EnamineStore

Welcome, Guest
Tutorials

Topoisomerase

StructureProduct infoAvailabilityQuantity / Price
BRC0408
Product IDBRC0408
Product classBioreference compound
CAS number389-08-2
MW232.2
Synonyms
NSC-82174
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Nalidixic Acid

Nalidixic acid is a quinolone antibacterial agent for oral administration. Nalidixic acid has marked antibacterial activity against gram-negative bacteria including Enterobacter species, Escherichia coli, Morganella Morganii; Proteus Mirabilis, Proteus vulgaris, and Providencia rettgeri. Pseudomonas species are generally resistant to the drug.

Product Page

In Stock(5 business days)  
BRC0364
Product IDBRC0364
Product classBioreference compound
CAS number70458-96-7
MW319.3
Synonyms
MK-0366
Transport conditionsNormal

Norfloxacin

Norfloxacin is a quinolone/fluoroquinolone antibiotic. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two.

Product Page

In Stock(5 business days)  
BRC0156
Product IDBRC0156
Product classBioreference compound
CAS number74011-58-8
MW320.3
Synonyms
Penetrex, Comprecin, AT-2266, CI919, Pd107779, NSC 629661
Transport conditionsNormal

Enoxacin

Enoxacin is a quinolone/fluoroquinolone antibiotic. Enoxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two.

Product Page

In Stock(5 business days)  
BRC0363
Product IDBRC0363
Product classBioreference compound
CAS number85721-33-1
MW331.3
Synonyms
Cipro IV, Bay o 9867
Transport conditionsNormal

Ciprofloxacin

Ciprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials.

Product Page

In Stock(5 business days)  
BRC0764
Product IDBRC0764
Product classBioreference compound
CAS number100986-85-4
MW361.4
Synonyms
MP-376, Cravit, DR 3355, HR 355
Transport conditionsNormal

Levofloxacin

Levofloxacin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. It inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase.

Product Page

In Stock(5 business days)  
BRC0369
Product IDBRC0369
Product classBioreference compound
CAS number82419-36-1
MW361.4
Synonyms
DL8280
Transport conditionsNormal

Ofloxacin

Ofloxacin is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two.

Product Page

In Stock(5 business days)  
BRC0727
Product IDBRC0727
Product classBioreference compound
CAS number110871-86-8
MW392.4
Synonyms
AT 4140, CI 978, CP 103826, PD 1315-1
Transport conditionsNormal

Sparfloxacin

Sparfloxacin is a synthetic fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Inhibits bacterial DNA gyrase (topoisomerase).

Product Page

In Stock(5 business days)  
BRC0864
Product IDBRC0864
Product classBioreference compound
CAS number123948-87-8
MW421.5
Synonyms
Hycamptin, NSC 609699, Nogitecan, SKF 10486
Transport conditionsNormal

Topotecan

Topotecan is a semi-synthetic derivative of camptothecin. It is anti-tumor drug with topoisomerase I inhibitory activity.

Product Page

In Stock(5 business days)  
BRC0663
Product IDBRC0663
Product classBioreference compound
CAS number1410809-37-8
MW483.4
Synonyms
Transport conditionsNormal

ACHN 975

ACHN 975 is a first-in-class LpxC inhibitor (IC50 = 0.02 nM).

Product Page

In Stock(5 business days)  
BRC0063
Product IDBRC0063
Product classBioreference compound
CAS number70476-82-3
MW517.4
Synonyms
DHAQ
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Mitoxantrone dihydrochloride

Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.

Product Page

In Stock(5 business days)  
BRC0053
Product IDBRC0053
Product classBioreference compound
CAS number25316-40-9
MW580.0
Synonyms
Adriamycin, Doxil, Adriablastin, Adriblastin, Rubex,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Doxorubicin hydrochloride

Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Product Page

In Stock(5 business days)  
BRC0117
Product IDBRC0117
Product classBioreference compound
CAS number100286-90-6
MW623.2
Synonyms
Camptosar, CPT-11, Irinotecanum
Transport conditionsNormal

Irinotecan hydrochloride

Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Irinotecan inhibits the action of topoisomerase I.

Product Page

In Stock(5 business days)  
BRC0231
Product IDBRC0231
Product classBioreference compound
CAS number1476-53-5
MW634.6
Synonyms
Streptonivicin, Inamycin
Transport conditionsNormal

Novobiocin sodium

Novobiocin is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by inhibiting the GyrB subunit of the enzyme involved in energy tranduction. Novobiocin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB.

Product Page

In Stock(5 business days)  
Display records per page

 

x
x