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Rho-associated protein kinase (ROCK)

StructureProduct infoAvailabilityQuantity / Price
BRC0302
Product IDBRC0302
Product classBioreference compound
CAS number103745-39-7
MW291.4
Synonyms
ZK-258594, HA-1077, AT-877
Transport conditionsNormal

Fasudil

Fasudil is a class of calcium antagonists. Fasudil is able to inhibit contractile responses to KCl, phenylephnne (PHE) and prostaglandin (PG) F2a. Fasudil also exhibits vasodilator actions by inhibition of 5-hydroxytryptamine, noradrenaline, histamine, angiotensin, and dopamine induced spiral strips contraction

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BRC0495
Product IDBRC0495
Product classBioreference compound
CAS number1347407-78-6
MW338.4
Synonyms
Transport conditionsNormal

4-{1H-pyrrolo[2,3-b]pyridin-3-yl}-N-[(thiophen-3-yl)methyl]-1,2,3,6-tetrahydropyridine-1-carboxamide

Rho-kinase inhibitor (IC50 = 10 μM).

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BRC0833
Product IDBRC0833
Product classBioreference compound
CAS number
MW394.9
Synonyms
Transport conditionsNormal

Rhosin hydrochloride

Rhosin hydrochloride is Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF.

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BRC0570
Product IDBRC0570
Product classBioreference compound
CAS number1596413-63-6
MW402.5
Synonyms
Transport conditionsNormal

2-(3-{4-[(1H-indazol-5-yl)imino]-1,4-dihydropyrimidin-2-yl}phenoxy)-N-(propan-2-yl)acetamide

The compound is ROCK1 and ROCK2 inhibitor (IC50 = 0.07 uM and > 3 uM respectively).

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