EnamineStore

Welcome, Guest
Tutorials

Anti-arrhythmia agents

StructureProduct infoAvailabilityQuantity / Price
BRC0996
Product IDBRC0996
Product classBioreference compound
CAS number31828-71-4
MW179.3
Synonyms
Kö 1173;
Transport conditionsNormal

Mexiletine

Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Use-dependent sodium channel blocker.

Product Page

In Stock(5 business days)  
BRC0967
Product IDBRC0967
Product classBioreference compound
CAS number137-58-6
MW234.3
Synonyms
ALGRX-3268; LSM-3165; NSC-40030;
Transport conditionsNormal

Lidocaine

Lidocaine is an anaesthetic agent and class Ib antiarrhythmic agent. It is a selective inverse peripheral histamine H1-receptor agonist. This compound is known to block voltage-gated sodium channels in the inactivated state.

Product Page

In Stock(5 business days)  
BRC0883
Product IDBRC0883
Product classBioreference compound
CAS number3575-80-2
MW263.4
Synonyms
FG-5111
Transport conditionsNormal

Melperone

Melperone is an atypical antipsychotic. It is 5-HT2A/D2 receptor antagonist (Ki = 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC.

Product Page

In Stock(5 business days)  
BRC0124
Product IDBRC0124
Product classBioreference compound
CAS number29122-68-7
MW266.3
Synonyms
Tenormin, Tenormine, Blokium, Normiten,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Atenolol

Atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.

Product Page

In Stock(5 business days)  
BRC0949
Product IDBRC0949
Product classBioreference compound
CAS number6673-35-4
MW266.3
Synonyms
Transport conditionsNormal

Practolol

Practolol is a beta-adrenergic receptor antagonist that has been used in the emergency treatment of cardiac arrhythmias.

Product Page

In Stock(5 business days)  
BRC0828
Product IDBRC0828
Product classBioreference compound
CAS number58-61-7
MW267.2
Synonyms
SR-96225; USAF CB-10; Ado;
Transport conditionsNormal

Adenosine

Adenosine is an endogenous nucleoside. It activates purine receptors, as well as relax vascular smooth muscles through the reduction in calcium uptake by inhibition of slow inward calcium current and activation of adenylate cyclase in smooth muscle cells.

Product Page

In Stock(5 business days)  
BRC0942
Product IDBRC0942
Product classBioreference compound
CAS number614-39-1
MW271.8
Synonyms
NSC-27461; Biocoryl;
Transport conditionsNormal

Procainamide hydrochloride

Procainamide hydrochloride is a potent blocker of sodium channels. It demonstrates antiarrhythmic effects correlated with blockade of the Na+ channels. Procainamide hydrochloride is DNA methyltransferase inhibitor.

Product Page

In Stock(5 business days)  
BRC0675
Product IDBRC0675
Product classBioreference compound
CAS number14556-46-8
MW271.8
Synonyms
Transport conditionsNormal

Bupranolol

Bupranolol is a competitive, nonselective beta-blocker without intrinsic sympathomimetic activity. It competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation.

Product Page

In Stock(5 business days)  
BRC0428
Product IDBRC0428
Product classBioreference compound
CAS number318-98-9
MW295.8
Synonyms
AY-64043, ICI-45520, NCS-91523, Angilol, Bedranol SR, Cardinol, Ciplar, Deralin, Dociton, Duranol, HEMANGEOL, Inderal, Inderal LA, Indobloc, INNOPRAN, Innopran XL, Prophylux, Sumial
Transport conditionsNormal

Propranolol hydrochloride

Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.

Product Page

In Stock(5 business days)  
BRC0992
Product IDBRC0992
Product classBioreference compound
CAS number42200-33-9
MW309.4
Synonyms
Corgard; Solgol;
Transport conditionsNormal

Nadolol

Nadolol is a nonselective beta-adrenergic receptor antagonist with a long half-life. Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension.

Product Page

In Stock(5 business days)  
BRC0825
Product IDBRC0825
Product classBioreference compound
CAS number56-54-2
MW324.4
Synonyms
CIN-QUIN; Conchinin; Conquinine; Pitayine;
Transport conditionsNormal

Quinidine

Quinidine is an optical isomer of quinine, antiarrhythmic. It dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.

Product Page

In Stock(5 business days)  
BRC0822
Product IDBRC0822
Product classBioreference compound
CAS number3737-09-5
MW339.5
Synonyms
H 3292, SC 7031, Searle 703
Transport conditionsNormal

Disopyramide

Disopyramide is a class I anti-arrhythmic agent and a sodium channel blocker with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.

Product Page

In Stock(5 business days)  
BRC0654
Product IDBRC0654
Product classBioreference compound
CAS number34183-22-7
MW377.9
Synonyms
GP 382, GPV 001, Polfenon, SA 79
Transport conditionsNormal

Propafenone hydrochloride

Propafenone Hydrochloride is a sodium channel protein inhibitor. It is a Class 1C antiarrhythmic drug with local anesthetic effects and a direct stabilizing action on myocardial membranes.

Product Page

In Stock(5 business days)  
BRC0417
Product IDBRC0417
Product classBioreference compound
CAS number72509-76-3
MW384.2
Synonyms
CGH-869, Felodur ER, Felogard, Plendil Depottab, Plendil ER, Plendil Retard, Renedil, Splendil, Agon, H 154/82
Transport conditionsNormal

Felodipine

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction.

Product Page

In Stock(5 business days)  
BRC0140
Product IDBRC0140
Product classBioreference compound
CAS number61-75-6
MW414.4
Synonyms
Bretylol; Bretylate; Ornid;
Transport conditionsNormal

Bretylium tosylate

Bretylium inhibits norepinephrine release by depressing adrenergic nerve terminal excitability.

Product Page

In Stock(5 business days)  
BRC0416
Product IDBRC0416
Product classBioreference compound
CAS number114798-26-4
MW422.9
Synonyms
Lortaan, DuP-753, MK 954
Transport conditionsNormal

Losartan

Losartan is the first of a class of antihypertensive agents called angiotensin II receptor blockers (ARBs). Losartan and its longer acting active metabolite, E-3174, are specific and selective type-1 angiotensin II receptor (AT1) antagonists which block the blood pressure increasing effects angiotensin II via the renin-angiotensin-aldosterone system (RAAS).

Product Page

In Stock(5 business days)  
BRC0418
Product IDBRC0418
Product classBioreference compound
CAS number57415-44-8
MW450.8
Synonyms
Almarytm, Apocard, Tambocor
Transport conditionsNormal

Flecainide hydrochloride

Flecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.

Product Page

In Stock(5 business days)  
BRC0871
Product IDBRC0871
Product classBioreference compound
CAS number93479-97-1
MW490.6
Synonyms
HOE-490
Transport conditionsNormal

Glimepiride

Glimepiride is potent Kir6 (KATP) channel blocker and anti-diabetic agent. It is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells.

Product Page

In Stock(5 business days)  
BRC0410
Product IDBRC0410
Product classBioreference compound
CAS number152-11-4
MW491.1
Synonyms
NSC 272366, NSC 657799, Bosoptin, Calan, Covera-HS, Isoptin, Verelan, Verisop, Vermin, Verogalid, Vertab, Vetrimil, Zolvera
Transport conditionsNormal

Verapamil hydrochloride

Verapamil is an L-type calcium channel blocker that also has antiarrythmic activity. The R-enantiomer is more effective at reducing blood pressure compared to the S-enantiomer. However, the S-enantiomer is 20 times more potent than the R-enantiomer at prolonging the PR interval in treating arrhythmias.

Product Page

In Stock(5 business days)  
BRC0049
Product IDBRC0049
Product classBioreference compound
CAS number141625-93-6
MW593.2
Synonyms
UNII-FA36DV299Q, Multaq, SR 33589, SR 33589b
Transport conditionsNormal

Dronedarone hydrochloride

It prolongs the duration of action potential and refractory period in myocardial tissue via inhibition of sodium and potassium channels. Via inhibition of calcium channels and blockage of beta1-adrenergic receptors, a decrease in AV conduction and sinus node function can be observed. Dronedarone can also cause an increase in blood pressure by inhibition of alpha1-adrenergic receptors.

Product Page

In Stock(5 business days)  
BRC0314
Product IDBRC0314
Product classBioreference compound
CAS number19774-82-4
MW681.8
Synonyms
Amio-Aqueous IV, Aratac, Arycor, Atlansil, Tachyra
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amiodarone hydrochloride

Broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death.

Product Page

In Stock(5 business days)  
BRC0077
Product IDBRC0077
Product classBioreference compound
CAS number71-63-6
MW765.0
Synonyms
Digitoxoside, Crystodigin, Unidigin, AC1L9AQX
Transport conditionsNormal

Digitoxin

Digitoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digitoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

Product Page

In Stock(5 business days)  
BRC0035
Product IDBRC0035
Product classBioreference compound
CAS number122647-32-9
MW885.2
Synonyms
Corvert, U-70226E
Transport conditionsNormal

Ibutilide hemifumarate

Ibutilide prolongs the action potential duration and increases both atrial and ventricular refractoriness in vivo, i.e., class III electrophysiologic effects. Voltage clamp studies indicate that ibutilide, at nanomolar concentrations, delays repolarization by activation of a slow, inward current (predominantly sodium), rather than by blocking outward potassium currents, which is the mechanism by which most other class III antiarrhythmics act.

Product Page

In Stock(5 business days)  
Display records per page

 

x
x