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Glutamate receptor

StructureProduct infoAvailabilityQuantity / Price
BRC1147
Product IDBRC1147
Product classBioreference compound
CAS number22059-21-8
MW101.1
Synonyms
ACC; NSC 98430;
Transport conditionsNormal

ACPC

ACPC is NMDA receptor activity modulator, acts as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 µM) in the presence of low levels (1 µM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 µM) of glutamate.

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BRC1068
Product IDBRC1068
Product classBioreference compound
CAS number3544-24-9
MW136.2
Synonyms
NSC 36962; SR 4294; WD 97-000835;
Transport conditionsNormal

INO-1001

INO-1001 is PARP (poly(ADP-ribose) polymerase) inhibitor (Ki = 1.8 μM), which protects cells from UV-B-induced apoptosis via influence on the cytoskeleton. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

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BRC0977
Product IDBRC0977
Product classBioreference compound
CAS number7491-74-9
MW142.2
Synonyms
UCB 6215;
Transport conditionsNormal

Piracetam

Piracetam is a nootropic drug that displays cognitive enhancing properties. It is a cyclic derivative of GABA. It has been shown to alter the physical properties of cell membranes and to protect against hypoxia, which might underlie neuroprotective and antithrombotic actions.

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BRC0818
Product IDBRC0818
Product classBioreference compound
CAS number616-91-1
MW163.2
Synonyms
5052; NSC-111180; RK-0202; NAC; Mercapturic acid;
Transport conditionsNormal

Acetylcysteine

Acetylcysteine (NAC) is an antioxidant and precursor of glutathione that has multiple effects in cells and animals. It is primarily used as a mucolytic agent and in the management of acetaminophen poisoning. It is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase 1) and absorbed in the intestine into the bloodstream. As an antioxidant, NAC scavenges hydrogen peroxide, hydroxyl radical, and hypochlorous acid.

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BRC0692
Product IDBRC0692
Product classBioreference compound
CAS number76-38-0
MW165.0
Synonyms
DA-759; NSC-110432;
Transport conditionsNormal

Methoxyflurane

Methoxyflurane is an anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability.

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BRC1066
Product IDBRC1066
Product classBioreference compound
CAS number498-02-2
MW166.2
Synonyms
NSC 209524; NSC 2146;
Transport conditionsNormal

Apocynin

Apocynin is a methoxy-substituted catechol that is commonly used as a selective NADPH-oxidase inhibitor with IC50 of 10 μM. Acts as an antioxidant in endothelial cells and vascular smooth muscle cells.

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BRC1007
Product IDBRC1007
Product classBioreference compound
CAS number146255-66-5
MW183.2
Synonyms
(RS)-3,5-Dihydroxyphenylglycine;
Transport conditionsNormal

DHPG

DHPG is an agonist of the group I metabotropic glutamate receptors, binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors. The (S)-enantiomer is about ten times more potent than the (R)-enantiomer.

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BRC0687
Product IDBRC0687
Product classBioreference compound
CAS number13838-16-9
MW184.5
Synonyms
Anesthetic 347; Alyrane;
Transport conditionsNormal

Enflurane

Enflurane is an anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. Enflurane acts as a positive allosteric modulator of the GABAA, glycine, and 5-HT3 receptors, and as a negative allosteric modulator of the AMPA, kainate, and NMDA receptors, as well as of nicotinic acetylcholine receptors.

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BRC0823
Product IDBRC0823
Product classBioreference compound
CAS number26675-46-7
MW184.5
Synonyms
R-E 235da1, HCFE 235da2,
Transport conditionsNormal

Isoflurane

Isoflurane is a general inhalation anesthetic. It induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times.

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BRC0523
Product IDBRC0523
Product classBioreference compound
CAS number176199-48-7
MW185.2
Synonyms
Eglumegad, Eglumetad
Transport conditionsNormal

LY354740

The compound is highly potent agonists for group 2/3 metabotropic glutamate receptors mGluR. mGlu2/3 receptors are targets for the treatment of anxiety, schizophrenia, convulsive disorders, Parkinson’s disease, pain, and neurodegeneration.

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BRC0260
Product IDBRC0260
Product classBioreference compound
CAS number665-66-7
MW187.7
Synonyms
Aminoadamantane, Viregyt, Virosol, PK-Merz, Symadine, Symmetrel
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amantadine hydrochloride

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance).

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BRC0628
Product IDBRC0628
Product classBioreference compound
CAS number13721-01-2
MW189.2
Synonyms
Transport conditionsNormal

4-Quinolone-3-carboxylic acid

4-Quinolone-3-carboxylic acidis a novel HIV-1 integrase strand transfer inhibitor.

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BRC1074
Product IDBRC1074
Product classBioreference compound
CAS number153322-05-5
MW198.3
Synonyms
ARL 15896; FPL 15896; AR-R15896; AZD6765;
Transport conditionsNormal

Lanicemine

Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 µM). It has been used in trials studying the treatment and basic science of Depression, Major Depressive Disorder, and Treatment-Resistant Major Depressive Disorder.

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BRC0550
Product IDBRC0550
Product classBioreference compound
CAS number19772-76-0
MW199.2
Synonyms
DL-Willardiine
Transport conditionsNormal

(±)-Willardiine

(±)-Willardiine is a selective inhibitor of specific binding of [3H]AMPA to Ionotropic glutamate receptor AMPA (IC50 = 1800 nM).

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BRC0857
Product IDBRC0857
Product classBioreference compound
CAS number28523-86-6
MW200.1
Synonyms
Transport conditionsNormal

Sevoflurane

Sevoflurane is one of the most commonly used volatile anesthetic agents, particularly for outpatient anesthesia, across all ages, as well as in veterinary medicine.

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BRC1178
Product IDBRC1178
Product classBioreference compound
CAS number209185-99-9
MW205.8
Synonyms
Transport conditionsNormal

Neramexane hydrochloride

Neramexane hydrochloride is an NMDA antagonist with neuroprotective effects. It targets the cognitive decline in Alzheimer’s Disease by altering neurotransmitter signaling. Neramexane also acts as a nicotinic acetylcholine receptor antagonist.

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BRC0150
Product IDBRC0150
Product classBioreference compound
CAS number1313437-84-1
MW209.9
Synonyms
Trilithium citrate
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Lithium Citrate

Lithium salts such as lithium carbonate, lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression.

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BRC0032
Product IDBRC0032
Product classBioreference compound
CAS number41100-52-1
MW215.8
Synonyms
Abixa, Akatinol, Axura, Memox
Transport conditionsNormal

Memantine hydrochloride

Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentially to the NMDA receptor-operated cation channels. Memantine also has antagonistic activity at the type 3 serotonergic (5-HT3) receptor with a potency that is similar to that at the NMDA receptor, and lower antagonistic activity at the nicotinic acetylcholine receptor. This drug has no affinity for γ-aminobutyric acid (GABA), benzodiazepine, dopamine, adrenergic, histamine, or glycine receptors or for voltage-dependent calcium, sodium, or potassium channels.

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BRC0226
Product IDBRC0226
Product classBioreference compound
CAS number125-33-7
MW218.3
Synonyms
Desoxyphenobarbital, Mysoline, Liskantin, Mizodin, Mylepsinum, Pridona, Primid, Prysoline, Sertan
Transport conditionsNormal
Restrictions Included in DEA controlled list

Primidone

An antiepileptic agent related to the barbiturates; it is partly metabolized to phenobarbital in the body and owes some of its actions to this metabolite. Primidone is a GABA receptor agonist.

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BRC1320
Product IDBRC1320
Product classBioreference compound
CAS number2482-00-0
MW228.3
Synonyms
NIH 11035; NSC 56332;
Transport conditionsNormal

Agmatine sulfate

Agmantine is a natural metabolite of the arginine. It binds to human adrenergic receptors and imidazoline (I) receptors. Agmatine acts as an antagonist of the NMDA receptor and nicotinic acetylcholine receptors. It is an antagonist of the serotonin receptor subtype 5-HT3 and blocks ATP-sensitive potassium channels. Agmatine competitively inhibits neuronal, macrophage, endothelial, and inducible nitric oxide synthase and irreversibly inactivates neuronal NOS in the presence of calmodulin.

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BRC0052
Product IDBRC0052
Product classBioreference compound
CAS number1744-22-5
MW234.2
Synonyms
Rilutek, RP-54274, PK 26124
Transport conditionsNormal

Riluzole

Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes; neuroprotective.

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BRC0217
Product IDBRC0217
Product classBioreference compound
CAS number106308-44-5
MW238.2
Synonyms
Banzel, RUF 331, Xilep, Inovelon
Transport conditionsNormal

Rufinamide

Rufinamide is a triazole derivative antiepileptic that prolongs the inactive state of voltage gated sodium channels thus stabilizing membranes, ultimately blocking the spread of partial seizure activity.

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BRC0239
Product IDBRC0239
Product classBioreference compound
CAS number25451-15-4
MW238.2
Synonyms
Taloxa, ADD-03055
Transport conditionsNormal

Felbamate

Felbamate is an anticonvulsant drug used in the treatment of epilepsy. It has a weak inhibitory effect on GABA receptor binding sites.

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BRC0464
Product IDBRC0464
Product classBioreference compound
CAS number4815-38-7
MW261.3
Synonyms
Transport conditionsNormal

Ethyl 2-Amino-4-methyl-5-phenylthiophene-3-carboxylate

Glutamate receptors inhibitor.

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BRC0817
Product IDBRC0817
Product classBioreference compound
CAS number133-16-4
MW270.8
Synonyms
Halestyn; Piocaine;
Transport conditionsNormal

Chloroprocaine

Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia. It blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rising of the action potential.

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BRC0941
Product IDBRC0941
Product classBioreference compound
CAS number51-05-8
MW272.8
Synonyms
Novocaine; Vitamin H3; Duracaine; NSC 169497; Nissocaine;
Transport conditionsNormal

Procaine Hydrochloride

Procaine hydrochloride is a local anesthetic. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. It is a sodium channel blocker with a variety of inhibitory effects. Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1.

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BRC0446
Product IDBRC0446
Product classBioreference compound
CAS number226878-01-9
MW307.4
Synonyms
Transport conditionsNormal

NPS 2390

NPS 2390 is a first generation quinoxaline derivative that displays noncompetitive antagonist activity at mGluR1 and mGluR5 receptors.

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BRC0184
Product IDBRC0184
Product classBioreference compound
CAS number97240-79-4
MW339.4
Synonyms
McN-4853, RWJ-17021, Topamax, TPM
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Topiramate

Topiramate is an anticonvulsant indicated in the treatment of epilepsy and migraine. Topiramate enhances GABA-activated chloride channels. In addition, topiramate inhibits excitatory neurotransmission, through actions on kainate and AMPA receptors. There is evidence that topiramate has a specific effect on GluR5 kainate receptors.

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BRC0730
Product IDBRC0730
Product classBioreference compound
CAS number52-86-8
MW375.9
Synonyms
MCN-JR-1625; NSC-170973; NSC-615296; R-1625; Dozic; Einalon S; Eukystol;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Haloperidol

Haloperidol is butyrophenone antipsychotic, D2, D3, and D4 dopamine receptor antagonist. It is used primarily to treat schizophrenia and other psychoses.

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BRC0721
Product IDBRC0721
Product classBioreference compound
CAS number556803-08-8
MW376.5
Synonyms
Transport conditionsNormal

TCN 213

TCN 201 selective blockage of GluN2A-containing NMDA receptors in GluN1 co-agonist dependent manner (IC50 = 0.55 µM GluN1/GluN2A).

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BRC1085
Product IDBRC1085
Product classBioreference compound
CAS number1216398-09-2
MW378.9
Synonyms
Transport conditionsNormal

[3H]-YM 298198 Hydrochloride

YM 298198 hydrochloride is noncompetitive antagonist selective for mGluR-1. This compound also displays the ability to inhibit glutamate-induced IP production more potently than CPCCOEt.

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BRC0702
Product IDBRC0702
Product classBioreference compound
CAS number599-79-1
MW398.4
Synonyms
NSC 203730, NSC 667219, Reupirin, Azulfin, Benzosulfa
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Sulfasalazine

Sulfasalazine is an anti-inflammatory (gastrointestinal). It is inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC).

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BRC0272
Product IDBRC0272
Product classBioreference compound
CAS number77337-73-6
MW400.5
Synonyms
N-acetyl homotaurine, N-Acetylhomotaurine, Campral, Regtect
Transport conditionsNormal

Acamprosate Calcium

Acamprosate Calcium is a GABA receptor agonist and modulator of glutamatergic systems.

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BRC0672
Product IDBRC0672
Product classBioreference compound
CAS number482584-49-6
MW439.5
Synonyms
Transport conditionsNormal

5-methyl-7-(2-methylpropyl)-2-[(naphthalen-1-yl)methyl]-3-(pyridin-4-yl)-2H,4H,5H,6H,7H-pyrazolo[3,4-d]pyrimidine-4,6-dione

The compound is selective Helicobacter pylori glutamate racemase inhibitor (IC50 = 1400 nM).

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BRC0517
Product IDBRC0517
Product classBioreference compound
CAS number866823-73-6
MW454.6
Synonyms
MRLSD 230, BINA
Transport conditionsNormal

Biphenylindanone A

Biphenyl-indanone A (BINA) is a potent selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). Exhibits antipsychotic and anxiolytic properties in mice.

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BRC0660
Product IDBRC0660
Product classBioreference compound
CAS number4682-36-4
MW461.5
Synonyms
BS 5930, Biorphen, Brocadisipal, ORP, WS 2434
Transport conditionsNormal

Orphenadrine citrate

Orphenadrine Citrate is muscarinic receptor antagonist (pKi 7.39), H1 histamine receptor antagonist (pIC50 6.79), a muscle relaxant. It also inhibits the noradrenergic transporter and to block the NMDA receptor ion channel.

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BRC0526
Product IDBRC0526
Product classBioreference compound
CAS number852918-02-6
MW461.9
Synonyms
Transport conditionsNormal

TCN 201

TCN 201 is the first selective antagonist of NMDA receptors containing the NR2A subunit. The pIC50 for NR2A NMDA receptors is 6.8. TCN-201has no effect on NR2B-containing receptors at concentrations up to 50 mM.

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BRC0671
Product IDBRC0671
Product classBioreference compound
CAS number946411-72-9
MW500.0
Synonyms
Transport conditionsNormal

5-{2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-methyl-4,6-dioxo-2H,4H,5H,6H,7H-pyrazolo[3,4-d]pyrimidin-3-yl}-1-methyl-1H-pyrrole-3-carbonitrile

The compound is selective Helicobacter pylori glutamate racemase inhibitor (IC50 = 25 nM).

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BRC0627
Product IDBRC0627
Product classBioreference compound
CAS number380560-89-4
MW558.4
Synonyms
DC 060015;
Transport conditionsNormal

DPQ-1105

DPQ-1105 is noncompetitive NMDA receptor antagonist that displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 uM, respectively). Reduces frequency of channel opening.

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BRC0280
Product IDBRC0280
Product classBioreference compound
CAS number70288-86-7
MW861.1
Synonyms
Ivermax, Ivomec, Mectizan, Noromectin, Privermectin, Sklice, Stromectol, Vetrimec, Zimecterin, MK933
Transport conditionsNormal

Ivermectin

Ivermectin is a semisynthetic, anthelminitic agent.

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