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Anticonvulsants

StructureProduct infoAvailabilityQuantity / Price
BRC0928
Product IDBRC0928
Product classBioreference compound
CAS number68506-86-5
MW129.2
Synonyms
CPP-109; MDL 71,754; MDL-71754; RMI-71754; GVG; Sabril™; γ-Vinyl GABA;
Transport conditionsNormal

Vigabatrin

Vigabatrin is a structural analogue of gamma-aminobutyric acid, irreversible inhibitor of 4-aminobutyrate transaminase, the enzyme responsible for the catabolism of gamma-aminobutyric acid.

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BRC0939
Product IDBRC0939
Product classBioreference compound
CAS number77-67-8
MW141.2
Synonyms
H 940; Mesentol; NSC 64013; PM 671; CN 10395;
Transport conditionsNormal

Ethosuximide

Ethosuximide is an anticonvulsant, used in the treatment of epilepsy. It binds to T-type voltage-sensitive calcium channels.

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BRC0288
Product IDBRC0288
Product classBioreference compound
CAS number127-48-0
MW143.1
Synonyms
Trimethinum, Troxidone, Tridione, Minoale,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Trimethadione

Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.

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BRC0249
Product IDBRC0249
Product classBioreference compound
CAS number99-66-1
MW144.2
Synonyms
DPA, n-DPA, Valproate, VPA, Convulex, Depakine, Encorate, Epilim, Valcote, Valparin
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Valproic Acid

Valproic acid is a fatty acid with anticonvulsant properties used in the treatment of epilepsy.

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BRC0935
Product IDBRC0935
Product classBioreference compound
CAS number115-67-3
MW157.2
Synonyms
Isoethadione;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Paramethadione

Paramethadione is an oxazolidinedione anticonvulsant that acts on the central nervous system (CNS) to reduce the number of absence seizures (often seen in epileptics). It reduce T-type calcium currents in thalamic neurons (including thalamic relay neurons).

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BRC0274
Product IDBRC0274
Product classBioreference compound
CAS number102767-28-2
MW170.2
Synonyms
UCB 22059, UCB L059, UCB-22059, UCB-L059, SIB-S1, Keppra
Transport conditionsNormal

Levetiracetam

Levetiracetam is an anticonvulsant medication used to treat epilepsy. Levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity.

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BRC0189
Product IDBRC0189
Product classBioreference compound
CAS number60142-96-3
MW171.2
Synonyms
Gabapentin GR, Neurontin, Aclonium
Transport conditionsNormal

Gabapentin

Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters.

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BRC0263
Product IDBRC0263
Product classBioreference compound
CAS number86-34-0
MW189.2
Synonyms
Fensuccimide; Milontin; Lifene; Milontin; Milonton; Succitimal; P-D 393;
Transport conditionsNormal

Phensuximide

Phensuximide is the succinimide class anticonvulsant.

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BRC1024
Product IDBRC1024
Product classBioreference compound
CAS number6300-95-4
MW190.2
Synonyms
6-Phenyldihydrouracil;
Transport conditionsNormal

NSC 44133

NSC 44133 is possible anticitogenic or antiepileptogenic agent.

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BRC0235
Product IDBRC0235
Product classBioreference compound
CAS number68291-97-4
MW212.2
Synonyms
Exceglan, CI-912
Transport conditionsNormal

Zonisamide

Zonisamide is an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents.

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BRC0226
Product IDBRC0226
Product classBioreference compound
CAS number125-33-7
MW218.3
Synonyms
Desoxyphenobarbital, Mysoline, Liskantin, Mizodin, Mylepsinum, Pridona, Primid, Prysoline, Sertan
Transport conditionsNormal
Restrictions Included in DEA controlled list

Primidone

An antiepileptic agent related to the barbiturates; it is partly metabolized to phenobarbital in the body and owes some of its actions to this metabolite. Primidone is a GABA receptor agonist.

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BRC0181
Product IDBRC0181
Product classBioreference compound
CAS number50-12-4
MW218.3
Synonyms
Mesantoin
Transport conditionsNormal

Mephenytoin

Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy.

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BRC0192
Product IDBRC0192
Product classBioreference compound
CAS number59-66-5
MW222.2
Synonyms
Defiltran, Diacarb, Diamox, Diluran, Glaupax
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Acetazolamide

Acetazolamide is a potent carbonic anhydrase inhibitor, effective in the control of fluid secretion, in the treatment of certain convulsive disorders and in the promotion of diuresis in instances of abnormal fluid retention.

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BRC1059
Product IDBRC1059
Product classBioreference compound
CAS number17557-67-4
MW228.3
Synonyms
Transport conditionsNormal

SKA 16

SKA 16 is an anticonvulsant agent.

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BRC0052
Product IDBRC0052
Product classBioreference compound
CAS number1744-22-5
MW234.2
Synonyms
Rilutek, RP-54274, PK 26124
Transport conditionsNormal

Riluzole

Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes; neuroprotective.

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BRC0926
Product IDBRC0926
Product classBioreference compound
CAS number298-46-4
MW236.3
Synonyms
G-32883; GEIGY 32883; NSC-169864; SPD417; CBZ;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Carbamazepine

Carbamazepine is an anticonvulsant used to control grand mal and psychomotor or focal seizures. It inhibits neuronal voltage-gated Na+ channels. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis.

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BRC0217
Product IDBRC0217
Product classBioreference compound
CAS number106308-44-5
MW238.2
Synonyms
Banzel, RUF 331, Xilep, Inovelon
Transport conditionsNormal

Rufinamide

Rufinamide is a triazole derivative antiepileptic that prolongs the inactive state of voltage gated sodium channels thus stabilizing membranes, ultimately blocking the spread of partial seizure activity.

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BRC0239
Product IDBRC0239
Product classBioreference compound
CAS number25451-15-4
MW238.2
Synonyms
Taloxa, ADD-03055
Transport conditionsNormal

Felbamate

Felbamate is an anticonvulsant drug used in the treatment of epilepsy. It has a weak inhibitory effect on GABA receptor binding sites.

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BRC0974
Product IDBRC0974
Product classBioreference compound
CAS number57-41-0
MW252.3
Synonyms
NSC-8722;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Phenytoin

Phenytoin is an antiepileptic drug. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.

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BRC0824
Product IDBRC0824
Product classBioreference compound
CAS number28721-07-5
MW252.3
Synonyms
GP 47680; KIN-493; SPN-804;
Transport conditionsNormal

Oxcarbazepine

Oxcarbazepine is a sodium channel protein inhibitor. It is structurally a derivative of carbamazepine.

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BRC0562
Product IDBRC0562
Product classBioreference compound
CAS number120537-47-5
MW252.3
Synonyms
Transport conditionsNormal

N,​N-​dimethyl-​1-​(phenylmethyl)​-1H-​Imidazo[4,​5-​c]​pyridin-​4-​amine

The compound has potent anticonvulsant activity against MES (ED50 = 2 mg/kg).

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BRC0155
Product IDBRC0155
Product classBioreference compound
CAS number84057-84-1
MW256.1
Synonyms
Lamictal, BW-430C
Transport conditionsNormal

Lamotrigine

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer.

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BRC0644
Product IDBRC0644
Product classBioreference compound
CAS number64461-82-1
MW290.2
Synonyms
AB 021, AN 021, DS 103-282, Sirdalud, Ternelin, Tizan
Transport conditionsNormal

Tizanidine hydrochloride

Tizanidine hydrochloride is an agonist at a2-adrenergic receptor sites (IC50 = 48 nM) and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons.

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BRC0184
Product IDBRC0184
Product classBioreference compound
CAS number97240-79-4
MW339.4
Synonyms
McN-4853, RWJ-17021, Topamax, TPM
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Topiramate

Topiramate is an anticonvulsant indicated in the treatment of epilepsy and migraine. Topiramate enhances GABA-activated chloride channels. In addition, topiramate inhibits excitatory neurotransmission, through actions on kainate and AMPA receptors. There is evidence that topiramate has a specific effect on GluR5 kainate receptors.

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BRC0108
Product IDBRC0108
Product classBioreference compound
CAS number145821-59-6
MW412.0
Synonyms
Gabitril, NO050328, NO328, TGB
Transport conditionsNormal

Tiagabine hydrochloride

Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.

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BRC0913
Product IDBRC0913
Product classBioreference compound
CAS number491864-61-0
MW450.5
Synonyms
Transport conditionsNormal

3-[2-(piperidin-1-yl)ethyl]-2-{3-[3-(trifluoromethyl)phenoxy]phenyl}-1,3-thiazolidin-4-one

The compound is sodium channel blocker (Ki = 90 nM).

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BRC0670
Product IDBRC0670
Product classBioreference compound
CAS number1280193-99-8
MW472.0
Synonyms
Transport conditionsNormal

({1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}methyl)[3-(4-ethoxyphenoxy)-2-methoxypropyl]methylamine

The compound is Toll-like receptor 4 inhibitor (IC50 = 19.8 µM). It displays TLR4-mediated inflammation inhibition, potential antiseptic.

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