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Histone deacetylases (HDAC)

StructureProduct infoAvailabilityQuantity / Price
BRC0249
Product IDBRC0249
Product classBioreference compound
CAS number99-66-1
MW144.2
Synonyms
DPA, n-DPA, Valproate, VPA, Convulex, Depakine, Encorate, Epilim, Valcote, Valparin
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Valproic Acid

Valproic acid is a fatty acid with anticonvulsant properties used in the treatment of epilepsy.

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BRC1034
Product IDBRC1034
Product classBioreference compound
CAS number3565-26-2
MW174.2
Synonyms
Hydron III;
Transport conditionsNormal

NSC 3852

NSC 3852 is histone deacetylase inhibitor that causes cell differentiation and has antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo.

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BRC0251
Product IDBRC0251
Product classBioreference compound
CAS number75448-53-2
MW180.2
Synonyms
Elixophyllin, Respbid, Theo-dur, Theolair, Uniphyl
Transport conditionsNormal

Theophylline

Theophylline, an xanthine derivative chemically similar to caffeine and theobromine, is used to treat asthma and bronchospasm. Theophylline has two distinct actions in the airways of patients with reversible (asthmatic) obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).

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BRC1053
Product IDBRC1053
Product classBioreference compound
CAS number537-98-4
MW194.2
Synonyms
Transport conditionsNormal

Fumalic acid

Fumalic acid is an antioxidant.

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BRC0648
Product IDBRC0648
Product classBioreference compound
CAS number926259-99-6
MW214.2
Synonyms
Pyrazin-2-carbonsaeure-(2-amino-anilid)
Transport conditionsNormal

BG45

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 0.1396 μM). HDACs represent novel targets for anti-tumor drugs treating various cancers including multiple myeloma cancer.

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BRC0299
Product IDBRC0299
Product classBioreference compound
CAS number99873-43-5
MW243.7
Synonyms
NS 41080,
Transport conditionsNormal

Droxinostat

Droxinostat inhibits proliferation and colony formation of the HCC cell lines examined. Droxinostat suppresses HDAC3 expression and induces histone acetylation and HCC cell death through activation of the mitochondrial apoptotic pathway and downregulation of FLIP, supporting its potential application in the treatment of HCC.

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BRC0112
Product IDBRC0112
Product classBioreference compound
CAS number149647-78-9
MW264.3
Synonyms
SAHA; Zolinza; Suberanilohydroxamic acid; MK0683;
Transport conditionsNormal

Vorinostat

Vorinostat inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50 86 nM).

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BRC0306
Product IDBRC0306
Product classBioreference compound
CAS number1299346-14-7
MW305.8
Synonyms
CI994, PD-123654, GOE-5549, Acetyldinaline,
Transport conditionsNormal

Tacedinaline hydrochloride

CI-994 is an anti-cancer drug which inhibits histone deacetylases.

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BRC0923
Product IDBRC0923
Product classBioreference compound
CAS number368859-38-5
MW362.3
Synonyms
Transport conditionsNormal

N-[2-(4-methylphenyl)-3-phenyl-1,2,4-thiadiazol-5(2H)-ylidene]-methanamine monohydrobromide

The compound has adenosine A1 receptor affinity.

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BRC0708
Product IDBRC0708
Product classBioreference compound
CAS number783355-60-2
MW397.4
Synonyms
PCI-24781, CRA 24781, PZP115891
Transport conditionsNormal

Abexinostat

PCI-24781 is a novel, broad spectrum hydroxamic acid-based inhibitor of HDAC that shows antitumor activity in vitro. PCI-24781 inhibit pure recombinant HDAC1 (Ki = 7 nM), as well as HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 in the nanomolar range.

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BRC0895
Product IDBRC0895
Product classBioreference compound
CAS number75330-75-5
MW404.5
Synonyms
C10AA02, L-154803, MK-803, ML-530B
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Lovastatin

Lovastatin is a cholesterol-lowering agent. It is fungal metabolite, a potent inhibitor of HMG-CoA reductase.

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BRC0738
Product IDBRC0738
Product classBioreference compound
CAS number1020149-73-8
MW461.5
Synonyms
Transport conditionsNormal

SGI-1027

SGI-1027 is a potent inhibitor of the DNA methyltransferases DNMT1 (IC50 = 0.85 µM) and DNMT3A (IC50 = 0.9 µM). It has been shown to cause the degradation of DNMT1 and to reactivate silenced tumor suppressor genes by reducing CpG island hypermethylation.

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BRC0710
Product IDBRC0710
Product classBioreference compound
CAS number1314890-29-3
MW514.5
Synonyms
Transport conditionsNormal

TMP269

TMP269 is a selective class IIa histone deacetylase (HDAC) inhibitor: HDAC4 (IC50 = 157 nM), HDAC5 (IC50 = 97 nM), HDAC7 (IC50 = 43 nM) and HDAC9 (IC50 = 23 nM); via a non chelating zinc-binding group.

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