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Anti-cancer agents

StructureProduct infoAvailabilityQuantity / Price
BRC0179
Product IDBRC0179
Product classBioreference compound
CAS number8029-68-3
MW76.1
Synonyms
Carbamohydroxamic Acid, Hidroxicarbamida, Hydrea, N-Hydroxyurea, Oxyurea, nci-c04831, nsc32065
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Hydroxyurea

An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

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BRC1070
Product IDBRC1070
Product classBioreference compound
CAS number66-22-8
MW112.1
Synonyms
4-Hydroxyuracil; Hybar X; NSC 3970; Pirod;
Transport conditionsNormal

Uracil

Uracil is a pyrimidine derivative, one of the four nucleobases in the nucleic acid of RNA can be used for drug delivery and as a pharmaceutical. Uracil serves as allosteric regulator and coenzyme for reactions in the human body and in plants.

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BRC0031
Product IDBRC0031
Product classBioreference compound
CAS number51-21-8
MW130.1
Synonyms
5-FU, Carzonal, Efudix, Efurix, Ftoruracil, NSC 19893
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

5-Fluorouracil

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances from becoming incorporated into DNA during the "S" phase (of the cell cycle), stopping normal development and division.

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BRC1068
Product IDBRC1068
Product classBioreference compound
CAS number3544-24-9
MW136.2
Synonyms
NSC 36962; SR 4294; WD 97-000835;
Transport conditionsNormal

INO-1001

INO-1001 is PARP (poly(ADP-ribose) polymerase) inhibitor (Ki = 1.8 μM), which protects cells from UV-B-induced apoptosis via influence on the cytoskeleton. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

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BRC1023
Product IDBRC1023
Product classBioreference compound
CAS number700-06-1
MW147.2
Synonyms
NSC 525801; Indinol; I3C;
Transport conditionsNormal

Indole-3-carbinol

Indole-3-carbinol is a cell growth inhibitor that reversibly suppresses incorporation of [3H]thymidine in cells. It has been shown to have anti-cancer effects, at least in part through inhibition of NF-κB and Akt signaling pathways. Indole-3-carbinol displays the ability to inhibit endogenous retinoblastoma protein phosphorylation. Mechanistic studies suggest that in vitro this compound inhibits cell adhesion, migration, and invasion.

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BRC1058
Product IDBRC1058
Product classBioreference compound
CAS number25769-03-3
MW147.2
Synonyms
Pyrrolidinecarbodithioic acid; Tetramethylenedithiocarbamic acid;
Transport conditionsNormal

PDTC

PDTC is a potent inhibitor of Nuclear Factor κB (IC50 = 3.35 µM). It prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.

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BRC1041
Product IDBRC1041
Product classBioreference compound
CAS number490-91-5
MW164.2
Synonyms
NSC 2228;
Transport conditionsNormal

Thymoquinone

Thymoquinone is a natural phytochemical with anti-inflammatory effects, blocking the synthesis of leukotrienes. It inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression.

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BRC0937
Product IDBRC0937
Product classBioreference compound
CAS number1821-12-1
MW164.2
Synonyms
NSC-295; PBA;
Transport conditionsNormal

Phenylbutyric acid

Phenylbutyric acid is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion, and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.

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BRC1051
Product IDBRC1051
Product classBioreference compound
CAS number20098-14-0
MW166.2
Synonyms
Kemantane;
Transport conditionsNormal

Idramantone

Idramantone is an immune agonist.

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BRC0952
Product IDBRC0952
Product classBioreference compound
CAS number154-42-7
MW167.2
Synonyms
6-TG; NSC-752; NSC-76504; Wellcome U 3 B;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Tioguanine

Thioguanine is an antineoplastic compound which also has antimetabolite action, used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia.

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BRC1078
Product IDBRC1078
Product classBioreference compound
CAS number149-91-7
MW170.1
Synonyms
NSC 20103; NSC 674319;
Transport conditionsNormal

Gallic acid

Gallic acid is an anti-inflammatory agent and cyclooxygenase inhibitor found in plants and has been shown to Induce apoptosis in human lung cancer cells. It is often used as a standard for determining the phenol content of various analytes by the Folin-Ciocalteau assay where results are reported in gallic acid equivalents.

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BRC0102
Product IDBRC0102
Product classBioreference compound
CAS number6112-76-1
MW170.2
Synonyms
Purinethol, 6-Thiopurine,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

6-Mercaptopurine monohydrate

Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.

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BRC1022
Product IDBRC1022
Product classBioreference compound
CAS number331-39-5
MW180.2
Synonyms
DHCA; NSC 57197; NSC 623438;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Caffeic Acid

Caffeic Acid is an endogenous phenolic phytochemical compound. It non-competitive inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets at high doses. It has been observed to stimulate prostaglandin synthesis at high doses. It is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.

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BRC0467
Product IDBRC0467
Product classBioreference compound
CAS number64984-31-2
MW181.2
Synonyms
NSC 30358
Transport conditionsNormal

Pifithrin-μ

Pifithrin-μ (PFT-μ) is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL and Bcl-2 at the mitochondria without affecting p53 transactivational activities.

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BRC0958
Product IDBRC0958
Product classBioreference compound
CAS number79416-27-6
MW181.6
Synonyms
Metvixia; Visonac; MAL;
Transport conditionsNormal

Methyl aminolevulinate Hydrochloride

Methyl aminolevulinate hydrochloride is a prodrug that is metabolized to Protoporphyrin IX (a photosensitizer) used in photodynamic therapy.

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BRC1104
Product IDBRC1104
Product classBioreference compound
CAS number459-86-9
MW184.2
Synonyms
NSC 32946; MGBG;
Transport conditionsNormal

Mitoguazone

Mitoguazone is a drug used in chemotherapy, in trials studying the treatment of Lymphoma, HIV Infections, and Non-Hodgkin Lymphoma.

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BRC1121
Product IDBRC1121
Product classBioreference compound
CAS number123-99-9
MW188.2
Synonyms
Finacea; Lepargylic acid; NSC 19493; Skinoren; ZK 62498;
Transport conditionsNormal

Azelaic Acid

Azelaic acid is an anti-inflammatory agent. It directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings.

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BRC1186
Product IDBRC1186
Product classBioreference compound
CAS number81424-67-1
MW189.2
Synonyms
NSC 253272;
Transport conditionsNormal

Caracemide

Caracemide is a potential antineoplastic agent. It inhibits ribonuclease reductase, resulting in decreased DNA synthesis and tumor growth; it also inhibits acetylcholinesterase.

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BRC0277
Product IDBRC0277
Product classBioreference compound
CAS number52-24-4
MW189.2
Synonyms
Thioplex;
Transport conditionsNormal

Thiotepa

Thiotepa is a cancer chemotherapeutic member of the alkylating agent group.

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BRC1024
Product IDBRC1024
Product classBioreference compound
CAS number6300-95-4
MW190.2
Synonyms
6-Phenyldihydrouracil;
Transport conditionsNormal

NSC 44133

NSC 44133 is possible anticitogenic or antiepileptogenic agent.

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BRC0164
Product IDBRC0164
Product classBioreference compound
CAS number85622-93-1
MW194.2
Synonyms
BRN 5547136, CCRG 81045, CCRIS 8996, MB 39831, Methazolastone, NSC 362856, Sch 52365, Temodal, Temodar, TMZ
Transport conditionsNormal

Temozolomide

Temozolomide is an imidazotetrazine deritave and an antineoplastic agent. It is a prodrug that has little to no pharmacological activity until it is hydrolyzed in vivo to 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC).

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BRC1030
Product IDBRC1030
Product classBioreference compound
CAS number92-84-2
MW199.3
Synonyms
Fenoverm; NSC 2037; Dibenzothiazine; ENT 38;
Transport conditionsNormal

Phenothiazine

Phenothiazine is a rigid, tricyclic thiazine useful as an electron donor. It was formerly used as an insecticide and as a drug to treat infections with parasitic worms (anthelminthic).

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BRC0429
Product IDBRC0429
Product classBioreference compound
CAS number17902-23-7
MW200.2
Synonyms
FT-207, NSC 148958, Atillon
Transport conditionsNormal

Tegafur

Tegafur is a chemotherapeutic prodrug of 5-flourouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil. When metabolised, it becomes 5-FU.

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BRC0724
Product IDBRC0724
Product classBioreference compound
CAS number420849-22-5
MW201.2
Synonyms
Transport conditionsNormal

TIQ-A

TIQ-A is a cell permeable, potent PARP-1 inhibitor (IC50 = 495 nM). Neuroprotective against oxygen-glucose deprivation injury in vitro in cultured murine cortical cells.

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BRC1411
Product IDBRC1411
Product classBioreference compound
CAS number156-72-9
MW204.2
Synonyms
Methylene dimethanesulfonate; NSC 171337;
Transport conditionsNormal

MDMS

MDMS is an antineoplastic agent.

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BRC1319
Product IDBRC1319
Product classBioreference compound
CAS number515-13-9
MW204.4
Synonyms
Levo-β-elemene;
Transport conditionsNormal

β-Elemen

β-Elemene is a natural sesquiterpene, inhibits the proliferation of a wide range of tumors. It has antioxidant and antimicrobial properties.

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BRC0322
Product IDBRC0322
Product classBioreference compound
CAS number6960-45-8
MW206.2
Synonyms
NSC 69877, 7-NO2-ICA, 7-Nitroindole-2-Carboxylic Acid
Transport conditionsNormal

CRT0044876

DNA Base Excision Repair Pathway Inhibitor is a potent, nontoxic, specific, and cell-permeable DNA repair enzyme inhibitor.

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BRC1313
Product IDBRC1313
Product classBioreference compound
CAS number1077-28-7
MW206.3
Synonyms
NSC 628502; NSC 90788; Octolipen; (±)-Lipoic acid; Thioctic acid;
Transport conditionsNormal

α-Liponic acid

α-Liponic acid is a metabolic antioxidant that regulates NFκB signal transduction and can protect against oxidative injury.

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BRC0745
Product IDBRC0745
Product classBioreference compound
CAS number2309-07-1
MW208.2
Synonyms
Methyl ferulate, NSC 74548
Transport conditionsNormal

Ferulic acid methyl ester

Ferulic acid is a naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid methyl ester, at 10-25 µg/ml, inhibits the release of pro-inflammatory cytokines, blocks the expression of COX-2, and reduces nitric oxide generation from LPS-stimulated macrophages.

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BRC0182
Product IDBRC0182
Product classBioreference compound
CAS number645-05-6
MW210.3
Synonyms
Hexalen, Hexamethylmelamine, HMM, NSC13875, ENT50852
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Altretamine

Altretamine is a novel antineoplastic agent. 

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BRC0323
Product IDBRC0323
Product classBioreference compound
CAS number19983-44-9
MW211.2
Synonyms
STAT3 Inhibitor V
Transport conditionsNormal

Stattic

Stat3 Inhibitor V, Stattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events.

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BRC0225
Product IDBRC0225
Product classBioreference compound
CAS number154-93-8
MW214.0
Synonyms
BCNU; Bicnu; Gliadel; Becenun; Nitrumon; NSC 409962;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Carmustine

Carmustine is a nitrogen mustard ?-chloro-nitrosourea compound that is used as an alkylating agent.

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BRC0648
Product IDBRC0648
Product classBioreference compound
CAS number926259-99-6
MW214.2
Synonyms
Pyrazin-2-carbonsaeure-(2-amino-anilid)
Transport conditionsNormal

BG45

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 0.1396 μM). HDACs represent novel targets for anti-tumor drugs treating various cancers including multiple myeloma cancer.

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BRC1020
Product IDBRC1020
Product classBioreference compound
CAS number2044796-52-1
MW223.7
Synonyms
Transport conditionsNormal

4-(Dimethylamino)-1-naphthol hydrochloride

4-(Dimethylamino)-1-naphthol hydrochloride is an indoleamine 2,3-dioxygenase inhibitor. May used in cancer therapy.

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BRC0412
Product IDBRC0412
Product classBioreference compound
CAS number2353-33-5
MW228.2
Synonyms
Deoxycytidine, 5-aza-2’-Deoxycytidine, DAC, Dacogen, NSC 127716,
Transport conditionsNormal

Decitabine

Decitabine is an analogue of the natural nucleoside 2’-deoxycytidine. It functions in the same way as 5-Azacytidine. The antineoplastic activity of this drug is dependent on its intracellular conversion to its 5'-triphosphate metabolite.

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BRC0408
Product IDBRC0408
Product classBioreference compound
CAS number389-08-2
MW232.2
Synonyms
NSC-82174
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Nalidixic Acid

Nalidixic acid is a quinolone antibacterial agent for oral administration. Nalidixic acid has marked antibacterial activity against gram-negative bacteria including Enterobacter species, Escherichia coli, Morganella Morganii; Proteus Mirabilis, Proteus vulgaris, and Providencia rettgeri. Pseudomonas species are generally resistant to the drug.

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BRC0623
Product IDBRC0623
Product classBioreference compound
CAS number125-84-8
MW232.3
Synonyms
BA 16038;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Aminoglutethimide

Aminoglutethimide is an aromatase inhibitor that blocks the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer.

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BRC0682
Product IDBRC0682
Product classBioreference compound
CAS number832115-62-5
MW234.3
Synonyms
Isoxazole 9
Transport conditionsNormal

ISX-9

Isx-9 is a neurogenic agent, mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors.

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BRC0207
Product IDBRC0207
Product classBioreference compound
CAS number96020-91-6
MW236.6
Synonyms
DFMO; α-difluoromethylornithine;
Transport conditionsNormal

Eflornithine hydrochloride hydrate

Eflornithine prevents hair growth by inhibiting the anagen phase of hair production.

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BRC1393
Product IDBRC1393
Product classBioreference compound
CAS number88343-72-0
MW236.7
Synonyms
Chlorethyl SOSO; NSC 338947;
Transport conditionsNormal

Clomesone

Clomesone is an antineoplastic agent, DNA inhibitor.

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BRC0703
Product IDBRC0703
Product classBioreference compound
CAS number83280-65-3
MW240.2
Synonyms
BBI 608
Transport conditionsNormal

Napabucasin

Napabucasin is a cell-permeable, bioactive, non-toxic naphthofurandione analog that blocks STAT3-driven gene transcription (IC50 ~ 0.25 µM). Selectively diminishes gene expression and self-renewal in stemness high cancer cells. Shown to be more effective in stemness high cancer cell population (IC50 = 142 nM) compared to regular cancer cells (IC50 = 395 nM).

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BRC1421
Product IDBRC1421
Product classBioreference compound
CAS number137-26-8
MW240.4
Synonyms
Basultra; Betoxin; ENT 987; NSC 1771; NSC 49512; NSC 59637; NSC 622696; Nobecutan; SQ 1489;
Transport conditionsNormal

Thiram

Thiram is a fungicide, ectoparasiticide, and animal repellent.

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BRC0543
Product IDBRC0543
Product classBioreference compound
CAS number2514-30-9
MW241.3
Synonyms
Transport conditionsNormal

PBIT

PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 µM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively).

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BRC0760
Product IDBRC0760
Product classBioreference compound
CAS number1018454-97-1
MW242.3
Synonyms
Transport conditionsNormal

Thienopyridone

Thienopyridone is selective phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage.

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BRC0057
Product IDBRC0057
Product classBioreference compound
CAS number147-94-4
MW243.2
Synonyms
Ara-C, Cytosine arabinoside, Cytosar, Arabinosylcytosine,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Cytarabine

Cytarabine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute myelogenous leukemia and meningeal leukemia.

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BRC0115
Product IDBRC0115
Product classBioreference compound
CAS number320-67-2
MW244.2
Synonyms
Ladakamycin, Vidaza, NSC 102816
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Azacitidine

Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is believed to exert its antineoplastic effects by causing hypomethylation of DNA and direct cytotoxicity on abnormal hematopoietic cells in the bone marrow. The concentration of azacitidine required for maximum inhibition of DNA methylation in vitro does not cause major suppression of DNA synthesis.

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BRC0351
Product IDBRC0351
Product classBioreference compound
CAS number50-91-9
MW246.2
Synonyms
NSC 26740, NSC 27640, 5-FDU, 5-Fluorodeoxyuridine
Transport conditionsNormal

Floxuridine

Antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.

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BRC0041
Product IDBRC0041
Product classBioreference compound
CAS number55-98-1
MW246.3
Synonyms
Busulphan, Mielosan, Milecitan, Myeloleukon, Mylecytan, Myleran, NCI C01592, NSC 750
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Busulfan

Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer.

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BRC0903
Product IDBRC0903
Product classBioreference compound
CAS number847163-28-4
MW249.3
Synonyms
CID 664510
Transport conditionsNormal

ML351

ML351 is selective inhibitor of 12/15-lipoxygenase. It was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.

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BRC0601
Product IDBRC0601
Product classBioreference compound
CAS number80025-67-8
MW252.2
Synonyms
Transport conditionsNormal

5-Amino-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carbonitrile

The compound is potent xanthine oxidase inhibitor (IC50 > 100 µM).

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