Oxyurea, nci-c04831, nsc32065
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Hydroxyurea

An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

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BRC0242
Product IDBRC0242
Product classBioreference compound
CAS number7554-65-6
MW82.1
Synonyms
Antizol
Transport conditionsNormal

Fomepizole

Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.

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BRC0622
Product IDBRC0622
Product classBioreference compound
CAS number73-24-5
MW135.1
Synonyms
Vitamin B4;
Transport conditionsNormal

Adenine

Adenine is a purine base that acts as a precursor, substrate, or cofactor in diverse biochemical pathways. It is a fundamental component of DNA, RNA, and ATP, as well as numerous other natural biochemicals.

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BRC0171
Product IDBRC0171
Product classBioreference compound
CAS number54-85-3
MW137.1
Synonyms
Isonicotinic acid hydrazide, Isonicotinohydrazide, Nydrazid, Laniazid, Rimifon, INH
Transport conditionsNormal

Isoniazid

Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex.

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BRC0859
Product IDBRC0859
Product classBioreference compound
CAS number69-72-7
MW138.1
Synonyms
FEMA NO. 3985; K-557; NSC-180;
Transport conditionsNormal

Salicylic acid

Salicylic acid is bacteriostatic, fungicide and keratolytic agent. It is directly and irreversibly inhibits the activity of COX-1 and COX-2 to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid.

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BRC0692
Product IDBRC0692
Product classBioreference compound
CAS number76-38-0
MW165.0
Synonyms
DA-759; NSC-110432;
Transport conditionsNormal

Methoxyflurane

Methoxyflurane is an anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability.

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BRC0170
Product IDBRC0170
Product classBioreference compound
CAS number443-48-1
MW171.2
Synonyms
Flagyl, Trichopol, Vagilen
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Metronidazole

Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa. Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form.

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BRC0936
Product IDBRC0936
Product classBioreference compound
CAS number50-78-2
MW180.2
Synonyms
BAY1019036; NSC-27223; NSC-406186; ASA; Aspirin;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Acetylsalicylic acid

Acetylsalicylic acid is an anti-inflammatory and antipyretic agent and acts as the inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. It also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.

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BRC1118
Product IDBRC1118
Product classBioreference compound
CAS number112-38-9
MW184.3
Synonyms
NSC 2013; Renselin; Sevinon;
Transport conditionsNormal

Undecenoic Acid

Undecenoic acid is a antifungal agent that treats skin infections such as athlete’s foot and relieves itching, burning, and irritation associated with the skin condition. It is also used as a linking molecule to conjugate other biomolecules such as proteins.

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BRC0210
Product IDBRC0210
Product classBioreference compound
CAS number4812-40-2
MW187.2
Synonyms
Metronidazole-OH;
Transport conditionsNormal

Hydroxymetronidazole

Hydroxymetronidazole is a metabolite of metronidazole.

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BRC1121
Product IDBRC1121
Product classBioreference compound
CAS number123-99-9
MW188.2
Synonyms
Finacea; Lepargylic acid; NSC 19493; Skinoren; ZK 62498;
Transport conditionsNormal

Azelaic Acid

Azelaic acid is an anti-inflammatory agent. It directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings.

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BRC0912
Product IDBRC0912
Product classBioreference compound
CAS number41814-78-2
MW189.2
Synonyms
EL-291, Dhanteam, Gain, MTB, Sivic
Transport conditionsNormal

Tricyclazole

Tricyclazole is a common active ingredient in fungicide products.

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BRC0321
Product IDBRC0321
Product classBioreference compound
CAS number4940-39-0
MW190.2
Synonyms
Atremon, Chromone-2-carboxylic acid,
Transport conditionsNormal

Chromocarb

Chromocarb is a vascular protective agent used in the treatment of venous disorders and microvascular affections.

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BRC0857
Product IDBRC0857
Product classBioreference compound
CAS number28523-86-6
MW200.1
Synonyms
Transport conditionsNormal

Sevoflurane

Sevoflurane is one of the most commonly used volatile anesthetic agents, particularly for outpatient anesthesia, across all ages, as well as in veterinary medicine.

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BRC0173
Product IDBRC0173
Product classBioreference compound
CAS number148-79-8
MW201.2
Synonyms
Equizole, Mintezol, MK 360, TBDZ, TBZ,
Transport conditionsNormal

Thiabendazole

Thiabendazole is a fungicide and parasiticide. Thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning.

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BRC0225
Product IDBRC0225
Product classBioreference compound
CAS number154-93-8
MW214.0
Synonyms
BCNU; Bicnu; Gliadel; Becenun; Nitrumon; NSC 409962;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Carmustine

Carmustine is a nitrogen mustard ?-chloro-nitrosourea compound that is used as an alkylating agent.

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BRC0951
Product IDBRC0951
Product classBioreference compound
CAS number83-12-5
MW222.2
Synonyms
PID; NSC 41693;
Transport conditionsNormal

Phenindione

Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. It inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2).

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BRC1059
Product IDBRC1059
Product classBioreference compound
CAS number17557-67-4
MW228.3
Synonyms
Transport conditionsNormal

SKA 16

SKA 16 is an anticonvulsant agent.

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BRC0695
Product IDBRC0695
Product classBioreference compound
CAS number58-14-0
MW248.7
Synonyms
NSC 3061, RP 4753, Tindurin, WR 2978, BW 50-63, Chloridin
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Pyrimethamine

Pyrimethamine is dihydrofolate reductase inhibitor (Ki = 0.19 nM), generally used in combination with other antimicrobial agents. It is a potent inhibitor of multi-drug and toxin extrusion transporters.

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BRC0771
Product IDBRC0771
Product classBioreference compound
CAS number95058-81-4
MW263.2
Synonyms
LY188011, NSC 613327, Zefei, DDFC
Transport conditionsNormal

Gemcitabine

Gemcitabine is an antineoplastic anti-metabolite that inhibits DNA synthesis.

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BRC0120
Product IDBRC0120
Product classBioreference compound
CAS number173903-47-4
MW265.2
Synonyms
Transport conditionsNormal

Tizoxanide

Tizoxanide is the active metabolite of nitazoxanide, anti-infective.

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BRC0143
Product IDBRC0143
Product classBioreference compound
CAS number54965-21-8
MW265.3
Synonyms
Eskazole, Zentel, Albenza, Valbazen, SKF-62979
Transport conditionsNormal

Albendazole

Albendazole is a broad-spectrum anthelmintic. The principal mode of action for albendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.

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BRC0499
Product IDBRC0499
Product classBioreference compound
CAS number965-52-6
MW275.2
Synonyms
RC 27109, RC 30-109, Adral, Antinal, Bacifurane, Diarlidan
Transport conditionsNormal

Nifuroxazide

Nifuroxazide is a broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin. Nifuroxazide also inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC50 = 10 µM).

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BRC0167
Product IDBRC0167
Product classBioreference compound
CAS number435-97-2
MW280.3
Synonyms
Phenprocoumarol, Falithrom, Marcoumar
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Phenprocoumon

Phenprocoumon, a coumarin anticoagulant, thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver.

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BRC0479
Product IDBRC0479
Product classBioreference compound
CAS number530-78-9
MW281.2
Synonyms
Arlef, CI 440, CN 27544, INF 1837, NSC 219007, NSC 82699
Transport conditionsNormal

Flufenamic acid

Flufenamic acid is an anthranilic acid-derived nonsteroidal anti-inflammatory drug (NSAID) thought to exert its actions by a prostanoid-independent mechanism.

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BRC0995
Product IDBRC0995
Product classBioreference compound
CAS number21679-14-1
MW285.2
Synonyms
NSC-118218; 2-F-ARAA;
Transport conditionsNormal

Fludarabine

Fludarabine is purine analog that inhibits DNA synthesis. It exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells). Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.

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BRC0128
Product IDBRC0128
Product classBioreference compound
CAS number152-53-4
MW288.2
Synonyms
Chloroguanide Triazine; NSC 3074;
Transport conditionsNormal

Cycloguanil hydrochloride

Cycloguanil hydrochloride is an active metabolite of proguanil, produced by the cytochrome P450 2C19 isoform. It acts as an inhibitor of dihydrofolate reductase (DHFR).

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BRC0036
Product IDBRC0036
Product classBioreference compound
CAS number637-32-1
MW290.2
Synonyms
Chloroguanide, Bigumal, Paludrin
Transport conditionsNormal

Proguanil hydrochloride

Proguanil is a biguanide derivative that is converted to an active metabolite called cycloguanil. It exerts its antimalarial action by inhibiting parasitic dihydrofolate reductase enzyme. It has causal prophylactic and suppressive activity against P. falciparum and cures the acute infection. It is also effective in suppressing the clinical attacks of vivax malaria.

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BRC0144
Product IDBRC0144
Product classBioreference compound
CAS number738-70-5
MW290.3
Synonyms
Proloprim, Trimpex, Monotrim, Bactramin, BW 56-72, NIH 204, NSC-106568
Transport conditionsNormal

Trimethoprim

Trimethoprim is a pyrimidine analogue that disrupts folate synthesis, an essential part of the thymidine synthesis pathway. Inhibition of the enzyme starves the bacteria of nucleotides necessary for DNA replication.The drug, therefore, exhibits bactericidal activity.

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BRC0209
Product IDBRC0209
Product classBioreference compound
CAS number123318-82-1
MW303.7
Synonyms
CAFdA, CL-F-Ara-a, Clofarex, Clolar, Evoltra, Clofarex,
Transport conditionsNormal

Clofarabine

Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer.

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BRC0918
Product IDBRC0918
Product classBioreference compound
CAS number70-18-8
MW307.3
Synonyms
GSH; Isethion; L-Glutathione Reduced;
Transport conditionsNormal

Glutathione

Glutathione reduces reactive oxygen species formed during cellular metabolism. Regulates activity of the redox-sensitive transcription factor NF-κB. Glutathione participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase.

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BRC0798
Product IDBRC0798
Product classBioreference compound
CAS number81-81-2
MW308.3
Synonyms
Warf 5, NSC 59813,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Warfarin

Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration.

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BRC0848
Product IDBRC0848
Product classBioreference compound
CAS number2447-57-6
MW310.3
Synonyms
J21.373J, RO-4-4393, WR-4073
Transport conditionsNormal

Sulfadoxine

Sulfadoxine is a long acting sulfonamide, usually used in combination with other drugs, for respiratory, urinary tract, and malarial infections.

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BRC0509
Product IDBRC0509
Product classBioreference compound
CAS number82158-86-9
MW319.4
Synonyms
Kinedak; ONO 2235; Sorbista;
Transport conditionsNormal

Epalrestat

Epalrestat is a carboxylic acid-based inhibitor of aldose reductase (IC50 = 0.01-15 μM). Epalrestat has been shown to reduce oxidative stress in type 2 diabetic patients, significantly decreasing lipid hydroperoxide levels in erythrocytes when administered at 150 mg/day.

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BRC0361
Product IDBRC0361
Product classBioreference compound
CAS number66-76-2
MW336.3
Synonyms
Dicumarol, 3,3'-Methylenebis(4-hydroxycoumarin), Bishydroxycoumarin, NSC 17860, NSC 41834, NSC 221570
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Dicoumarol

Dicoumarol is a reductase inhibitor possessing anticoagulant properties. Dicoumarol also aids in apoptosis induction via stimulation of SAPK-JNK and NF-κB pathway blocking.

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BRC0367
Product IDBRC0367
Product classBioreference compound
CAS number53-86-1
MW357.8
Synonyms
Indocin
Transport conditionsNormal

Indomethacin

Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

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BRC0349
Product IDBRC0349
Product classBioreference compound
CAS number75607-67-9
MW365.2
Synonyms
F-ara-A (NSC 312887) Phosphate, NSC-118218
Transport conditionsNormal

Fludarabine phosphate

Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.

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BRC1060
Product IDBRC1060
Product classBioreference compound
CAS number94875-80-6
MW368.4
Synonyms
E100; INS-100(I); NSC-32982;
Transport conditionsNormal

Curcumin

Curcumin is a yellow-orange dye and possesses a vast number of biological targets. It is an antitumor, anti-inflammatory, and antioxidant agent.

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BRC0887
Product IDBRC0887
Product classBioreference compound
CAS number474-25-9
MW392.6
Synonyms
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Chenodeoxycholic acid

Chenodeoxycholic acid is an epimer of ursodeoxycholic acid. Chenodeoxycholic acid is a bile acid naturally found in the body. It is potent selective inhibitors of DD2 (AKR1C2).

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BRC0389
Product IDBRC0389
Product classBioreference compound
CAS number128-13-2
MW392.6
Synonyms
Cholit-ursan, Delursan, Destolit, Deursil, Litursol, Solutrat, Ursacol, Ursochol, Ursolvan
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Ursodeoxycholic acid

Ursodiol (also known as ursodeoxycholic acid) is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Ursodeoxycholic acid helps regulate cholesterol by reducing the rate at which the intestine absorbs cholesterol molecules while breaking up micelles containing cholesterol. Because of this property, ursodeoxycholic acid is used to treat gall stones non-surgically.

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BRC0895
Product IDBRC0895
Product classBioreference compound
CAS number75330-75-5
MW404.5
Synonyms
C10AA02, L-154803, MK-803, ML-530B
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Lovastatin

Lovastatin is a cholesterol-lowering agent. It is fungal metabolite, a potent inhibitor of HMG-CoA reductase.

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BRC0768
Product IDBRC0768
Product classBioreference compound
CAS number79902-63-9
MW418.6
Synonyms
C10AA01, MK 733, Eucor, Kolestevan, L 644128-000U
Transport conditionsNormal

Simvastatin

Simvastatin is the methylated form of lovastatin, an oral antilipemic agent which inhibits HMG-CoA reductase.

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BRC0927
Product IDBRC0927
Product classBioreference compound
CAS number93957-55-2
MW433.5
Synonyms
Lescol®
Transport conditionsNormal

Fluvastatin Sodium

Fluvastatin sodium is selective and competitive hepatic enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Exhibits antihypercholesterolemic and antioxidant activity and inhibits vascular smooth muscle proliferation.

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BRC0089
Product IDBRC0089
Product classBioreference compound
CAS number59-05-2
MW454.4
Synonyms
Amethopterin, Rheumatrex, Trexall, Abitrexate
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Methotrexate

Methotrexate is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division.

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BRC0650
Product IDBRC0650
Product classBioreference compound
CAS number150399-23-8
MW471.4
Synonyms
LY-231514, LY231514, NSC-698037, Alimta
Transport conditionsNormal

Pemetrexed disodium

Pemetrexed disodium is high-affinity dihydrofolate reductase inhibitor (Ki = 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Indirectly activates AMPK. Inhibits proliferation of cancer cell lines in vitro.

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BRC0701
Product IDBRC0701
Product classBioreference compound
CAS number2030-63-9
MW473.4
Synonyms
B 663, G 30320, Hansepran, Lampren, NSC 141046
Transport conditionsNormal

Clofazimine

Clofazimine is a fat-soluble rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity.

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BRC0559
Product IDBRC0559
Product classBioreference compound
CAS number147098-18-8
MW503.5
Synonyms
X-Plended, ZD 4522
Transport conditionsNormal

Rosuvastatin sodium

Rosuvastatin is a synthetic statin, antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase with an IC50 value of 5 nM.

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BRC0070
Product IDBRC0070
Product classBioreference compound
CAS number164656-23-9
MW528.5
Synonyms
Avodart, Avolve, GG-745, GI198745
Transport conditionsNormal

Dutasteride

Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT).

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BRC0434
Product IDBRC0434
Product classBioreference compound
CAS number1347797-73-2
MW1005.2
Synonyms
Transport conditionsNormal

calcium (3R,5R)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyheptanoate

Is rosuvastatin enantiomer compound that inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, also has inhibitory activity against human recombinant p38 MAP kinase expressed in Escherichia coli using myelin basic protein (MBP).

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BRC0271
Product IDBRC0271
Product classBioreference compound
CAS number3546-41-6
MW1151.4
Synonyms
Poquil, Vanquil, Viprynium embonate
Transport conditionsNormal

Pyrvinium Pamoate

Pyrvinium (Viprynium) is an anthelmintic effective for pinworms. Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. Pyrvinium salts can also inhibit the growth of cancer cells.

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