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Renin angiotensin aldosterone system (RAAS) inhibitors

StructureProduct infoAvailabilityQuantity / Price
BRC0095
Product IDBRC0095
Product classBioreference compound
CAS number84680-54-6
MW384.4
Synonyms
Enalapril acid, MK-422 Dihydrate
Transport conditionsNormal

Enalaprilat dihydrate

Enalaprilat is the active metabolite of the orally available pro-drug, enalapril. Used in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II.

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BRC0093
Product IDBRC0093
Product classBioreference compound
CAS number144689-63-4
MW558.6
Synonyms
Benicar, Cs 866,
Transport conditionsNormal

Olmesartan medoxomil

Prodrug metabolised in vivo to Olmesartan, a selective non-peptide angiotensin II type I receptor (AT1) antagonist. Selectively inhibits angiotensin II binding to AT1 receptors in bovine adrenal cortical membranes (IC50 = 7.7 nM), with no effect on AT2 receptors.

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BRC0002
Product IDBRC0002
Product classBioreference compound
CAS number173334-58-2
MW1219.6
Synonyms
Tekturna, Rasilez
Transport conditionsNormal

Aliskiren hemifumarate

Renin, the first enzyme in the renin–angiotensin–aldosterone system, plays a role in blood pressure control. It cleaves angiotensinogen to angiotensin I, which is in turn converted by angiotensin-converting enzyme (ACE) to angiotensin II. Angiotensin II has both direct and indirect effects on blood pressure.

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