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Antidiabetic

StructureProduct infoAvailabilityQuantity / Price
BRC0148
Product IDBRC0148
Product classBioreference compound
CAS number1115-70-4
MW165.6
Synonyms
Glucophage, Dimethylbiguanide, Glumetza, Metiguanide
Transport conditionsNormal

Metformin hydrochloride

Metformin is an oral antihyperglycemic agent that improves glucose tolerance in patients with NIDDM, lowering both basal and postprandial plasma glucose.

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BRC1078
Product IDBRC1078
Product classBioreference compound
CAS number149-91-7
MW170.1
Synonyms
NSC 20103; NSC 674319;
Transport conditionsNormal

Gallic acid

Gallic acid is an anti-inflammatory agent and cyclooxygenase inhibitor found in plants and has been shown to Induce apoptosis in human lung cancer cells. It is often used as a standard for determining the phenol content of various analytes by the Folin-Ciocalteau assay where results are reported in gallic acid equivalents.

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BRC1022
Product IDBRC1022
Product classBioreference compound
CAS number331-39-5
MW180.2
Synonyms
DHCA; NSC 57197; NSC 623438;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Caffeic Acid

Caffeic Acid is an endogenous phenolic phytochemical compound. It non-competitive inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets at high doses. It has been observed to stimulate prostaglandin synthesis at high doses. It is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.

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BRC1171
Product IDBRC1171
Product classBioreference compound
CAS number1190-53-0
MW193.7
Synonyms
Sindiatil; Tidemol; Ziavetine; W-37;
Transport conditionsNormal

Buformin hydrochloride

Buformin hydrochloride is a antihyperglycemic agent. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis.

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BRC0159
Product IDBRC0159
Product classBioreference compound
CAS number72432-03-2
MW207.2
Synonyms
Glyset, Diastabol, Seibule, Plumarol, BAY-M-1099
Transport conditionsNormal

Miglitol

Miglitol, an oral alpha-glucosidase inhibitor, is a desoxynojirimycin derivative that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. As a consequence of plasma glucose reduction, miglitol reduce levels of glycosylated hemoglobin in patients with Type II (non-insulin-dependent) diabetes mellitus.

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BRC0947
Product IDBRC0947
Product classBioreference compound
CAS number68-35-9
MW250.3
Synonyms
Adiazine;
Transport conditionsNormal

Sulfadiazine

Sulfadiazine is a sulfonamide antibiotic with a wide spectrum against most gram-positive and many gram-negative organisms. It is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase.

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BRC0986
Product IDBRC0986
Product classBioreference compound
CAS number723-46-6
MW253.3
Synonyms
NSC-147832; RO 4-2130; STX-608; Gantanol; SMX;
Transport conditionsNormal

Sulfamethoxazole

Sulfamethoxazole is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid for binding to dihydropteroate synthetase (dihydrofolate synthetase).

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BRC1049
Product IDBRC1049
Product classBioreference compound
CAS number486-66-8
MW254.2
Synonyms
Daidzin aglycone; FW 635I-1; Isoaurostatin; K 251b; NPI 031E;
Transport conditionsNormal

Daidzein

Daidzein is the aglucon of Daidzin, an inactive analog of Genistein, a tyrosine kinase inhibitor, that allows it to act as a negative control for such experiments. It is a phytoestrogen which may play a role in hormone-produced cancers.

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BRC1000
Product IDBRC1000
Product classBioreference compound
CAS number127-69-5
MW267.3
Synonyms
NSC 13120; NSC 33807; NSC 38588; NSC 683536; Sulsoxin; Thiasin; Gantrosan; Isoxamin;
Transport conditionsNormal

Sulfisoxazole

Sulfisoxazole is a sulfonamide antibiotic with a wide spectrum against most gram-positive and many gram-negative organisms. It is a competitive inhibitor of the enzyme dihydropteroate synthetase, selective ETA endothelin receptor antagonist.

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BRC0964
Product IDBRC0964
Product classBioreference compound
CAS number64-77-7
MW270.4
Synonyms
NSC-23813; NSC-87833; D 860; U-2043;
Transport conditionsNormal

Tolbutamide

Tolbutamide is a first-generation sulfonylurea antidiabetic agent, used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Tolbutamide is an inhibitor of sulfonylurea receptor 1 linked to inwardly rectifying potassium channel KIR6.2.

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BRC1045
Product IDBRC1045
Product classBioreference compound
CAS number1376324-09-2
MW283.2
Synonyms
Transport conditionsNormal

N-(cyclohexylmethyl)guanidine hydroiodide

N-(cyclohexylmethyl)guanidine hydroiodide is posible antidiabetic agent.

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BRC0534
Product IDBRC0534
Product classBioreference compound
CAS number300851-67-6
MW294.8
Synonyms
Transport conditionsNormal

4-CMTB

4-CMTB is a free fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. It modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).

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BRC0779
Product IDBRC0779
Product classBioreference compound
CAS number274901-16-5
MW303.4
Synonyms
DSP 7238, Equa, Galvus, LAF 237, NVP-LAF 237
Transport conditionsNormal

Vildagliptin

Vildagliptin is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase.

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BRC0734
Product IDBRC0734
Product classBioreference compound
CAS number1156-19-0
MW311.4
Synonyms
NSC 70762, Norglycin, Tolinase, U 17835
Transport conditionsNormal

Tolazamide

Tolazamide is an oral blood glucose lowering drug. It appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets.

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BRC0065
Product IDBRC0065
Product classBioreference compound
CAS number361442-04-8
MW315.4
Synonyms
Onglyza, BMS-477118,
Transport conditionsNormal

Saxagliptin

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes.

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BRC0163
Product IDBRC0163
Product classBioreference compound
CAS number105816-04-4
MW317.4
Synonyms
Starlix, Starsis, Fastic, Senaglinide, A-4166
Transport conditionsNormal

Nateglinide

Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release.

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BRC0509
Product IDBRC0509
Product classBioreference compound
CAS number82158-86-9
MW319.4
Synonyms
Kinedak; ONO 2235; Sorbista;
Transport conditionsNormal

Epalrestat

Epalrestat is a carboxylic acid-based inhibitor of aldose reductase (IC50 = 0.01-15 μM). Epalrestat has been shown to reduce oxidative stress in type 2 diabetic patients, significantly decreasing lipid hydroperoxide levels in erythrocytes when administered at 150 mg/day.

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BRC0761
Product IDBRC0761
Product classBioreference compound
CAS number1469924-27-3
MW319.8
Synonyms
Transport conditionsNormal

Atglistatin hydrochloride

Atglistatin hydrochloride is a selective inhibitor of adipose triglyceride lipase (IC50 = 0.7 μM) and reduces fatty acid mobilization in vitro and in vivo.

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BRC0240
Product IDBRC0240
Product classBioreference compound
CAS number968-81-0
MW324.4
Synonyms
Dimelin, Dymelor, Gamadiabet
Transport conditionsNormal

Acetohexamide

Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea. Sulfonylureas such as acetohexamide bind to an ATP-dependent K+ channel on the cell membrane of pancreatic beta cells.

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BRC0696
Product IDBRC0696
Product classBioreference compound
CAS number332939-46-5
MW326.8
Synonyms
Transport conditionsNormal

N-[(5-Chloro-8-hydroxyquinolin-7-yl)(phenyl)methyl]acetamide

The compound is inhibitor of HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction (IC50 = 3 µM).

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BRC0763
Product IDBRC0763
Product classBioreference compound
CAS number1798751-25-3
MW337.4
Synonyms
Transport conditionsNormal

4-[(5-Methyl-2-phenyl-4-oxazolyl)methoxy]benzenepropanoic acid

The compound is a potent and selective agonists of free fatty acid receptor 1 (GPR40) (EC50 = 0.058 µM) and has potential antidiabetic activity.

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BRC1047
Product IDBRC1047
Product classBioreference compound
CAS number133039-73-3
MW338.2
Synonyms
LDN 0097519; Lagistase; C.I. 55005; C.I. 75270; Alizarin yellow;
Transport conditionsNormal

Ellagic Acid

Ellagic acid is selective ATP-competitive inhibitor of casein kinase 2. It exhibits antioxidant, antitumor and antiproliferative activity.

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BRC0868
Product IDBRC0868
Product classBioreference compound
CAS number112529-15-4
MW392.9
Synonyms
U72107A
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Pioglitazone hydrochloride

Pioglitazone hydrochloride is a selective agonist at peroxisome proliferator activated receptor gamma (PPARγ) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. It is used as an antidiabetic.

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BRC0485
Product IDBRC0485
Product classBioreference compound
CAS number303126-97-8
MW397.7
Synonyms
Transport conditionsNormal

SR 0987

SR 0987 is an T cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.

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BRC0061
Product IDBRC0061
Product classBioreference compound
CAS number486460-32-6
MW407.3
Synonyms
Januvia, Xelevia, Sitagliptan,
Transport conditionsNormal

Sitagliptin

Sitagliptin is a highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones, thereby increasing the concentration and prolonging the action of these hormones.

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BRC0739
Product IDBRC0739
Product classBioreference compound
CAS number851331-58-3
MW417.4
Synonyms
Transport conditionsNormal

6,​7-​dimethoxy-​1-​[(4-​methoxy-​1-​naphthalenyl)​carbonyl]​-4-​Isoquinolinecarboxyl​ic acid

The compound is acylisoquinoline, glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitor (IC50 = 3.25 µM).

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BRC0881
Product IDBRC0881
Product classBioreference compound
CAS number777075-57-7
MW418.3
Synonyms
Transport conditionsNormal

GQ-16

GQ-16 is a novel effective inhibitor of Cdk5-mediated phosphorylation of PPARγ, promotes insulin sensitization without weight gain.

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BRC0754
Product IDBRC0754
Product classBioreference compound
CAS number602293-00-5
MW419.5
Synonyms
Transport conditionsNormal

N-(3-Acetylphenyl)-9-amino-2,3-dihydro-1,4-dioxino[2,3-g]thieno[2,3-b]quinoline-8-carboxamide

The compound is a novel disruptor of the PKCε/RACK2 protein-protein interaction.

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BRC0636
Product IDBRC0636
Product classBioreference compound
CAS number865231-46-5
MW438.4
Synonyms
Transport conditionsNormal

[3H]-AMG 837

[3H]-AMG 837 is a potent free fatty acid receptor 1 agonist (EC50 = 1.3 nM).

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BRC0735
Product IDBRC0735
Product classBioreference compound
CAS number29094-61-9
MW445.5
Synonyms
Aldiab, CP 28720, Digrin, K 4024, Melizide
Transport conditionsNormal

Glipizide

Glipizide is an oral hypoglycemic agent which is rapidly absorbed and completely metabolized. It is a second-generation sulfonylurea, is used with diet to lower blood glucose in patients with diabetes mellitus type II.

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BRC0762
Product IDBRC0762
Product classBioreference compound
CAS number135062-02-1
MW452.6
Synonyms
AG-EE 623ZW, AGEE 623, Eurepa
Transport conditionsNormal

Repaglinide

Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release.

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BRC0670
Product IDBRC0670
Product classBioreference compound
CAS number1280193-99-8
MW472.0
Synonyms
Transport conditionsNormal

({1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}methyl)[3-(4-ethoxyphenoxy)-2-methoxypropyl]methylamine

The compound is Toll-like receptor 4 inhibitor (IC50 = 19.8 µM). It displays TLR4-mediated inflammation inhibition, potential antiseptic.

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BRC0016
Product IDBRC0016
Product classBioreference compound
CAS number155141-29-0
MW473.5
Synonyms
Avandia, Brl-49653, Rosiglizole, BRL49653,
Transport conditionsNormal

Rosiglitazone maleate

Rosiglitazone acts as a highly selective and potent agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin.

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BRC0871
Product IDBRC0871
Product classBioreference compound
CAS number93479-97-1
MW490.6
Synonyms
HOE-490
Transport conditionsNormal

Glimepiride

Glimepiride is potent Kir6 (KATP) channel blocker and anti-diabetic agent. It is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells.

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BRC0377
Product IDBRC0377
Product classBioreference compound
CAS number10238-21-8
MW494.0
Synonyms
Glibenclamide, Micronase
Transport conditionsNormal

Glyburide

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production.

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BRC0723
Product IDBRC0723
Product classBioreference compound
CAS number1589527-65-0
MW518.5
Synonyms
Transport conditionsNormal

KIRA 6

KIRA 6 is an allosteric inhibitor of IRE1α RNase, preserves cell viability and function in ER-stressed retinitis pigmentosa and diabetes model cells.

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BRC0366
Product IDBRC0366
Product classBioreference compound
CAS number33342-05-1
MW527.6
Synonyms
Glurenorm
Transport conditionsNormal

Gliquidone

Gliquidone is an anti-diabetic drug in the sulfonylurea class.

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BRC0075
Product IDBRC0075
Product classBioreference compound
CAS number56180-94-0
MW645.6
Synonyms
Precose, Glucobay, Prandase, AC1L9APL, BAY g 5421
Transport conditionsNormal

Acarbose

Acarbose is a complex oligosaccharide that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. Acarbose binds to and inhibits alpha amylase and alpha-gluocside hydrolases. In diabetic patients, this enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia.

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