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Antimalarial

StructureProduct infoAvailabilityQuantity / Price
BRC0945
Product IDBRC0945
Product classBioreference compound
CAS number80-08-0
MW248.3
Synonyms
J04BA02; NSC-6091; DDS; DADPS;
Transport conditionsNormal

Dapsone

Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties. It is also used with pyrimethamine in the treatment of malaria. Dapsone is a leukotriene B4 (LTB4) antagonist, inhibits LTB4 induced lysozyme release.

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BRC0695
Product IDBRC0695
Product classBioreference compound
CAS number58-14-0
MW248.7
Synonyms
NSC 3061, RP 4753, Tindurin, WR 2978, BW 50-63, Chloridin
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Pyrimethamine

Pyrimethamine is dihydrofolate reductase inhibitor (Ki = 0.19 nM), generally used in combination with other antimicrobial agents. It is a potent inhibitor of multi-drug and toxin extrusion transporters.

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BRC0953
Product IDBRC0953
Product classBioreference compound
CAS number152-47-6
MW280.3
Synonyms
AS-18908; NSC-110433; Sulfalen;
Transport conditionsNormal

Sulfametopyrazine

Sulfametopyrazine is a sulfonamide antibiotic with a wide spectrum against most gram-positive and many gram-negative organisms. It is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase.

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BRC0514
Product IDBRC0514
Product classBioreference compound
CAS number116970-50-4
MW287.8
Synonyms
Protein kinase inhibitor H-9
Transport conditionsNormal

H-9 hydrochloride

H-9 (hydrochloride), an isoquinolinesulfonamide protein kinase inhibitor, is a competitive inhibitor of PKC, PKG, and PKA with Ki values of 18, 0.87, and 1.9 µM, respectively.

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BRC0128
Product IDBRC0128
Product classBioreference compound
CAS number152-53-4
MW288.2
Synonyms
Chloroguanide Triazine; NSC 3074;
Transport conditionsNormal

Cycloguanil hydrochloride

Cycloguanil hydrochloride is an active metabolite of proguanil, produced by the cytochrome P450 2C19 isoform. It acts as an inhibitor of dihydrofolate reductase (DHFR).

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BRC0036
Product IDBRC0036
Product classBioreference compound
CAS number637-32-1
MW290.2
Synonyms
Chloroguanide, Bigumal, Paludrin
Transport conditionsNormal

Proguanil hydrochloride

Proguanil is a biguanide derivative that is converted to an active metabolite called cycloguanil. It exerts its antimalarial action by inhibiting parasitic dihydrofolate reductase enzyme. It has causal prophylactic and suppressive activity against P. falciparum and cures the acute infection. It is also effective in suppressing the clinical attacks of vivax malaria.

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BRC0144
Product IDBRC0144
Product classBioreference compound
CAS number738-70-5
MW290.3
Synonyms
Proloprim, Trimpex, Monotrim, Bactramin, BW 56-72, NIH 204, NSC-106568
Transport conditionsNormal

Trimethoprim

Trimethoprim is a pyrimidine analogue that disrupts folate synthesis, an essential part of the thymidine synthesis pathway. Inhibition of the enzyme starves the bacteria of nucleotides necessary for DNA replication.The drug, therefore, exhibits bactericidal activity.

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BRC0806
Product IDBRC0806
Product classBioreference compound
CAS number3685-84-5
MW294.2
Synonyms
ANP 235, Analux, CPH, NSC 169411
Transport conditionsNormal

Meclofenoxate hydrochloride

Meclofenoxate hydrochloride is a cerebral stimulant. It is used as plant growth regulator. Also, it shows antimalarial activity.

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BRC0848
Product IDBRC0848
Product classBioreference compound
CAS number2447-57-6
MW310.3
Synonyms
J21.373J, RO-4-4393, WR-4073
Transport conditionsNormal

Sulfadoxine

Sulfadoxine is a long acting sulfonamide, usually used in combination with other drugs, for respiratory, urinary tract, and malarial infections.

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BRC0232
Product IDBRC0232
Product classBioreference compound
CAS number130-95-0
MW324.4
Synonyms
(-)-Quinine, (8S,9R)-Quinine, Chinin, Jasoquin, QSM, Sulquin
Transport conditionsNormal

Quinine

Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Quinine acts as a blood schizonticide although it also has gametocytocidal activity against P. vivax and P. malariae.

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BRC0825
Product IDBRC0825
Product classBioreference compound
CAS number56-54-2
MW324.4
Synonyms
CIN-QUIN; Conchinin; Conquinine; Pitayine;
Transport conditionsNormal

Quinidine

Quinidine is an optical isomer of quinine, antiarrhythmic. It dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.

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BRC0778
Product IDBRC0778
Product classBioreference compound
CAS number63-45-6
MW357.3
Synonyms
SN 13272, WR 2975, NSC 27296
Transport conditionsNormal

Primaquine phosphate

Primaquine phosphate is an antimalarial agent with genotoxicity (Ames test) and cardiotoxicity (inhibitor of cardiac Na+ current).

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BRC0218
Product IDBRC0218
Product classBioreference compound
CAS number95233-18-4
MW366.8
Synonyms
Acuvel, Mepron, Wellvone, Atovaquone
Transport conditionsNormal

Atovaquone

Atovaquone is antipneumocystic hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport.

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BRC0375
Product IDBRC0375
Product classBioreference compound
CAS number83-89-6
MW400.0
Synonyms
Atebrine, Mepacrine
Transport conditionsNormal

Quinacrine

Quinacrine is commonly used as an anti-protozoal agent. It potently prevents misfolding of prion protein (EC50 = 0.3 μM), blocks voltage-dependent sodium channels (IC50 = 3.3 μM), and inhibits aldehyde oxidase (IC50 = 3.3 μM).

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BRC0129
Product IDBRC0129
Product classBioreference compound
CAS number51773-92-3
MW414.8
Synonyms
Mefloquinum, Mefloquina, Mephloquine,
Transport conditionsNormal

Mefloquine hydrochloride

Mefloquine is an antimalarial agent which acts as a blood schizonticide. Mefloquine is active against the erythrocytic stages of Plasmodium species.

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BRC0018
Product IDBRC0018
Product classBioreference compound
CAS number747-36-4
MW434.0
Synonyms
Plaquenil, Oxichloroquine, Oxychlorochin, Oxichlorochinum
Transport conditionsNormal

Hydroxychloroquine sulfate

Hydroxychloroquine possesses antimalarial properties and also exerts a beneficial effect in lupus erythematosus (chronic discoid or systemic) and acute or chronic rheumatoid arthritis.

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BRC0376
Product IDBRC0376
Product classBioreference compound
CAS number1042432-58-5
MW438.9
Synonyms
Transport conditionsNormal

CTx-0152960

CTx-0152960, was reported as a new member of the broad spectrum PKI family and developed as a Sepharose-supported kinase capture reagent in the identification of 235 protein kinases from a digest of human breast adenocarcinoma, MDA-MB-231, cells.

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BRC0015
Product IDBRC0015
Product classBioreference compound
CAS number6398-98-7
MW464.8
Synonyms
Flavoquine, Camoquin
Transport conditionsNormal

Amodiaquine dihydrochloride dihydrate

Amodiaquine, a 4-aminoquinoline similar to chloroquine in structure and activity, has been used as both an antimalarial and an anti-inflammatory agent for more than 40 years. The mode of action of amodiaquine has not yet been determined. 4-Aminoquinolines depress cardiac muscle, impair cardiac conductivity, and produce vasodilatation with resultant hypotension.

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BRC0003
Product IDBRC0003
Product classBioreference compound
CAS number50-63-5
MW515.9
Synonyms
Aralen, Artrichin, Bemaphate, Capquin, Malarex, Nivaquine B, Resoquine, Reumachlor, Sanoquin
Transport conditionsNormal

Chloroquine diphosphate

Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. Chloroquine inhibits the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. It may also interfere with the biosynthesis of nucleic acids.

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BRC0130
Product IDBRC0130
Product classBioreference compound
CAS number82186-77-4
MW528.9
Synonyms
Benflumetol, HSDB 7210
Transport conditionsNormal

Lumefantrine

Lumefantrine is a blood schizonticide active against erythrocytic stages of Plasmodium falciparum.

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BRC0199
Product IDBRC0199
Product classBioreference compound
CAS number36167-63-2
MW536.9
Synonyms
Halfan;
Transport conditionsNormal

Halofantrine hydrochloride

Halofantrine is a synthetic antimalarial which acts as a blood schizonticide.

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BRC0579
Product IDBRC0579
Product classBioreference compound
CAS number1049771-07-4
MW546.5
Synonyms
Transport conditionsNormal

TCMDC-124020

The compound is an inhibitor of Plasmodium falciparum 3D7 in whole red blood cells.

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BRC0469
Product IDBRC0469
Product classBioreference compound
CAS number320368-47-6
MW557.5
Synonyms
Transport conditionsNormal

GNF-Pf-2679

Inhibitor of Plasmodium falciparum 3D7 and W2 (drug-susceptible) proliferation in erythrocyte-based infection assay. Cytotoxicity against human hepatocellular carcinoma cell line (Huh7).

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BRC0722
Product IDBRC0722
Product classBioreference compound
CAS number733004-60-9
MW561.0
Synonyms
Transport conditionsNormal

GNF-Pf-1556

Inhibition of Plasmodium falciparum W2 (drug-resistant) and 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay (EC50 = 7310 nM and 8400 nM respectively).

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BRC0709
Product IDBRC0709
Product classBioreference compound
CAS number749889-38-1
MW599.8
Synonyms
Transport conditionsNormal

GNF-Pf-3107

Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) and W2 (drug-resistant) proliferation in erythrocyte-based infection assay (EC50 = 470 nM and 1176 nM respectively).

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BRC0486
Product IDBRC0486
Product classBioreference compound
CAS number301312-85-6
MW603.5
Synonyms
Transport conditionsNormal

GNF-Pf-4487

GNF-Pf-4487 is an inhibitor of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay.

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BRC0487
Product IDBRC0487
Product classBioreference compound
CAS number300568-73-4
MW620.9
Synonyms
Transport conditionsNormal

GNF-Pf-520

GNF-Pf-520 is an inhibitor of Plasmodium falciparum 3D7 (drug-susceptible) and Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay.

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BRC0440
Product IDBRC0440
Product classBioreference compound
CAS number24390-14-5
MW1025.9
Synonyms
WC 2031,
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Doxycycline hydrochloride hemiethanolate hemihydrate

Doxycycline is an antimicrobial tetracycline that acts as an inhibitor of a wide range of matrix metalloproteinases (MMPs). Increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibiting plasminogen systems.

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