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Aurora kinases (AUR A)

StructureProduct infoAvailabilityQuantity / Price
BRC0300
Product IDBRC0300
Product classBioreference compound
CAS number129-56-6
MW220.2
Synonyms
Nsc75890,
Transport conditionsNormal

SP600125

SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.

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BRC0947
Product IDBRC0947
Product classBioreference compound
CAS number68-35-9
MW250.3
Synonyms
Adiazine;
Transport conditionsNormal

Sulfadiazine

Sulfadiazine is a sulfonamide antibiotic with a wide spectrum against most gram-positive and many gram-negative organisms. It is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase.

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BRC0480
Product IDBRC0480
Product classBioreference compound
CAS number329907-28-0
MW330.4
Synonyms
Transport conditionsNormal

TTP 22

TTP 22 is a high affinity casein kinase 2 (CK2) inhibitor (IC50 = 100 nM). Displays no inhibitory effects at 10 μM over JNK3, ROCK1, and MET.

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BRC0432
Product IDBRC0432
Product classBioreference compound
CAS number639089-54-6
MW464.6
Synonyms
VX-680, MK-0457
Transport conditionsNormal

Tozasertib

Tozasertib is a potent pan-ARK inhibitor but favors ARK-1 (Ki = 0.6 nM) over ARK-2 (Ki = 18 nM) or ARK-3 (Ki = 4.6 nM).

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BRC0344
Product IDBRC0344
Product classBioreference compound
CAS number1639009-81-6
MW522.5
Synonyms
Transport conditionsNormal

CD532

A cell permeable diaminopyrimidine derived compound that acts as a highly potent and selective inhibitor of Aurora A (IC50 = 48 nM).

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