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Antiparkinson

StructureProduct infoAvailabilityQuantity / Price
BRC0260
Product IDBRC0260
Product classBioreference compound
CAS number665-66-7
MW187.7
Synonyms
Aminoadamantane, Viregyt, Virosol, PK-Merz, Symadine, Symmetrel
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amantadine hydrochloride

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance).

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BRC0840
Product IDBRC0840
Product classBioreference compound
CAS number59-92-7
MW197.2
Synonyms
V-1512; Pardopa; Syndopa; L-dopa;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Levodopa

Levodopa is a metabolic precursor of dopamine that is capable of crossing the blood-brain barrier. It is used to replace dopamine lost in Parkinsons disease.

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BRC0032
Product IDBRC0032
Product classBioreference compound
CAS number41100-52-1
MW215.8
Synonyms
Abixa, Akatinol, Axura, Memox
Transport conditionsNormal

Memantine hydrochloride

Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentially to the NMDA receptor-operated cation channels. Memantine also has antagonistic activity at the type 3 serotonergic (5-HT3) receptor with a potency that is similar to that at the NMDA receptor, and lower antagonistic activity at the nicotinic acetylcholine receptor. This drug has no affinity for γ-aminobutyric acid (GABA), benzodiazepine, dopamine, adrenergic, histamine, or glycine receptors or for voltage-dependent calcium, sodium, or potassium channels.

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BRC0886
Product IDBRC0886
Product classBioreference compound
CAS number14611-52-0
MW223.7
Synonyms
Transport conditionsNormal

Selegiline hydrochloride

Selegiline hydrochloride is a selective, irreversible inhibitor of Type B monoamine oxidase. It is used in Parkinsons disease treatment.

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BRC0511
Product IDBRC0511
Product classBioreference compound
CAS number199167-79-8
MW249.2
Synonyms
Transport conditionsNormal

4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid

Is MAO inhibitor. Has antibacterial activity against Escherichia coli K-12.

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BRC0903
Product IDBRC0903
Product classBioreference compound
CAS number847163-28-4
MW249.3
Synonyms
CID 664510
Transport conditionsNormal

ML351

ML351 is selective inhibitor of 12/15-lipoxygenase. It was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.

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BRC0781
Product IDBRC0781
Product classBioreference compound
CAS number161735-79-1
MW267.3
Synonyms
AGN-1135, RAS, Azilect
Transport conditionsNormal

Rasagiline mesylate

Rasagiline is a propargylamine and an irreversible inhibitor of monoamine oxidase (MAO). It is used to increase the availability of dopamine at striatal receptors as a method to treat Parkinson’s disease.

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BRC0404
Product IDBRC0404
Product classBioreference compound
CAS number91374-20-8
MW296.8
Synonyms
Adartrel, ReQuip, Ronirol, SKandF 101468
Transport conditionsNormal

Ropinirole hydrochloride

Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes.

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BRC0076
Product IDBRC0076
Product classBioreference compound
CAS number130929-57-6
MW305.3
Synonyms
Comtan, Comtess, OR-611
Transport conditionsNormal

Entacapone

Entacapone is used in the treatment of Parkinson’s disease as an adjunct to levodopa/carbidopa therapy. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).

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BRC0042
Product IDBRC0042
Product classBioreference compound
CAS number52-49-3
MW337.9
Synonyms
Apo-trihex, Benzhexol Hydrochloride
Transport conditionsNormal

Trihexyphenidyl hydrochloride

Trihexyphenidyl is an anticholinergic used in the symptomatic treatment of all etiologic groups of parkinsonism and drug induced extrapyramidal reactions (except tardive dyskinesia). Trihexyphenidyl possesses both anticholinergic and antihistaminic effects, although only the former has been established as therapeutically significant in the management of parkinsonism.

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BRC0608
Product IDBRC0608
Product classBioreference compound
CAS number1187159-50-7
MW360.5
Synonyms
Transport conditionsNormal

1-(2-{[(1R)-2,3-dihydro-1H-inden-1-yl]amino}quinolin-6-yl)-3-(propan-2-yl)urea

The compound is 5-HT5A receptor antagonist (Ki 2.5 nM).

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BRC0740
Product IDBRC0740
Product classBioreference compound
CAS number1351758-81-0
MW377.8
Synonyms
Transport conditionsNormal

HG-10-102-01

HG-10-102-01 is an aminopyrimidine derivative, LRRK2 inhibitor (IC50 is 3 - 29 nM).

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BRC0485
Product IDBRC0485
Product classBioreference compound
CAS number303126-97-8
MW397.7
Synonyms
Transport conditionsNormal

SR 0987

SR 0987 is an T cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.

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BRC0577
Product IDBRC0577
Product classBioreference compound
CAS number1809862-74-5
MW424.5
Synonyms
Transport conditionsNormal

3-methyloxetan-3-yl 4-[3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl]piperazine-1-carboxylate

The compound is potent, brain penetrant inhibitor of AP2-associated protein kinase 1 (IC50 = 4.7 nM).

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BRC0539
Product IDBRC0539
Product classBioreference compound
CAS number420831-40-9
MW437.4
Synonyms
Transport conditionsNormal

AK 7

AK 7 is a selective SIRT2 inhibitor (IC50 = 15.5 μM), that displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels and improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.

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BRC0660
Product IDBRC0660
Product classBioreference compound
CAS number4682-36-4
MW461.5
Synonyms
BS 5930, Biorphen, Brocadisipal, ORP, WS 2434
Transport conditionsNormal

Orphenadrine citrate

Orphenadrine Citrate is muscarinic receptor antagonist (pKi 7.39), H1 histamine receptor antagonist (pIC50 6.79), a muscle relaxant. It also inhibits the noradrenergic transporter and to block the NMDA receptor ion channel.

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BRC0505
Product IDBRC0505
Product classBioreference compound
CAS number304896-28-4
MW470.7
Synonyms
Transport conditionsNormal

AGK-2 hydrochloride

AGK-2 is selective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in vitro and in vivo models of Parkinson's disease.

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BRC0723
Product IDBRC0723
Product classBioreference compound
CAS number1589527-65-0
MW518.5
Synonyms
Transport conditionsNormal

KIRA 6

KIRA 6 is an allosteric inhibitor of IRE1α RNase, preserves cell viability and function in ER-stressed retinitis pigmentosa and diabetes model cells.

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