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5-hydroxytryptamine receptor (5-HT receptor) inhibitors

StructureProduct infoAvailabilityQuantity / Price
BRC0888
Product IDBRC0888
Product classBioreference compound
CAS number4424-20-8
MW147.2
Synonyms
Transport conditionsNormal

5-Azabenzocycloheptene

5-Azabenzocycloheptene is a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

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BRC0466
Product IDBRC0466
Product classBioreference compound
CAS number87-52-5
MW174.2
Synonyms
Donaxine, NSC 16892
Transport conditionsNormal

Gramine

Gramine is a naturally occurring indole alkaloid present in several plant species. Has been found to act as an agonist of the adiponectin receptor 1 (LD50 = 44.6 - 62.9 mg/kg). Gramine is a norepinephrine reuptake inhibitor in synaptic vesicles.

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BRC0023
Product IDBRC0023
Product classBioreference compound
CAS number62-31-7
MW189.6
Synonyms
3-Hydroxytyramine, Deoxyepinephrine, Oxytyramine, Intropin, Revimine
Transport conditionsNormal

Dopamine hydrochloride

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility.

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BRC1077
Product IDBRC1077
Product classBioreference compound
CAS number94-26-8
MW194.2
Synonyms
NSC 13164; NSC 8475; Nipabutyl; SPF;
Transport conditionsNormal

Butylparaben

Butylparaben is an antifungal preservative in cosmetic products.

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BRC1178
Product IDBRC1178
Product classBioreference compound
CAS number209185-99-9
MW205.8
Synonyms
Transport conditionsNormal

Neramexane hydrochloride

Neramexane hydrochloride is an NMDA antagonist with neuroprotective effects. It targets the cognitive decline in Alzheimer’s Disease by altering neurotransmitter signaling. Neramexane also acts as a nicotinic acetylcholine receptor antagonist.

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BRC0032
Product IDBRC0032
Product classBioreference compound
CAS number41100-52-1
MW215.8
Synonyms
Abixa, Akatinol, Axura, Memox
Transport conditionsNormal

Memantine hydrochloride

Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentially to the NMDA receptor-operated cation channels. Memantine also has antagonistic activity at the type 3 serotonergic (5-HT3) receptor with a potency that is similar to that at the NMDA receptor, and lower antagonistic activity at the nicotinic acetylcholine receptor. This drug has no affinity for γ-aminobutyric acid (GABA), benzodiazepine, dopamine, adrenergic, histamine, or glycine receptors or for voltage-dependent calcium, sodium, or potassium channels.

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BRC0155
Product IDBRC0155
Product classBioreference compound
CAS number84057-84-1
MW256.1
Synonyms
Lamictal, BW-430C
Transport conditionsNormal

Lamotrigine

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer.

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BRC0309
Product IDBRC0309
Product classBioreference compound
CAS number155584-74-0
MW262.7
Synonyms
Transport conditionsNormal

VUF 10166

VUF10166 is 5-HT3A receptor antagonist. At 5-HT3AB receptors, it is also an antagonist but is less potent.

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BRC0883
Product IDBRC0883
Product classBioreference compound
CAS number3575-80-2
MW263.4
Synonyms
FG-5111
Transport conditionsNormal

Melperone

Melperone is an atypical antipsychotic. It is 5-HT2A/D2 receptor antagonist (Ki = 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC.

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BRC0421
Product IDBRC0421
Product classBioreference compound
CAS number85650-52-8
MW265.4
Synonyms
Org 3770, 6-Azamianserin, Avanza, Axit, Mirtabene, Mirtaz, Mirtazon, Norset, Promyrtil, Remergil, Remergon, Remeron, Remeron SolTab, Rexer, Zispin
Transport conditionsNormal

Mirtazapine

Mirtazapine, an antidepressant of the piperazinoazepine class, is a tetracyclic compound with an anxiolytic effect. Mirtazapine has fewer ADRs than tricyclic antidepressants and is better tolerated. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants.

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BRC0817
Product IDBRC0817
Product classBioreference compound
CAS number133-16-4
MW270.8
Synonyms
Halestyn; Piocaine;
Transport conditionsNormal

Chloroprocaine

Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia. It blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rising of the action potential.

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BRC0941
Product IDBRC0941
Product classBioreference compound
CAS number51-05-8
MW272.8
Synonyms
Novocaine; Vitamin H3; Duracaine; NSC 169497; Nissocaine;
Transport conditionsNormal

Procaine Hydrochloride

Procaine hydrochloride is a local anesthetic. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. It is a sodium channel blocker with a variety of inhibitory effects. Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1.

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BRC0499
Product IDBRC0499
Product classBioreference compound
CAS number965-52-6
MW275.2
Synonyms
RC 27109, RC 30-109, Adral, Antinal, Bacifurane, Diarlidan
Transport conditionsNormal

Nifuroxazide

Nifuroxazide is a broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin. Nifuroxazide also inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC50 = 10 µM).

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BRC0348
Product IDBRC0348
Product classBioreference compound
CAS number7416-34-4
MW276.4
Synonyms
Moban
Transport conditionsNormal

Molindone

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder.

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BRC0784
Product IDBRC0784
Product classBioreference compound
CAS number99614-02-5
MW293.4
Synonyms
GR 38032, Setron, Yatrox
Transport conditionsNormal

Ondansetron

Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.

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BRC0518
Product IDBRC0518
Product classBioreference compound
CAS number2444-46-4
MW293.4
Synonyms
8-Nordihydrocapsaicin, AH 23491X, NSC 172795, Pseudocapsaicin
Transport conditionsNormal

Nonivamide

Nonivamide is an capsaicinoid. Like capsaicin, it can deter mammals (but not birds or insects) from consuming plants or seeds. Nonivamide is a TRPV1 ion channel agonist. Mammalian TRPV1 is activated by heat and capsaicin, but the avian form is insensitive to capsaicin.

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BRC0428
Product IDBRC0428
Product classBioreference compound
CAS number318-98-9
MW295.8
Synonyms
AY-64043, ICI-45520, NCS-91523, Angilol, Bedranol SR, Cardinol, Ciplar, Deralin, Dociton, Duranol, HEMANGEOL, Inderal, Inderal LA, Indobloc, INNOPRAN, Innopran XL, Prophylux, Sumial
Transport conditionsNormal

Propranolol hydrochloride

Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.

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BRC0283
Product IDBRC0283
Product classBioreference compound
CAS number135729-61-2
MW296.4
Synonyms
Jiouting, Onicit, Palnox, Paloxi, Palzen, Themiset, Zhiruo, RS 25259, RS 25259 197
Transport conditionsNormal

Palonosetron

Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

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BRC0404
Product IDBRC0404
Product classBioreference compound
CAS number91374-20-8
MW296.8
Synonyms
Adartrel, ReQuip, Ronirol, SKandF 101468
Transport conditionsNormal

Ropinirole hydrochloride

Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes.

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BRC0685
Product IDBRC0685
Product classBioreference compound
CAS number364-62-5
MW299.8
Synonyms
Afipran, Clopromate, DEL 1267
Transport conditionsNormal

Metoclopramide

Metoclopramide is dopamine D2 receptor antagonist. A labelled substituted benzamide with neuroleptic activity. Antiemetic.

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BRC0932
Product IDBRC0932
Product classBioreference compound
CAS number894-71-3
MW299.8
Synonyms
NCI-169453; Acetexa; Pamelor®;
Transport conditionsNormal

Nortriptyline Hydrochloride

Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant that blocks norepinephrine and serotonin transporters more potently than the dopamine transporter. It also antagonizes serotonin, histamine, muscarinic, and α-adrenergic receptors.

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BRC0011
Product IDBRC0011
Product classBioreference compound
CAS number191217-81-9
MW302.3
Synonyms
Mirapexin, Sifrol, (-)-Pramipexole, Pramipexol, SND 919
Transport conditionsNormal

Pramipexole hydrate dihydrochloride

Pramipexole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes.

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BRC0731
Product IDBRC0731
Product classBioreference compound
CAS number6202-23-9
MW311.8
Synonyms
Lisseril, MK 130 hydrochloride, Miosan, Multi-Relax, Proheptatriene hydrochloride, TNX-102
Transport conditionsNormal

Cyclobenzaprine hydrochloride

Cyclobenzaprine is a skeletal muscle relaxant, reduces muscle spasm by depression of brainstem neurons; 5-HT2 serotonin receptor antagonist.

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BRC0748
Product IDBRC0748
Product classBioreference compound
CAS number132539-06-1
MW312.4
Synonyms
ADAMED, Arenbil, Integrol, LY 170053
Transport conditionsNormal

Olanzapine

Olanzapine is serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic and antipsychotic activity.

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BRC0109
Product IDBRC0109
Product classBioreference compound
CAS number14028-44-5
MW313.8
Synonyms
Asendin, Demolox, CL 67772
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amoxapine

Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants; amoxapine inhibits GLYT2a transport activity with IC50 of 92 M.

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BRC0006
Product IDBRC0006
Product classBioreference compound
CAS number10347-81-6
MW313.9
Synonyms
Deprilept; Ludiomil; Psymion;
Transport conditionsNormal

Maprotiline hydrochloride

Maprotiline is a tetracyclic antidepressant. Although its main therapeutic use is in the treatment of depression, it has also been shown to exert a sedative effect on the anxiety component that often accompanies depression.

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BRC0391
Product IDBRC0391
Product classBioreference compound
CAS number1229-29-4
MW315.8
Synonyms
Adapin, Aponal, Curatin, Doxepine, Quitaxon, Sinequan
Transport conditionsNormal

Doxepin hydrochloride

Doxepin, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema. Doxepin has substantial anticholinergic and sedative effects. The E (trans)-isomer is more active as a serotonin reuptake inhibitor while the Z-isomer acts as a sedative.

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BRC0360
Product IDBRC0360
Product classBioreference compound
CAS number113-59-7
MW315.9
Synonyms
NSC 169899
Transport conditionsNormal

Chlorprothixene

Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.

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BRC0044
Product IDBRC0044
Product classBioreference compound
CAS number113-52-0
MW316.9
Synonyms
Antideprin, Melipramine, Imidobenzyle, Berkomine, Melipramin
Transport conditionsNormal

Imipramine hydrochloride

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use.

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BRC0392
Product IDBRC0392
Product classBioreference compound
CAS number58-33-3
MW320.9
Synonyms
Avomine, Fargan, Farganesse, Lergigan,PHENADOZ, Phenergan, Promethegan, Prothiazine, Receptozine, Romergan, Sominex
Transport conditionsNormal

Promethazine hydrochloride

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties.

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BRC0385
Product IDBRC0385
Product classBioreference compound
CAS number53-60-1
MW320.9
Synonyms
Sparine, Talofen
Transport conditionsNormal

Promazine hydrochloride

Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors.

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BRC0770
Product IDBRC0770
Product classBioreference compound
CAS number5786-21-0
MW326.8
Synonyms
HF-1854, LX 100-129, W 108, Iprox, Klozapol, Leponex, Sizopin
Transport conditionsNormal

Clozapine

Clozapine is a psychotropic, selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 and 2 adrenergic, and H1 histaminergic receptors. Clozapine acts as an antagonist at other receptors, but with lower potency.

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BRC0885
Product IDBRC0885
Product classBioreference compound
CAS number5322-53-2
MW337.4
Synonyms
NSC 313681, Oxyperomide, R 4714
Transport conditionsNormal

Peromide

Peromide is an antipsychotic agent, dopaminergic antagonist.

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BRC0838
Product IDBRC0838
Product classBioreference compound
CAS number56296-78-7
MW345.8
Synonyms
Lilly 103472; Lilly 110 140; Prozac;
Transport conditionsNormal

Fluoxetine Hydrochloride

Fluoxetine hydrochloride is the first-in-class antidepressant, selective serotonin-reuptake inhibitor. It displays a selectivity for the serotonin transporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3,600 nM). It is used in the clinical treatment of major depression as well as other psychiatric disorders.

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BRC0014
Product IDBRC0014
Product classBioreference compound
CAS number221180-26-3
MW350.2
Synonyms
Ticalopride hydrochloride;
Transport conditionsNormal

Norcisapride hydrochloride

A metabolite of Cisapride, serotonin 4 (5-HT4) receptor agonist.

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BRC0291
Product IDBRC0291
Product classBioreference compound
CAS number69-09-0
MW355.3
Synonyms
Chlorpromanyl, Largactil, Thorazine, J2.794D, NSC-167745, NSC-226514
Transport conditionsNormal

Chlorpromazine

Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It antagonizes a range of receptors, including post-synaptic dopamine and serotonin receptors.

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BRC0608
Product IDBRC0608
Product classBioreference compound
CAS number1187159-50-7
MW360.5
Synonyms
Transport conditionsNormal

1-(2-{[(1R)-2,3-dihydro-1H-inden-1-yl]amino}quinolin-6-yl)-3-(propan-2-yl)urea

The compound is 5-HT5A receptor antagonist (Ki 2.5 nM).

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BRC0409
Product IDBRC0409
Product classBioreference compound
CAS number78246-49-8
MW365.8
Synonyms
BRL-29060A, FG-7051, Aropax, Brisdelle, Paxil, Pexeva, Sereupin, Seroxat,
Transport conditionsNormal

Paroxetine hydrochloride

Paroxetine, an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) type, has no active metabolites and has the highest specificity for serotonin receptors of all the SSRIs.

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BRC0730
Product IDBRC0730
Product classBioreference compound
CAS number52-86-8
MW375.9
Synonyms
MCN-JR-1625; NSC-170973; NSC-615296; R-1625; Dozic; Einalon S; Eukystol;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Haloperidol

Haloperidol is butyrophenone antipsychotic, D2, D3, and D4 dopamine receptor antagonist. It is used primarily to treat schizophrenia and other psychoses.

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BRC0777
Product IDBRC0777
Product classBioreference compound
CAS number120014-06-4
MW379.5
Synonyms
BNAG, E 2020, Neuripezil, Tonizep
Transport conditionsNormal

Donepezil

Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.

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BRC0605
Product IDBRC0605
Product classBioreference compound
CAS number863657-12-9
MW386.4
Synonyms
Transport conditionsNormal

N-[(2,6-dimethoxyphenyl)methyl]-N-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]guanidine

The compound is 5-HT5A antagonist.

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BRC0256
Product IDBRC0256
Product classBioreference compound
CAS number1098-60-8
MW388.9
Synonyms
Fluopromazine; Adazine; Psyquil;
Transport conditionsNormal

Triflupromazine hydrochloride

Triflupromazine hydrochloride binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity.

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BRC0257
Product IDBRC0257
Product classBioreference compound
CAS number125481-61-0
MW401.5
Synonyms
BMS 528215; BMY 28674;
Transport conditionsNormal

6-Hydroxybuspirone

A major active metabolite of buspirone.

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BRC0013
Product IDBRC0013
Product classBioreference compound
CAS number85650-56-2
MW401.8
Synonyms
Saphris,
Transport conditionsNormal

Asenapine maleate

Asenapine is a serotonin, dopamine, noradrenaline, and histamine antagonist in which asenapine possess more potent activity with serotonin receptors than dopamine. Asenapine is an atypical antipsychotic multireceptor neuroleptic drug which shows strong 5HT2A (serotonin) and D2 (dopamine) receptor antagonism, which has been shown to enhance dopamine (DA) and acetylcholine (Ach) efflux in rat brains. Asenapine may improve cognitive function and negative symptoms in patients with schizophrenia.

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BRC0397
Product IDBRC0397
Product classBioreference compound
CAS number130-61-0
MW407.0
Synonyms
Aldazine, Mallorol, Meleril, Mellaril, Mellerette, Melleretten, Melleril, Novoridazine, Ridazin, Ridazine, Sonapax, Thioril
Transport conditionsNormal

Thioridazine hydrochloride

Thioridazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. It is a calcium channel protein inhibitor as well as a D2DR/D4DR inhibitor. It is an intercalating agent for analyzing the integrity of double stranded DNA by using the square-wave voltammetry.

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BRC0134
Product IDBRC0134
Product classBioreference compound
CAS number25332-39-2
MW408.3
Synonyms
Beneficat, Desirel, Trialodine, Sideril, AF-1161, KB-831
Transport conditionsNormal

Trazodone hydrochloride

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents.

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BRC0068
Product IDBRC0068
Product classBioreference compound
CAS number106266-06-2
MW410.5
Synonyms
Risperdal, Risperidal, Rispolept,
Transport conditionsNormal

Risperidone

Risperidone, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is used primarily in the management of schizophrenia, inappropriate behavior in severe dementia and manic episodes associated with bipolar I disorder.

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BRC0060
Product IDBRC0060
Product classBioreference compound
CAS number103628-48-4
MW413.5
Synonyms
Sumax, Imitrex, Sumatran, Imigran, Sumatriptanum, GR 43175 A, GR 43175 C, GR 43175 X, SN 308
Transport conditionsNormal

Sumatriptan succinate

Sumatriptan, an antimigraine drug, is a selective agonist of vascular serotonin ((5-hydroxytryptamine; 5-HT) type 1-like receptors, likely the 5-HT1D and 5-HT1B subtypes).

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BRC0262
Product IDBRC0262
Product classBioreference compound
CAS number33386-08-2
MW422.0
Synonyms
Ansial, Bespar, Anxiron
Transport conditionsNormal

Buspirone hydrochloride

An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam.

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BRC0803
Product IDBRC0803
Product classBioreference compound
CAS number133454-47-4
MW426.5
Synonyms
HP-873
Transport conditionsNormal

Iloperidone

Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms.

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