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Dihydrofolate Reductase (DHFR)

StructureProduct infoAvailabilityQuantity / Price
BRC0171
Product IDBRC0171
Product classBioreference compound
CAS number54-85-3
MW137.1
Synonyms
Isonicotinic acid hydrazide, Isonicotinohydrazide, Nydrazid, Laniazid, Rimifon, INH
Transport conditionsNormal

Isoniazid

Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex.

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BRC1059
Product IDBRC1059
Product classBioreference compound
CAS number17557-67-4
MW228.3
Synonyms
Transport conditionsNormal

SKA 16

SKA 16 is an anticonvulsant agent.

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BRC0695
Product IDBRC0695
Product classBioreference compound
CAS number58-14-0
MW248.7
Synonyms
NSC 3061, RP 4753, Tindurin, WR 2978, BW 50-63, Chloridin
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Pyrimethamine

Pyrimethamine is dihydrofolate reductase inhibitor (Ki = 0.19 nM), generally used in combination with other antimicrobial agents. It is a potent inhibitor of multi-drug and toxin extrusion transporters.

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BRC0161
Product IDBRC0161
Product classBioreference compound
CAS number651-06-9
MW280.3
Synonyms
5-Methoxysulfadiazine
Transport conditionsNormal

Sulfameter

Sulfameter is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent in the treatment of urinary tract infections.

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BRC0128
Product IDBRC0128
Product classBioreference compound
CAS number152-53-4
MW288.2
Synonyms
Chloroguanide Triazine; NSC 3074;
Transport conditionsNormal

Cycloguanil hydrochloride

Cycloguanil hydrochloride is an active metabolite of proguanil, produced by the cytochrome P450 2C19 isoform. It acts as an inhibitor of dihydrofolate reductase (DHFR).

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BRC0036
Product IDBRC0036
Product classBioreference compound
CAS number637-32-1
MW290.2
Synonyms
Chloroguanide, Bigumal, Paludrin
Transport conditionsNormal

Proguanil hydrochloride

Proguanil is a biguanide derivative that is converted to an active metabolite called cycloguanil. It exerts its antimalarial action by inhibiting parasitic dihydrofolate reductase enzyme. It has causal prophylactic and suppressive activity against P. falciparum and cures the acute infection. It is also effective in suppressing the clinical attacks of vivax malaria.

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BRC0144
Product IDBRC0144
Product classBioreference compound
CAS number738-70-5
MW290.3
Synonyms
Proloprim, Trimpex, Monotrim, Bactramin, BW 56-72, NIH 204, NSC-106568
Transport conditionsNormal

Trimethoprim

Trimethoprim is a pyrimidine analogue that disrupts folate synthesis, an essential part of the thymidine synthesis pathway. Inhibition of the enzyme starves the bacteria of nucleotides necessary for DNA replication.The drug, therefore, exhibits bactericidal activity.

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BRC0848
Product IDBRC0848
Product classBioreference compound
CAS number2447-57-6
MW310.3
Synonyms
J21.373J, RO-4-4393, WR-4073
Transport conditionsNormal

Sulfadoxine

Sulfadoxine is a long acting sulfonamide, usually used in combination with other drugs, for respiratory, urinary tract, and malarial infections.

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BRC0089
Product IDBRC0089
Product classBioreference compound
CAS number59-05-2
MW454.4
Synonyms
Amethopterin, Rheumatrex, Trexall, Abitrexate
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Methotrexate

Methotrexate is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division.

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BRC0650
Product IDBRC0650
Product classBioreference compound
CAS number150399-23-8
MW471.4
Synonyms
LY-231514, LY231514, NSC-698037, Alimta
Transport conditionsNormal

Pemetrexed disodium

Pemetrexed disodium is high-affinity dihydrofolate reductase inhibitor (Ki = 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Indirectly activates AMPK. Inhibits proliferation of cancer cell lines in vitro.

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BRC0271
Product IDBRC0271
Product classBioreference compound
CAS number3546-41-6
MW1151.4
Synonyms
Poquil, Vanquil, Viprynium embonate
Transport conditionsNormal

Pyrvinium Pamoate

Pyrvinium (Viprynium) is an anthelmintic effective for pinworms. Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. Pyrvinium salts can also inhibit the growth of cancer cells.

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