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Antihypertensive

StructureProduct infoAvailabilityQuantity / Price
BRC0030
Product IDBRC0030
Product classBioreference compound
CAS number555-57-7
MW159.2
Synonyms
Eudatin, Supirdyl, Pargylamine, Eutonyl, Lopac-P-8013
Transport conditionsNormal

Pargyline

Pargyline is a monoamine oxidase B (MAO-B) inhibitor with antihypertensive properties. MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability.

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BRC0202
Product IDBRC0202
Product classBioreference compound
CAS number672-87-7
MW195.2
Synonyms
Demser, 357 O, L 588, L 588357-0, MK 781, α-MPT,
Transport conditionsNormal

Metyrosine

Metyrosine inhibits tyrosine hydroxylase, which catalyzes the first transformation in catecholamine biosynthesis, i.e., the conversion of tyrosine to dihydroxyphenylalanine (DOPA).

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BRC0105
Product IDBRC0105
Product classBioreference compound
CAS number304-20-1
MW196.6
Synonyms
Phthalazin-1-ylhydrazine, 1-Hydrazinophthalazine, Apresoline, Hydrazinophthalazine, Hypophthalin, Hydralazi
Transport conditionsNormal

Hydralazine hydrochloride

Hydralazine is a vasodilator, that works by relaxing blood vessels (arterioles more than venules) and increasing the supply of blood and oxygen to the heart while reducing its workload. It also functions as an antioxidant. It inhibits membrane-bound enzymes that form reactive oxygen species, such as superoxides. Excessive superoxide counteracts NO-induced vasodilation.

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BRC0125
Product IDBRC0125
Product classBioreference compound
CAS number59-97-2
MW196.7
Synonyms
Priscoline, Benzidazol, Priscol, Divascol,
Transport conditionsNormal

Tolazoline hydrochloride

Tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.

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BRC0390
Product IDBRC0390
Product classBioreference compound
CAS number55-65-2
MW198.3
Synonyms
Ismedine, Ismelin
Transport conditionsNormal

Guanethidine

Guanethidine works by decreasing the heart rate and relaxing the blood vessels so that blood can flow more easily through the body, thereby reducing these risks. It is a postganglionic sympathetic nerve terminal blocker that prevents the release of norepinephrine from nerve terminals.

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BRC0098
Product IDBRC0098
Product classBioreference compound
CAS number826-39-1
MW203.8
Synonyms
Inversine; Versamine;
Transport conditionsNormal

Mecamylamine hydrochloride

Mecamylamine hydrochloride is a potent, oral antihypertensive agent and ganglion blocker.

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BRC0040
Product IDBRC0040
Product classBioreference compound
CAS number38304-91-5
MW209.3
Synonyms
Loniten, Regaine, Minoximen
Transport conditionsNormal

Minoxidil

Minoxidil is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance.

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BRC0890
Product IDBRC0890
Product classBioreference compound
CAS number62571-86-2
MW217.3
Synonyms
C09AA01, SA-333, SQ-14225
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Captopril

Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS).

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BRC0180
Product IDBRC0180
Product classBioreference compound
CAS number364-98-7
MW230.7
Synonyms
Eudemine, Hyperstat, Sch-6783, SRG-95213, Proglycem
Transport conditionsNormal

Diazoxide

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

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BRC1054
Product IDBRC1054
Product classBioreference compound
CAS number15574-49-9
MW233.3
Synonyms
Ba 2676; Dimecarbin;
Transport conditionsNormal

Mecarbinate

Mecarbinate is a chemical intermediate of arbidol hydrochloride.

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BRC0258
Product IDBRC0258
Product classBioreference compound
CAS number85371-64-8
MW263.3
Synonyms
Pindac;
Transport conditionsNormal

Pinacidil hydrate

Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles.

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BRC0124
Product IDBRC0124
Product classBioreference compound
CAS number29122-68-7
MW266.3
Synonyms
Tenormin, Tenormine, Blokium, Normiten,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Atenolol

Atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.

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BRC0889
Product IDBRC0889
Product classBioreference compound
CAS number4205-91-8
MW266.6
Synonyms
ST 155, ST 155-BS
Transport conditionsNormal

Clonidine hydrochloride

Clonidine is an hypotensive agent, centrally-acting α2-adrenergic agonist.

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BRC0632
Product IDBRC0632
Product classBioreference compound
CAS number23113-43-1
MW267.5
Synonyms
NSC 68982, Wy 8678
Transport conditionsNormal

Guanabenz hydrochloride

Guanabenz is a centrally acting α-2 adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand, indicated for treatment of hypertension.

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BRC1295
Product IDBRC1295
Product classBioreference compound
CAS number51298-62-5
MW269.7
Synonyms
Transport conditionsNormal

L-NAME hydrochloride

L-NAME hydrochloride is a nonselective inhibitor of nitric oxide synthetases.

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BRC0675
Product IDBRC0675
Product classBioreference compound
CAS number14556-46-8
MW271.8
Synonyms
Transport conditionsNormal

Bupranolol

Bupranolol is a competitive, nonselective beta-blocker without intrinsic sympathomimetic activity. It competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation.

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BRC0273
Product IDBRC0273
Product classBioreference compound
CAS number29110-48-3
MW282.6
Synonyms
Estulic, Guanfacina, Guanfacinum, Estulic, SPD 503
Transport conditionsNormal

Guanfacine hydrochloride

Guanfacine selectively stimulates central alpha(2)-adrenergic receptors, resulting in inhibition of sympathetic vasomotor centers, which contributes predominantly to the hypotensive effects of the drug.

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BRC0127
Product IDBRC0127
Product classBioreference compound
CAS number83701-22-8
MW289.3
Synonyms
Loniten, Regaine, Minoximen
Transport conditionsNormal

Minoxidil Sulfate

Minoxidil sulfate is a K+ channel agonist and a strong vascular smooth muscle relaxant. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability.

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BRC0350
Product IDBRC0350
Product classBioreference compound
CAS number59803-98-4
MW292.1
Synonyms
UK 14,304
Transport conditionsNormal

Brimonidine

Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2).

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BRC0651
Product IDBRC0651
Product classBioreference compound
CAS number58-94-6
MW295.7
Synonyms
Diutrid, Flumen, Minzil, NSC 25693, Alurene, Chlorosal
Transport conditionsNormal

Chlorothiazide

Chlorothiazide is an inhibitor of carbonic anhydrase (IC50 = 0.06 µM). This compound has been shown to block reabsorption of sodium and chloride ions.

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BRC0428
Product IDBRC0428
Product classBioreference compound
CAS number318-98-9
MW295.8
Synonyms
AY-64043, ICI-45520, NCS-91523, Angilol, Bedranol SR, Cardinol, Ciplar, Deralin, Dociton, Duranol, HEMANGEOL, Inderal, Inderal LA, Indobloc, INNOPRAN, Innopran XL, Prophylux, Sumial
Transport conditionsNormal

Propranolol hydrochloride

Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.

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BRC0370
Product IDBRC0370
Product classBioreference compound
CAS number58-93-5
MW297.7
Synonyms
HCTZ, NSC 53477, SU 5879
Transport conditionsNormal

Hydrochlorothiazide

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. Hydrochlorothiazide results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium.

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BRC0357
Product IDBRC0357
Product classBioreference compound
CAS number1052540-65-4
MW303.1
Synonyms
Isocaramidine, Bonipress, Declinax, Tendor
Transport conditionsNormal

Debrisoquin

Debrisoquin is an adrenergic neuron-blocking drug similar in effects to guanethidine. It is a substrate for a polymorphic cytochrome P-450 enzyme.

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BRC0241
Product IDBRC0241
Product classBioreference compound
CAS number120-97-8
MW305.1
Synonyms
Diclofenamide
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Dichlorphenamide

Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure.

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BRC0892
Product IDBRC0892
Product classBioreference compound
CAS number2863-34-5
MW305.2
Synonyms
Transport conditionsNormal

Bethanidine iodide

Bethanidine iodide is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission.

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BRC0992
Product IDBRC0992
Product classBioreference compound
CAS number42200-33-9
MW309.4
Synonyms
Corgard; Solgol;
Transport conditionsNormal

Nadolol

Nadolol is a nonselective beta-adrenergic receptor antagonist with a long half-life. Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension.

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BRC0732
Product IDBRC0732
Product classBioreference compound
CAS number135-09-1
MW331.3
Synonyms
Leodrine, Metflorylthiazidine, NSC 44627, NaClex
Transport conditionsNormal

Hydroflumethiazide

Hydroflumethiazide is a anti-hypertensive and a diuretic. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0645
Product IDBRC0645
Product classBioreference compound
CAS number63-92-3
MW340.3
Synonyms
NSC 37448, Dibenzyran
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Phenoxybenzamine hydrochloride

Phenoxybenzamine is a cell-permeable, non-specific, irreversible AR (alpha-adrenergic) antagonist (IC50 = 2E-09 M) that also acts as an CaM inhibitor. Phenoxybenzamine inhibits calmodulin-stimulated phosphodiesterase activity.

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BRC0266
Product IDBRC0266
Product classBioreference compound
CAS number1443980-00-4
MW341.2
Synonyms
Anarel, Hylorel
Transport conditionsNormal

Guanadrel hydroiodide

Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter. Guanadrel slowly displaces norepinephrine from its storage in nerve endings and thereby blocks the release of norepinephrine normally produced by nerve stimulation.

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BRC0356
Product IDBRC0356
Product classBioreference compound
CAS number249607-96-3
MW341.4
Synonyms
Regitine, Vasomax
Transport conditionsNormal

Phentolamine acetate

Phentolamine is a reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities.

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BRC0846
Product IDBRC0846
Product classBioreference compound
CAS number56211-40-6
MW348.4
Synonyms
AC4464, BM02.015, JDL 464
Transport conditionsNormal

Torasemide

Torasemide is a loop diuretic. It inhibits the Na+/K+/2Cl- carrier system.

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BRC0867
Product IDBRC0867
Product classBioreference compound
CAS number26807-65-8
MW365.8
Synonyms
RHC 2555, S 1520, SE 1520, USV 2555
Transport conditionsNormal

Indapamide

Indapamide is an antihypertensive agent that reduces intracellular calcium levels.

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BRC0488
Product IDBRC0488
Product classBioreference compound
CAS number71653-63-9
MW367.3
Synonyms
Foridon, Foridone, PP 1466
Transport conditionsNormal

Riodipine

Riodipine is a calcium channel blocker.

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BRC0819
Product IDBRC0819
Product classBioreference compound
CAS number133-67-5
MW380.6
Synonyms
NSC 61560
Transport conditionsNormal

Trichlormethiazide

Trichloromethiazide is a thiazide diuretic, inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0383
Product IDBRC0383
Product classBioreference compound
CAS number19216-56-9
MW383.4
Synonyms
Adversuten, CP 12,299-1, NSC 292810, Hypovase, Minipress Xl, Pressin, Vasoflex
Transport conditionsNormal

Prazosin

Prazosin is an adrenergic α, α2B-adrenoceptor and a potent melatonin MT3 receptor antagonist.

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BRC0417
Product IDBRC0417
Product classBioreference compound
CAS number72509-76-3
MW384.2
Synonyms
CGH-869, Felodur ER, Felogard, Plendil Depottab, Plendil ER, Plendil Retard, Renedil, Splendil, Agon, H 154/82
Transport conditionsNormal

Felodipine

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction.

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BRC0095
Product IDBRC0095
Product classBioreference compound
CAS number84680-54-6
MW384.4
Synonyms
Enalapril acid, MK-422 Dihydrate
Transport conditionsNormal

Enalaprilat dihydrate

Enalaprilat is the active metabolite of the orally available pro-drug, enalapril. Used in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II.

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BRC0538
Product IDBRC0538
Product classBioreference compound
CAS number113578-26-0
MW388.4
Synonyms
KR 100
Transport conditionsNormal

m-Nisolpidine

The compound is Ca2+ channel antagonist.

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BRC0059
Product IDBRC0059
Product classBioreference compound
CAS number63675-72-9
MW388.4
Synonyms
Sular, Baymycard, Nisocor, Syscor, BAY K 5552
Transport conditionsNormal

Nisoldipine

Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction.

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BRC0757
Product IDBRC0757
Product classBioreference compound
CAS number67227-57-0
MW401.9
Synonyms
SKF 82526
Transport conditionsNormal

Fenoldopam mesylate

Fenoldopam is selective D1-like dopamine receptor partial agonist (EC50 = 57 nM) that is being considered for the parenteral treatment of systemic hypertension. Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α2-adrenoceptor antagonist in vitro (Ki = 15 - 25 nM).

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BRC0855
Product IDBRC0855
Product classBioreference compound
CAS number76547-98-3
MW405.5
Synonyms
MK 521, MK 522
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Lisinopril

Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII is a key component of the renin-angiotensin-aldosterone system (RAAS).

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BRC0853
Product IDBRC0853
Product classBioreference compound
CAS number72956-09-3
MW406.5
Synonyms
BM 14190, SKF 105517
Transport conditionsNormal

Carvedilol

Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity. Indicated for the treatment of hypertension and mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

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BRC0716
Product IDBRC0716
Product classBioreference compound
CAS number87333-19-5
MW416.5
Synonyms
Corpril, Delix, Ecator, HOE 498
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Ramipril

Ramipril is non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). It is prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction.

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BRC0371
Product IDBRC0371
Product classBioreference compound
CAS number66085-59-4
MW418.4
Synonyms
BAY E 9736, Admon, BAY-e 9736, Periplum
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Nimodipine

Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction.

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BRC0813
Product IDBRC0813
Product classBioreference compound
CAS number73-48-3
MW421.4
Synonyms
BE 724-A, FT 81
Transport conditionsNormal

Bendroflumethiazide

Bendroflumethiazide is a thiazide diuretic, inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0416
Product IDBRC0416
Product classBioreference compound
CAS number114798-26-4
MW422.9
Synonyms
Lortaan, DuP-753, MK 954
Transport conditionsNormal

Losartan

Losartan is the first of a class of antihypertensive agents called angiotensin II receptor blockers (ARBs). Losartan and its longer acting active metabolite, E-3174, are specific and selective type-1 angiotensin II receptor (AT1) antagonists which block the blood pressure increasing effects angiotensin II via the renin-angiotensin-aldosterone system (RAAS).

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BRC0028
Product IDBRC0028
Product classBioreference compound
CAS number144689-24-7
MW446.5
Synonyms
Erastapex, Golme, Olmetec, WinBP
Transport conditionsNormal

Olmesartan

Olmesartan is a specific angiotensin II type 1 (AT1) receptor antagonist, which blocks the blood pressure increasing effects of angiotensin II via the renin-angiotensin-aldosterone system (RAAS).

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BRC0785
Product IDBRC0785
Product classBioreference compound
CAS number33286-22-5
MW451.0
Synonyms
Adizem XL, Balcor, Cartia XT, Coras
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Diltiazem hydrochloride

Diltiazem hydrochloride is an antihypertensive and cardioprotective agent, calcium channel protein inhibitor. It regulates Ca2+ release from intracellular stores in neutrophils.

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BRC0353
Product IDBRC0353
Product classBioreference compound
CAS number74191-85-8
MW451.5
Synonyms
UK 33274, Cardura, Cascor
Transport conditionsNormal

Doxazosin

Doxazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Doxazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors.

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BRC0850
Product IDBRC0850
Product classBioreference compound
CAS number82586-55-8
MW475.0
Synonyms
C09AA06
Transport conditionsNormal

Quinapril hydrochloride

Quinapril hydrochloride is a prodrug, angiotensin-converting enzyme (ACE) inhibitor. It is metabolized to quinaprilat (quinapril diacid) following oral administration. Quinaprilat is a competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).

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