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Phosphodiesterases (PDE)

StructureProduct infoAvailabilityQuantity / Price
BRC0968
Product IDBRC0968
Product classBioreference compound
CAS number83-67-0
MW180.2
Synonyms
NSC-5039; SC-15090; Diurobromine;
Transport conditionsNormal

Theobromine

Theobromine is a purine alkaloid that is an adenosine receptor antagonist, weak PDE (phosphodiesterase) inhibitor. It is a diuretic and smooth-muscle relaxant.

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BRC0251
Product IDBRC0251
Product classBioreference compound
CAS number75448-53-2
MW180.2
Synonyms
Elixophyllin, Respbid, Theo-dur, Theolair, Uniphyl
Transport conditionsNormal

Theophylline

Theophylline, an xanthine derivative chemically similar to caffeine and theobromine, is used to treat asthma and bronchospasm. Theophylline has two distinct actions in the airways of patients with reversible (asthmatic) obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).

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BRC0719
Product IDBRC0719
Product classBioreference compound
CAS number41078-02-8
MW194.2
Synonyms
3-Propylxanthine, D 4028
Transport conditionsNormal

Enprofylline

Enprofylline is a synthetic dimethylxanthine derivative, it antagonizes erythrocyte phosphodiesterase, increasing cAMP activity.

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BRC0295
Product IDBRC0295
Product classBioreference compound
CAS number58-08-2
MW194.2
Synonyms
Methyltheobromine, NSC 5036
Transport conditionsNormal

Caffeine

Central nervous system stimulant. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.

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BRC0365
Product IDBRC0365
Product classBioreference compound
CAS number15421-84-8
MW205.3
Synonyms
Rocornal, Trapymin, Avantrin, Trapymine
Transport conditionsNormal

Trapidil

Trapidil interrupts the autocrine loop at the PDGF and PDGF-receptor level.Trapidil has proved to possess a significant antiproliferative activity. Trapidil is an anti-platelet drug active against various aggregating agents, such as collagen, ADP, arachidonic acid, PAF and calcium ionophore.

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BRC0079
Product IDBRC0079
Product classBioreference compound
CAS number78415-72-2
MW211.2
Synonyms
Primacor, Corotrop, Corotrope, Milrila, Win 47203
Transport conditionsNormal

Milrinone

Milrinone inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP (Cyclic adenosine monophosphate) activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Milrinone also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.

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BRC0178
Product IDBRC0178
Product classBioreference compound
CAS number36791-04-5
MW244.2
Synonyms
RBV; Rebretron; Ribamide; Vilona; Viramid; Virazide; NSC-163039; ICN-1229; RTCA; Tribavirin;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Ribavirin

Ribavirin is a guanosine analog with antiviral properties against DNA and RNA viruses, including respiratory syncytial virus, hepatitis C, and influenza.

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BRC0082
Product IDBRC0082
Product classBioreference compound
CAS number51-30-9
MW247.7
Synonyms
Norisodrine, Novodrin, Isopropydrin, Aludrine
Transport conditionsNormal

Isoproterenol hydrochloride

Isoproterenol is a relatively selective beta2-adrenergic bronchodilator. Isoproterenol is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease.

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BRC1295
Product IDBRC1295
Product classBioreference compound
CAS number51298-62-5
MW269.7
Synonyms
Transport conditionsNormal

L-NAME hydrochloride

L-NAME hydrochloride is a nonselective inhibitor of nitric oxide synthetases.

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BRC0655
Product IDBRC0655
Product classBioreference compound
CAS number58579-51-4
MW292.5
Synonyms
BL-4162A, Xagrid
Transport conditionsNormal

Anagrelide hydrochloride

Anagrelide hydrochloride is a potent PDE3 (type III phosphodiesterase) inhibitor (IC50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.

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BRC0473
Product IDBRC0473
Product classBioreference compound
CAS number34086-51-6
MW298.3
Synonyms
7-O-Methylbiochanin A, Biochanin A 7-methyl ether, Genistein-4,7-dimethylether
Transport conditionsNormal

NSC 604926

Derivative of Genistein. Genistein described as an angiogenesis inhibitor and a phytoestrogen.

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BRC0522
Product IDBRC0522
Product classBioreference compound
CAS number223500-15-0
MW299.2
Synonyms
Transport conditionsNormal

1-(4-aminophenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester

The compound is potent and selective inhibitors of PDE4 for use in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders.

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BRC0301
Product IDBRC0301
Product classBioreference compound
CAS number77469-98-8
MW334.4
Synonyms
UD-CG 115 BS, Vetmedin, Acardi, Heartmedin
Transport conditionsNormal

Pimobendan hydrochloride

Pimobendan is a positive inotrope (increases myocardial contractility). It sensitizes and increases the binding efficiency of cardiac troponin in the myofibril to the calcium ions that are already present in systole. Pimobendan also causes peripheral vasodilation by inhibiting the function of phosphodiesterase III.

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BRC0291
Product IDBRC0291
Product classBioreference compound
CAS number69-09-0
MW355.3
Synonyms
Chlorpromanyl, Largactil, Thorazine, J2.794D, NSC-167745, NSC-226514
Transport conditionsNormal

Chlorpromazine

Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It antagonizes a range of receptors, including post-synaptic dopamine and serotonin receptors.

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BRC0863
Product IDBRC0863
Product classBioreference compound
CAS number73963-72-1
MW369.5
Synonyms
OPC-13013, OPC-21
Transport conditionsNormal

Cilostazol

Cilostazol is cyclic AMP phosphodiesterase III inhibitor (PDE III inhibitor). It is used in the alleviation of the symptom of intermittent claudication in individuals with peripheral vascular disease.

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BRC0417
Product IDBRC0417
Product classBioreference compound
CAS number72509-76-3
MW384.2
Synonyms
CGH-869, Felodur ER, Felogard, Plendil Depottab, Plendil ER, Plendil Retard, Renedil, Splendil, Agon, H 154/82
Transport conditionsNormal

Felodipine

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction.

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BRC0865
Product IDBRC0865
Product classBioreference compound
CAS number171596-29-5
MW389.4
Synonyms
IC351, ICOS 351, Tadanafil, GF 196960, UK 336017
Transport conditionsNormal

Tadalafil

Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor. It is an orally adminstered drug used to treat male erectile dysfunction (impotence).

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BRC0382
Product IDBRC0382
Product classBioreference compound
CAS number985-12-6
MW434.0
Synonyms
Drotin, No-Spa, Taverin
Transport conditionsNormal

Drotaverine hydrochloride

Drotaverine is a spasmolytic agent by inhibiting PDE4 in smooth muscle cells. Drotaverine inhibits phosphodiesterases hydrolysing cAMP, thereby increasing cAMP concentration, decreasing Ca uptake of the cells and changing the distribution of calcium among the cells. It may also have minor allosteric calcium channel blocking properties.

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BRC0073
Product IDBRC0073
Product classBioreference compound
CAS number139755-83-2
MW474.6
Synonyms
VIAGRA, Revatio, UK-92480
Transport conditionsNormal

Sildenafil

Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5).

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BRC0394
Product IDBRC0394
Product classBioreference compound
CAS number224785-90-4
MW488.6
Synonyms
Levitra, Staxyn, Vivanza, BAY38-9456
Transport conditionsNormal

Vardenafil

Vardenafil is a PDE (phosphodiesterase) inhibitor that is selective for PDE5 and PDE1 (IC50 = 0.7 and 180 nM, respectively). Vardenafil is closely related to sildenafil and tadalafil in structure as well as function. Inhibition of PDE enzymes prevents the breakdown of secondary messenger molecules, enhancing the effect of signal transduction.

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BRC0122
Product IDBRC0122
Product classBioreference compound
CAS number58-32-2
MW504.6
Synonyms
Curantyl, Persantin, Dipyridamine, Persantine, NSC-515776
Transport conditionsNormal

Dipyridamole

Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders.

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BRC0411
Product IDBRC0411
Product classBioreference compound
CAS number54527-84-3
MW516.0
Synonyms
RS-69216, Cardene
Transport conditionsNormal

Nicardipine hydrochloride

Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

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BRC0662
Product IDBRC0662
Product classBioreference compound
CAS number111470-99-6
MW567.0
Synonyms
AM Arya 5, Alkapress, Regcor, Tensivask, UK 48340-26
Transport conditionsNormal

Amlodipine besylate

Amlodipine besylate is an L-type calcium channel blocker that displays antihypertensive properties. It also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).

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