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Antiemetic agents

StructureProduct infoAvailabilityQuantity / Price
BRC0421
Product IDBRC0421
Product classBioreference compound
CAS number85650-52-8
MW265.4
Synonyms
Org 3770, 6-Azamianserin, Avanza, Axit, Mirtabene, Mirtaz, Mirtazon, Norset, Promyrtil, Remergil, Remergon, Remeron, Remeron SolTab, Rexer, Zispin
Transport conditionsNormal

Mirtazapine

Mirtazapine, an antidepressant of the piperazinoazepine class, is a tetracyclic compound with an anxiolytic effect. Mirtazapine has fewer ADRs than tricyclic antidepressants and is better tolerated. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants.

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BRC0642
Product IDBRC0642
Product classBioreference compound
CAS number469-21-6
MW270.4
Synonyms
LS 127
Transport conditionsNormal

Doxylamine

Doxylamine is H1 histamine receptor antagonist. Doxylamine suppresses histamine at the H1 receptor.

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BRC0941
Product IDBRC0941
Product classBioreference compound
CAS number51-05-8
MW272.8
Synonyms
Novocaine; Vitamin H3; Duracaine; NSC 169497; Nissocaine;
Transport conditionsNormal

Procaine Hydrochloride

Procaine hydrochloride is a local anesthetic. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. It is a sodium channel blocker with a variety of inhibitory effects. Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1.

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BRC0930
Product IDBRC0930
Product classBioreference compound
CAS number147-24-0
MW291.8
Synonyms
Difenhydramine; DPH;
Transport conditionsNormal

Diphenhydramine Hydrochloride

Diphenhydramine hydrochloride is an analytical reference standard that is categorized as an antihistamine. It competes with free histamine for binding at HA-receptor sites.

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BRC0784
Product IDBRC0784
Product classBioreference compound
CAS number99614-02-5
MW293.4
Synonyms
GR 38032, Setron, Yatrox
Transport conditionsNormal

Ondansetron

Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.

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BRC0283
Product IDBRC0283
Product classBioreference compound
CAS number135729-61-2
MW296.4
Synonyms
Jiouting, Onicit, Palnox, Paloxi, Palzen, Themiset, Zhiruo, RS 25259, RS 25259 197
Transport conditionsNormal

Palonosetron

Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

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BRC0685
Product IDBRC0685
Product classBioreference compound
CAS number364-62-5
MW299.8
Synonyms
Afipran, Clopromate, DEL 1267
Transport conditionsNormal

Metoclopramide

Metoclopramide is dopamine D2 receptor antagonist. A labelled substituted benzamide with neuroleptic activity. Antiemetic.

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BRC0748
Product IDBRC0748
Product classBioreference compound
CAS number132539-06-1
MW312.4
Synonyms
ADAMED, Arenbil, Integrol, LY 170053
Transport conditionsNormal

Olanzapine

Olanzapine is serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic and antipsychotic activity.

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BRC0385
Product IDBRC0385
Product classBioreference compound
CAS number53-60-1
MW320.9
Synonyms
Sparine, Talofen
Transport conditionsNormal

Promazine hydrochloride

Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors.

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BRC0029
Product IDBRC0029
Product classBioreference compound
CAS number3254-89-5
MW345.9
Synonyms
Satanolon, Verterge, Vontro
Transport conditionsNormal

Diphenidol hydrochloride

Diphenidol is used for control of nausea and vomiting. It has an antivertigo effect on the vestibular apparatus, inhibiting the chemoreceptor trigger zone to control nausea and vomiting, thus preventing motion sickness.

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BRC0014
Product IDBRC0014
Product classBioreference compound
CAS number221180-26-3
MW350.2
Synonyms
Ticalopride hydrochloride;
Transport conditionsNormal

Norcisapride hydrochloride

A metabolite of Cisapride, serotonin 4 (5-HT4) receptor agonist.

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BRC0730
Product IDBRC0730
Product classBioreference compound
CAS number52-86-8
MW375.9
Synonyms
MCN-JR-1625; NSC-170973; NSC-615296; R-1625; Dozic; Einalon S; Eukystol;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Haloperidol

Haloperidol is butyrophenone antipsychotic, D2, D3, and D4 dopamine receptor antagonist. It is used primarily to treat schizophrenia and other psychoses.

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BRC0131
Product IDBRC0131
Product classBioreference compound
CAS number138-56-7
MW388.5
Synonyms
Benzacot, Stemetic, Tebamide, Tribenzagan, Tigan
Transport conditionsNormal

Trimethobenzamide

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

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BRC0352
Product IDBRC0352
Product classBioreference compound
CAS number50-02-2
MW392.5
Synonyms
MK 125, NSC 34521
Transport conditionsNormal

Dexamethasone

Dexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein in vitro.

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BRC0372
Product IDBRC0372
Product classBioreference compound
CAS number1104-22-9
MW463.9
Synonyms
Bonamine, Meclozine, NSC 28728, Parachloramine, Postafen
Transport conditionsNormal

Meclizine dihydrochloride

Meclizine Dihydrochloride is a pregnane X receptor (PXR) agonist and histamine H1 receptor antagonist. The compound also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor.

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BRC0264
Product IDBRC0264
Product classBioreference compound
CAS number170729-80-3
MW534.4
Synonyms
Emend; MK 869; UNII-1NF15YR6U; Aprecap;
Transport conditionsNormal

Aprepitant

Aprepitant is an anti-emetic compound that selectively antagonizes the human NK1 receptor (Kis = 3 and 454.1 nM for hNK1 and hNK3, respectively; IC50 = 0.09 nM for hNK1).

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BRC0402
Product IDBRC0402
Product classBioreference compound
CAS number84-02-6
MW606.1
Synonyms
Buccastem, Emetiral, Stemzine, Volimin
Transport conditionsNormal

Prochlorperazine dimaleate

Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.

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