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Dehydrogenase

StructureProduct infoAvailabilityQuantity / Price
BRC0242
Product IDBRC0242
Product classBioreference compound
CAS number7554-65-6
MW82.1
Synonyms
Antizol
Transport conditionsNormal

Fomepizole

Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.

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BRC1070
Product IDBRC1070
Product classBioreference compound
CAS number66-22-8
MW112.1
Synonyms
4-Hydroxyuracil; Hybar X; NSC 3970; Pirod;
Transport conditionsNormal

Uracil

Uracil is a pyrimidine derivative, one of the four nucleobases in the nucleic acid of RNA can be used for drug delivery and as a pharmaceutical. Uracil serves as allosteric regulator and coenzyme for reactions in the human body and in plants.

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BRC0961
Product IDBRC0961
Product classBioreference compound
CAS number98-92-0
MW122.1
Synonyms
Niacinamide; Nicotinic Acid Amide; NSC 13128; NSC 27452;
Transport conditionsNormal

Nicotinamide

Nicotinamide is an amide form of vitamin B3 (niacin), anti-inflammatory agent. It is poly(ADP-ribose) polymerase (PARP-1) enzymes inhibitor. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin-producing cells when used in combination with growth factors and high glucose concentration.

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BRC0248
Product IDBRC0248
Product classBioreference compound
CAS number98-97-5
MW124.1
Synonyms
2-Carboxypyrazine
Transport conditionsNormal

Pyrazinoic Acid

Pyrazinamide inhibits the activity of purified FAS I. It has also been suggested that the accumulation of pyrazinoic acid disrupts membrane potential and interferes with energy production, necessary for survival of M. tuberculosis at an acidic site of infection. Pyrazinoic acid has also been shown to bind to the ribosomal protein S1 (RpsA) and inhibit trans-translation.

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BRC0191
Product IDBRC0191
Product classBioreference compound
CAS number315-30-0
MW136.1
Synonyms
AL-100, Zyloprim
Transport conditionsNormal

Allopurinol

Allopurinol and its active metabolite, oxypurinol, inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypoxanthine and xanthine to uric acid.

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BRC0249
Product IDBRC0249
Product classBioreference compound
CAS number99-66-1
MW144.2
Synonyms
DPA, n-DPA, Valproate, VPA, Convulex, Depakine, Encorate, Epilim, Valcote, Valparin
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Valproic Acid

Valproic acid is a fatty acid with anticonvulsant properties used in the treatment of epilepsy.

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BRC1316
Product IDBRC1316
Product classBioreference compound
CAS number328-50-7
MW146.1
Synonyms
NSC 17391; 2-Ketoglutaric acid;
Transport conditionsNormal

2-Oxoglutaric acid

2-Oxoglutaric acid is an intermediate in the Krebs cycle catalyzed by glutamate dehydrogenase enzyme on glutamate.

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BRC1362
Product IDBRC1362
Product classBioreference compound
CAS number19771-63-2
MW147.2
Synonyms
L-2-Oxo-4-thiazolidinecarboxylic acid; R-2-Oxo-1,3-thiazolidine-4-carboxylic acid;
Transport conditionsNormal

Procysteine

Procysteine is a precursor to glutathione (GSH) which is an important antioxidant. This compound has also been found to stimulate gene expression of insulin-like growth factor-1, cardiotrophin-1, and ciliary neurotrophic factor.

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BRC1013
Product IDBRC1013
Product classBioreference compound
CAS number65-86-1
MW156.1
Synonyms
NSC 79560; NSC 9791; Animal galactose factor;
Transport conditionsNormal

Orotic Acid

Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid, forming pyrophosphate and orotidine 5′-monophosphate (OMP). It may be used to study dependent cell signaling pathways and transcription regulation mechanisms that induce hepatic lipogenesis.

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BRC1051
Product IDBRC1051
Product classBioreference compound
CAS number20098-14-0
MW166.2
Synonyms
Kemantane;
Transport conditionsNormal

Idramantone

Idramantone is an immune agonist.

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BRC0102
Product IDBRC0102
Product classBioreference compound
CAS number6112-76-1
MW170.2
Synonyms
Purinethol, 6-Thiopurine,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

6-Mercaptopurine monohydrate

Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.

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BRC1022
Product IDBRC1022
Product classBioreference compound
CAS number331-39-5
MW180.2
Synonyms
DHCA; NSC 57197; NSC 623438;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Caffeic Acid

Caffeic Acid is an endogenous phenolic phytochemical compound. It non-competitive inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets at high doses. It has been observed to stimulate prostaglandin synthesis at high doses. It is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.

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BRC1121
Product IDBRC1121
Product classBioreference compound
CAS number123-99-9
MW188.2
Synonyms
Finacea; Lepargylic acid; NSC 19493; Skinoren; ZK 62498;
Transport conditionsNormal

Azelaic Acid

Azelaic acid is an anti-inflammatory agent. It directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings.

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BRC0628
Product IDBRC0628
Product classBioreference compound
CAS number13721-01-2
MW189.2
Synonyms
Transport conditionsNormal

4-Quinolone-3-carboxylic acid

4-Quinolone-3-carboxylic acidis a novel HIV-1 integrase strand transfer inhibitor.

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BRC1186
Product IDBRC1186
Product classBioreference compound
CAS number81424-67-1
MW189.2
Synonyms
NSC 253272;
Transport conditionsNormal

Caracemide

Caracemide is a potential antineoplastic agent. It inhibits ribonuclease reductase, resulting in decreased DNA synthesis and tumor growth; it also inhibits acetylcholinesterase.

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BRC1053
Product IDBRC1053
Product classBioreference compound
CAS number537-98-4
MW194.2
Synonyms
Transport conditionsNormal

Fumalic acid

Fumalic acid is an antioxidant.

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BRC1313
Product IDBRC1313
Product classBioreference compound
CAS number1077-28-7
MW206.3
Synonyms
NSC 628502; NSC 90788; Octolipen; (±)-Lipoic acid; Thioctic acid;
Transport conditionsNormal

α-Liponic acid

α-Liponic acid is a metabolic antioxidant that regulates NFκB signal transduction and can protect against oxidative injury.

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BRC0585
Product IDBRC0585
Product classBioreference compound
CAS number73-31-4
MW232.3
Synonyms
BCI-049; J5.258B; NSC-113928; NSC-56423;
Transport conditionsNormal

Melatonin

Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate.

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BRC0178
Product IDBRC0178
Product classBioreference compound
CAS number36791-04-5
MW244.2
Synonyms
RBV; Rebretron; Ribamide; Vilona; Viramid; Virazide; NSC-163039; ICN-1229; RTCA; Tribavirin;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Ribavirin

Ribavirin is a guanosine analog with antiviral properties against DNA and RNA viruses, including respiratory syncytial virus, hepatitis C, and influenza.

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BRC0601
Product IDBRC0601
Product classBioreference compound
CAS number80025-67-8
MW252.2
Synonyms
Transport conditionsNormal

5-Amino-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carbonitrile

The compound is potent xanthine oxidase inhibitor (IC50 > 100 µM).

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BRC0203
Product IDBRC0203
Product classBioreference compound
CAS number108605-62-5
MW270.2
Synonyms
a 77-1726; Aubagio; HMR1726;
Transport conditionsNormal

(E, Z) - Teriflunomide

Teriflunomide is an immunomodulatory agent that decreases the amount of activated CNS lymphocytes, which results in anti-inflammatory and antiproliferative effects.

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BRC0243
Product IDBRC0243
Product classBioreference compound
CAS number75706-12-6
MW270.2
Synonyms
Arava, HW 486, Avara, SU 101
Transport conditionsNormal

Leflunomide

Leflunomide is a pyrimidine synthesis inhibitor indicated in adults for the treatment of active rheumatoid arthritis (RA).

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BRC0493
Product IDBRC0493
Product classBioreference compound
CAS number327093-42-5
MW271.4
Synonyms
T 0504
Transport conditionsNormal

Merck 544

Merck 544 is an inhibitor of human 11beta-HSD1.

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BRC0753
Product IDBRC0753
Product classBioreference compound
CAS number50-28-2
MW272.4
Synonyms
E3A, NSC 17590, NSC-20293, NSC-9895, SQ 16150, WC-3011
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Estradiol

Estradiol is endogenous estrogen receptor (ER) agonist (Ki = 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.

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BRC0062
Product IDBRC0062
Product classBioreference compound
CAS number97-77-8
MW296.5
Synonyms
Tetraethylthiuram disulfide, Antabuse, Anticol, Esperal, NSC 190940
Transport conditionsNormal

Disulfiram

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase. 

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BRC0043
Product IDBRC0043
Product classBioreference compound
CAS number797-63-7
MW312.5
Synonyms
Levonorgestrel, Methylnorethindrone, Logynon, Nordette, Eugynon, Microgynon, Ovran, Ovranette, Trinordiol
Transport conditionsNormal
Restrictions Included in DEA controlled list

(-) - Norgestrel

(-) - Norgestrel is a synthetic progesterone analog and the biologically active component of norgestrel, which is a racemic mixture. Levonorgestrel prevents pregnancy by inhibiting ovulation and by causing the cervical mucous to thicken, which makes it harder for sperm to move toward the uterus. Levonorgestrel exhibits approximately three-times higher binding affinity than progesterone for the progesterone receptor.

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BRC0215
Product IDBRC0215
Product classBioreference compound
CAS number144060-53-7
MW316.4
Synonyms
Uloric, Adenuric, TMX 67, TEI-6720, Atenurix, Barif, Feburic
Transport conditionsNormal

Febuxostat

Febuxostat, a xanthine oxidase inhibitor, achieves its therapeutic effect by decreasing serum uric acid. Febuxostat is not expected to inhibit other enzymes involved in purine and pyrimidine synthesis and metabolism at therapeutic concentrations.

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BRC0458
Product IDBRC0458
Product classBioreference compound
CAS number4727-31-5
MW317.3
Synonyms
Transport conditionsNormal

Kartogenin

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM.

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BRC0509
Product IDBRC0509
Product classBioreference compound
CAS number82158-86-9
MW319.4
Synonyms
Kinedak; ONO 2235; Sorbista;
Transport conditionsNormal

Epalrestat

Epalrestat is a carboxylic acid-based inhibitor of aldose reductase (IC50 = 0.01-15 μM). Epalrestat has been shown to reduce oxidative stress in type 2 diabetic patients, significantly decreasing lipid hydroperoxide levels in erythrocytes when administered at 150 mg/day.

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BRC0165
Product IDBRC0165
Product classBioreference compound
CAS number24280-93-1
MW320.3
Synonyms
Mycophenolate, Myfortic, Melbex, Mycophenolsaeure, RS-61443
Transport conditionsNormal

Mycophenolic Acid

Mycophenolic acid is an antibiotic substance derived from Penicillium stoloniferum. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase.

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BRC0195
Product IDBRC0195
Product classBioreference compound
CAS number13647-35-3
MW329.4
Synonyms
WIN 24540, Desopan, Modrefen, Vetoryl
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Trilostane

Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol.

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BRC0361
Product IDBRC0361
Product classBioreference compound
CAS number66-76-2
MW336.3
Synonyms
Dicumarol, 3,3'-Methylenebis(4-hydroxycoumarin), Bishydroxycoumarin, NSC 17860, NSC 41834, NSC 221570
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Dicoumarol

Dicoumarol is a reductase inhibitor possessing anticoagulant properties. Dicoumarol also aids in apoptosis induction via stimulation of SAPK-JNK and NF-κB pathway blocking.

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BRC0778
Product IDBRC0778
Product classBioreference compound
CAS number63-45-6
MW357.3
Synonyms
SN 13272, WR 2975, NSC 27296
Transport conditionsNormal

Primaquine phosphate

Primaquine phosphate is an antimalarial agent with genotoxicity (Ames test) and cardiotoxicity (inhibitor of cardiac Na+ current).

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BRC0836
Product IDBRC0836
Product classBioreference compound
CAS number50-23-7
MW362.5
Synonyms
NSC-10483
Transport conditionsNormal

Hydrocortisone

Hydrocortisone is steroid hormone of the adrenal cortex with anti-inflammatory properties.

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BRC0218
Product IDBRC0218
Product classBioreference compound
CAS number95233-18-4
MW366.8
Synonyms
Acuvel, Mepron, Wellvone, Atovaquone
Transport conditionsNormal

Atovaquone

Atovaquone is antipneumocystic hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport.

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BRC0786
Product IDBRC0786
Product classBioreference compound
CAS number98319-26-7
MW372.6
Synonyms
MK 906,
Transport conditionsNormal

Finasteride

Finasteride is a competitive and specific inhibitor of Type II 5a-reductase, an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT).

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BRC0305
Product IDBRC0305
Product classBioreference compound
CAS number83-44-3
MW392.6
Synonyms
NSC-8797, Deoxycholate, Desoxycholic acid, Cholerebic, Cholorebic, ATX-101
Transport conditionsNormal

Deoxycholic acid

Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue.

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BRC0853
Product IDBRC0853
Product classBioreference compound
CAS number72956-09-3
MW406.5
Synonyms
BM 14190, SKF 105517
Transport conditionsNormal

Carvedilol

Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity. Indicated for the treatment of hypertension and mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

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BRC0919
Product IDBRC0919
Product classBioreference compound
CAS number1191951-57-1
MW409.6
Synonyms
Transport conditionsNormal

PHT 427

PHT-427 is a pleckstrin homology domain inhibitor to Akt and PKB Kinase (PDPK1).

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BRC0677
Product IDBRC0677
Product classBioreference compound
CAS number459147-39-8
MW412.6
Synonyms
Transport conditionsNormal

SW 033291

SW033291 is an inhibitor of of the enzyme 15-hydroxy prostaglandin dehydrogenase (IC50 = 0.54 nM), which initiates the catabolism of PGs and related eicosanoids. It increases prostaglandin PGE2 levels in vitro which was shown to effect the liver, bones, tissues, and cancer cells in vitro.

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BRC0072
Product IDBRC0072
Product classBioreference compound
CAS number52-01-7
MW416.6
Synonyms
Aldactone, Verospiron, Spiroctan
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Spironolactone

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM. Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics.

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BRC0506
Product IDBRC0506
Product classBioreference compound
CAS number312276-03-2
MW454.5
Synonyms
Transport conditionsNormal

2,6-bis(3,4,5-trimethoxyphenylmethylene)cyclohexanone

Inhibits human 17β-HSD3 with IC50 of 0.1 μM.

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BRC0271
Product IDBRC0271
Product classBioreference compound
CAS number3546-41-6
MW1151.4
Synonyms
Poquil, Vanquil, Viprynium embonate
Transport conditionsNormal

Pyrvinium Pamoate

Pyrvinium (Viprynium) is an anthelmintic effective for pinworms. Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. Pyrvinium salts can also inhibit the growth of cancer cells.

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