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StructureProduct infoAvailabilityQuantity / Price
BRC0494
Product IDBRC0494
Product classBioreference compound
CAS number314245-33-5
MW300.4
Synonyms
Transport conditionsNormal

IU1

IU1 is an inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome. IU1 inhibits USP14-mediated ubiquitin "chain-trimming" thereby enhancing substrate degradation by the proteasome. The compound may help to eliminate toxic proteins more effectively by enhancing their degradation.

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BRC0465
Product IDBRC0465
Product classBioreference compound
CAS number509102-00-5
MW347.4
Synonyms
Transport conditionsNormal

MIM1

MIM1 is inhibitor of Mcl-1, selectively targets the BH3-binding pocket.

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BRC0024
Product IDBRC0024
Product classBioreference compound
CAS number179324-69-7
MW384.2
Synonyms
PS-341, Velcade, Neomib, Bortecad, LDP-341, MLM341
Transport conditionsNormal

Bortezomib

Bortezomib is a drug that inhibits the mammalian 26S proteasome. The ubiquitin-proteasome pathway plays an essential role in regulating the intracellular concentration of specific proteins, thereby maintaining homeostasis within cells. Inhibition of the 26S proteasome prevents this targeted proteolysis, which can affect multiple signaling cascades within the cell. This disruption of normal homeostatic mechanisms can lead to cell death. Experiments have demonstrated that bortezomib is cytotoxic to a variety of cancer cell types in vitro.

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BRC0333
Product IDBRC0333
Product classBioreference compound
CAS number1624602-30-7
MW477.9
Synonyms
Transport conditionsNormal

VR23

VR23 is a chloroquine derivative that functions as a proteasome inhibitor (IC50s = 1 nM, 50-100 nM, and 3 µM for trypsin-like, chymotrypsin-like, and caspase-like proteasomes, respectively).

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BRC0571
Product IDBRC0571
Product classBioreference compound
CAS number884198-11-2
MW623.8
Synonyms
Transport conditionsNormal

(2S)-2-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}-4-methyl-N-[(1S)-3-methyl-1-{[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]carbamoyl}butyl]pentanamide

The compound is an inhibitor of N-terminal nucleophile hydrolases.

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