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P-glycoprotein/ABCB1

StructureProduct infoAvailabilityQuantity / Price
BRC0981
Product IDBRC0981
Product classBioreference compound
CAS number103-90-2
MW151.2
Synonyms
NSC-109028; NSC-3991; APAP; Acenol; Paracetamol;
Transport conditionsNormal

Acetaminophen

Acetaminophen is a widely used analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin synthesis.

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BRC0966
Product IDBRC0966
Product classBioreference compound
CAS number94-09-7
MW165.2
Synonyms
AR01; NSC-41531; NSC-4688;
Transport conditionsNormal

Benzocaine

Benzocaine is a local anesthetic commonly used as a topical pain reliever. It binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.

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BRC0652
Product IDBRC0652
Product classBioreference compound
CAS number61-78-9
MW194.2
Synonyms
PAHA;
Transport conditionsNormal

Aminohippuric acid

Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.

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BRC0295
Product IDBRC0295
Product classBioreference compound
CAS number58-08-2
MW194.2
Synonyms
Methyltheobromine, NSC 5036
Transport conditionsNormal

Caffeine

Central nervous system stimulant. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.

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BRC0886
Product IDBRC0886
Product classBioreference compound
CAS number14611-52-0
MW223.7
Synonyms
Transport conditionsNormal

Selegiline hydrochloride

Selegiline hydrochloride is a selective, irreversible inhibitor of Type B monoamine oxidase. It is used in Parkinsons disease treatment.

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BRC0967
Product IDBRC0967
Product classBioreference compound
CAS number137-58-6
MW234.3
Synonyms
ALGRX-3268; LSM-3165; NSC-40030;
Transport conditionsNormal

Lidocaine

Lidocaine is an anaesthetic agent and class Ib antiarrhythmic agent. It is a selective inverse peripheral histamine H1-receptor agonist. This compound is known to block voltage-gated sodium channels in the inactivated state.

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BRC0926
Product IDBRC0926
Product classBioreference compound
CAS number298-46-4
MW236.3
Synonyms
G-32883; GEIGY 32883; NSC-169864; SPD417; CBZ;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Carbamazepine

Carbamazepine is an anticonvulsant used to control grand mal and psychomotor or focal seizures. It inhibits neuronal voltage-gated Na+ channels. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis.

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BRC0380
Product IDBRC0380
Product classBioreference compound
CAS number6055-19-2
MW279.1
Synonyms
B 518, NSC 26271, Endoxan
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Cyclophosphamide monohydrate

Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders. In cells with low levels of aldehyde dehydrogenase, cyclophosphamide acts as a prodrug since it is metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.

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BRC0144
Product IDBRC0144
Product classBioreference compound
CAS number738-70-5
MW290.3
Synonyms
Proloprim, Trimpex, Monotrim, Bactramin, BW 56-72, NIH 204, NSC-106568
Transport conditionsNormal

Trimethoprim

Trimethoprim is a pyrimidine analogue that disrupts folate synthesis, an essential part of the thymidine synthesis pathway. Inhibition of the enzyme starves the bacteria of nucleotides necessary for DNA replication.The drug, therefore, exhibits bactericidal activity.

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BRC0428
Product IDBRC0428
Product classBioreference compound
CAS number318-98-9
MW295.8
Synonyms
AY-64043, ICI-45520, NCS-91523, Angilol, Bedranol SR, Cardinol, Ciplar, Deralin, Dociton, Duranol, HEMANGEOL, Inderal, Inderal LA, Indobloc, INNOPRAN, Innopran XL, Prophylux, Sumial
Transport conditionsNormal

Propranolol hydrochloride

Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.

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BRC0989
Product IDBRC0989
Product classBioreference compound
CAS number15307-86-5
MW296.2
Synonyms
ISV-205;
Transport conditionsNormal

Diclofenac

Diclofenac is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties. It inhibits both leukocyte migration and the enzyme cyclooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis.

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BRC0420
Product IDBRC0420
Product classBioreference compound
CAS number86386-73-4
MW306.3
Synonyms
UK 49858, Diflucan, Elazor, Flucazol, Flucostat, Flunizol, Monicure, Pritenzol, Trican, Triflucan
Transport conditionsNormal

Fluconazole

Fluconazole, a synthetic antifungal agent of the imidazole class, is used to treat vaginal candidiasis. It inhibits the fungal lanosterol 14 alpha-demethylase which thereby prevents the formation of ergosterol which is an essential component in the fungal cell membrane.

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BRC0403
Product IDBRC0403
Product classBioreference compound
CAS number99300-78-4
MW313.9
Synonyms
Elafax, Effexor, Efexor, Wy 45030
Transport conditionsNormal

Venlafaxine hydrochloride

Venlafaxine potentiates the neurotransmitter activity in the central nervous system. Furthermore, venlafaxine and its metabolite, O-desmethylvenlafaxine (ODV) potently inhibit the reuptake of serotonin and norepinephrine and weakly inhibit dopamine reuptake.

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BRC0391
Product IDBRC0391
Product classBioreference compound
CAS number1229-29-4
MW315.8
Synonyms
Adapin, Aponal, Curatin, Doxepine, Quitaxon, Sinequan
Transport conditionsNormal

Doxepin hydrochloride

Doxepin, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema. Doxepin has substantial anticholinergic and sedative effects. The E (trans)-isomer is more active as a serotonin reuptake inhibitor while the Z-isomer acts as a sedative.

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BRC0392
Product IDBRC0392
Product classBioreference compound
CAS number58-33-3
MW320.9
Synonyms
Avomine, Fargan, Farganesse, Lergigan,PHENADOZ, Phenergan, Promethegan, Prothiazine, Receptozine, Romergan, Sominex
Transport conditionsNormal

Promethazine hydrochloride

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties.

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BRC0805
Product IDBRC0805
Product classBioreference compound
CAS number73590-58-6
MW345.4
Synonyms
Omez, OMP, OMZ
Transport conditionsNormal

Omeprazole

Omeprazole is a cell-permeable, selective proton pump inhibitor. It inhibits gastric acid secretion (IC50 = 0.16 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro.

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BRC0838
Product IDBRC0838
Product classBioreference compound
CAS number56296-78-7
MW345.8
Synonyms
Lilly 103472; Lilly 110 140; Prozac;
Transport conditionsNormal

Fluoxetine Hydrochloride

Fluoxetine hydrochloride is the first-in-class antidepressant, selective serotonin-reuptake inhibitor. It displays a selectivity for the serotonin transporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3,600 nM). It is used in the clinical treatment of major depression as well as other psychiatric disorders.

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BRC0764
Product IDBRC0764
Product classBioreference compound
CAS number100986-85-4
MW361.4
Synonyms
MP-376, Cravit, DR 3355, HR 355
Transport conditionsNormal

Levofloxacin

Levofloxacin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. It inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase.

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BRC0836
Product IDBRC0836
Product classBioreference compound
CAS number50-23-7
MW362.5
Synonyms
NSC-10483
Transport conditionsNormal

Hydrocortisone

Hydrocortisone is steroid hormone of the adrenal cortex with anti-inflammatory properties.

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BRC0409
Product IDBRC0409
Product classBioreference compound
CAS number78246-49-8
MW365.8
Synonyms
BRL-29060A, FG-7051, Aropax, Brisdelle, Paxil, Pexeva, Sereupin, Seroxat,
Transport conditionsNormal

Paroxetine hydrochloride

Paroxetine, an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) type, has no active metabolites and has the highest specificity for serotonin receptors of all the SSRIs.

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BRC0730
Product IDBRC0730
Product classBioreference compound
CAS number52-86-8
MW375.9
Synonyms
MCN-JR-1625; NSC-170973; NSC-615296; R-1625; Dozic; Einalon S; Eukystol;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Haloperidol

Haloperidol is butyrophenone antipsychotic, D2, D3, and D4 dopamine receptor antagonist. It is used primarily to treat schizophrenia and other psychoses.

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BRC0654
Product IDBRC0654
Product classBioreference compound
CAS number34183-22-7
MW377.9
Synonyms
GP 382, GPV 001, Polfenon, SA 79
Transport conditionsNormal

Propafenone hydrochloride

Propafenone Hydrochloride is a sodium channel protein inhibitor. It is a Class 1C antiarrhythmic drug with local anesthetic effects and a direct stabilizing action on myocardial membranes.

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BRC0774
Product IDBRC0774
Product classBioreference compound
CAS number79794-75-5
MW382.9
Synonyms
SCH-29851,
Transport conditionsNormal

Loratadine

Loratadine is a long acting second generation antihistamine. It is a competitive, specific, and selective antagonist of H1 receptors. Loratadine does not penetrate the CNS effectively and has a low affinity for CNS H1-receptors.

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BRC0383
Product IDBRC0383
Product classBioreference compound
CAS number19216-56-9
MW383.4
Synonyms
Adversuten, CP 12,299-1, NSC 292810, Hypovase, Minipress Xl, Pressin, Vasoflex
Transport conditionsNormal

Prazosin

Prazosin is an adrenergic α, α2B-adrenoceptor and a potent melatonin MT3 receptor antagonist.

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BRC0417
Product IDBRC0417
Product classBioreference compound
CAS number72509-76-3
MW384.2
Synonyms
CGH-869, Felodur ER, Felogard, Plendil Depottab, Plendil ER, Plendil Retard, Renedil, Splendil, Agon, H 154/82
Transport conditionsNormal

Felodipine

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction.

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BRC0110
Product IDBRC0110
Product classBioreference compound
CAS number63590-64-7
MW387.4
Synonyms
Hytrin, Flumarc, Fosfomic, Blavin, Abbott 45975
Transport conditionsNormal

Terazosin

Terazosin, classified as a quinazoline, is similar to doxazosin and prazosin. As an α-adrenergic blocking agent, terazosin is used to treat hypertension and BPH. Terazosin produces vasodilation and reduces peripheral resistance but in general has only a slight effect on cardiac output. The antihypertensive effect with chronic dosing is not usually accompanied by reflex tachycardia.

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BRC0375
Product IDBRC0375
Product classBioreference compound
CAS number83-89-6
MW400.0
Synonyms
Atebrine, Mepacrine
Transport conditionsNormal

Quinacrine

Quinacrine is commonly used as an anti-protozoal agent. It potently prevents misfolding of prion protein (EC50 = 0.3 μM), blocks voltage-dependent sodium channels (IC50 = 3.3 μM), and inhibits aldehyde oxidase (IC50 = 3.3 μM).

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BRC0257
Product IDBRC0257
Product classBioreference compound
CAS number125481-61-0
MW401.5
Synonyms
BMS 528215; BMY 28674;
Transport conditionsNormal

6-Hydroxybuspirone

A major active metabolite of buspirone.

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BRC0895
Product IDBRC0895
Product classBioreference compound
CAS number75330-75-5
MW404.5
Synonyms
C10AA02, L-154803, MK-803, ML-530B
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Lovastatin

Lovastatin is a cholesterol-lowering agent. It is fungal metabolite, a potent inhibitor of HMG-CoA reductase.

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BRC0853
Product IDBRC0853
Product classBioreference compound
CAS number72956-09-3
MW406.5
Synonyms
BM 14190, SKF 105517
Transport conditionsNormal

Carvedilol

Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity. Indicated for the treatment of hypertension and mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

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BRC0129
Product IDBRC0129
Product classBioreference compound
CAS number51773-92-3
MW414.8
Synonyms
Mefloquinum, Mefloquina, Mephloquine,
Transport conditionsNormal

Mefloquine hydrochloride

Mefloquine is an antimalarial agent which acts as a blood schizonticide. Mefloquine is active against the erythrocytic stages of Plasmodium species.

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BRC0768
Product IDBRC0768
Product classBioreference compound
CAS number79902-63-9
MW418.6
Synonyms
C10AA01, MK 733, Eucor, Kolestevan, L 644128-000U
Transport conditionsNormal

Simvastatin

Simvastatin is the methylated form of lovastatin, an oral antilipemic agent which inhibits HMG-CoA reductase.

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BRC0416
Product IDBRC0416
Product classBioreference compound
CAS number114798-26-4
MW422.9
Synonyms
Lortaan, DuP-753, MK 954
Transport conditionsNormal

Losartan

Losartan is the first of a class of antihypertensive agents called angiotensin II receptor blockers (ARBs). Losartan and its longer acting active metabolite, E-3174, are specific and selective type-1 angiotensin II receptor (AT1) antagonists which block the blood pressure increasing effects angiotensin II via the renin-angiotensin-aldosterone system (RAAS).

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BRC0785
Product IDBRC0785
Product classBioreference compound
CAS number33286-22-5
MW451.0
Synonyms
Adizem XL, Balcor, Cartia XT, Coras
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Diltiazem hydrochloride

Diltiazem hydrochloride is an antihypertensive and cardioprotective agent, calcium channel protein inhibitor. It regulates Ca2+ release from intracellular stores in neutrophils.

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BRC0353
Product IDBRC0353
Product classBioreference compound
CAS number74191-85-8
MW451.5
Synonyms
UK 33274, Cardura, Cascor
Transport conditionsNormal

Doxazosin

Doxazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Doxazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors.

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BRC0414
Product IDBRC0414
Product classBioreference compound
CAS number2062-78-4
MW461.6
Synonyms
NSC 170984, Orap, R 6238, Neoperidole, Opiran
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Pimozide

Pimozide is an orally active antipsychotic drug product which shares with other antipsychotics the ability to blockade dopaminergic receptors on neurons in the central nervous system.

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BRC0701
Product IDBRC0701
Product classBioreference compound
CAS number2030-63-9
MW473.4
Synonyms
B 663, G 30320, Hansepran, Lampren, NSC 141046
Transport conditionsNormal

Clofazimine

Clofazimine is a fat-soluble rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity.

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BRC0410
Product IDBRC0410
Product classBioreference compound
CAS number152-11-4
MW491.1
Synonyms
NSC 272366, NSC 657799, Bosoptin, Calan, Covera-HS, Isoptin, Verelan, Verisop, Vermin, Verogalid, Vertab, Vetrimil, Zolvera
Transport conditionsNormal

Verapamil hydrochloride

Verapamil is an L-type calcium channel blocker that also has antiarrythmic activity. The R-enantiomer is more effective at reducing blood pressure compared to the S-enantiomer. However, the S-enantiomer is 20 times more potent than the R-enantiomer at prolonging the PR interval in treating arrhythmias.

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BRC0377
Product IDBRC0377
Product classBioreference compound
CAS number10238-21-8
MW494.0
Synonyms
Glibenclamide, Micronase
Transport conditionsNormal

Glyburide

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production.

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BRC0646
Product IDBRC0646
Product classBioreference compound
CAS number146-56-5
MW510.4
Synonyms
SQ 10733, Squibb 16144, Moditen, OMCA, Anatensol, Trancin, Valamina
Transport conditionsNormal

Fluphenazine dihydrochloride

Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. Intended for the management of schizophrenia and other psychotic disorders.

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BRC0679
Product IDBRC0679
Product classBioreference compound
CAS number144701-48-4
MW514.6
Synonyms
BIBR 277, BIBR 277SE, Kinzalmono, Micardis, Pritor, Telday
Transport conditionsNormal

Telmisartan

Telmisartan is a non-peptide AT1 angiotensin receptor antagonist (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Telmisartan also have PPAR-gamma agonistic properties (EC50 = 4 nM) that could potentially confer beneficial metabolic effects.

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BRC0411
Product IDBRC0411
Product classBioreference compound
CAS number54527-84-3
MW516.0
Synonyms
RS-69216, Cardene
Transport conditionsNormal

Nicardipine hydrochloride

Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

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BRC0662
Product IDBRC0662
Product classBioreference compound
CAS number111470-99-6
MW567.0
Synonyms
AM Arya 5, Alkapress, Regcor, Tensivask, UK 48340-26
Transport conditionsNormal

Amlodipine besylate

Amlodipine besylate is an L-type calcium channel blocker that displays antihypertensive properties. It also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).

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BRC0851
Product IDBRC0851
Product classBioreference compound
CAS number81103-11-9
MW748.0
Synonyms
A-56268, ABBOTT-56268, TE-031
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Clarithromycin

Clarithromycin is a macrolide antibiotic whose spectrum of activity includes many gram-positive and gram-negative aerobic bacteria, many anaerobic bacteria, some mycobacteria, and some other organisms.

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BRC0769
Product IDBRC0769
Product classBioreference compound
CAS number33069-62-4
MW853.9
Synonyms
ABI 007, Abraxane, BMS 181339-01, DHP 107, EndoTAG 1, NK 105, NSC 125973
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Paclitaxel

Paclitaxel is a taxoid antineoplastic agent indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast cancer. It promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.

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BRC0444
Product IDBRC0444
Product classBioreference compound
CAS number 1264-62-6
MW862.1
Synonyms
Anamycin, Arpimycin, Durapaediat, Eryc, Ilosone, Staticin, T-stat
Transport conditionsNormal

Erythromycin Ethylsuccinate

Erythromycin is a macrolide antibiotic produced by Saccharopolyspora erythraea. It binds to bacterial 50S ribosomal subunits and inhibits protein synthesis.

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BRC0959
Product IDBRC0959
Product classBioreference compound
CAS number344423-98-9
MW1209.4
Synonyms
Cardyl; Lipitor®; Lipovastatinklonal;
Transport conditionsNormal

Atorvastatin Calcium Trihydrate

Atorvastatin calcium trihydrate is selective, competitive HMG-CoA reductase inhibitor (IC50 = 8 nM) used to lower serum total and LDL cholesterol, apoB, and triglyceride levels while increasing HDL cholesterol.

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