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Ubiquitin Proteasome System Inhibitors

StructureProduct infoAvailabilityQuantity / Price
BRC0342
Product IDBRC0342
Product classBioreference compound
CAS number343351-67-7
MW267.3
Synonyms
Transport conditionsNormal

NSC697923

Selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo.

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BRC0494
Product IDBRC0494
Product classBioreference compound
CAS number314245-33-5
MW300.4
Synonyms
Transport conditionsNormal

IU1

IU1 is an inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome. IU1 inhibits USP14-mediated ubiquitin "chain-trimming" thereby enhancing substrate degradation by the proteasome. The compound may help to eliminate toxic proteins more effectively by enhancing their degradation.

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BRC0335
Product IDBRC0335
Product classBioreference compound
CAS number222716-34-9
MW420.5
Synonyms
Transport conditionsNormal

SZL P1-41

Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

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BRC0442
Product IDBRC0442
Product classBioreference compound
CAS number924198-81-2
MW451.5
Synonyms
A17(SMURF1 inhibitor)
Transport conditionsNormal

A17

A17 is an inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smuf1) that is a major regulator of bone morphogenetic protein (BMP) signaling. A17 strongly inhibits Smad1/5 ubiquitination mediated by Smuf1, increases BMP signal responsiveness and enhances BMP-2 induced osteoblastic activity.

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BRC0437
Product IDBRC0437
Product classBioreference compound
CAS number691881-87-5
MW455.9
Synonyms
Transport conditionsNormal

3-(benzo[d][1,3]dioxol-5-ylmethyl)-5-((5-(2-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one

Inhibitor of MDM2-mediated p53 ubiquitynation.

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BRC0921
Product IDBRC0921
Product classBioreference compound
CAS number1007647-73-5
MW512.9
Synonyms
Transport conditionsNormal

A01 (Smurf1 inhibitor)

A01 is an inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smuf1) that is a major regulator of bone morphogenetic protein (BMP) signaling. AO1 strongly inhibits Smad1/5 ubiquitination mediated by Smuf1, increases BMP signal responsiveness and enhances BMP-2 induced osteoblastic activity.

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