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Muscarinic acetylcholine receptor (mAChR)

StructureProduct infoAvailabilityQuantity / Price
BRC0439
Product IDBRC0439
Product classBioreference compound
CAS number173850-51-6
MW181.2
Synonyms
Transport conditionsNormal

1-[(5-methylisoxazol-3-yl)methyl]piperazine

Muscarinic acetylcholine receptor antagonist.

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BRC0012
Product IDBRC0012
Product classBioreference compound
CAS number51-83-2
MW182.6
Synonyms
Carboptic, Isopto Carbachol, Mioticol
Transport conditionsNormal

Carbachol

Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known.

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BRC0749
Product IDBRC0749
Product classBioreference compound
CAS number71970-74-6
MW194.3
Synonyms
Transport conditionsNormal

AKS-19

AKS-19 is muscarinic acetylcholine receptor agonist.

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BRC0910
Product IDBRC0910
Product classBioreference compound
CAS number66-23-9
MW226.1
Synonyms
Transport conditionsNormal

Acetylcholine Bromide

Acetylcholine bromide is endogenous neurotransmitter. Acts at nicotinic and muscarinic acetylcholine receptors.

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BRC0529
Product IDBRC0529
Product classBioreference compound
CAS number5465-86-1
MW226.3
Synonyms
NSC 25850, CID-230710, 2-piperidino-Lepidine
Transport conditionsNormal

ML 204

ML-204 is a selective blocker of transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It demonstrates 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.

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BRC0313
Product IDBRC0313
Product classBioreference compound
CAS number300-08-3
MW236.1
Synonyms
Taeniolin, NSC 31750
Transport conditionsNormal

Arecoline hydrobromide

An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors.

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BRC0883
Product IDBRC0883
Product classBioreference compound
CAS number3575-80-2
MW263.4
Synonyms
FG-5111
Transport conditionsNormal

Melperone

Melperone is an atypical antipsychotic. It is 5-HT2A/D2 receptor antagonist (Ki = 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC.

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BRC0642
Product IDBRC0642
Product classBioreference compound
CAS number469-21-6
MW270.4
Synonyms
LS 127
Transport conditionsNormal

Doxylamine

Doxylamine is H1 histamine receptor antagonist. Doxylamine suppresses histamine at the H1 receptor.

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BRC0348
Product IDBRC0348
Product classBioreference compound
CAS number7416-34-4
MW276.4
Synonyms
Moban
Transport conditionsNormal

Molindone

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder.

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BRC0930
Product IDBRC0930
Product classBioreference compound
CAS number147-24-0
MW291.8
Synonyms
Difenhydramine; DPH;
Transport conditionsNormal

Diphenhydramine Hydrochloride

Diphenhydramine hydrochloride is an analytical reference standard that is categorized as an antihistamine. It competes with free histamine for binding at HA-receptor sites.

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BRC0685
Product IDBRC0685
Product classBioreference compound
CAS number364-62-5
MW299.8
Synonyms
Afipran, Clopromate, DEL 1267
Transport conditionsNormal

Metoclopramide

Metoclopramide is dopamine D2 receptor antagonist. A labelled substituted benzamide with neuroleptic activity. Antiemetic.

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BRC0932
Product IDBRC0932
Product classBioreference compound
CAS number894-71-3
MW299.8
Synonyms
NCI-169453; Acetexa; Pamelor®;
Transport conditionsNormal

Nortriptyline Hydrochloride

Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant that blocks norepinephrine and serotonin transporters more potently than the dopamine transporter. It also antagonizes serotonin, histamine, muscarinic, and α-adrenergic receptors.

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BRC0731
Product IDBRC0731
Product classBioreference compound
CAS number6202-23-9
MW311.8
Synonyms
Lisseril, MK 130 hydrochloride, Miosan, Multi-Relax, Proheptatriene hydrochloride, TNX-102
Transport conditionsNormal

Cyclobenzaprine hydrochloride

Cyclobenzaprine is a skeletal muscle relaxant, reduces muscle spasm by depression of brainstem neurons; 5-HT2 serotonin receptor antagonist.

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BRC0748
Product IDBRC0748
Product classBioreference compound
CAS number132539-06-1
MW312.4
Synonyms
ADAMED, Arenbil, Integrol, LY 170053
Transport conditionsNormal

Olanzapine

Olanzapine is serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic and antipsychotic activity.

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BRC0109
Product IDBRC0109
Product classBioreference compound
CAS number14028-44-5
MW313.8
Synonyms
Asendin, Demolox, CL 67772
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amoxapine

Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants; amoxapine inhibits GLYT2a transport activity with IC50 of 92 M.

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BRC0006
Product IDBRC0006
Product classBioreference compound
CAS number10347-81-6
MW313.9
Synonyms
Deprilept; Ludiomil; Psymion;
Transport conditionsNormal

Maprotiline hydrochloride

Maprotiline is a tetracyclic antidepressant. Although its main therapeutic use is in the treatment of depression, it has also been shown to exert a sedative effect on the anxiety component that often accompanies depression.

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BRC0391
Product IDBRC0391
Product classBioreference compound
CAS number1229-29-4
MW315.8
Synonyms
Adapin, Aponal, Curatin, Doxepine, Quitaxon, Sinequan
Transport conditionsNormal

Doxepin hydrochloride

Doxepin, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema. Doxepin has substantial anticholinergic and sedative effects. The E (trans)-isomer is more active as a serotonin reuptake inhibitor while the Z-isomer acts as a sedative.

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BRC0360
Product IDBRC0360
Product classBioreference compound
CAS number113-59-7
MW315.9
Synonyms
NSC 169899
Transport conditionsNormal

Chlorprothixene

Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.

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BRC0451
Product IDBRC0451
Product classBioreference compound
CAS number79183-37-2
MW316.2
Synonyms
N-4-Bromobenzylisati
Transport conditionsNormal

VU0119498

M1 muscarinic receptor agonist, pan mAChR M3, M5 positive allosteric modulator and neuroprotective agent.

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BRC0044
Product IDBRC0044
Product classBioreference compound
CAS number113-52-0
MW316.9
Synonyms
Antideprin, Melipramine, Imidobenzyle, Berkomine, Melipramin
Transport conditionsNormal

Imipramine hydrochloride

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use.

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BRC0385
Product IDBRC0385
Product classBioreference compound
CAS number53-60-1
MW320.9
Synonyms
Sparine, Talofen
Transport conditionsNormal

Promazine hydrochloride

Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors.

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BRC0392
Product IDBRC0392
Product classBioreference compound
CAS number58-33-3
MW320.9
Synonyms
Avomine, Fargan, Farganesse, Lergigan,PHENADOZ, Phenergan, Promethegan, Prothiazine, Receptozine, Romergan, Sominex
Transport conditionsNormal

Promethazine hydrochloride

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties.

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BRC0584
Product IDBRC0584
Product classBioreference compound
CAS number174794-02-6
MW328.4
Synonyms
LY 170238
Transport conditionsNormal

Olanzapine N-Oxide

A metabolite of Olanzapine.

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BRC0885
Product IDBRC0885
Product classBioreference compound
CAS number5322-53-2
MW337.4
Synonyms
NSC 313681, Oxyperomide, R 4714
Transport conditionsNormal

Peromide

Peromide is an antipsychotic agent, dopaminergic antagonist.

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BRC0042
Product IDBRC0042
Product classBioreference compound
CAS number52-49-3
MW337.9
Synonyms
Apo-trihex, Benzhexol Hydrochloride
Transport conditionsNormal

Trihexyphenidyl hydrochloride

Trihexyphenidyl is an anticholinergic used in the symptomatic treatment of all etiologic groups of parkinsonism and drug induced extrapyramidal reactions (except tardive dyskinesia). Trihexyphenidyl possesses both anticholinergic and antihistaminic effects, although only the former has been established as therapeutically significant in the management of parkinsonism.

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BRC0822
Product IDBRC0822
Product classBioreference compound
CAS number3737-09-5
MW339.5
Synonyms
H 3292, SC 7031, Searle 703
Transport conditionsNormal

Disopyramide

Disopyramide is a class I anti-arrhythmic agent and a sodium channel blocker with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.

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BRC0029
Product IDBRC0029
Product classBioreference compound
CAS number3254-89-5
MW345.9
Synonyms
Satanolon, Verterge, Vontro
Transport conditionsNormal

Diphenidol hydrochloride

Diphenidol is used for control of nausea and vomiting. It has an antivertigo effect on the vestibular apparatus, inhibiting the chemoreceptor trigger zone to control nausea and vomiting, thus preventing motion sickness.

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BRC0291
Product IDBRC0291
Product classBioreference compound
CAS number69-09-0
MW355.3
Synonyms
Chlorpromanyl, Largactil, Thorazine, J2.794D, NSC-167745, NSC-226514
Transport conditionsNormal

Chlorpromazine

Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It antagonizes a range of receptors, including post-synaptic dopamine and serotonin receptors.

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BRC0409
Product IDBRC0409
Product classBioreference compound
CAS number78246-49-8
MW365.8
Synonyms
BRL-29060A, FG-7051, Aropax, Brisdelle, Paxil, Pexeva, Sereupin, Seroxat,
Transport conditionsNormal

Paroxetine hydrochloride

Paroxetine, an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) type, has no active metabolites and has the highest specificity for serotonin receptors of all the SSRIs.

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BRC1017
Product IDBRC1017
Product classBioreference compound
CAS number316-07-4
MW371.3
Synonyms
Chlorpromazine sulfoxide hydrochloride; NSC 17470;
Transport conditionsNormal

Opromazine Hydrochloride

Opromazine hydrochloride is a derivative of Chlorpromazine, which is a dopamine antagonist of the typical antipsychotic class of medications possessing additional antiadrenergic, antiserotonergic, anticholinergic and antihistaminergic properties.

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BRC0307
Product IDBRC0307
Product classBioreference compound
CAS number2870-71-5
MW384.3
Synonyms
Atropine methyl bromide, Methylatropine,
Transport conditionsNormal

N-Methylatropine bromide

A belladonna derivative used as a muscarinic antagonist.

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BRC0256
Product IDBRC0256
Product classBioreference compound
CAS number1098-60-8
MW388.9
Synonyms
Fluopromazine; Adazine; Psyquil;
Transport conditionsNormal

Triflupromazine hydrochloride

Triflupromazine hydrochloride binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity.

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BRC0393
Product IDBRC0393
Product classBioreference compound
CAS number1508-65-2
MW394.0
Synonyms
Ditropan, Gelnique, Lenditro, Lyrinel XL, Oxytrol
Transport conditionsNormal

Oxybutynin hydrochloride

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination, by decreasing muscle spasms of the bladder. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor.

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BRC0261
Product IDBRC0261
Product classBioreference compound
CAS number6101-15-1
MW397.3
Synonyms
Dicholine succinate, Suxamethonium, Scoline, Sucostrin,
Transport conditionsNormal

Succinylcholine Chloride Dihydrate

Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization.

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BRC0198
Product IDBRC0198
Product classBioreference compound
CAS number59729-32-7
MW405.3
Synonyms
Nitalapram, Celexa, Cipram, Lu 10-171
Transport conditionsNormal

Citalopram hydrobromide

Citalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety.

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BRC0386
Product IDBRC0386
Product classBioreference compound
CAS number3717-88-2
MW427.9
Synonyms
NSC-114649, Rec 7/0040, Bladuril, Flavosert, Progut, Sawadaron, Uridron, Uripax, Urispas, Uroxal
Transport conditionsNormal

Flavoxate hydrochloride

Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.

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BRC0712
Product IDBRC0712
Product classBioreference compound
CAS number10405-02-4
MW428.0
Synonyms
As XVII, Keptan, Relaspium, Sanctura
Transport conditionsNormal

Trospium chloride

Trospium chloride is an antispasmodic, antimuscarinic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.

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BRC0022
Product IDBRC0022
Product classBioreference compound
CAS number50-10-2
MW428.4
Synonyms
A-Spasm, Antispasmin, Antrenex, Antreny
Transport conditionsNormal

Oxyphenonium Bromide

Oxyphenonium is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle.

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BRC0084
Product IDBRC0084
Product classBioreference compound
CAS number129722-12-9
MW448.4
Synonyms
Abilify, Abilitat, Abilify Discmelt
Transport conditionsNormal

Aripiprazole

Aripiprazole is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Aripiprazole is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 and 2 adrenergic, and H1 histaminergic receptors.

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BRC0399
Product IDBRC0399
Product classBioreference compound
CAS number133099-07-7
MW507.5
Synonyms
Emselex, Enablex, Xelena, UK-88525
Transport conditionsNormal

Darifenacin hydrobromide

Darifenacin is a competitive muscarinic receptor antagonist.

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BRC0411
Product IDBRC0411
Product classBioreference compound
CAS number54527-84-3
MW516.0
Synonyms
RS-69216, Cardene
Transport conditionsNormal

Nicardipine hydrochloride

Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

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BRC0668
Product IDBRC0668
Product classBioreference compound
CAS number111974-72-2
MW883.1
Synonyms
Transport conditionsNormal

Quetiapine hemifumarate

Quetiapine hemifumarate is atypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 = 148 and 329 nM respectively). It is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder.

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BRC0829
Product IDBRC0829
Product classBioreference compound
CAS number65-29-2
MW891.5
Synonyms
F 2559, HL 8583, RP 3697
Transport conditionsNormal

Gallamine triethiodide

Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug used as an adjunct to anesthesia to induce skeletal muscle relaxation. It competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate.

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