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Mammalian target of rapamycin (mTOR)

StructureProduct infoAvailabilityQuantity / Price
BRC1316
Product IDBRC1316
Product classBioreference compound
CAS number328-50-7
MW146.1
Synonyms
NSC 17391; 2-Ketoglutaric acid;
Transport conditionsNormal

2-Oxoglutaric acid

2-Oxoglutaric acid is an intermediate in the Krebs cycle catalyzed by glutamate dehydrogenase enzyme on glutamate.

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BRC0525
Product IDBRC0525
Product classBioreference compound
CAS number915019-65-7
MW469.5
Synonyms
NVP-BEZ 235NX, BEZ 235, Dactolisib
Transport conditionsNormal

NVP-BEZ235

NVP-BEZ235 is a dual PI3K/mammalian target of rapamycin (mTOR) inhibitor in gliomas with specificity against several PI3K kinases. The compound suppressed glioma cell proliferation with IC(50) values in the low nanomolar range by specifically inhibiting the activity of target proteins including Akt, S6K1, S6, and 4EBP1 in the PI3K/Akt/mTOR signaling pathway.

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BRC0196
Product IDBRC0196
Product classBioreference compound
CAS number159351-69-6
MW958.2
Synonyms
40-O-(2-hydroxyethyl)-rapamycin, Votubia, RAD001
Transport conditionsNormal

Everolimus

Everolimus is a mTOR inhibitor that binds with high affinity to the FK506 binding protein-12 (FKBP-12), thereby forming a drug complex that inhibits the activation of mTOR.

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