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Carbonic Anhydrase

StructureProduct infoAvailabilityQuantity / Price
BRC0906
Product IDBRC0906
Product classBioreference compound
CAS number25363-69-3
MW141.2
Synonyms
Transport conditionsNormal

1-Hydroxy-4-methyl-2-pyridinethione

The compound is human carbonic anhydrase inhibitor.

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BRC1071
Product IDBRC1071
Product classBioreference compound
CAS number120-47-8
MW166.2
Synonyms
Mycocten; NSC 23514; NSC 8510; E 214; Easeptol;
Transport conditionsNormal

Ethylparaben

Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an anti-microbial agent and food additive. It is a standardized chemical allergen. The physiologic effect of ethylparaben is by means of increased histamine release, and cell-mediated immunity.

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BRC1057
Product IDBRC1057
Product classBioreference compound
CAS number4991-65-5
MW168.2
Synonyms
Camyna; OL 110; Stepin; Acnosan;
Transport conditionsNormal

Tioxolone

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor (Ki of 91 nM). It possess cytostatic, antipsoriatic, antibacterial and anti-mycotic properties. Tioxolone is also added to some cosmetics.

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BRC1078
Product IDBRC1078
Product classBioreference compound
CAS number149-91-7
MW170.1
Synonyms
NSC 20103; NSC 674319;
Transport conditionsNormal

Gallic acid

Gallic acid is an anti-inflammatory agent and cyclooxygenase inhibitor found in plants and has been shown to Induce apoptosis in human lung cancer cells. It is often used as a standard for determining the phenol content of various analytes by the Folin-Ciocalteau assay where results are reported in gallic acid equivalents.

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BRC0998
Product IDBRC0998
Product classBioreference compound
CAS number138-39-6
MW186.2
Synonyms
D06BA03; NSC-34632; Bensulfamide;
Transport conditionsNormal

Mafenide

Mafenide is a sulfonamide-type medication used to treat severe burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa.

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BRC1053
Product IDBRC1053
Product classBioreference compound
CAS number537-98-4
MW194.2
Synonyms
Transport conditionsNormal

Fumalic acid

Fumalic acid is an antioxidant.

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BRC0192
Product IDBRC0192
Product classBioreference compound
CAS number59-66-5
MW222.2
Synonyms
Defiltran, Diacarb, Diamox, Diluran, Glaupax
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Acetazolamide

Acetazolamide is a potent carbonic anhydrase inhibitor, effective in the control of fluid secretion, in the treatment of certain convulsive disorders and in the promotion of diuresis in instances of abnormal fluid retention.

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BRC0994
Product IDBRC0994
Product classBioreference compound
CAS number554-57-4
MW236.3
Synonyms
L-584601; VVP-808;
Transport conditionsNormal

Methazolamide

Methazolamide is a potent inhibitor of carbonic anhydrase. Used as a diuretic and in the treatment of glaucoma.

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BRC0843
Product IDBRC0843
Product classBioreference compound
CAS number532-03-6
MW241.2
Synonyms
NSC 170960
Transport conditionsNormal

Methocarbamol

Methocarbamol is centrally acting muscle relaxant whose mode of action has not been established.

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BRC1043
Product IDBRC1043
Product classBioreference compound
CAS number452-35-7
MW258.3
Synonyms
L 643786; NSC 10679; PNU 4191; Redupresin; U 4191;
Transport conditionsNormal

Ethoxzolamide

Ethoxzolamide is a membrane permeable carbonic anhydrase inhibitor. It causes inhibition of insulin degradation in vitro.

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BRC1019
Product IDBRC1019
Product classBioreference compound
CAS number146533-50-8
MW263.3
Synonyms
Transport conditionsNormal

4-(benzyloxy)benzenesulfonamide

4-(benzyloxy)benzenesulfonamide is an carbonic anhydrase inhibitor for cerebral ischemia therapy.

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BRC0651
Product IDBRC0651
Product classBioreference compound
CAS number58-94-6
MW295.7
Synonyms
Diutrid, Flumen, Minzil, NSC 25693, Alurene, Chlorosal
Transport conditionsNormal

Chlorothiazide

Chlorothiazide is an inhibitor of carbonic anhydrase (IC50 = 0.06 µM). This compound has been shown to block reabsorption of sodium and chloride ions.

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BRC0241
Product IDBRC0241
Product classBioreference compound
CAS number120-97-8
MW305.1
Synonyms
Diclofenamide
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Dichlorphenamide

Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure.

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BRC1076
Product IDBRC1076
Product classBioreference compound
CAS number130-26-7
MW305.5
Synonyms
Lekosept; NSC 3531; NSC 74938; Nioform;
Transport conditionsNormal

Clioquinol

Clioquinol is a broad-spectrum antibacterial with antifungal properties. It inhibits certain enzymes related to DNA replication.

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BRC1011
Product IDBRC1011
Product classBioreference compound
CAS number178606-66-1
MW309.3
Synonyms
NSC 213841; SLC 0111;
Transport conditionsNormal

U-104

U-104 is a ureido-sulfonamide inhibitor of transmembrane Carbonic anhydrase 9 (Ki = 45.1 nM) and Carbonic anhydrase 12 (Ki = 4.5 nM). It associates with CA9/CA12 only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.

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BRC1065
Product IDBRC1065
Product classBioreference compound
CAS number654-62-6
MW319.3
Synonyms
2,4-Disulfamoyl-5-trifluoromethylaniline; 5-Trifluoromethyl-2,4-disulfamoylaniline;
Transport conditionsNormal

NSC 44625

NSC 44625 is a carbonic anhydrase inhibitor. It is potential anti-tumor and antiglaucoma drug. Metabolite of hydroflumethazide, a diuretic.

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BRC0732
Product IDBRC0732
Product classBioreference compound
CAS number135-09-1
MW331.3
Synonyms
Leodrine, Metflorylthiazidine, NSC 44627, NaClex
Transport conditionsNormal

Hydroflumethiazide

Hydroflumethiazide is a anti-hypertensive and a diuretic. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC1047
Product IDBRC1047
Product classBioreference compound
CAS number133039-73-3
MW338.2
Synonyms
LDN 0097519; Lagistase; C.I. 55005; C.I. 75270; Alizarin yellow;
Transport conditionsNormal

Ellagic Acid

Ellagic acid is selective ATP-competitive inhibitor of casein kinase 2. It exhibits antioxidant, antitumor and antiproliferative activity.

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BRC0184
Product IDBRC0184
Product classBioreference compound
CAS number97240-79-4
MW339.4
Synonyms
McN-4853, RWJ-17021, Topamax, TPM
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Topiramate

Topiramate is an anticonvulsant indicated in the treatment of epilepsy and migraine. Topiramate enhances GABA-activated chloride channels. In addition, topiramate inhibits excitatory neurotransmission, through actions on kainate and AMPA receptors. There is evidence that topiramate has a specific effect on GluR5 kainate receptors.

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BRC0997
Product IDBRC0997
Product classBioreference compound
CAS number15676-16-1
MW341.4
Synonyms
Transport conditionsNormal

Sulpiride

Sulpiride is selective dopamine D2 antagonist with antipsychotic and antidepressant activity.

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BRC0819
Product IDBRC0819
Product classBioreference compound
CAS number133-67-5
MW380.6
Synonyms
NSC 61560
Transport conditionsNormal

Trichlormethiazide

Trichloromethiazide is a thiazide diuretic, inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0680
Product IDBRC0680
Product classBioreference compound
CAS number169590-42-5
MW381.4
Synonyms
Eurocox, Medicoxib, SC 58635, Xilebao, YM 177
Transport conditionsNormal

Celecoxib

Celecoxib is a selective cyclooxygenase-2 (Cox-2) inhibitor (IC50 = 40 nM) with low sensitivity against Cox-1. Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms.

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BRC0813
Product IDBRC0813
Product classBioreference compound
CAS number73-48-3
MW421.4
Synonyms
BE 724-A, FT 81
Transport conditionsNormal

Bendroflumethiazide

Bendroflumethiazide is a thiazide diuretic, inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0733
Product IDBRC0733
Product classBioreference compound
CAS number91-33-8
MW431.9
Synonyms
Freeuril, HyDrine, Lemazide, P 1393, Pfizer 1393, Proaqua
Transport conditionsNormal

Benzthiazide

Benzthiazide is used to treat hypertension and edema. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0662
Product IDBRC0662
Product classBioreference compound
CAS number111470-99-6
MW567.0
Synonyms
AM Arya 5, Alkapress, Regcor, Tensivask, UK 48340-26
Transport conditionsNormal

Amlodipine besylate

Amlodipine besylate is an L-type calcium channel blocker that displays antihypertensive properties. It also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).

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