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Adrenergic receptor

StructureProduct infoAvailabilityQuantity / Price
BRC0133
Product IDBRC0133
Product classBioreference compound
CAS number51-43-4
MW183.2
Synonyms
Adrenalin; L-epinephrine; Levoepinephrine;
Transport conditionsNormal

Epinephrine

Epinephrine is indicated for intravenous injection in treatment of acute hypersensitivity, treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome).

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BRC0125
Product IDBRC0125
Product classBioreference compound
CAS number59-97-2
MW196.7
Synonyms
Priscoline, Benzidazol, Priscol, Divascol,
Transport conditionsNormal

Tolazoline hydrochloride

Tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.

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BRC0972
Product IDBRC0972
Product classBioreference compound
CAS number835-31-4
MW210.3
Synonyms
Antan; Rhinazine; Imidin;
Transport conditionsNormal

Naphazoline

Naphazoline is sympathomimetic adrenergic alpha-agonist. It is used to induce systemic vasoconstriction, thereby decreasing nasal congestion and inducing constriction around the conjunctiva.

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BRC1012
Product IDBRC1012
Product classBioreference compound
CAS number3811-25-4
MW213.7
Synonyms
E 241; Isoprofenamine;
Transport conditionsNormal

Clorprenaline

Clorprenaline is a β-2 adrenergic receptor agonist.

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BRC0308
Product IDBRC0308
Product classBioreference compound
CAS number7361-61-7
MW220.3
Synonyms
Anased, ROMPUN, Solvazine, Gemini, Chanazine, Bayer 1470, Tranquived, Xyla-Ject
Transport conditionsNormal

Xylazine

Xylazine is a potent α2 adrenergic agonist. Due to xylazine’s highly lipophilic nature, xylazine directly stimulates central α2 receptors as well as peripheral α-adrenoceptors in a variety of tissues.

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BRC0905
Product IDBRC0905
Product classBioreference compound
CAS number951323-36-7
MW223.1
Synonyms
Transport conditionsNormal

4-Aminophenylguanidine dihydrochloride

The compound has α2-adrenoreceptor antagonist activity.

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BRC0529
Product IDBRC0529
Product classBioreference compound
CAS number5465-86-1
MW226.3
Synonyms
NSC 25850, CID-230710, 2-piperidino-Lepidine
Transport conditionsNormal

ML 204

ML-204 is a selective blocker of transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It demonstrates 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.

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BRC1320
Product IDBRC1320
Product classBioreference compound
CAS number2482-00-0
MW228.3
Synonyms
NIH 11035; NSC 56332;
Transport conditionsNormal

Agmatine sulfate

Agmantine is a natural metabolite of the arginine. It binds to human adrenergic receptors and imidazoline (I) receptors. Agmatine acts as an antagonist of the NMDA receptor and nicotinic acetylcholine receptors. It is an antagonist of the serotonin receptor subtype 5-HT3 and blocks ATP-sensitive potassium channels. Agmatine competitively inhibits neuronal, macrophage, endothelial, and inducible nitric oxide synthase and irreversibly inactivates neuronal NOS in the presence of calmodulin.

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BRC0337
Product IDBRC0337
Product classBioreference compound
CAS number522-48-5
MW236.7
Synonyms
Visine
Transport conditionsNormal

Tetryzoline hydrochloride

Tetrahydrozoline hydrochloride is an alpha agonist which causes constriction of conjunctival blood vessels.

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BRC0004
Product IDBRC0004
Product classBioreference compound
CAS number145108-58-3
MW236.7
Synonyms
Precedex, Dex, Dexmedetomidine HCL, (S)-Medetomidine hydrochloride
Transport conditionsNormal

Dexmedetomidine hydrochloride

Dexmedetomidine (hydrochloride) is the (S)-enantiomer of medetomidine (racemic form of this compound), a highly selective, potent and specific agonist of 2-adrenergic receptor (2-adrenoceptor).

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BRC0934
Product IDBRC0934
Product classBioreference compound
CAS number18559-94-9
MW239.3
Synonyms
Albuterol; AH 3365;
Transport conditionsNormal

Salbutamol

Salbutamol is a short-acting, selective beta(2)-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29-fold more selective for β2 adrenoceptors than β1 receptors. Binding of salbutamol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles.

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BRC0445
Product IDBRC0445
Product classBioreference compound
CAS number33125-97-2
MW244.3
Synonyms
Lipuro, Propiscin, R 16659, Hypnomidate, Amidate
Transport conditionsNormal

Etomidate

Etomidate is an imidazole compound that appears to depress CNS function via GABA and categorized as an anesthetic. Etomidate also inhibits adrenal cortisol biosynthesis and mitigates hypercortisolism, as is found in Cushing syndrome.

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BRC0373
Product IDBRC0373
Product classBioreference compound
CAS number61-16-5
MW247.7
Synonyms
NRL001, Mexan
Transport conditionsNormal

Methoxamine hydrochloride

Methoxamine is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Methoxamine acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.

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BRC0082
Product IDBRC0082
Product classBioreference compound
CAS number51-30-9
MW247.7
Synonyms
Norisodrine, Novodrin, Isopropydrin, Aludrine
Transport conditionsNormal

Isoproterenol hydrochloride

Isoproterenol is a relatively selective beta2-adrenergic bronchodilator. Isoproterenol is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease.

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BRC0421
Product IDBRC0421
Product classBioreference compound
CAS number85650-52-8
MW265.4
Synonyms
Org 3770, 6-Azamianserin, Avanza, Axit, Mirtabene, Mirtaz, Mirtazon, Norset, Promyrtil, Remergil, Remergon, Remeron, Remeron SolTab, Rexer, Zispin
Transport conditionsNormal

Mirtazapine

Mirtazapine, an antidepressant of the piperazinoazepine class, is a tetracyclic compound with an anxiolytic effect. Mirtazapine has fewer ADRs than tricyclic antidepressants and is better tolerated. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants.

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BRC0949
Product IDBRC0949
Product classBioreference compound
CAS number6673-35-4
MW266.3
Synonyms
Transport conditionsNormal

Practolol

Practolol is a beta-adrenergic receptor antagonist that has been used in the emergency treatment of cardiac arrhythmias.

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BRC0124
Product IDBRC0124
Product classBioreference compound
CAS number29122-68-7
MW266.3
Synonyms
Tenormin, Tenormine, Blokium, Normiten,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Atenolol

Atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.

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BRC0889
Product IDBRC0889
Product classBioreference compound
CAS number4205-91-8
MW266.6
Synonyms
ST 155, ST 155-BS
Transport conditionsNormal

Clonidine hydrochloride

Clonidine is an hypotensive agent, centrally-acting α2-adrenergic agonist.

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BRC0639
Product IDBRC0639
Product classBioreference compound
CAS number1193389-39-7
MW270.6
Synonyms
Transport conditionsNormal

N-(3-Chloropyridin-2-yl)piperazine dihydrochloride

The compound is selective α2-​adrenoceptor antagonist (Ki = 7.8 nM).

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BRC0675
Product IDBRC0675
Product classBioreference compound
CAS number14556-46-8
MW271.8
Synonyms
Transport conditionsNormal

Bupranolol

Bupranolol is a competitive, nonselective beta-blocker without intrinsic sympathomimetic activity. It competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation.

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BRC0273
Product IDBRC0273
Product classBioreference compound
CAS number29110-48-3
MW282.6
Synonyms
Estulic, Guanfacina, Guanfacinum, Estulic, SPD 503
Transport conditionsNormal

Guanfacine hydrochloride

Guanfacine selectively stimulates central alpha(2)-adrenergic receptors, resulting in inhibition of sympathetic vasomotor centers, which contributes predominantly to the hypotensive effects of the drug.

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BRC0644
Product IDBRC0644
Product classBioreference compound
CAS number64461-82-1
MW290.2
Synonyms
AB 021, AN 021, DS 103-282, Sirdalud, Ternelin, Tizan
Transport conditionsNormal

Tizanidine hydrochloride

Tizanidine hydrochloride is an agonist at a2-adrenergic receptor sites (IC50 = 48 nM) and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons.

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BRC0350
Product IDBRC0350
Product classBioreference compound
CAS number59803-98-4
MW292.1
Synonyms
UK 14,304
Transport conditionsNormal

Brimonidine

Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2).

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BRC0518
Product IDBRC0518
Product classBioreference compound
CAS number2444-46-4
MW293.4
Synonyms
8-Nordihydrocapsaicin, AH 23491X, NSC 172795, Pseudocapsaicin
Transport conditionsNormal

Nonivamide

Nonivamide is an capsaicinoid. Like capsaicin, it can deter mammals (but not birds or insects) from consuming plants or seeds. Nonivamide is a TRPV1 ion channel agonist. Mammalian TRPV1 is activated by heat and capsaicin, but the avian form is insensitive to capsaicin.

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BRC0428
Product IDBRC0428
Product classBioreference compound
CAS number318-98-9
MW295.8
Synonyms
AY-64043, ICI-45520, NCS-91523, Angilol, Bedranol SR, Cardinol, Ciplar, Deralin, Dociton, Duranol, HEMANGEOL, Inderal, Inderal LA, Indobloc, INNOPRAN, Innopran XL, Prophylux, Sumial
Transport conditionsNormal

Propranolol hydrochloride

Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.

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BRC0404
Product IDBRC0404
Product classBioreference compound
CAS number91374-20-8
MW296.8
Synonyms
Adartrel, ReQuip, Ronirol, SKandF 101468
Transport conditionsNormal

Ropinirole hydrochloride

Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes.

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BRC0932
Product IDBRC0932
Product classBioreference compound
CAS number894-71-3
MW299.8
Synonyms
NCI-169453; Acetexa; Pamelor®;
Transport conditionsNormal

Nortriptyline Hydrochloride

Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant that blocks norepinephrine and serotonin transporters more potently than the dopamine transporter. It also antagonizes serotonin, histamine, muscarinic, and α-adrenergic receptors.

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BRC0011
Product IDBRC0011
Product classBioreference compound
CAS number191217-81-9
MW302.3
Synonyms
Mirapexin, Sifrol, (-)-Pramipexole, Pramipexol, SND 919
Transport conditionsNormal

Pramipexole hydrate dihydrochloride

Pramipexole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes.

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BRC0892
Product IDBRC0892
Product classBioreference compound
CAS number2863-34-5
MW305.2
Synonyms
Transport conditionsNormal

Bethanidine iodide

Bethanidine iodide is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission.

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BRC0992
Product IDBRC0992
Product classBioreference compound
CAS number42200-33-9
MW309.4
Synonyms
Corgard; Solgol;
Transport conditionsNormal

Nadolol

Nadolol is a nonselective beta-adrenergic receptor antagonist with a long half-life. Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension.

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BRC0748
Product IDBRC0748
Product classBioreference compound
CAS number132539-06-1
MW312.4
Synonyms
ADAMED, Arenbil, Integrol, LY 170053
Transport conditionsNormal

Olanzapine

Olanzapine is serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic and antipsychotic activity.

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BRC0109
Product IDBRC0109
Product classBioreference compound
CAS number14028-44-5
MW313.8
Synonyms
Asendin, Demolox, CL 67772
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amoxapine

Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants; amoxapine inhibits GLYT2a transport activity with IC50 of 92 M.

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BRC0006
Product IDBRC0006
Product classBioreference compound
CAS number10347-81-6
MW313.9
Synonyms
Deprilept; Ludiomil; Psymion;
Transport conditionsNormal

Maprotiline hydrochloride

Maprotiline is a tetracyclic antidepressant. Although its main therapeutic use is in the treatment of depression, it has also been shown to exert a sedative effect on the anxiety component that often accompanies depression.

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BRC0391
Product IDBRC0391
Product classBioreference compound
CAS number1229-29-4
MW315.8
Synonyms
Adapin, Aponal, Curatin, Doxepine, Quitaxon, Sinequan
Transport conditionsNormal

Doxepin hydrochloride

Doxepin, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema. Doxepin has substantial anticholinergic and sedative effects. The E (trans)-isomer is more active as a serotonin reuptake inhibitor while the Z-isomer acts as a sedative.

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BRC0044
Product IDBRC0044
Product classBioreference compound
CAS number113-52-0
MW316.9
Synonyms
Antideprin, Melipramine, Imidobenzyle, Berkomine, Melipramin
Transport conditionsNormal

Imipramine hydrochloride

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use.

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BRC0385
Product IDBRC0385
Product classBioreference compound
CAS number53-60-1
MW320.9
Synonyms
Sparine, Talofen
Transport conditionsNormal

Promazine hydrochloride

Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors.

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BRC0392
Product IDBRC0392
Product classBioreference compound
CAS number58-33-3
MW320.9
Synonyms
Avomine, Fargan, Farganesse, Lergigan,PHENADOZ, Phenergan, Promethegan, Prothiazine, Receptozine, Romergan, Sominex
Transport conditionsNormal

Promethazine hydrochloride

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties.

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BRC0825
Product IDBRC0825
Product classBioreference compound
CAS number56-54-2
MW324.4
Synonyms
CIN-QUIN; Conchinin; Conquinine; Pitayine;
Transport conditionsNormal

Quinidine

Quinidine is an optical isomer of quinine, antiarrhythmic. It dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.

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BRC0584
Product IDBRC0584
Product classBioreference compound
CAS number174794-02-6
MW328.4
Synonyms
LY 170238
Transport conditionsNormal

Olanzapine N-Oxide

A metabolite of Olanzapine.

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BRC0645
Product IDBRC0645
Product classBioreference compound
CAS number63-92-3
MW340.3
Synonyms
NSC 37448, Dibenzyran
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Phenoxybenzamine hydrochloride

Phenoxybenzamine is a cell-permeable, non-specific, irreversible AR (alpha-adrenergic) antagonist (IC50 = 2E-09 M) that also acts as an CaM inhibitor. Phenoxybenzamine inhibits calmodulin-stimulated phosphodiesterase activity.

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BRC0356
Product IDBRC0356
Product classBioreference compound
CAS number249607-96-3
MW341.4
Synonyms
Regitine, Vasomax
Transport conditionsNormal

Phentolamine acetate

Phentolamine is a reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities.

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BRC0528
Product IDBRC0528
Product classBioreference compound
CAS number59170-23-9
MW345.4
Synonyms
NSC 13234
Transport conditionsNormal

Bevantolol

Bevantolol is a beta-1 adrenoceptor antagonist, effective beta blocker for the treatment of angina pectoris and hypertension.

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BRC0291
Product IDBRC0291
Product classBioreference compound
CAS number69-09-0
MW355.3
Synonyms
Chlorpromanyl, Largactil, Thorazine, J2.794D, NSC-167745, NSC-226514
Transport conditionsNormal

Chlorpromazine

Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It antagonizes a range of receptors, including post-synaptic dopamine and serotonin receptors.

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BRC1017
Product IDBRC1017
Product classBioreference compound
CAS number316-07-4
MW371.3
Synonyms
Chlorpromazine sulfoxide hydrochloride; NSC 17470;
Transport conditionsNormal

Opromazine Hydrochloride

Opromazine hydrochloride is a derivative of Chlorpromazine, which is a dopamine antagonist of the typical antipsychotic class of medications possessing additional antiadrenergic, antiserotonergic, anticholinergic and antihistaminergic properties.

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BRC0654
Product IDBRC0654
Product classBioreference compound
CAS number34183-22-7
MW377.9
Synonyms
GP 382, GPV 001, Polfenon, SA 79
Transport conditionsNormal

Propafenone hydrochloride

Propafenone Hydrochloride is a sodium channel protein inhibitor. It is a Class 1C antiarrhythmic drug with local anesthetic effects and a direct stabilizing action on myocardial membranes.

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BRC0640
Product IDBRC0640
Product classBioreference compound
CAS number548-73-2
MW379.4
Synonyms
McN-JR 4749, NSC 169874, Neurolidol, R 4749, Sintodril
Transport conditionsNormal

Droperidol

Droperidol is a D2 receptor antagonist (Ki = 0.4 nM). Also exhibits affinity for 5-HT2 (pIC50 8.57) and 5-HT1 (pIC50 6.42), alpha-adrenergic (Ki = 0.7 nM) and histamine receptors,and hERG channels. Antipsychotic and antiemetic.

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BRC0383
Product IDBRC0383
Product classBioreference compound
CAS number19216-56-9
MW383.4
Synonyms
Adversuten, CP 12,299-1, NSC 292810, Hypovase, Minipress Xl, Pressin, Vasoflex
Transport conditionsNormal

Prazosin

Prazosin is an adrenergic α, α2B-adrenoceptor and a potent melatonin MT3 receptor antagonist.

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BRC0110
Product IDBRC0110
Product classBioreference compound
CAS number63590-64-7
MW387.4
Synonyms
Hytrin, Flumarc, Fosfomic, Blavin, Abbott 45975
Transport conditionsNormal

Terazosin

Terazosin, classified as a quinazoline, is similar to doxazosin and prazosin. As an α-adrenergic blocking agent, terazosin is used to treat hypertension and BPH. Terazosin produces vasodilation and reduces peripheral resistance but in general has only a slight effect on cardiac output. The antihypertensive effect with chronic dosing is not usually accompanied by reflex tachycardia.

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BRC0013
Product IDBRC0013
Product classBioreference compound
CAS number85650-56-2
MW401.8
Synonyms
Saphris,
Transport conditionsNormal

Asenapine maleate

Asenapine is a serotonin, dopamine, noradrenaline, and histamine antagonist in which asenapine possess more potent activity with serotonin receptors than dopamine. Asenapine is an atypical antipsychotic multireceptor neuroleptic drug which shows strong 5HT2A (serotonin) and D2 (dopamine) receptor antagonism, which has been shown to enhance dopamine (DA) and acetylcholine (Ach) efflux in rat brains. Asenapine may improve cognitive function and negative symptoms in patients with schizophrenia.

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BRC0757
Product IDBRC0757
Product classBioreference compound
CAS number67227-57-0
MW401.9
Synonyms
SKF 82526
Transport conditionsNormal

Fenoldopam mesylate

Fenoldopam is selective D1-like dopamine receptor partial agonist (EC50 = 57 nM) that is being considered for the parenteral treatment of systemic hypertension. Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α2-adrenoceptor antagonist in vitro (Ki = 15 - 25 nM).

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