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Platelet-derived growth factor (PDGF)

StructureProduct infoAvailabilityQuantity / Price
BRC0365
Product IDBRC0365
Product classBioreference compound
CAS number15421-84-8
MW205.3
Synonyms
Rocornal, Trapymin, Avantrin, Trapymine
Transport conditionsNormal

Trapidil

Trapidil interrupts the autocrine loop at the PDGF and PDGF-receptor level.Trapidil has proved to possess a significant antiproliferative activity. Trapidil is an anti-platelet drug active against various aggregating agents, such as collagen, ADP, arachidonic acid, PAF and calcium ionophore.

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BRC0609
Product IDBRC0609
Product classBioreference compound
CAS number776-53-4
MW213.3
Synonyms
Transport conditionsNormal

NSC 9310

NSC 9310 is CDK inhibitor.

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BRC0630
Product IDBRC0630
Product classBioreference compound
CAS number71897-07-9
MW234.3
Synonyms
AG-1295, NSC 380341
Transport conditionsNormal

Tyrphostin AG-1295

Tyrphostin AG 1295 is a cell-permeable, reversible, ATP-competitive and selective inhibitor of PDGFR (platelet-derived growth factor receptor) protein tyrosine kinase (PDGF-receptor PTK)(IC50 = 500 nM) and PDGF-dependent DNA synthesis (IC50 = 2.5 μM) in Swiss/3T3 cells, and demonstrates about 50% inhibition on neointimal formation after balloon injury in porcine femoral arteries.

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BRC0472
Product IDBRC0472
Product classBioreference compound
CAS number380491-32-7
MW330.4
Synonyms
SJ000170251
Transport conditionsNormal

GNF-Pf-2466

GNF-Pf-2466 is kinase inhibitor. Also potential antitubercular agent (TB IC90 = 3.2).

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BRC0071
Product IDBRC0071
Product classBioreference compound
CAS number557795-19-4
MW398.5
Synonyms
Sutent, SU-11248, sunitinibum
Transport conditionsNormal

Sunitinib

Sunitinib is a small molecule that inhibits multiple RTKs (receptor tyrosine kinase), some of which are implicated in tumor growth, pathologic angiogenesis, and metastatic progression of cancer.

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BRC0234
Product IDBRC0234
Product classBioreference compound
CAS number444731-52-6
MW437.5
Synonyms
GW 78603, GW786034,
Transport conditionsNormal

Pazopanib

Pazopanib is a second-generation multitargeted tyrosine kinase inhibitor against vascular endothelial growth factor receptor-1, -2, and -3, platelet-derived growth factor receptor-alpha, platelet-derived growth factor receptor-beta, and c-kit. These receptor targets are part of the angiogenesis pathway that facilitates the formation of tumour blood vessel for tumour survival and growth.

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BRC0219
Product IDBRC0219
Product classBioreference compound
CAS number284461-73-0
MW464.8
Synonyms
BAY 43-9006, Nexavar,
Transport conditionsNormal

Sorafenib

Sorafenib is a small molecular inhibitor of Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 and 3 kinases and c Kit the receptor for Stem cell factor. A growing number of drugs target most of these pathways. The originality of Sorafenib lays in its simultaneous targeting of the Raf/Mek/Erk pathway.

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BRC0330
Product IDBRC0330
Product classBioreference compound
CAS number302962-49-8
MW488.0
Synonyms
BMS 354825, Sprycel
Transport conditionsNormal

Dasatinib

Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.

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BRC0114
Product IDBRC0114
Product classBioreference compound
CAS number152459-95-5
MW493.6
Synonyms
Glivec, STI 571, CGP057148B
Transport conditionsNormal

Imatinib

Imatinib is an antineoplastic agent used to treat chronic myelogenous leukemia. Imatinib is a 2-phenylaminopyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes.

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