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Cyclooxygenase (COX)

StructureProduct infoAvailabilityQuantity / Price
BRC0993
Product IDBRC0993
Product classBioreference compound
CAS number65-45-2
MW137.1
Synonyms
OHB;
Transport conditionsNormal

Salicylamide

Salicylamide is an analgesic and antipyretic agent. Its medicinal uses are similar to those of aspirin.

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BRC0859
Product IDBRC0859
Product classBioreference compound
CAS number69-72-7
MW138.1
Synonyms
FEMA NO. 3985; K-557; NSC-180;
Transport conditionsNormal

Salicylic acid

Salicylic acid is bacteriostatic, fungicide and keratolytic agent. It is directly and irreversibly inhibits the activity of COX-1 and COX-2 to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid.

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BRC0319
Product IDBRC0319
Product classBioreference compound
CAS number62-44-2
MW179.2
Synonyms
Achrocidin, Codempiral, Commotional, Contradol, Contradouleur
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Phenacetin

Phenacetin was the first NSAID and fever reducer to go on the market. Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action of the heart, where it acts as a negative inotrope.

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BRC0936
Product IDBRC0936
Product classBioreference compound
CAS number50-78-2
MW180.2
Synonyms
BAY1019036; NSC-27223; NSC-406186; ASA; Aspirin;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Acetylsalicylic acid

Acetylsalicylic acid is an anti-inflammatory and antipyretic agent and acts as the inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. It also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.

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BRC1046
Product IDBRC1046
Product classBioreference compound
CAS number4460-86-0
MW196.2
Synonyms
Gazarin; NSC 89299; TMBA;
Transport conditionsNormal

Asaraldehyde

Asaraldehyde is a COX-2 inhibitor with 17-fold selectivity over COX-1.

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BRC1030
Product IDBRC1030
Product classBioreference compound
CAS number92-84-2
MW199.3
Synonyms
Fenoverm; NSC 2037; Dibenzothiazine; ENT 38;
Transport conditionsNormal

Phenothiazine

Phenothiazine is a rigid, tricyclic thiazine useful as an electron donor. It was formerly used as an insecticide and as a drug to treat infections with parasitic worms (anthelminthic).

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BRC0827
Product IDBRC0827
Product classBioreference compound
CAS number51146-56-6
MW206.3
Synonyms
d-ibuproten; S(+)-ibuprofen;
Transport conditionsNormal

Dexibuprofen

Dexibuprofen is a non-steroidal anti-inflammatory drug. It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties.

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BRC0814
Product IDBRC0814
Product classBioreference compound
CAS number15687-27-1
MW206.3
Synonyms
NSC 256857; U-18753;
Transport conditionsNormal

Ibuprofen

Ibuprofen is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. It is a non-selective, reversible COX inhibitor (IC50 for human recombinant COX-1 and COX-2 are 2.6 and 1.53 µM, respectively).

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BRC1038
Product IDBRC1038
Product classBioreference compound
CAS number7598-91-6
MW219.2
Synonyms
Transport conditionsNormal

NSC 405600

NSC 405600 is cyclooxygenase inhibitor.

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BRC0329
Product IDBRC0329
Product classBioreference compound
CAS number66000-40-6
MW229.2
Synonyms
Transport conditionsNormal

BW 755C

BW-755C is a dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.

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BRC0826
Product IDBRC0826
Product classBioreference compound
CAS number22204-53-1
MW230.3
Synonyms
RS-3540;
Transport conditionsNormal

Naproxen

Naproxen is a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs with analgesic and antipyretic properties. It is non-selective cyclooxygenase inhibitor. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress.

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BRC0971
Product IDBRC0971
Product classBioreference compound
CAS number61-68-7
MW241.3
Synonyms
CI-473; CN-35355; INF-3355; J2.344B; M01AG01;
Transport conditionsNormal

Mefenamic acid

Mefenamic acid is a member of the fenamate group of nonsteroidal anti-inflammatory drugs. It exhibits anti-inflammatory, analgesic, and antipyretic activities. Mefenamic acid is a noncompetitive inhibitor of 2-arachidonoylglycerol oxygenation and a competitive inhibitor of COX-2 oxygenation of arachidonic acid.

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BRC1004
Product IDBRC1004
Product classBioreference compound
CAS number36330-85-5
MW254.3
Synonyms
CL 82,204;
Transport conditionsNormal

Fenbufen

Fenbufen is a non-steroidal anti-inflammatory drug. Used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures.

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BRC0718
Product IDBRC0718
Product classBioreference compound
CAS number22071-15-4
MW254.3
Synonyms
Orudis; Oruvail;
Transport conditionsNormal

Ketoprofen

Ketoprofen is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. It is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and alleviate moderate pain. Ketoprofen is a non-selective NSAID exhibiting IC50 values of 0.5 µM and 2.33 µM for human recombinant COX-1 and COX-2, respectively.

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BRC0413
Product IDBRC0413
Product classBioreference compound
CAS number74103-06-3
MW255.3
Synonyms
Acular LS®, Acular PF®, RS 37619, Sprix®, Bedoral, Dolten,
Transport conditionsNormal

Ketorolac

Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) chemically related to indomethacin and tolmetin. Ketorolac tromethamine is a racemic mixture of [-]S- and [+]R-enantiomeric forms, with the S-form having analgesic activity.

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BRC0479
Product IDBRC0479
Product classBioreference compound
CAS number530-78-9
MW281.2
Synonyms
Arlef, CI 440, CN 27544, INF 1837, NSC 219007, NSC 82699
Transport conditionsNormal

Flufenamic acid

Flufenamic acid is an anthranilic acid-derived nonsteroidal anti-inflammatory drug (NSAID) thought to exert its actions by a prostanoid-independent mechanism.

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BRC0980
Product IDBRC0980
Product classBioreference compound
CAS number4394-00-7
MW282.2
Synonyms
Lopac-N-0630; UP 83; NFA; Niflugel; Actol; Donalgin; Nifluril;
Transport conditionsNormal

Niflumic Acid

Niflumic acid is a nonsteroidal anti-inflammatory fenamate, is a Ca2+-activated Cl- channel blocker. It inhibits both phospholipase A2 as well as COX-2.

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BRC0989
Product IDBRC0989
Product classBioreference compound
CAS number15307-86-5
MW296.2
Synonyms
ISV-205;
Transport conditionsNormal

Diclofenac

Diclofenac is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties. It inhibits both leukocyte migration and the enzyme cyclooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis.

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BRC0166
Product IDBRC0166
Product classBioreference compound
CAS number67254-91-5
MW318.1
Synonyms
Meclofenamate, Arquel, Acide meclofenamique, Meclomen
Transport conditionsNormal

Meclofenamate sodium

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

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BRC0415
Product IDBRC0415
Product classBioreference compound
CAS number36322-90-4
MW331.4
Synonyms
Feldene; Larapam; NSC 666076; CP 16171; Bruxicam; Dolonex; Erazon; Improntal; Roxam; Roxiden; Sasulen; Solocalm; Trast;
Transport conditionsNormal

Piroxicam

Piroxicam is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Piroxicam works by reducing hormones that cause inflammation and pain in the body.

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BRC0367
Product IDBRC0367
Product classBioreference compound
CAS number53-86-1
MW357.8
Synonyms
Indocin
Transport conditionsNormal

Indomethacin

Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

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BRC0900
Product IDBRC0900
Product classBioreference compound
CAS number30544-47-9
MW369.3
Synonyms
BAY-D-1107, TVX485, WHR-5020
Transport conditionsNormal

Etofenamate

Etofenamate is a non-steroidal anti-inflammatory drug.

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BRC0680
Product IDBRC0680
Product classBioreference compound
CAS number169590-42-5
MW381.4
Synonyms
Eurocox, Medicoxib, SC 58635, Xilebao, YM 177
Transport conditionsNormal

Celecoxib

Celecoxib is a selective cyclooxygenase-2 (Cox-2) inhibitor (IC50 = 40 nM) with low sensitivity against Cox-1. Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms.

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BRC0229
Product IDBRC0229
Product classBioreference compound
CAS number57-96-5
MW404.5
Synonyms
Anturane, (+/-)-Sulfinpyrazone, Sulfoxyphenylpyrazolidine
Transport conditionsNormal

Sulfinpyrazone

A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

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BRC0540
Product IDBRC0540
Product classBioreference compound
CAS number261766-32-9
MW461.0
Synonyms
Transport conditionsNormal

LM 4108

LM 4108 is amide derivative of the nonsteroidal anti-inflammatory drug, indomethacin. It selective cyclooxygenase-2 inhibitor (IC50 = 0.04 µM).

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