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G-Protein-Coupled Receptors (GPCRs)

StructureProduct infoAvailabilityQuantity / Price
BRC1048
Product IDBRC1048
Product classBioreference compound
CAS number62613-82-5
MW
Synonyms
CGP 21690; CT 848; Hydroxypiracetam; ISF 2522; Neuractiv;
Transport conditionsNormal

Oxiracetam

Oxiracetam, a cyclic derivative of gamma-aminobutyric acid (GABA), is a nootropic drug of the racetam family and very mild stimulant.

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BRC0254
Product IDBRC0254
Product classBioreference compound
CAS number142-63-2
MW86.1
Synonyms
Diethylenediamine, Piperazidine, Piperazin, Antepar, Uvilon, Vermidol, Vermizine
Transport conditionsNormal

Piperazine Hexahydrate

Piperazine is a GABA receptor agonist.

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BRC1147
Product IDBRC1147
Product classBioreference compound
CAS number22059-21-8
MW101.1
Synonyms
ACC; NSC 98430;
Transport conditionsNormal

ACPC

ACPC is NMDA receptor activity modulator, acts as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 µM) in the presence of low levels (1 µM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 µM) of glutamate.

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BRC0928
Product IDBRC0928
Product classBioreference compound
CAS number68506-86-5
MW129.2
Synonyms
CPP-109; MDL 71,754; MDL-71754; RMI-71754; GVG; Sabril™; γ-Vinyl GABA;
Transport conditionsNormal

Vigabatrin

Vigabatrin is a structural analogue of gamma-aminobutyric acid, irreversible inhibitor of 4-aminobutyrate transaminase, the enzyme responsible for the catabolism of gamma-aminobutyric acid.

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BRC1062
Product IDBRC1062
Product classBioreference compound
CAS number4393-06-0
MW134.2
Synonyms
Phenylvinylcarbinol; α-Phenylallyl alcohol; α-Vinylbenzyl alcohol;
Transport conditionsNormal

NSC 167595

NSC 167595 is an anti-allergic agent.

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BRC0622
Product IDBRC0622
Product classBioreference compound
CAS number73-24-5
MW135.1
Synonyms
Vitamin B4;
Transport conditionsNormal

Adenine

Adenine is a purine base that acts as a precursor, substrate, or cofactor in diverse biochemical pathways. It is a fundamental component of DNA, RNA, and ATP, as well as numerous other natural biochemicals.

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BRC1068
Product IDBRC1068
Product classBioreference compound
CAS number3544-24-9
MW136.2
Synonyms
NSC 36962; SR 4294; WD 97-000835;
Transport conditionsNormal

INO-1001

INO-1001 is PARP (poly(ADP-ribose) polymerase) inhibitor (Ki = 1.8 μM), which protects cells from UV-B-induced apoptosis via influence on the cytoskeleton. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

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BRC0982
Product IDBRC0982
Product classBioreference compound
CAS number5638-76-6
MW136.2
Synonyms
Transport conditionsNormal

Betahistine

Betahistine is an antivertigo drug, a histamine analog, and H1 receptor agonist. It serves as a vasodilator and is most commonly used to treat the symptoms of vertigo. Betahistine also has a strong affinity as an antagonist for histamine H3 receptors.

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BRC1417
Product IDBRC1417
Product classBioreference compound
CAS number3687-18-1
MW139.2
Synonyms
Alzhemed; Homotaurine; NC 758; NSC 77071; γ-Aminopropylsulfonic acid;
Transport conditionsNormal

Tramiprosate

Tramiprosate is a GABA mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibit amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also, a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.

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BRC0977
Product IDBRC0977
Product classBioreference compound
CAS number7491-74-9
MW142.2
Synonyms
UCB 6215;
Transport conditionsNormal

Piracetam

Piracetam is a nootropic drug that displays cognitive enhancing properties. It is a cyclic derivative of GABA. It has been shown to alter the physical properties of cell membranes and to protect against hypoxia, which might underlie neuroprotective and antithrombotic actions.

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BRC1029
Product IDBRC1029
Product classBioreference compound
CAS number59-50-7
MW142.6
Synonyms
NSC 4166; Neopredisan; Parol; Raschit; PCMC;
Transport conditionsNormal

Chlorocresol

Chlorocresol is a chlorinated phenol which is used as an antiseptic and preservative.

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BRC0888
Product IDBRC0888
Product classBioreference compound
CAS number4424-20-8
MW147.2
Synonyms
Transport conditionsNormal

5-Azabenzocycloheptene

5-Azabenzocycloheptene is a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

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BRC1035
Product IDBRC1035
Product classBioreference compound
CAS number41862-09-3
MW155.2
Synonyms
Transport conditionsNormal

6-Amino-1-ethyluracil

6-Amino-1-ethyluracil is A2B adenosine receptor antagonist, may used in prevention and treatment of liver disease.

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BRC1033
Product IDBRC1033
Product classBioreference compound
CAS number64-65-3
MW155.2
Synonyms
Mikedimide; NP 13; NSC 168667; NSC 58187; Zentraleptin;
Transport conditionsNormal

Bemegride

Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning as its chemoreceptor agonism increases mean tidal volume, thereby increasing respiration and the concentration of O2 in blood.

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BRC1305
Product IDBRC1305
Product classBioreference compound
CAS number68252-28-8
MW158.2
Synonyms
Transport conditionsNormal

(R)-(+)-Oxiracetam

(R)-(+)-Oxiracetam is enantiomer of Oxiracetam, nootropic drug.

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BRC0909
Product IDBRC0909
Product classBioreference compound
CAS number182485-36-5
MW161.1
Synonyms
Transport conditionsNormal

TPMPA

TPMPA is GABA receptor antagonist.

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BRC0818
Product IDBRC0818
Product classBioreference compound
CAS number616-91-1
MW163.2
Synonyms
5052; NSC-111180; RK-0202; NAC; Mercapturic acid;
Transport conditionsNormal

Acetylcysteine

Acetylcysteine (NAC) is an antioxidant and precursor of glutathione that has multiple effects in cells and animals. It is primarily used as a mucolytic agent and in the management of acetaminophen poisoning. It is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase 1) and absorbed in the intestine into the bloodstream. As an antioxidant, NAC scavenges hydrogen peroxide, hydroxyl radical, and hypochlorous acid.

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BRC0692
Product IDBRC0692
Product classBioreference compound
CAS number76-38-0
MW165.0
Synonyms
DA-759; NSC-110432;
Transport conditionsNormal

Methoxyflurane

Methoxyflurane is an anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability.

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BRC1066
Product IDBRC1066
Product classBioreference compound
CAS number498-02-2
MW166.2
Synonyms
NSC 209524; NSC 2146;
Transport conditionsNormal

Apocynin

Apocynin is a methoxy-substituted catechol that is commonly used as a selective NADPH-oxidase inhibitor with IC50 of 10 μM. Acts as an antioxidant in endothelial cells and vascular smooth muscle cells.

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BRC0189
Product IDBRC0189
Product classBioreference compound
CAS number60142-96-3
MW171.2
Synonyms
Gabapentin GR, Neurontin, Aclonium
Transport conditionsNormal

Gabapentin

Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters.

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BRC0466
Product IDBRC0466
Product classBioreference compound
CAS number87-52-5
MW174.2
Synonyms
Donaxine, NSC 16892
Transport conditionsNormal

Gramine

Gramine is a naturally occurring indole alkaloid present in several plant species. Has been found to act as an agonist of the adiponectin receptor 1 (LD50 = 44.6 - 62.9 mg/kg). Gramine is a norepinephrine reuptake inhibitor in synaptic vesicles.

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BRC0615
Product IDBRC0615
Product classBioreference compound
CAS number2078-54-8
MW178.3
Synonyms
ICI 35868; Disoprivan; Disoprofol;
Transport conditionsNormal

Propofol

Propofol is a sedative-hypnotic agent for use in the induction and maintenance of anesthesia or sedation. It acts as a potentiator of the GABAA receptor.

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BRC0936
Product IDBRC0936
Product classBioreference compound
CAS number50-78-2
MW180.2
Synonyms
BAY1019036; NSC-27223; NSC-406186; ASA; Aspirin;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Acetylsalicylic acid

Acetylsalicylic acid is an anti-inflammatory and antipyretic agent and acts as the inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. It also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.

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BRC0251
Product IDBRC0251
Product classBioreference compound
CAS number75448-53-2
MW180.2
Synonyms
Elixophyllin, Respbid, Theo-dur, Theolair, Uniphyl
Transport conditionsNormal

Theophylline

Theophylline, an xanthine derivative chemically similar to caffeine and theobromine, is used to treat asthma and bronchospasm. Theophylline has two distinct actions in the airways of patients with reversible (asthmatic) obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).

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BRC0968
Product IDBRC0968
Product classBioreference compound
CAS number83-67-0
MW180.2
Synonyms
NSC-5039; SC-15090; Diurobromine;
Transport conditionsNormal

Theobromine

Theobromine is a purine alkaloid that is an adenosine receptor antagonist, weak PDE (phosphodiesterase) inhibitor. It is a diuretic and smooth-muscle relaxant.

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BRC0439
Product IDBRC0439
Product classBioreference compound
CAS number173850-51-6
MW181.2
Synonyms
Transport conditionsNormal

1-[(5-methylisoxazol-3-yl)methyl]piperazine

Muscarinic acetylcholine receptor antagonist.

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BRC0958
Product IDBRC0958
Product classBioreference compound
CAS number79416-27-6
MW181.6
Synonyms
Metvixia; Visonac; MAL;
Transport conditionsNormal

Methyl aminolevulinate Hydrochloride

Methyl aminolevulinate hydrochloride is a prodrug that is metabolized to Protoporphyrin IX (a photosensitizer) used in photodynamic therapy.

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BRC0012
Product IDBRC0012
Product classBioreference compound
CAS number51-83-2
MW182.6
Synonyms
Carboptic, Isopto Carbachol, Mioticol
Transport conditionsNormal

Carbachol

Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known.

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BRC1007
Product IDBRC1007
Product classBioreference compound
CAS number146255-66-5
MW183.2
Synonyms
(RS)-3,5-Dihydroxyphenylglycine;
Transport conditionsNormal

DHPG

DHPG is an agonist of the group I metabotropic glutamate receptors, binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors. The (S)-enantiomer is about ten times more potent than the (R)-enantiomer.

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BRC0133
Product IDBRC0133
Product classBioreference compound
CAS number51-43-4
MW183.2
Synonyms
Adrenalin; L-epinephrine; Levoepinephrine;
Transport conditionsNormal

Epinephrine

Epinephrine is indicated for intravenous injection in treatment of acute hypersensitivity, treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome).

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BRC0633
Product IDBRC0633
Product classBioreference compound
CAS number56-92-8
MW184.1
Synonyms
NSC-257873; NSC-33792;
Transport conditionsNormal

Histamine Dihydrochloride

Histamine is a depressor amine. It is a powerful stimulant of gastric secretion, a bronchoconstrictor, vasodilator, and also a centrally acting neurotransmitter.

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BRC0956
Product IDBRC0956
Product classBioreference compound
CAS number138-92-1
MW184.1
Synonyms
Ametazole;
Transport conditionsNormal

Betazole Dihydrochloride

Betazole dihydrochloride is a histamine H2 agonist used in a test for measuring maximal production of gastric acidity or anacidity.

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BRC0687
Product IDBRC0687
Product classBioreference compound
CAS number13838-16-9
MW184.5
Synonyms
Anesthetic 347; Alyrane;
Transport conditionsNormal

Enflurane

Enflurane is an anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. Enflurane acts as a positive allosteric modulator of the GABAA, glycine, and 5-HT3 receptors, and as a negative allosteric modulator of the AMPA, kainate, and NMDA receptors, as well as of nicotinic acetylcholine receptors.

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BRC0823
Product IDBRC0823
Product classBioreference compound
CAS number26675-46-7
MW184.5
Synonyms
R-E 235da1, HCFE 235da2,
Transport conditionsNormal

Isoflurane

Isoflurane is a general inhalation anesthetic. It induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times.

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BRC0523
Product IDBRC0523
Product classBioreference compound
CAS number176199-48-7
MW185.2
Synonyms
Eglumegad, Eglumetad
Transport conditionsNormal

LY354740

The compound is highly potent agonists for group 2/3 metabotropic glutamate receptors mGluR. mGlu2/3 receptors are targets for the treatment of anxiety, schizophrenia, convulsive disorders, Parkinson’s disease, pain, and neurodegeneration.

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BRC0260
Product IDBRC0260
Product classBioreference compound
CAS number665-66-7
MW187.7
Synonyms
Aminoadamantane, Viregyt, Virosol, PK-Merz, Symadine, Symmetrel
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amantadine hydrochloride

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance).

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BRC0628
Product IDBRC0628
Product classBioreference compound
CAS number13721-01-2
MW189.2
Synonyms
Transport conditionsNormal

4-Quinolone-3-carboxylic acid

4-Quinolone-3-carboxylic acidis a novel HIV-1 integrase strand transfer inhibitor.

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BRC0023
Product IDBRC0023
Product classBioreference compound
CAS number62-31-7
MW189.6
Synonyms
3-Hydroxytyramine, Deoxyepinephrine, Oxytyramine, Intropin, Revimine
Transport conditionsNormal

Dopamine hydrochloride

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility.

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BRC0295
Product IDBRC0295
Product classBioreference compound
CAS number58-08-2
MW194.2
Synonyms
Methyltheobromine, NSC 5036
Transport conditionsNormal

Caffeine

Central nervous system stimulant. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.

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BRC0719
Product IDBRC0719
Product classBioreference compound
CAS number41078-02-8
MW194.2
Synonyms
3-Propylxanthine, D 4028
Transport conditionsNormal

Enprofylline

Enprofylline is a synthetic dimethylxanthine derivative, it antagonizes erythrocyte phosphodiesterase, increasing cAMP activity.

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BRC1077
Product IDBRC1077
Product classBioreference compound
CAS number94-26-8
MW194.2
Synonyms
NSC 13164; NSC 8475; Nipabutyl; SPF;
Transport conditionsNormal

Butylparaben

Butylparaben is an antifungal preservative in cosmetic products.

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BRC0749
Product IDBRC0749
Product classBioreference compound
CAS number71970-74-6
MW194.3
Synonyms
Transport conditionsNormal

AKS-19

AKS-19 is muscarinic acetylcholine receptor agonist.

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BRC0125
Product IDBRC0125
Product classBioreference compound
CAS number59-97-2
MW196.7
Synonyms
Priscoline, Benzidazol, Priscol, Divascol,
Transport conditionsNormal

Tolazoline hydrochloride

Tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.

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BRC0840
Product IDBRC0840
Product classBioreference compound
CAS number59-92-7
MW197.2
Synonyms
V-1512; Pardopa; Syndopa; L-dopa;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Levodopa

Levodopa is a metabolic precursor of dopamine that is capable of crossing the blood-brain barrier. It is used to replace dopamine lost in Parkinsons disease.

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BRC1074
Product IDBRC1074
Product classBioreference compound
CAS number153322-05-5
MW198.3
Synonyms
ARL 15896; FPL 15896; AR-R15896; AZD6765;
Transport conditionsNormal

Lanicemine

Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 µM). It has been used in trials studying the treatment and basic science of Depression, Major Depressive Disorder, and Treatment-Resistant Major Depressive Disorder.

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BRC0550
Product IDBRC0550
Product classBioreference compound
CAS number19772-76-0
MW199.2
Synonyms
DL-Willardiine
Transport conditionsNormal

(±)-Willardiine

(±)-Willardiine is a selective inhibitor of specific binding of [3H]AMPA to Ionotropic glutamate receptor AMPA (IC50 = 1800 nM).

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BRC0857
Product IDBRC0857
Product classBioreference compound
CAS number28523-86-6
MW200.1
Synonyms
Transport conditionsNormal

Sevoflurane

Sevoflurane is one of the most commonly used volatile anesthetic agents, particularly for outpatient anesthesia, across all ages, as well as in veterinary medicine.

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BRC1178
Product IDBRC1178
Product classBioreference compound
CAS number209185-99-9
MW205.8
Synonyms
Transport conditionsNormal

Neramexane hydrochloride

Neramexane hydrochloride is an NMDA antagonist with neuroprotective effects. It targets the cognitive decline in Alzheimer’s Disease by altering neurotransmitter signaling. Neramexane also acts as a nicotinic acetylcholine receptor antagonist.

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BRC0637
Product IDBRC0637
Product classBioreference compound
CAS number2809-21-4
MW206.0
Synonyms
M05BA01; NSC-227995; EHDP; HEDP; Hydroxyethylidene Diphosphonic Acid;
Transport conditionsNormal

Etidronic acid

Etidronate is a first generation, non-nitrogenous diphosphonate analog of endogenous pyrophosphate. It affects on calcium metabolism, inhibits ectopic calcification and slows down bone resorption and bone turnover.

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BRC0827
Product IDBRC0827
Product classBioreference compound
CAS number51146-56-6
MW206.3
Synonyms
d-ibuproten; S(+)-ibuprofen;
Transport conditionsNormal

Dexibuprofen

Dexibuprofen is a non-steroidal anti-inflammatory drug. It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties.

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