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Cytochrome P450 (CYP)

StructureProduct infoAvailabilityQuantity / Price
BRC0171
Product IDBRC0171
Product classBioreference compound
CAS number54-85-3
MW137.1
Synonyms
Isonicotinic acid hydrazide, Isonicotinohydrazide, Nydrazid, Laniazid, Rimifon, INH
Transport conditionsNormal

Isoniazid

Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex.

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BRC0582
Product IDBRC0582
Product classBioreference compound
CAS number487-19-4
MW158.2
Synonyms
NSC 127943, NSC 407276
Transport conditionsNormal

β-Nicotyrine

β-Nicotyrine is an alkaloid metabolite of nicotine. It binds CYP2A6 (IC50 = 2200nM), which is prominently involved in the metabolism of xenobiotics in the airways.

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BRC0878
Product IDBRC0878
Product classBioreference compound
CAS number54-11-5
MW162.2
Synonyms
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Nicotine

Nicotine is highly toxic alkaloid, nicotinic acetylcholine receptors agonist. In the brain, nicotine binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. It exhibits vasoconstrictive, hypertensive and prothrombotic activity.

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BRC0181
Product IDBRC0181
Product classBioreference compound
CAS number50-12-4
MW218.3
Synonyms
Mesantoin
Transport conditionsNormal

Mephenytoin

Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy.

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BRC0441
Product IDBRC0441
Product classBioreference compound
CAS number912291-11-3
MW231.3
Synonyms
Transport conditionsNormal

2-methyl-N-[[3-(trifluoromethyl)phenyl]methyl]propan-1-amine

Cytochrome P-450 enzyme inhibitor.

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BRC0623
Product IDBRC0623
Product classBioreference compound
CAS number125-84-8
MW232.3
Synonyms
BA 16038;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Aminoglutethimide

Aminoglutethimide is an aromatase inhibitor that blocks the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer.

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BRC0007
Product IDBRC0007
Product classBioreference compound
CAS number87-33-2
MW236.1
Synonyms
Carvasin; Cedocard retard; Flindix; ISDN; Isoket; Nitrosorbide; Sorbide nitrate;
Transport conditionsNormal

Isosorbide Dinitrate

Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris.

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BRC0796
Product IDBRC0796
Product classBioreference compound
CAS number53-16-7
MW270.4
Synonyms
NSC 9699, WAY 164397
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Estrone

Estrone is an estradiol metabolite, estrogen receptor agonist.

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BRC0787
Product IDBRC0787
Product classBioreference compound
CAS number112809-51-5
MW285.3
Synonyms
CGS 20267, Femara
Transport conditionsNormal

Letrozole

Letrozole is an aromatase inhibitor used in the treatment of breast cancer.

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BRC0144
Product IDBRC0144
Product classBioreference compound
CAS number738-70-5
MW290.3
Synonyms
Proloprim, Trimpex, Monotrim, Bactramin, BW 56-72, NIH 204, NSC-106568
Transport conditionsNormal

Trimethoprim

Trimethoprim is a pyrimidine analogue that disrupts folate synthesis, an essential part of the thymidine synthesis pathway. Inhibition of the enzyme starves the bacteria of nucleotides necessary for DNA replication.The drug, therefore, exhibits bactericidal activity.

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BRC0085
Product IDBRC0085
Product classBioreference compound
CAS number120511-73-1
MW293.4
Synonyms
Arimidex, anastrazole, Anastrozol, ZD-1033
Transport conditionsNormal

Anastrozole

Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. IC50 = 15 nM. Anastrozole is a potent and selective non-steroidal aromatase inhibitor indicated for the treatment of advanced breast cancer in post-menopausal women with disease progression following tamoxifen therapy.

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BRC0518
Product IDBRC0518
Product classBioreference compound
CAS number2444-46-4
MW293.4
Synonyms
8-Nordihydrocapsaicin, AH 23491X, NSC 172795, Pseudocapsaicin
Transport conditionsNormal

Nonivamide

Nonivamide is an capsaicinoid. Like capsaicin, it can deter mammals (but not birds or insects) from consuming plants or seeds. Nonivamide is a TRPV1 ion channel agonist. Mammalian TRPV1 is activated by heat and capsaicin, but the avian form is insensitive to capsaicin.

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BRC0918
Product IDBRC0918
Product classBioreference compound
CAS number70-18-8
MW307.3
Synonyms
GSH; Isethion; L-Glutathione Reduced;
Transport conditionsNormal

Glutathione

Glutathione reduces reactive oxygen species formed during cellular metabolism. Regulates activity of the redox-sensitive transcription factor NF-κB. Glutathione participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase.

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BRC0894
Product IDBRC0894
Product classBioreference compound
CAS number60628-96-8
MW310.4
Synonyms
Bay h 4502;
Transport conditionsNormal

Bifonazole

Bifonazole is antifungal, inhibits the production of ergosterol, which is an essential component of fungal cell membranes.

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BRC0169
Product IDBRC0169
Product classBioreference compound
CAS number53-19-0
MW320.0
Synonyms
Lysodren, Chlodithane, Mitotan, Chloditan, o,p'-DDD, NSC 38721, NCI-C04933
Transport conditionsNormal

Mitotane

A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

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BRC0072
Product IDBRC0072
Product classBioreference compound
CAS number52-01-7
MW416.6
Synonyms
Aldactone, Verospiron, Spiroctan
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Spironolactone

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM. Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics.

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BRC0767
Product IDBRC0767
Product classBioreference compound
CAS number144598-75-4
MW426.5
Synonyms
9-Hydroxyrisperidone, Paliperidone, Ro-76477
Transport conditionsNormal

Paliperidone

Paliperidone is an atypical antipsychotic, metabolite of risperidone. It exhibits high affinity for 5-HT2A receptors (Ki = 0.4 nM for cloned human 5-HT2A receptors). Also, displays high affinity for human D2 receptors.

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BRC0535
Product IDBRC0535
Product classBioreference compound
CAS number277309-46-3
MW452.4
Synonyms
Transport conditionsNormal

Vivid 2C9 Green

Vivid 2C9 Green is an inhibitor of human Cytochrome P450.

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BRC0766
Product IDBRC0766
Product classBioreference compound
CAS number863405-60-1
MW456.5
Synonyms
Transport conditionsNormal

JW74

JW 74 is an inhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3 beta /AXIN/APC). Decreases active β-catenin levels in colorectal cancer (CRC) cells. Also, arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro.

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BRC0130
Product IDBRC0130
Product classBioreference compound
CAS number82186-77-4
MW528.9
Synonyms
Benflumetol, HSDB 7210
Transport conditionsNormal

Lumefantrine

Lumefantrine is a blood schizonticide active against erythrocytic stages of Plasmodium falciparum.

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BRC0901
Product IDBRC0901
Product classBioreference compound
CAS number65277-42-1
MW531.4
Synonyms
Phytorol, R 41400, Tocon
Transport conditionsNormal

Ketoconazole

Ketoconazole is anti-fungal agent with potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. It is an inhibitor of cytochrome P-450 in steroid biosynthesis. Also acts as an inhibitor of 5-lipoxygenase and thromboxane synthase activities.

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