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Epidermal growth factor receptor (EGFR)

StructureProduct infoAvailabilityQuantity / Price
BRC0472
Product IDBRC0472
Product classBioreference compound
CAS number380491-32-7
MW330.4
Synonyms
SJ000170251
Transport conditionsNormal

GNF-Pf-2466

GNF-Pf-2466 is kinase inhibitor. Also potential antitubercular agent (TB IC90 = 3.2).

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BRC0574
Product IDBRC0574
Product classBioreference compound
CAS number848057-98-7
MW354.3
Synonyms
MVRL1
Transport conditionsNormal

SPHINX

SPHINX is SRPK1 kinase inhibitor (IC50 = 440 nM).

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BRC0331
Product IDBRC0331
Product classBioreference compound
CAS number183319-69-9
MW429.9
Synonyms
CP358774, NSC 718781
Transport conditionsNormal

Erlotinib hydrochloride

Erlotinib inhibits the intracellular phosphorylation of tyrosine kinase associated with the epidermal growth factor receptor (EGFR).

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BRC0234
Product IDBRC0234
Product classBioreference compound
CAS number444731-52-6
MW437.5
Synonyms
GW 78603, GW786034,
Transport conditionsNormal

Pazopanib

Pazopanib is a second-generation multitargeted tyrosine kinase inhibitor against vascular endothelial growth factor receptor-1, -2, and -3, platelet-derived growth factor receptor-alpha, platelet-derived growth factor receptor-beta, and c-kit. These receptor targets are part of the angiogenesis pathway that facilitates the formation of tumour blood vessel for tumour survival and growth.

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BRC0205
Product IDBRC0205
Product classBioreference compound
CAS number184475-35-2
MW446.9
Synonyms
Gefitinib, Iressa, ZD 1839
Transport conditionsNormal

Gefitinib

Gefitinib inhibits the epidermal growth factor receptor (EGFR) tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme. Thus the function of the EGFR tyrosine kinase in activating the Ras signal transduction cascade is inhibited; and malignant cells are inhibited.

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BRC0332
Product IDBRC0332
Product classBioreference compound
CAS number388082-78-8
MW581.1
Synonyms
FMM, GW 572016, Tykerb
Transport conditionsNormal

Lapatinib ditosylate

Lapatinib is a 4-anilinoquinazoline kinase inhibitor of the intracellular tyrosine kinase domains of both epidermal growth factor receptor (HER1/EGFR/ERBB1) and human epidermal growth factor receptor type 2 (HER2/ERBB2)with a dissociation half-life of ≥300 minutes. Lapatinib inhibits ERBB-driven tumor cell growth in vitro and in various animal models.

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BRC0454
Product IDBRC0454
Product classBioreference compound
CAS number587841-73-4
MW584.9
Synonyms
Transport conditionsNormal

ZCL 278

ZCL 278 is a selective inhibitor of Cdc42. It inhibits Cdc42-mediated microspike formation and neuronal branching in 3T3 fibroblast and neonatal cortical neurons, respectively. It also exhibits potent antiviral activity by inhibiting cellular entry of Junin virus (JUNV) and other enveloped viruses into cells and inhibiting viral replication in mice.

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