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Dopamine receptor

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BRC0523
Product IDBRC0523
Product classBioreference compound
CAS number176199-48-7
MW185.2
Synonyms
Eglumegad, Eglumetad
Transport conditionsNormal

LY354740

The compound is highly potent agonists for group 2/3 metabotropic glutamate receptors mGluR. mGlu2/3 receptors are targets for the treatment of anxiety, schizophrenia, convulsive disorders, Parkinson’s disease, pain, and neurodegeneration.

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BRC0260
Product IDBRC0260
Product classBioreference compound
CAS number665-66-7
MW187.7
Synonyms
Aminoadamantane, Viregyt, Virosol, PK-Merz, Symadine, Symmetrel
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amantadine hydrochloride

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance).

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BRC0023
Product IDBRC0023
Product classBioreference compound
CAS number62-31-7
MW189.6
Synonyms
3-Hydroxytyramine, Deoxyepinephrine, Oxytyramine, Intropin, Revimine
Transport conditionsNormal

Dopamine hydrochloride

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility.

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BRC0840
Product IDBRC0840
Product classBioreference compound
CAS number59-92-7
MW197.2
Synonyms
V-1512; Pardopa; Syndopa; L-dopa;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Levodopa

Levodopa is a metabolic precursor of dopamine that is capable of crossing the blood-brain barrier. It is used to replace dopamine lost in Parkinsons disease.

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BRC1008
Product IDBRC1008
Product classBioreference compound
CAS number55206-24-1
MW214.7
Synonyms
Transport conditionsNormal

6-fluorotryptamine hydrochloride

6-fluorotryptamine hydrochloride is a tryptamine derivative that potentially agonizes 5-HT serotonin receptors (EC50 = 4.56 nM).

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BRC0032
Product IDBRC0032
Product classBioreference compound
CAS number41100-52-1
MW215.8
Synonyms
Abixa, Akatinol, Axura, Memox
Transport conditionsNormal

Memantine hydrochloride

Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentially to the NMDA receptor-operated cation channels. Memantine also has antagonistic activity at the type 3 serotonergic (5-HT3) receptor with a potency that is similar to that at the NMDA receptor, and lower antagonistic activity at the nicotinic acetylcholine receptor. This drug has no affinity for γ-aminobutyric acid (GABA), benzodiazepine, dopamine, adrenergic, histamine, or glycine receptors or for voltage-dependent calcium, sodium, or potassium channels.

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BRC1086
Product IDBRC1086
Product classBioreference compound
CAS number1955540-15-4
MW239.7
Synonyms
Transport conditionsNormal

3-phenoxy-8-azabicyclo[3.2.1]octane hydrochloride

3-phenoxy-8-azabicyclo[3.2.1]octane hydrochloride is inhibitor of [3H]noradrenaline, [3H]dopamine and [3H]serotonin reuptake.

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BRC0898
Product IDBRC0898
Product classBioreference compound
CAS number38175-32-5
MW244.1
Synonyms
Transport conditionsNormal

3-(3-Hydroxyphenyl)pyrrolidine hydrobromide

The compound is dopamine receptor antagonist.

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BRC0883
Product IDBRC0883
Product classBioreference compound
CAS number3575-80-2
MW263.4
Synonyms
FG-5111
Transport conditionsNormal

Melperone

Melperone is an atypical antipsychotic. It is 5-HT2A/D2 receptor antagonist (Ki = 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC.

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BRC0421
Product IDBRC0421
Product classBioreference compound
CAS number85650-52-8
MW265.4
Synonyms
Org 3770, 6-Azamianserin, Avanza, Axit, Mirtabene, Mirtaz, Mirtazon, Norset, Promyrtil, Remergil, Remergon, Remeron, Remeron SolTab, Rexer, Zispin
Transport conditionsNormal

Mirtazapine

Mirtazapine, an antidepressant of the piperazinoazepine class, is a tetracyclic compound with an anxiolytic effect. Mirtazapine has fewer ADRs than tricyclic antidepressants and is better tolerated. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants.

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BRC0817
Product IDBRC0817
Product classBioreference compound
CAS number133-16-4
MW270.8
Synonyms
Halestyn; Piocaine;
Transport conditionsNormal

Chloroprocaine

Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia. It blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rising of the action potential.

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BRC0941
Product IDBRC0941
Product classBioreference compound
CAS number51-05-8
MW272.8
Synonyms
Novocaine; Vitamin H3; Duracaine; NSC 169497; Nissocaine;
Transport conditionsNormal

Procaine Hydrochloride

Procaine hydrochloride is a local anesthetic. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. It is a sodium channel blocker with a variety of inhibitory effects. Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1.

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BRC0348
Product IDBRC0348
Product classBioreference compound
CAS number7416-34-4
MW276.4
Synonyms
Moban
Transport conditionsNormal

Molindone

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder.

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BRC0404
Product IDBRC0404
Product classBioreference compound
CAS number91374-20-8
MW296.8
Synonyms
Adartrel, ReQuip, Ronirol, SKandF 101468
Transport conditionsNormal

Ropinirole hydrochloride

Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes.

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BRC0685
Product IDBRC0685
Product classBioreference compound
CAS number364-62-5
MW299.8
Synonyms
Afipran, Clopromate, DEL 1267
Transport conditionsNormal

Metoclopramide

Metoclopramide is dopamine D2 receptor antagonist. A labelled substituted benzamide with neuroleptic activity. Antiemetic.

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BRC0932
Product IDBRC0932
Product classBioreference compound
CAS number894-71-3
MW299.8
Synonyms
NCI-169453; Acetexa; Pamelor®;
Transport conditionsNormal

Nortriptyline Hydrochloride

Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant that blocks norepinephrine and serotonin transporters more potently than the dopamine transporter. It also antagonizes serotonin, histamine, muscarinic, and α-adrenergic receptors.

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BRC0011
Product IDBRC0011
Product classBioreference compound
CAS number191217-81-9
MW302.3
Synonyms
Mirapexin, Sifrol, (-)-Pramipexole, Pramipexol, SND 919
Transport conditionsNormal

Pramipexole hydrate dihydrochloride

Pramipexole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes.

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BRC0748
Product IDBRC0748
Product classBioreference compound
CAS number132539-06-1
MW312.4
Synonyms
ADAMED, Arenbil, Integrol, LY 170053
Transport conditionsNormal

Olanzapine

Olanzapine is serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic and antipsychotic activity.

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BRC0109
Product IDBRC0109
Product classBioreference compound
CAS number14028-44-5
MW313.8
Synonyms
Asendin, Demolox, CL 67772
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amoxapine

Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants; amoxapine inhibits GLYT2a transport activity with IC50 of 92 M.

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BRC0006
Product IDBRC0006
Product classBioreference compound
CAS number10347-81-6
MW313.9
Synonyms
Deprilept; Ludiomil; Psymion;
Transport conditionsNormal

Maprotiline hydrochloride

Maprotiline is a tetracyclic antidepressant. Although its main therapeutic use is in the treatment of depression, it has also been shown to exert a sedative effect on the anxiety component that often accompanies depression.

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BRC0391
Product IDBRC0391
Product classBioreference compound
CAS number1229-29-4
MW315.8
Synonyms
Adapin, Aponal, Curatin, Doxepine, Quitaxon, Sinequan
Transport conditionsNormal

Doxepin hydrochloride

Doxepin, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema. Doxepin has substantial anticholinergic and sedative effects. The E (trans)-isomer is more active as a serotonin reuptake inhibitor while the Z-isomer acts as a sedative.

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BRC0360
Product IDBRC0360
Product classBioreference compound
CAS number113-59-7
MW315.9
Synonyms
NSC 169899
Transport conditionsNormal

Chlorprothixene

Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.

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BRC0044
Product IDBRC0044
Product classBioreference compound
CAS number113-52-0
MW316.9
Synonyms
Antideprin, Melipramine, Imidobenzyle, Berkomine, Melipramin
Transport conditionsNormal

Imipramine hydrochloride

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use.

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BRC0096
Product IDBRC0096
Product classBioreference compound
CAS number58-46-8
MW317.4
Synonyms
Nitoman, Rubigen,
Transport conditionsNormal

Tetrabenazine

A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. Tetrabenazine is a reversible human vesicular monoamine transporter type 2 inhibitor (Ki = 100 nM). It acts within the basal ganglia and promotes depletion of monoamine neurotransmitters serotonin, norepinephrine, and dopamine from stores. It also decreases uptake into synaptic vesicles.

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BRC0385
Product IDBRC0385
Product classBioreference compound
CAS number53-60-1
MW320.9
Synonyms
Sparine, Talofen
Transport conditionsNormal

Promazine hydrochloride

Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors.

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BRC0392
Product IDBRC0392
Product classBioreference compound
CAS number58-33-3
MW320.9
Synonyms
Avomine, Fargan, Farganesse, Lergigan,PHENADOZ, Phenergan, Promethegan, Prothiazine, Receptozine, Romergan, Sominex
Transport conditionsNormal

Promethazine hydrochloride

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties.

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BRC0770
Product IDBRC0770
Product classBioreference compound
CAS number5786-21-0
MW326.8
Synonyms
HF-1854, LX 100-129, W 108, Iprox, Klozapol, Leponex, Sizopin
Transport conditionsNormal

Clozapine

Clozapine is a psychotropic, selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 and 2 adrenergic, and H1 histaminergic receptors. Clozapine acts as an antagonist at other receptors, but with lower potency.

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BRC0584
Product IDBRC0584
Product classBioreference compound
CAS number174794-02-6
MW328.4
Synonyms
LY 170238
Transport conditionsNormal

Olanzapine N-Oxide

A metabolite of Olanzapine.

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BRC0736
Product IDBRC0736
Product classBioreference compound
CAS number136434-34-9
MW333.9
Synonyms
LY 248686 HCl, Yentreve
Transport conditionsNormal

Duloxetine hydrochloride

Duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake. The antidepressant and pain inhibitory actions of duloxetine are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS.

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BRC0885
Product IDBRC0885
Product classBioreference compound
CAS number5322-53-2
MW337.4
Synonyms
NSC 313681, Oxyperomide, R 4714
Transport conditionsNormal

Peromide

Peromide is an antipsychotic agent, dopaminergic antagonist.

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BRC0997
Product IDBRC0997
Product classBioreference compound
CAS number15676-16-1
MW341.4
Synonyms
Transport conditionsNormal

Sulpiride

Sulpiride is selective dopamine D2 antagonist with antipsychotic and antidepressant activity.

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BRC0291
Product IDBRC0291
Product classBioreference compound
CAS number69-09-0
MW355.3
Synonyms
Chlorpromanyl, Largactil, Thorazine, J2.794D, NSC-167745, NSC-226514
Transport conditionsNormal

Chlorpromazine

Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It antagonizes a range of receptors, including post-synaptic dopamine and serotonin receptors.

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BRC1017
Product IDBRC1017
Product classBioreference compound
CAS number316-07-4
MW371.3
Synonyms
Chlorpromazine sulfoxide hydrochloride; NSC 17470;
Transport conditionsNormal

Opromazine Hydrochloride

Opromazine hydrochloride is a derivative of Chlorpromazine, which is a dopamine antagonist of the typical antipsychotic class of medications possessing additional antiadrenergic, antiserotonergic, anticholinergic and antihistaminergic properties.

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BRC0730
Product IDBRC0730
Product classBioreference compound
CAS number52-86-8
MW375.9
Synonyms
MCN-JR-1625; NSC-170973; NSC-615296; R-1625; Dozic; Einalon S; Eukystol;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Haloperidol

Haloperidol is butyrophenone antipsychotic, D2, D3, and D4 dopamine receptor antagonist. It is used primarily to treat schizophrenia and other psychoses.

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BRC0640
Product IDBRC0640
Product classBioreference compound
CAS number548-73-2
MW379.4
Synonyms
McN-JR 4749, NSC 169874, Neurolidol, R 4749, Sintodril
Transport conditionsNormal

Droperidol

Droperidol is a D2 receptor antagonist (Ki = 0.4 nM). Also exhibits affinity for 5-HT2 (pIC50 8.57) and 5-HT1 (pIC50 6.42), alpha-adrenergic (Ki = 0.7 nM) and histamine receptors,and hERG channels. Antipsychotic and antiemetic.

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BRC0131
Product IDBRC0131
Product classBioreference compound
CAS number138-56-7
MW388.5
Synonyms
Benzacot, Stemetic, Tebamide, Tribenzagan, Tigan
Transport conditionsNormal

Trimethobenzamide

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

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BRC0256
Product IDBRC0256
Product classBioreference compound
CAS number1098-60-8
MW388.9
Synonyms
Fluopromazine; Adazine; Psyquil;
Transport conditionsNormal

Triflupromazine hydrochloride

Triflupromazine hydrochloride binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity.

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BRC0693
Product IDBRC0693
Product classBioreference compound
CAS number1159788-59-6
MW390.9
Synonyms
Haynon, Allergican
Transport conditionsNormal

Chlorpheniramine 2-butenedioate

Chlorpheniramine 2-butenedioate is a histamine H1 antagonist (Kd = 0.4 nM) used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications.

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BRC0257
Product IDBRC0257
Product classBioreference compound
CAS number125481-61-0
MW401.5
Synonyms
BMS 528215; BMY 28674;
Transport conditionsNormal

6-Hydroxybuspirone

A major active metabolite of buspirone.

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BRC0013
Product IDBRC0013
Product classBioreference compound
CAS number85650-56-2
MW401.8
Synonyms
Saphris,
Transport conditionsNormal

Asenapine maleate

Asenapine is a serotonin, dopamine, noradrenaline, and histamine antagonist in which asenapine possess more potent activity with serotonin receptors than dopamine. Asenapine is an atypical antipsychotic multireceptor neuroleptic drug which shows strong 5HT2A (serotonin) and D2 (dopamine) receptor antagonism, which has been shown to enhance dopamine (DA) and acetylcholine (Ach) efflux in rat brains. Asenapine may improve cognitive function and negative symptoms in patients with schizophrenia.

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BRC0757
Product IDBRC0757
Product classBioreference compound
CAS number67227-57-0
MW401.9
Synonyms
SKF 82526
Transport conditionsNormal

Fenoldopam mesylate

Fenoldopam is selective D1-like dopamine receptor partial agonist (EC50 = 57 nM) that is being considered for the parenteral treatment of systemic hypertension. Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α2-adrenoceptor antagonist in vitro (Ki = 15 - 25 nM).

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BRC0717
Product IDBRC0717
Product classBioreference compound
CAS number58-39-9
MW404.0
Synonyms
Mutabom, NSC 150866, PZC, Sch 3940
Transport conditionsNormal

Perphenazine

Perphenazine is a D2DR inhibitor (IC50 = 0.0244 nM) which inhibits the glutamate dehydrogenase in vitro. Perphenazine also acts as a α-adrenergic receptor antagonist and σ-receptor agonist.

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BRC0397
Product IDBRC0397
Product classBioreference compound
CAS number130-61-0
MW407.0
Synonyms
Aldazine, Mallorol, Meleril, Mellaril, Mellerette, Melleretten, Melleril, Novoridazine, Ridazin, Ridazine, Sonapax, Thioril
Transport conditionsNormal

Thioridazine hydrochloride

Thioridazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. It is a calcium channel protein inhibitor as well as a D2DR/D4DR inhibitor. It is an intercalating agent for analyzing the integrity of double stranded DNA by using the square-wave voltammetry.

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BRC0068
Product IDBRC0068
Product classBioreference compound
CAS number106266-06-2
MW410.5
Synonyms
Risperdal, Risperidal, Rispolept,
Transport conditionsNormal

Risperidone

Risperidone, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is used primarily in the management of schizophrenia, inappropriate behavior in severe dementia and manic episodes associated with bipolar I disorder.

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BRC0262
Product IDBRC0262
Product classBioreference compound
CAS number33386-08-2
MW422.0
Synonyms
Ansial, Bespar, Anxiron
Transport conditionsNormal

Buspirone hydrochloride

An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam.

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BRC0803
Product IDBRC0803
Product classBioreference compound
CAS number133454-47-4
MW426.5
Synonyms
HP-873
Transport conditionsNormal

Iloperidone

Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms.

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BRC0767
Product IDBRC0767
Product classBioreference compound
CAS number144598-75-4
MW426.5
Synonyms
9-Hydroxyrisperidone, Paliperidone, Ro-76477
Transport conditionsNormal

Paliperidone

Paliperidone is an atypical antipsychotic, metabolite of risperidone. It exhibits high affinity for 5-HT2A receptors (Ki = 0.4 nM for cloned human 5-HT2A receptors). Also, displays high affinity for human D2 receptors.

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BRC0084
Product IDBRC0084
Product classBioreference compound
CAS number129722-12-9
MW448.4
Synonyms
Abilify, Abilitat, Abilify Discmelt
Transport conditionsNormal

Aripiprazole

Aripiprazole is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Aripiprazole is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 and 2 adrenergic, and H1 histaminergic receptors.

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BRC0414
Product IDBRC0414
Product classBioreference compound
CAS number2062-78-4
MW461.6
Synonyms
NSC 170984, Orap, R 6238, Neoperidole, Opiran
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Pimozide

Pimozide is an orally active antipsychotic drug product which shares with other antipsychotics the ability to blockade dopaminergic receptors on neurons in the central nervous system.

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BRC0025
Product IDBRC0025
Product classBioreference compound
CAS number440-17-5
MW480.4
Synonyms
Stelazine, Terfluzine, 440-17-5,
Transport conditionsNormal

Trifluoperazine dihydrochloride

Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Trifluoperazine has not been shown effective in the management of behaviorial complications in patients with mental retardation. Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

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