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Histamine receptor

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BRC0982
Product IDBRC0982
Product classBioreference compound
CAS number5638-76-6
MW136.2
Synonyms
Transport conditionsNormal

Betahistine

Betahistine is an antivertigo drug, a histamine analog, and H1 receptor agonist. It serves as a vasodilator and is most commonly used to treat the symptoms of vertigo. Betahistine also has a strong affinity as an antagonist for histamine H3 receptors.

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BRC0956
Product IDBRC0956
Product classBioreference compound
CAS number138-92-1
MW184.1
Synonyms
Ametazole;
Transport conditionsNormal

Betazole Dihydrochloride

Betazole dihydrochloride is a histamine H2 agonist used in a test for measuring maximal production of gastric acidity or anacidity.

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BRC0633
Product IDBRC0633
Product classBioreference compound
CAS number56-92-8
MW184.1
Synonyms
NSC-257873; NSC-33792;
Transport conditionsNormal

Histamine Dihydrochloride

Histamine is a depressor amine. It is a powerful stimulant of gastric secretion, a bronchoconstrictor, vasodilator, and also a centrally acting neurotransmitter.

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BRC0125
Product IDBRC0125
Product classBioreference compound
CAS number59-97-2
MW196.7
Synonyms
Priscoline, Benzidazol, Priscol, Divascol,
Transport conditionsNormal

Tolazoline hydrochloride

Tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.

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BRC0529
Product IDBRC0529
Product classBioreference compound
CAS number5465-86-1
MW226.3
Synonyms
NSC 25850, CID-230710, 2-piperidino-Lepidine
Transport conditionsNormal

ML 204

ML-204 is a selective blocker of transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It demonstrates 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.

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BRC0653
Product IDBRC0653
Product classBioreference compound
CAS number51481-61-9
MW252.3
Synonyms
NSC-335308, SKF 92334, SKF-92334
Transport conditionsNormal

Cimetidine

Cimetidine is competitive histamine H2-receptor antagonist (pA2 6.6 - 7.3) which inhibits gastric acid secretion and reduces pepsin output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.

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BRC0907
Product IDBRC0907
Product classBioreference compound
CAS number51721-62-1
MW260.2
Synonyms
Transport conditionsNormal

2-Phenylhistamine dihydrochloride

The compound is selective histamine H1 receptor antagonist.

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BRC0421
Product IDBRC0421
Product classBioreference compound
CAS number85650-52-8
MW265.4
Synonyms
Org 3770, 6-Azamianserin, Avanza, Axit, Mirtabene, Mirtaz, Mirtazon, Norset, Promyrtil, Remergil, Remergon, Remeron, Remeron SolTab, Rexer, Zispin
Transport conditionsNormal

Mirtazapine

Mirtazapine, an antidepressant of the piperazinoazepine class, is a tetracyclic compound with an anxiolytic effect. Mirtazapine has fewer ADRs than tricyclic antidepressants and is better tolerated. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants.

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BRC0461
Product IDBRC0461
Product classBioreference compound
CAS number115-46-8
MW267.4
Synonyms
Frenoton, MDL 4829, MER 17, Psychosan, Calmeran, γ-pipradol,
Transport conditionsNormal

Azacyclonol

Azacyclonol is ataractive agent, terfenadine metabolite. Inhibits shock-induced elevation of catecholamine levels in the brain. Shows central depressant effects in vivo. Azacyclonol is a drug used to decrease hallucinations in psychotic individuals.

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BRC0642
Product IDBRC0642
Product classBioreference compound
CAS number469-21-6
MW270.4
Synonyms
LS 127
Transport conditionsNormal

Doxylamine

Doxylamine is H1 histamine receptor antagonist. Doxylamine suppresses histamine at the H1 receptor.

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BRC0396
Product IDBRC0396
Product classBioreference compound
CAS number154-69-8
MW291.8
Synonyms
Azaron, Pyribenzamine, Tripel
Transport conditionsNormal

Tripelennamine hydrochloride

Tripelennamine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract.

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BRC0930
Product IDBRC0930
Product classBioreference compound
CAS number147-24-0
MW291.8
Synonyms
Difenhydramine; DPH;
Transport conditionsNormal

Diphenhydramine Hydrochloride

Diphenhydramine hydrochloride is an analytical reference standard that is categorized as an antihistamine. It competes with free histamine for binding at HA-receptor sites.

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BRC0932
Product IDBRC0932
Product classBioreference compound
CAS number894-71-3
MW299.8
Synonyms
NCI-169453; Acetexa; Pamelor®;
Transport conditionsNormal

Nortriptyline Hydrochloride

Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant that blocks norepinephrine and serotonin transporters more potently than the dopamine transporter. It also antagonizes serotonin, histamine, muscarinic, and α-adrenergic receptors.

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BRC0731
Product IDBRC0731
Product classBioreference compound
CAS number6202-23-9
MW311.8
Synonyms
Lisseril, MK 130 hydrochloride, Miosan, Multi-Relax, Proheptatriene hydrochloride, TNX-102
Transport conditionsNormal

Cyclobenzaprine hydrochloride

Cyclobenzaprine is a skeletal muscle relaxant, reduces muscle spasm by depression of brainstem neurons; 5-HT2 serotonin receptor antagonist.

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BRC0748
Product IDBRC0748
Product classBioreference compound
CAS number132539-06-1
MW312.4
Synonyms
ADAMED, Arenbil, Integrol, LY 170053
Transport conditionsNormal

Olanzapine

Olanzapine is serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic and antipsychotic activity.

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BRC0109
Product IDBRC0109
Product classBioreference compound
CAS number14028-44-5
MW313.8
Synonyms
Asendin, Demolox, CL 67772
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amoxapine

Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants; amoxapine inhibits GLYT2a transport activity with IC50 of 92 M.

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BRC0006
Product IDBRC0006
Product classBioreference compound
CAS number10347-81-6
MW313.9
Synonyms
Deprilept; Ludiomil; Psymion;
Transport conditionsNormal

Maprotiline hydrochloride

Maprotiline is a tetracyclic antidepressant. Although its main therapeutic use is in the treatment of depression, it has also been shown to exert a sedative effect on the anxiety component that often accompanies depression.

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BRC0379
Product IDBRC0379
Product classBioreference compound
CAS number550-70-9
MW314.9
Synonyms
Actidil, Myidil, Actifed
Transport conditionsNormal

Triprolidine hydrochloride monohydrate

Triprolidine, is a histamine H1 antagonist that competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. Triprolidine has anticholinergic and sedative effects.

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BRC0391
Product IDBRC0391
Product classBioreference compound
CAS number1229-29-4
MW315.8
Synonyms
Adapin, Aponal, Curatin, Doxepine, Quitaxon, Sinequan
Transport conditionsNormal

Doxepin hydrochloride

Doxepin, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema. Doxepin has substantial anticholinergic and sedative effects. The E (trans)-isomer is more active as a serotonin reuptake inhibitor while the Z-isomer acts as a sedative.

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BRC0360
Product IDBRC0360
Product classBioreference compound
CAS number113-59-7
MW315.9
Synonyms
NSC 169899
Transport conditionsNormal

Chlorprothixene

Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.

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BRC0044
Product IDBRC0044
Product classBioreference compound
CAS number113-52-0
MW316.9
Synonyms
Antideprin, Melipramine, Imidobenzyle, Berkomine, Melipramin
Transport conditionsNormal

Imipramine hydrochloride

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use.

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BRC0385
Product IDBRC0385
Product classBioreference compound
CAS number53-60-1
MW320.9
Synonyms
Sparine, Talofen
Transport conditionsNormal

Promazine hydrochloride

Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors.

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BRC0392
Product IDBRC0392
Product classBioreference compound
CAS number58-33-3
MW320.9
Synonyms
Avomine, Fargan, Farganesse, Lergigan,PHENADOZ, Phenergan, Promethegan, Prothiazine, Receptozine, Romergan, Sominex
Transport conditionsNormal

Promethazine hydrochloride

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties.

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BRC0584
Product IDBRC0584
Product classBioreference compound
CAS number174794-02-6
MW328.4
Synonyms
LY 170238
Transport conditionsNormal

Olanzapine N-Oxide

A metabolite of Olanzapine.

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BRC0118
Product IDBRC0118
Product classBioreference compound
CAS number76963-41-2
MW331.4
Synonyms
Axid, Acinon, Zanizal, Nizax, Tazac
Transport conditionsNormal

Nizatidine

Nizatidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells. By inhibiting the action of histamine on stomach cells, nizatidine reduces stomach acid production.

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BRC0801
Product IDBRC0801
Product classBioreference compound
CAS number76824-35-6
MW337.4
Synonyms
YM 11170, L 643341, MK-208
Transport conditionsNormal

Famotidine

Famotidine is a competitive histamine H2-receptor antagonist, anti-ulcer agent.

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BRC1075
Product IDBRC1075
Product classBioreference compound
CAS number123-03-5
MW340.0
Synonyms
Pionin B 651P; Septolete; TsPKh;
Transport conditionsNormal

Cetylpyridinium Chloride

Cetylpyridinium chloride is a quaternary ammonium with broad-spectrum antiseptic properties. It has been used to study the mechanisms of bacterial and virus inactivation by cationic quaternary ammonium detergents.

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BRC0291
Product IDBRC0291
Product classBioreference compound
CAS number69-09-0
MW355.3
Synonyms
Chlorpromanyl, Largactil, Thorazine, J2.794D, NSC-167745, NSC-226514
Transport conditionsNormal

Chlorpromazine

Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It antagonizes a range of receptors, including post-synaptic dopamine and serotonin receptors.

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BRC0425
Product IDBRC0425
Product classBioreference compound
CAS number15686-51-8
MW380.4
Synonyms
HS-592, Dayhist
Transport conditionsNormal

Clemastine hydrochloride

Clemastine is an antihistamine with anticholinergic (drying) and sedative side effects.

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BRC0774
Product IDBRC0774
Product classBioreference compound
CAS number79794-75-5
MW382.9
Synonyms
SCH-29851,
Transport conditionsNormal

Loratadine

Loratadine is a long acting second generation antihistamine. It is a competitive, specific, and selective antagonist of H1 receptors. Loratadine does not penetrate the CNS effectively and has a low affinity for CNS H1-receptors.

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BRC0693
Product IDBRC0693
Product classBioreference compound
CAS number1159788-59-6
MW390.9
Synonyms
Haynon, Allergican
Transport conditionsNormal

Chlorpheniramine 2-butenedioate

Chlorpheniramine 2-butenedioate is a histamine H1 antagonist (Kd = 0.4 nM) used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications.

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BRC0204
Product IDBRC0204
Product classBioreference compound
CAS number2438-32-6
MW390.9
Synonyms
S-(+)-Chlorpheniramine maleate salt
Transport conditionsNormal

Dexchlorpheniramine maleate

Dexchlorpheniramine is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.

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BRC0013
Product IDBRC0013
Product classBioreference compound
CAS number85650-56-2
MW401.8
Synonyms
Saphris,
Transport conditionsNormal

Asenapine maleate

Asenapine is a serotonin, dopamine, noradrenaline, and histamine antagonist in which asenapine possess more potent activity with serotonin receptors than dopamine. Asenapine is an atypical antipsychotic multireceptor neuroleptic drug which shows strong 5HT2A (serotonin) and D2 (dopamine) receptor antagonism, which has been shown to enhance dopamine (DA) and acetylcholine (Ach) efflux in rat brains. Asenapine may improve cognitive function and negative symptoms in patients with schizophrenia.

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BRC0198
Product IDBRC0198
Product classBioreference compound
CAS number59729-32-7
MW405.3
Synonyms
Nitalapram, Celexa, Cipram, Lu 10-171
Transport conditionsNormal

Citalopram hydrobromide

Citalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety.

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BRC0358
Product IDBRC0358
Product classBioreference compound
CAS number3505-38-2
MW406.9
Synonyms
Arbinoxa, Satinmin, Allergefon, Clistin, Histin, Karbinal, Rotoxamine
Transport conditionsNormal

Carbinoxamine maleate

Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites.

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BRC0134
Product IDBRC0134
Product classBioreference compound
CAS number25332-39-2
MW408.3
Synonyms
Beneficat, Desirel, Trialodine, Sideril, AF-1161, KB-831
Transport conditionsNormal

Trazodone hydrochloride

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents.

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BRC0068
Product IDBRC0068
Product classBioreference compound
CAS number106266-06-2
MW410.5
Synonyms
Risperdal, Risperidal, Rispolept,
Transport conditionsNormal

Risperidone

Risperidone, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is used primarily in the management of schizophrenia, inappropriate behavior in severe dementia and manic episodes associated with bipolar I disorder.

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BRC0803
Product IDBRC0803
Product classBioreference compound
CAS number133454-47-4
MW426.5
Synonyms
HP-873
Transport conditionsNormal

Iloperidone

Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms.

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BRC0767
Product IDBRC0767
Product classBioreference compound
CAS number144598-75-4
MW426.5
Synonyms
9-Hydroxyrisperidone, Paliperidone, Ro-76477
Transport conditionsNormal

Paliperidone

Paliperidone is an atypical antipsychotic, metabolite of risperidone. It exhibits high affinity for 5-HT2A receptors (Ki = 0.4 nM for cloned human 5-HT2A receptors). Also, displays high affinity for human D2 receptors.

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BRC0872
Product IDBRC0872
Product classBioreference compound
CAS number2192-20-3
MW447.8
Synonyms
NSC 169188, Tran-Q, Tranquizine, U.C.B 4492
Transport conditionsNormal

Hydroxyzine dihydrochloride

Hydroxyzine dihydrochloride is a histamine H1 receptor antagonist.

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BRC0084
Product IDBRC0084
Product classBioreference compound
CAS number129722-12-9
MW448.4
Synonyms
Abilify, Abilitat, Abilify Discmelt
Transport conditionsNormal

Aripiprazole

Aripiprazole is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Aripiprazole is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 and 2 adrenergic, and H1 histaminergic receptors.

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BRC0660
Product IDBRC0660
Product classBioreference compound
CAS number4682-36-4
MW461.5
Synonyms
BS 5930, Biorphen, Brocadisipal, ORP, WS 2434
Transport conditionsNormal

Orphenadrine citrate

Orphenadrine Citrate is muscarinic receptor antagonist (pKi 7.39), H1 histamine receptor antagonist (pIC50 6.79), a muscle relaxant. It also inhibits the noradrenergic transporter and to block the NMDA receptor ion channel.

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BRC0914
Product IDBRC0914
Product classBioreference compound
CAS number83881-52-1
MW461.8
Synonyms
Transport conditionsNormal

Cetirizine dihydrochloride

Cetirizine is a potent second-generation histamine H1 antagonist.

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BRC0372
Product IDBRC0372
Product classBioreference compound
CAS number1104-22-9
MW463.9
Synonyms
Bonamine, Meclozine, NSC 28728, Parachloramine, Postafen
Transport conditionsNormal

Meclizine dihydrochloride

Meclizine Dihydrochloride is a pregnane X receptor (PXR) agonist and histamine H1 receptor antagonist. The compound also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor.

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BRC0015
Product IDBRC0015
Product classBioreference compound
CAS number6398-98-7
MW464.8
Synonyms
Flavoquine, Camoquin
Transport conditionsNormal

Amodiaquine dihydrochloride dihydrate

Amodiaquine, a 4-aminoquinoline similar to chloroquine in structure and activity, has been used as both an antimalarial and an anti-inflammatory agent for more than 40 years. The mode of action of amodiaquine has not yet been determined. 4-Aminoquinolines depress cardiac muscle, impair cardiac conductivity, and produce vasodilatation with resultant hypotension.

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BRC0010
Product IDBRC0010
Product classBioreference compound
CAS number1445763-73-4
MW522.6
Synonyms
Idumed, Optimine, Zadine
Transport conditionsNormal

Azatadine 2-​butenedioate

Azatadine is an antihistamine, related to cyproheptadine, with anti-serotonin, anticholinergic (drying), and sedative effects. Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells.

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BRC0347
Product IDBRC0347
Product classBioreference compound
CAS number153439-40-8
MW538.1
Synonyms
MDL 16455A
Transport conditionsNormal

Fexofenadine hydrochloride

Fexofenadine HCl, an active metabolite of terfenadine, has demonstrated to be a nonsedating Histamine H1 receptor antagonist. Mechanistic studies have reported that high concentrations of this compound can inhibit Cox-1 activity while low concentrations of Fexofenadine HCl inhibits Cox-2 activity.

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BRC0668
Product IDBRC0668
Product classBioreference compound
CAS number111974-72-2
MW883.1
Synonyms
Transport conditionsNormal

Quetiapine hemifumarate

Quetiapine hemifumarate is atypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 = 148 and 329 nM respectively). It is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder.

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