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BRC1366
Product IDBRC1366
Product classBioreference compound
CAS number106-57-0
MW114.1
Synonyms
Glycylglycine lactam; NSC 26345; Diketopiperazine; Cyclodiglycine; Glycine anhydride;
Transport conditionsNormal

Piperazinedione

Piperazinedione is an intermediate in the preparation of various pharmaceutical and biologically active compounds. It has enzyme inhibitory activity towards Matrix metalloproteases.

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BRC1015
Product IDBRC1015
Product classBioreference compound
CAS number125078-15-1
MW167.1
Synonyms
Transport conditionsNormal

P-(1-Amino-2,2-dimethylpropyl)phosphonic acid

The compound is methionyl aminopeptidase inhibitor.

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BRC1034
Product IDBRC1034
Product classBioreference compound
CAS number3565-26-2
MW174.2
Synonyms
Hydron III;
Transport conditionsNormal

NSC 3852

NSC 3852 is histone deacetylase inhibitor that causes cell differentiation and has antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo.

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BRC1081
Product IDBRC1081
Product classBioreference compound
CAS number130-16-5
MW179.6
Synonyms
Dermofungin; NSC 35083; NSC 53182; NSC 74943;
Transport conditionsNormal

Cloxiquine

Cloxiquine is an antibacterial, antifungal, antiaging and antituberculosis agent.

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BRC0427
Product IDBRC0427
Product classBioreference compound
CAS number4008-48-4
MW190.2
Synonyms
5-NOK, 8-Hydroxy-5-nitroquinoline
Transport conditionsNormal

Nitroxoline

Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases. This drug may also have antitumor activity by inhibition of type 2 methionine aminopeptidase (MetAP2) protein which is involved in angiogenesis.

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BRC0890
Product IDBRC0890
Product classBioreference compound
CAS number62571-86-2
MW217.3
Synonyms
C09AA01, SA-333, SQ-14225
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Captopril

Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS).

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BRC0632
Product IDBRC0632
Product classBioreference compound
CAS number23113-43-1
MW267.5
Synonyms
NSC 68982, Wy 8678
Transport conditionsNormal

Guanabenz hydrochloride

Guanabenz is a centrally acting α-2 adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand, indicated for treatment of hypertension.

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BRC1295
Product IDBRC1295
Product classBioreference compound
CAS number51298-62-5
MW269.7
Synonyms
Transport conditionsNormal

L-NAME hydrochloride

L-NAME hydrochloride is a nonselective inhibitor of nitric oxide synthetases.

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BRC0494
Product IDBRC0494
Product classBioreference compound
CAS number314245-33-5
MW300.4
Synonyms
Transport conditionsNormal

IU1

IU1 is an inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome. IU1 inhibits USP14-mediated ubiquitin "chain-trimming" thereby enhancing substrate degradation by the proteasome. The compound may help to eliminate toxic proteins more effectively by enhancing their degradation.

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BRC0017
Product IDBRC0017
Product classBioreference compound
CAS number17440-83-4
MW302.1
Synonyms
Amipramidin, Amipramidine, Midamor
Transport conditionsNormal

Amiloride hydrochloride dihydrate

Amiloride, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. This promotes the loss of sodium and water from the body, but without depleting potassium.

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BRC1032
Product IDBRC1032
Product classBioreference compound
CAS number521-74-4
MW303.0
Synonyms
Fenilor; Intensopan; NSC 1810; NSC 74937;
Transport conditionsNormal

Broxyquinoline

Broxyquinoline is an antiprotozoal agent.

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BRC0779
Product IDBRC0779
Product classBioreference compound
CAS number274901-16-5
MW303.4
Synonyms
DSP 7238, Equa, Galvus, LAF 237, NVP-LAF 237
Transport conditionsNormal

Vildagliptin

Vildagliptin is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase.

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BRC1076
Product IDBRC1076
Product classBioreference compound
CAS number130-26-7
MW305.5
Synonyms
Lekosept; NSC 3531; NSC 74938; Nioform;
Transport conditionsNormal

Clioquinol

Clioquinol is a broad-spectrum antibacterial with antifungal properties. It inhibits certain enzymes related to DNA replication.

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BRC0065
Product IDBRC0065
Product classBioreference compound
CAS number361442-04-8
MW315.4
Synonyms
Onglyza, BMS-477118,
Transport conditionsNormal

Saxagliptin

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes.

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BRC0509
Product IDBRC0509
Product classBioreference compound
CAS number82158-86-9
MW319.4
Synonyms
Kinedak; ONO 2235; Sorbista;
Transport conditionsNormal

Epalrestat

Epalrestat is a carboxylic acid-based inhibitor of aldose reductase (IC50 = 0.01-15 μM). Epalrestat has been shown to reduce oxidative stress in type 2 diabetic patients, significantly decreasing lipid hydroperoxide levels in erythrocytes when administered at 150 mg/day.

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BRC0430
Product IDBRC0430
Product classBioreference compound
CAS number1811-28-5
MW343.4
Synonyms
Diaminoacridine
Transport conditionsNormal

Proflavine hemisulfate

Proflavine is an acriflavine derivative which is a disinfectant bacteriostatic against many gram-positive bacteria. Proflavine is toxic and carcinogenic in mammals and so it is used only as a surface disinfectant or for treating superficial wounds.

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BRC0465
Product IDBRC0465
Product classBioreference compound
CAS number509102-00-5
MW347.4
Synonyms
Transport conditionsNormal

MIM1

MIM1 is inhibitor of Mcl-1, selectively targets the BH3-binding pocket.

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BRC0759
Product IDBRC0759
Product classBioreference compound
CAS number1110650-72-0
MW354.4
Synonyms
Transport conditionsNormal

HFI-419

HFI-419 is a substrate competitive inhibitor of insulin-regulated aminopeptidase (IRAP) activity (Ki = 0.48 µM against 25 µM Leu-AMC).

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BRC0208
Product IDBRC0208
Product classBioreference compound
CAS number82009-34-5
MW358.4
Synonyms
Cilastatin-Natrium
Transport conditionsNormal

Cilastatin

Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

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BRC0024
Product IDBRC0024
Product classBioreference compound
CAS number179324-69-7
MW384.2
Synonyms
PS-341, Velcade, Neomib, Bortecad, LDP-341, MLM341
Transport conditionsNormal

Bortezomib

Bortezomib is a drug that inhibits the mammalian 26S proteasome. The ubiquitin-proteasome pathway plays an essential role in regulating the intracellular concentration of specific proteins, thereby maintaining homeostasis within cells. Inhibition of the 26S proteasome prevents this targeted proteolysis, which can affect multiple signaling cascades within the cell. This disruption of normal homeostatic mechanisms can lead to cell death. Experiments have demonstrated that bortezomib is cytotoxic to a variety of cancer cell types in vitro.

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BRC0095
Product IDBRC0095
Product classBioreference compound
CAS number84680-54-6
MW384.4
Synonyms
Enalapril acid, MK-422 Dihydrate
Transport conditionsNormal

Enalaprilat dihydrate

Enalaprilat is the active metabolite of the orally available pro-drug, enalapril. Used in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II.

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BRC0635
Product IDBRC0635
Product classBioreference compound
CAS number256477-09-5
MW385.8
Synonyms
Transport conditionsNormal

UK-371804

UK-371804 is a potent and selective inhibitor of urokinase-type plasmogen activator (uPA) (Ki=10 nM). Selectivity is 4000-fold versus tPA and 2700-fold versus plasmin.

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BRC0776
Product IDBRC0776
Product classBioreference compound
CAS number153-61-7
MW396.4
Synonyms
CT,
Transport conditionsNormal

Cefalotin

Cephalothin is a first generation cephalosporin antibiotic with a wide range antibacterial activity. It is effective against gram-positive and gram-negative bacteria, and has been tested in respiratory disease and neuromuscular junction studies.

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BRC0855
Product IDBRC0855
Product classBioreference compound
CAS number76547-98-3
MW405.5
Synonyms
MK 521, MK 522
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Lisinopril

Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII is a key component of the renin-angiotensin-aldosterone system (RAAS).

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BRC0061
Product IDBRC0061
Product classBioreference compound
CAS number486460-32-6
MW407.3
Synonyms
Januvia, Xelevia, Sitagliptan,
Transport conditionsNormal

Sitagliptin

Sitagliptin is a highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones, thereby increasing the concentration and prolonging the action of these hormones.

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BRC0066
Product IDBRC0066
Product classBioreference compound
CAS number163222-33-1
MW409.4
Synonyms
Zetia, Ezetrol, Ezedoc, Sch 58235,
Transport conditionsNormal

Ezetimibe

Ezetimibe is an anti-hyperlipidemic medication which is used to lower cholesterol levels. Specifically, it appears to bind to a critical mediator of cholesterol absorption, the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells as well as in hepatocytes.

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BRC0716
Product IDBRC0716
Product classBioreference compound
CAS number87333-19-5
MW416.5
Synonyms
Corpril, Delix, Ecator, HOE 498
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Ramipril

Ramipril is non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). It is prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction.

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BRC0491
Product IDBRC0491
Product classBioreference compound
CAS number4506-25-6
MW456.4
Synonyms
Transport conditionsNormal

NSC 373937

NSC 373937 is HIV-1 protease inhibitor (IC50 = 30 μM).

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BRC0850
Product IDBRC0850
Product classBioreference compound
CAS number82586-55-8
MW475.0
Synonyms
C09AA06
Transport conditionsNormal

Quinapril hydrochloride

Quinapril hydrochloride is a prodrug, angiotensin-converting enzyme (ACE) inhibitor. It is metabolized to quinaprilat (quinapril diacid) following oral administration. Quinaprilat is a competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).

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BRC0405
Product IDBRC0405
Product classBioreference compound
CAS number7081-44-9
MW475.9
Synonyms
Aclox, Apo-Cloxi, Auropen Inj., Cloxacil, Cloxam, Orbenin, Vaclox, Vamcloxil
Transport conditionsNormal

Cloxacillin sodium

Cloxacillin is a semi-synthetic β-lactam antibiotic, related to penicillin, which suppresses the growth of gram-positive bacteria such as Staphylococcus by inhibiting the synthesis of peptidoglycan.

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BRC0333
Product IDBRC0333
Product classBioreference compound
CAS number1624602-30-7
MW477.9
Synonyms
Transport conditionsNormal

VR23

VR23 is a chloroquine derivative that functions as a proteasome inhibitor (IC50s = 1 nM, 50-100 nM, and 3 µM for trypsin-like, chymotrypsin-like, and caspase-like proteasomes, respectively).

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BRC0172
Product IDBRC0172
Product classBioreference compound
CAS number161814-49-9
MW505.6
Synonyms
Agenerase, Prozei, VX-478, Vertex, 141W94, KVX-478
Transport conditionsNormal

Amprenavir

Amprenavir is a first generation inhibitor of the HIV-1 aspartic protease (Ki = 0.04 nM) that blocks replication of HIV-1 in the human T cell MT-4 cell line (IC50 = 150 nM) as well as in peripheral blood lymphocytes (IC50 = 80 nM). Through this action, it blocks the post-translational processing of gag and gag-pol gene products into key structural proteins and replication enzymes.

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BRC0400
Product IDBRC0400
Product classBioreference compound
CAS number13412-64-1
MW510.3
Synonyms
Amcidil, Betaclox, Cloxagen, Dacocilin, Damacir, Dicillin, Diclex, Diclocil, Dicloplus, Dicloson, Dicloxal, Dicloxgen, Dicloxina, Dyclobiot, Dynapen, Posipen, Quimocyclar, Staklox, Terbocloxil, Ziefmycin, Veracillin, BRL1702
Transport conditionsNormal

Dicloxacillin sodium monohydrate

Dicloxacillin is a beta-lactamase resistant penicillin similar to oxacillin. Dicloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria.

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BRC0008
Product IDBRC0008
Product classBioreference compound
CAS number141396-28-3
MW526.6
Synonyms
MCI-9038
Transport conditionsNormal

Argatroban

Argatroban is a synthetic direct thrombin inhibitor derived from L-arginine indicated as an anticoagulant for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia.

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BRC0681
Product IDBRC0681
Product classBioreference compound
CAS number98048-97-6
MW563.7
Synonyms
Fozitec
Transport conditionsNormal

Fosinopril

Fosinopril is an inhibitor of Angiotensin-converting enzyme (ACE). In nature, ACE converts angiotensin I to angiotensin II, which causes blood vessels to constrict, and thereby increasing blood pressure.

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BRC0571
Product IDBRC0571
Product classBioreference compound
CAS number884198-11-2
MW623.8
Synonyms
Transport conditionsNormal

(2S)-2-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}-4-methyl-N-[(1S)-3-methyl-1-{[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]carbamoyl}butyl]pentanamide

The compound is an inhibitor of N-terminal nucleophile hydrolases.

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BRC0641
Product IDBRC0641
Product classBioreference compound
CAS number157810-81-6
MW711.9
Synonyms
L 735524, Crixivan, MK 639,
Transport conditionsNormal

Indinavir sulfate

Indinavir is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors (IC50 = 3E-05 µM).

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BRC0845
Product IDBRC0845
Product classBioreference compound
CAS number155213-67-5
MW721.0
Synonyms
ABT-538, NSC-693184
Transport conditionsNormal

Ritonavir

Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1.

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BRC0959
Product IDBRC0959
Product classBioreference compound
CAS number344423-98-9
MW1209.4
Synonyms
Cardyl; Lipitor®; Lipovastatinklonal;
Transport conditionsNormal

Atorvastatin Calcium Trihydrate

Atorvastatin calcium trihydrate is selective, competitive HMG-CoA reductase inhibitor (IC50 = 8 nM) used to lower serum total and LDL cholesterol, apoB, and triglyceride levels while increasing HDL cholesterol.

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