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Lipoxygenases

StructureProduct infoAvailabilityQuantity / Price
BRC1041
Product IDBRC1041
Product classBioreference compound
CAS number490-91-5
MW164.2
Synonyms
NSC 2228;
Transport conditionsNormal

Thymoquinone

Thymoquinone is a natural phytochemical with anti-inflammatory effects, blocking the synthesis of leukotrienes. It inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression.

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BRC1082
Product IDBRC1082
Product classBioreference compound
CAS number520-45-6
MW168.1
Synonyms
Biocide 470F; DHAA; DHS; Geogard 111A; NSC 8770;
Transport conditionsNormal

Dehydroacetic acid

Dehydroacetic acid is a fungicide and bactericide agent.

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BRC1022
Product IDBRC1022
Product classBioreference compound
CAS number331-39-5
MW180.2
Synonyms
DHCA; NSC 57197; NSC 623438;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Caffeic Acid

Caffeic Acid is an endogenous phenolic phytochemical compound. It non-competitive inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets at high doses. It has been observed to stimulate prostaglandin synthesis at high doses. It is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.

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BRC1030
Product IDBRC1030
Product classBioreference compound
CAS number92-84-2
MW199.3
Synonyms
Fenoverm; NSC 2037; Dibenzothiazine; ENT 38;
Transport conditionsNormal

Phenothiazine

Phenothiazine is a rigid, tricyclic thiazine useful as an electron donor. It was formerly used as an insecticide and as a drug to treat infections with parasitic worms (anthelminthic).

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BRC0580
Product IDBRC0580
Product classBioreference compound
CAS number773-76-2
MW214.0
Synonyms
Endiaron; NSC 3904; Quesyl; CHQ;
Transport conditionsNormal

Chloroxine

Chloroxine is a synthetic antibacterial compound. It inhibits the growth of gram-positive as well as some gram-negative organisms.

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BRC0329
Product IDBRC0329
Product classBioreference compound
CAS number66000-40-6
MW229.2
Synonyms
Transport conditionsNormal

BW 755C

BW-755C is a dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.

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BRC0187
Product IDBRC0187
Product classBioreference compound
CAS number111406-87-2
MW236.3
Synonyms
Zyflo, ICI D2138
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Zileuton

Zileuton is an asthma drug that differs chemically and pharmacologically from other antiasthmatic agents. It blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.

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BRC0903
Product IDBRC0903
Product classBioreference compound
CAS number847163-28-4
MW249.3
Synonyms
CID 664510
Transport conditionsNormal

ML351

ML351 is selective inhibitor of 12/15-lipoxygenase. It was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.

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BRC0989
Product IDBRC0989
Product classBioreference compound
CAS number15307-86-5
MW296.2
Synonyms
ISV-205;
Transport conditionsNormal

Diclofenac

Diclofenac is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties. It inhibits both leukocyte migration and the enzyme cyclooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis.

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BRC0842
Product IDBRC0842
Product classBioreference compound
CAS number80573-04-2
MW357.3
Synonyms
Colazide, Giazo
Transport conditionsNormal

Balsalazide

Balsalazide is a prodrug that produce mesalamine (5-aminosalicylic acid), an anti inflammatory drug.

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BRC0900
Product IDBRC0900
Product classBioreference compound
CAS number30544-47-9
MW369.3
Synonyms
BAY-D-1107, TVX485, WHR-5020
Transport conditionsNormal

Etofenamate

Etofenamate is a non-steroidal anti-inflammatory drug.

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BRC0702
Product IDBRC0702
Product classBioreference compound
CAS number599-79-1
MW398.4
Synonyms
NSC 203730, NSC 667219, Reupirin, Azulfin, Benzosulfa
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Sulfasalazine

Sulfasalazine is an anti-inflammatory (gastrointestinal). It is inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC).

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