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c-Jun N-terminal kinases (JNKs)

StructureProduct infoAvailabilityQuantity / Price
BRC0300
Product IDBRC0300
Product classBioreference compound
CAS number129-56-6
MW220.2
Synonyms
Nsc75890,
Transport conditionsNormal

SP600125

SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.

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BRC0556
Product IDBRC0556
Product classBioreference compound
CAS number325979-58-6
MW300.4
Synonyms
Transport conditionsNormal

SB-347804

SB-347804 is a potent and selective inhibitor of JNK3 kinase (IC50 = 3.16 μM).

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BRC0003
Product IDBRC0003
Product classBioreference compound
CAS number50-63-5
MW515.9
Synonyms
Aralen, Artrichin, Bemaphate, Capquin, Malarex, Nivaquine B, Resoquine, Reumachlor, Sanoquin
Transport conditionsNormal

Chloroquine diphosphate

Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. Chloroquine inhibits the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. It may also interfere with the biosynthesis of nucleic acids.

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