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Neurotransmitter Agents

StructureProduct infoAvailabilityQuantity / Price
BRC1419
Product IDBRC1419
Product classBioreference compound
CAS number107-97-1
MW89.1
Synonyms
Methylglycine; N-Methylaminoacetic acid; Sarcosin; Sarcosinic acid;
Transport conditionsNormal

Sarcosine

Sarcosine is an endogenous inhibitor of GlyT1 with antipsychotic activity. It potentiates the action of glycine on the NMDA glycine binding site.

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BRC0982
Product IDBRC0982
Product classBioreference compound
CAS number5638-76-6
MW136.2
Synonyms
Transport conditionsNormal

Betahistine

Betahistine is an antivertigo drug, a histamine analog, and H1 receptor agonist. It serves as a vasodilator and is most commonly used to treat the symptoms of vertigo. Betahistine also has a strong affinity as an antagonist for histamine H3 receptors.

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BRC0288
Product IDBRC0288
Product classBioreference compound
CAS number127-48-0
MW143.1
Synonyms
Trimethinum, Troxidone, Tridione, Minoale,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Trimethadione

Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.

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BRC0878
Product IDBRC0878
Product classBioreference compound
CAS number54-11-5
MW162.2
Synonyms
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Nicotine

Nicotine is highly toxic alkaloid, nicotinic acetylcholine receptors agonist. In the brain, nicotine binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. It exhibits vasoconstrictive, hypertensive and prothrombotic activity.

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BRC1056
Product IDBRC1056
Product classBioreference compound
CAS number51-15-0
MW172.6
Synonyms
Protopam chloride; 2-PAM chloride; NSC 164614; UNII-P7MU9UTP52;
Transport conditionsNormal

Pralidoxime chloride

Pralidoxime is an antidote to organophosphate pesticides and chemicals. It binds to inactivated acetylcholinesterases.

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BRC0251
Product IDBRC0251
Product classBioreference compound
CAS number75448-53-2
MW180.2
Synonyms
Elixophyllin, Respbid, Theo-dur, Theolair, Uniphyl
Transport conditionsNormal

Theophylline

Theophylline, an xanthine derivative chemically similar to caffeine and theobromine, is used to treat asthma and bronchospasm. Theophylline has two distinct actions in the airways of patients with reversible (asthmatic) obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).

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BRC0956
Product IDBRC0956
Product classBioreference compound
CAS number138-92-1
MW184.1
Synonyms
Ametazole;
Transport conditionsNormal

Betazole Dihydrochloride

Betazole dihydrochloride is a histamine H2 agonist used in a test for measuring maximal production of gastric acidity or anacidity.

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BRC0633
Product IDBRC0633
Product classBioreference compound
CAS number56-92-8
MW184.1
Synonyms
NSC-257873; NSC-33792;
Transport conditionsNormal

Histamine Dihydrochloride

Histamine is a depressor amine. It is a powerful stimulant of gastric secretion, a bronchoconstrictor, vasodilator, and also a centrally acting neurotransmitter.

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BRC0023
Product IDBRC0023
Product classBioreference compound
CAS number62-31-7
MW189.6
Synonyms
3-Hydroxytyramine, Deoxyepinephrine, Oxytyramine, Intropin, Revimine
Transport conditionsNormal

Dopamine hydrochloride

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility.

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BRC0719
Product IDBRC0719
Product classBioreference compound
CAS number41078-02-8
MW194.2
Synonyms
3-Propylxanthine, D 4028
Transport conditionsNormal

Enprofylline

Enprofylline is a synthetic dimethylxanthine derivative, it antagonizes erythrocyte phosphodiesterase, increasing cAMP activity.

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BRC0840
Product IDBRC0840
Product classBioreference compound
CAS number59-92-7
MW197.2
Synonyms
V-1512; Pardopa; Syndopa; L-dopa;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Levodopa

Levodopa is a metabolic precursor of dopamine that is capable of crossing the blood-brain barrier. It is used to replace dopamine lost in Parkinsons disease.

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BRC0390
Product IDBRC0390
Product classBioreference compound
CAS number55-65-2
MW198.3
Synonyms
Ismedine, Ismelin
Transport conditionsNormal

Guanethidine

Guanethidine works by decreasing the heart rate and relaxing the blood vessels so that blood can flow more easily through the body, thereby reducing these risks. It is a postganglionic sympathetic nerve terminal blocker that prevents the release of norepinephrine from nerve terminals.

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BRC0098
Product IDBRC0098
Product classBioreference compound
CAS number826-39-1
MW203.8
Synonyms
Inversine; Versamine;
Transport conditionsNormal

Mecamylamine hydrochloride

Mecamylamine hydrochloride is a potent, oral antihypertensive agent and ganglion blocker.

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BRC1178
Product IDBRC1178
Product classBioreference compound
CAS number209185-99-9
MW205.8
Synonyms
Transport conditionsNormal

Neramexane hydrochloride

Neramexane hydrochloride is an NMDA antagonist with neuroprotective effects. It targets the cognitive decline in Alzheimer’s Disease by altering neurotransmitter signaling. Neramexane also acts as a nicotinic acetylcholine receptor antagonist.

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BRC0972
Product IDBRC0972
Product classBioreference compound
CAS number835-31-4
MW210.3
Synonyms
Antan; Rhinazine; Imidin;
Transport conditionsNormal

Naphazoline

Naphazoline is sympathomimetic adrenergic alpha-agonist. It is used to induce systemic vasoconstriction, thereby decreasing nasal congestion and inducing constriction around the conjunctiva.

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BRC0910
Product IDBRC0910
Product classBioreference compound
CAS number66-23-9
MW226.1
Synonyms
Transport conditionsNormal

Acetylcholine Bromide

Acetylcholine bromide is endogenous neurotransmitter. Acts at nicotinic and muscarinic acetylcholine receptors.

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BRC0313
Product IDBRC0313
Product classBioreference compound
CAS number300-08-3
MW236.1
Synonyms
Taeniolin, NSC 31750
Transport conditionsNormal

Arecoline hydrobromide

An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors.

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BRC0004
Product IDBRC0004
Product classBioreference compound
CAS number145108-58-3
MW236.7
Synonyms
Precedex, Dex, Dexmedetomidine HCL, (S)-Medetomidine hydrochloride
Transport conditionsNormal

Dexmedetomidine hydrochloride

Dexmedetomidine (hydrochloride) is the (S)-enantiomer of medetomidine (racemic form of this compound), a highly selective, potent and specific agonist of 2-adrenergic receptor (2-adrenoceptor).

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BRC0902
Product IDBRC0902
Product classBioreference compound
CAS number46817-91-8
MW237.3
Synonyms
Transport conditionsNormal

Viloxazine

Viloxazine is a selective noradrenaline reuptake inhibitor with minimal inhibitory effect on the reuptake of 5-HT.

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BRC0934
Product IDBRC0934
Product classBioreference compound
CAS number18559-94-9
MW239.3
Synonyms
Albuterol; AH 3365;
Transport conditionsNormal

Salbutamol

Salbutamol is a short-acting, selective beta(2)-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29-fold more selective for β2 adrenoceptors than β1 receptors. Binding of salbutamol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles.

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BRC0373
Product IDBRC0373
Product classBioreference compound
CAS number61-16-5
MW247.7
Synonyms
NRL001, Mexan
Transport conditionsNormal

Methoxamine hydrochloride

Methoxamine is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Methoxamine acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.

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BRC0246
Product IDBRC0246
Product classBioreference compound
CAS number28311-31-1
MW250.1
Synonyms
(+-)-Baclofen, Baclon, Kemstro, Lioresal Intrathecal,
Transport conditionsNormal

Baclofen hydrochloride

Baclofen is a direct agonist at GABAB receptors.

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BRC0653
Product IDBRC0653
Product classBioreference compound
CAS number51481-61-9
MW252.3
Synonyms
NSC-335308, SKF 92334, SKF-92334
Transport conditionsNormal

Cimetidine

Cimetidine is competitive histamine H2-receptor antagonist (pA2 6.6 - 7.3) which inhibits gastric acid secretion and reduces pepsin output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.

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BRC0464
Product IDBRC0464
Product classBioreference compound
CAS number4815-38-7
MW261.3
Synonyms
Transport conditionsNormal

Ethyl 2-Amino-4-methyl-5-phenylthiophene-3-carboxylate

Glutamate receptors inhibitor.

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BRC0422
Product IDBRC0422
Product classBioreference compound
CAS number55142-85-3
MW263.8
Synonyms
Ticlid
Transport conditionsNormal

Ticlopidine

Ticlopidine is a prodrug that is metabolised to an as yet undetermined metabolite that acts as a platelet aggregation inhibitor. Inhibition of platelet aggregation causes a prolongation of bleeding time. In its prodrug form, ticlopidine has no significant in vitro activity at the concentrations attained in vivo.

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BRC0949
Product IDBRC0949
Product classBioreference compound
CAS number6673-35-4
MW266.3
Synonyms
Transport conditionsNormal

Practolol

Practolol is a beta-adrenergic receptor antagonist that has been used in the emergency treatment of cardiac arrhythmias.

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BRC0889
Product IDBRC0889
Product classBioreference compound
CAS number4205-91-8
MW266.6
Synonyms
ST 155, ST 155-BS
Transport conditionsNormal

Clonidine hydrochloride

Clonidine is an hypotensive agent, centrally-acting α2-adrenergic agonist.

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BRC0828
Product IDBRC0828
Product classBioreference compound
CAS number58-61-7
MW267.2
Synonyms
SR-96225; USAF CB-10; Ado;
Transport conditionsNormal

Adenosine

Adenosine is an endogenous nucleoside. It activates purine receptors, as well as relax vascular smooth muscles through the reduction in calcium uptake by inhibition of slow inward calcium current and activation of adenylate cyclase in smooth muscle cells.

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BRC0642
Product IDBRC0642
Product classBioreference compound
CAS number469-21-6
MW270.4
Synonyms
LS 127
Transport conditionsNormal

Doxylamine

Doxylamine is H1 histamine receptor antagonist. Doxylamine suppresses histamine at the H1 receptor.

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BRC0675
Product IDBRC0675
Product classBioreference compound
CAS number14556-46-8
MW271.8
Synonyms
Transport conditionsNormal

Bupranolol

Bupranolol is a competitive, nonselective beta-blocker without intrinsic sympathomimetic activity. It competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation.

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BRC0273
Product IDBRC0273
Product classBioreference compound
CAS number29110-48-3
MW282.6
Synonyms
Estulic, Guanfacina, Guanfacinum, Estulic, SPD 503
Transport conditionsNormal

Guanfacine hydrochloride

Guanfacine selectively stimulates central alpha(2)-adrenergic receptors, resulting in inhibition of sympathetic vasomotor centers, which contributes predominantly to the hypotensive effects of the drug.

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BRC0644
Product IDBRC0644
Product classBioreference compound
CAS number64461-82-1
MW290.2
Synonyms
AB 021, AN 021, DS 103-282, Sirdalud, Ternelin, Tizan
Transport conditionsNormal

Tizanidine hydrochloride

Tizanidine hydrochloride is an agonist at a2-adrenergic receptor sites (IC50 = 48 nM) and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons.

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BRC0396
Product IDBRC0396
Product classBioreference compound
CAS number154-69-8
MW291.8
Synonyms
Azaron, Pyribenzamine, Tripel
Transport conditionsNormal

Tripelennamine hydrochloride

Tripelennamine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract.

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BRC0784
Product IDBRC0784
Product classBioreference compound
CAS number99614-02-5
MW293.4
Synonyms
GR 38032, Setron, Yatrox
Transport conditionsNormal

Ondansetron

Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.

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BRC0283
Product IDBRC0283
Product classBioreference compound
CAS number135729-61-2
MW296.4
Synonyms
Jiouting, Onicit, Palnox, Paloxi, Palzen, Themiset, Zhiruo, RS 25259, RS 25259 197
Transport conditionsNormal

Palonosetron

Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

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BRC0685
Product IDBRC0685
Product classBioreference compound
CAS number364-62-5
MW299.8
Synonyms
Afipran, Clopromate, DEL 1267
Transport conditionsNormal

Metoclopramide

Metoclopramide is dopamine D2 receptor antagonist. A labelled substituted benzamide with neuroleptic activity. Antiemetic.

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BRC0932
Product IDBRC0932
Product classBioreference compound
CAS number894-71-3
MW299.8
Synonyms
NCI-169453; Acetexa; Pamelor®;
Transport conditionsNormal

Nortriptyline Hydrochloride

Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant that blocks norepinephrine and serotonin transporters more potently than the dopamine transporter. It also antagonizes serotonin, histamine, muscarinic, and α-adrenergic receptors.

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BRC0357
Product IDBRC0357
Product classBioreference compound
CAS number1052540-65-4
MW303.1
Synonyms
Isocaramidine, Bonipress, Declinax, Tendor
Transport conditionsNormal

Debrisoquin

Debrisoquin is an adrenergic neuron-blocking drug similar in effects to guanethidine. It is a substrate for a polymorphic cytochrome P-450 enzyme.

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BRC0892
Product IDBRC0892
Product classBioreference compound
CAS number2863-34-5
MW305.2
Synonyms
Transport conditionsNormal

Bethanidine iodide

Bethanidine iodide is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission.

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BRC0992
Product IDBRC0992
Product classBioreference compound
CAS number42200-33-9
MW309.4
Synonyms
Corgard; Solgol;
Transport conditionsNormal

Nadolol

Nadolol is a nonselective beta-adrenergic receptor antagonist with a long half-life. Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension.

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BRC0748
Product IDBRC0748
Product classBioreference compound
CAS number132539-06-1
MW312.4
Synonyms
ADAMED, Arenbil, Integrol, LY 170053
Transport conditionsNormal

Olanzapine

Olanzapine is serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic and antipsychotic activity.

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BRC0109
Product IDBRC0109
Product classBioreference compound
CAS number14028-44-5
MW313.8
Synonyms
Asendin, Demolox, CL 67772
Transport conditionsNormal
Restrictions Included in California Proposition 65 list Restriction  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amoxapine

Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants; amoxapine inhibits GLYT2a transport activity with IC50 of 92 M.

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BRC0403
Product IDBRC0403
Product classBioreference compound
CAS number99300-78-4
MW313.9
Synonyms
Elafax, Effexor, Efexor, Wy 45030
Transport conditionsNormal

Venlafaxine hydrochloride

Venlafaxine potentiates the neurotransmitter activity in the central nervous system. Furthermore, venlafaxine and its metabolite, O-desmethylvenlafaxine (ODV) potently inhibit the reuptake of serotonin and norepinephrine and weakly inhibit dopamine reuptake.

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BRC0379
Product IDBRC0379
Product classBioreference compound
CAS number550-70-9
MW314.9
Synonyms
Actidil, Myidil, Actifed
Transport conditionsNormal

Triprolidine hydrochloride monohydrate

Triprolidine, is a histamine H1 antagonist that competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. Triprolidine has anticholinergic and sedative effects.

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BRC0391
Product IDBRC0391
Product classBioreference compound
CAS number1229-29-4
MW315.8
Synonyms
Adapin, Aponal, Curatin, Doxepine, Quitaxon, Sinequan
Transport conditionsNormal

Doxepin hydrochloride

Doxepin, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema. Doxepin has substantial anticholinergic and sedative effects. The E (trans)-isomer is more active as a serotonin reuptake inhibitor while the Z-isomer acts as a sedative.

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BRC0825
Product IDBRC0825
Product classBioreference compound
CAS number56-54-2
MW324.4
Synonyms
CIN-QUIN; Conchinin; Conquinine; Pitayine;
Transport conditionsNormal

Quinidine

Quinidine is an optical isomer of quinine, antiarrhythmic. It dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.

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BRC0770
Product IDBRC0770
Product classBioreference compound
CAS number5786-21-0
MW326.8
Synonyms
HF-1854, LX 100-129, W 108, Iprox, Klozapol, Leponex, Sizopin
Transport conditionsNormal

Clozapine

Clozapine is a psychotropic, selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 and 2 adrenergic, and H1 histaminergic receptors. Clozapine acts as an antagonist at other receptors, but with lower potency.

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BRC0736
Product IDBRC0736
Product classBioreference compound
CAS number136434-34-9
MW333.9
Synonyms
LY 248686 HCl, Yentreve
Transport conditionsNormal

Duloxetine hydrochloride

Duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake. The antidepressant and pain inhibitory actions of duloxetine are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS.

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BRC0284
Product IDBRC0284
Product classBioreference compound
CAS number57564-91-7
MW336.3
Synonyms
SNOG; GSNO;
Transport conditionsNormal

S-Nitrosoglutathione

S-Nitrosoglutathione (GSNO) is an endogenous S-nitrosothiol (SNO) that plays a critical role in nitric oxide (NO) signaling and is a source of bioavailable NO.

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BRC0801
Product IDBRC0801
Product classBioreference compound
CAS number76824-35-6
MW337.4
Synonyms
YM 11170, L 643341, MK-208
Transport conditionsNormal

Famotidine

Famotidine is a competitive histamine H2-receptor antagonist, anti-ulcer agent.

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