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Neurotransmitter transporter

StructureProduct infoAvailabilityQuantity / Price
BRC1419
Product IDBRC1419
Product classBioreference compound
CAS number107-97-1
MW89.1
Synonyms
Methylglycine; N-Methylaminoacetic acid; Sarcosin; Sarcosinic acid;
Transport conditionsNormal

Sarcosine

Sarcosine is an endogenous inhibitor of GlyT1 with antipsychotic activity. It potentiates the action of glycine on the NMDA glycine binding site.

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BRC1147
Product IDBRC1147
Product classBioreference compound
CAS number22059-21-8
MW101.1
Synonyms
ACC; NSC 98430;
Transport conditionsNormal

ACPC

ACPC is NMDA receptor activity modulator, acts as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 µM) in the presence of low levels (1 µM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 µM) of glutamate.

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BRC1023
Product IDBRC1023
Product classBioreference compound
CAS number700-06-1
MW147.2
Synonyms
NSC 525801; Indinol; I3C;
Transport conditionsNormal

Indole-3-carbinol

Indole-3-carbinol is a cell growth inhibitor that reversibly suppresses incorporation of [3H]thymidine in cells. It has been shown to have anti-cancer effects, at least in part through inhibition of NF-κB and Akt signaling pathways. Indole-3-carbinol displays the ability to inhibit endogenous retinoblastoma protein phosphorylation. Mechanistic studies suggest that in vitro this compound inhibits cell adhesion, migration, and invasion.

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BRC0818
Product IDBRC0818
Product classBioreference compound
CAS number616-91-1
MW163.2
Synonyms
5052; NSC-111180; RK-0202; NAC; Mercapturic acid;
Transport conditionsNormal

Acetylcysteine

Acetylcysteine (NAC) is an antioxidant and precursor of glutathione that has multiple effects in cells and animals. It is primarily used as a mucolytic agent and in the management of acetaminophen poisoning. It is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase 1) and absorbed in the intestine into the bloodstream. As an antioxidant, NAC scavenges hydrogen peroxide, hydroxyl radical, and hypochlorous acid.

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BRC0633
Product IDBRC0633
Product classBioreference compound
CAS number56-92-8
MW184.1
Synonyms
NSC-257873; NSC-33792;
Transport conditionsNormal

Histamine Dihydrochloride

Histamine is a depressor amine. It is a powerful stimulant of gastric secretion, a bronchoconstrictor, vasodilator, and also a centrally acting neurotransmitter.

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BRC0023
Product IDBRC0023
Product classBioreference compound
CAS number62-31-7
MW189.6
Synonyms
3-Hydroxytyramine, Deoxyepinephrine, Oxytyramine, Intropin, Revimine
Transport conditionsNormal

Dopamine hydrochloride

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility.

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BRC0390
Product IDBRC0390
Product classBioreference compound
CAS number55-65-2
MW198.3
Synonyms
Ismedine, Ismelin
Transport conditionsNormal

Guanethidine

Guanethidine works by decreasing the heart rate and relaxing the blood vessels so that blood can flow more easily through the body, thereby reducing these risks. It is a postganglionic sympathetic nerve terminal blocker that prevents the release of norepinephrine from nerve terminals.

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BRC1008
Product IDBRC1008
Product classBioreference compound
CAS number55206-24-1
MW214.7
Synonyms
Transport conditionsNormal

6-fluorotryptamine hydrochloride

6-fluorotryptamine hydrochloride is a tryptamine derivative that potentially agonizes 5-HT serotonin receptors (EC50 = 4.56 nM).

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BRC0052
Product IDBRC0052
Product classBioreference compound
CAS number1744-22-5
MW234.2
Synonyms
Rilutek, RP-54274, PK 26124
Transport conditionsNormal

Riluzole

Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes; neuroprotective.

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BRC1086
Product IDBRC1086
Product classBioreference compound
CAS number1955540-15-4
MW239.7
Synonyms
Transport conditionsNormal

3-phenoxy-8-azabicyclo[3.2.1]octane hydrochloride

3-phenoxy-8-azabicyclo[3.2.1]octane hydrochloride is inhibitor of [3H]noradrenaline, [3H]dopamine and [3H]serotonin reuptake.

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BRC0421
Product IDBRC0421
Product classBioreference compound
CAS number85650-52-8
MW265.4
Synonyms
Org 3770, 6-Azamianserin, Avanza, Axit, Mirtabene, Mirtaz, Mirtazon, Norset, Promyrtil, Remergil, Remergon, Remeron, Remeron SolTab, Rexer, Zispin
Transport conditionsNormal

Mirtazapine

Mirtazapine, an antidepressant of the piperazinoazepine class, is a tetracyclic compound with an anxiolytic effect. Mirtazapine has fewer ADRs than tricyclic antidepressants and is better tolerated. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants.

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BRC0817
Product IDBRC0817
Product classBioreference compound
CAS number133-16-4
MW270.8
Synonyms
Halestyn; Piocaine;
Transport conditionsNormal

Chloroprocaine

Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia. It blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rising of the action potential.

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BRC0941
Product IDBRC0941
Product classBioreference compound
CAS number51-05-8
MW272.8
Synonyms
Novocaine; Vitamin H3; Duracaine; NSC 169497; Nissocaine;
Transport conditionsNormal

Procaine Hydrochloride

Procaine hydrochloride is a local anesthetic. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. It is a sodium channel blocker with a variety of inhibitory effects. Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1.

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BRC0932
Product IDBRC0932
Product classBioreference compound
CAS number894-71-3
MW299.8
Synonyms
NCI-169453; Acetexa; Pamelor®;
Transport conditionsNormal

Nortriptyline Hydrochloride

Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant that blocks norepinephrine and serotonin transporters more potently than the dopamine transporter. It also antagonizes serotonin, histamine, muscarinic, and α-adrenergic receptors.

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BRC0357
Product IDBRC0357
Product classBioreference compound
CAS number1052540-65-4
MW303.1
Synonyms
Isocaramidine, Bonipress, Declinax, Tendor
Transport conditionsNormal

Debrisoquin

Debrisoquin is an adrenergic neuron-blocking drug similar in effects to guanethidine. It is a substrate for a polymorphic cytochrome P-450 enzyme.

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BRC0109
Product IDBRC0109
Product classBioreference compound
CAS number14028-44-5
MW313.8
Synonyms
Asendin, Demolox, CL 67772
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Amoxapine

Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants; amoxapine inhibits GLYT2a transport activity with IC50 of 92 M.

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BRC0006
Product IDBRC0006
Product classBioreference compound
CAS number10347-81-6
MW313.9
Synonyms
Deprilept; Ludiomil; Psymion;
Transport conditionsNormal

Maprotiline hydrochloride

Maprotiline is a tetracyclic antidepressant. Although its main therapeutic use is in the treatment of depression, it has also been shown to exert a sedative effect on the anxiety component that often accompanies depression.

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BRC0403
Product IDBRC0403
Product classBioreference compound
CAS number99300-78-4
MW313.9
Synonyms
Elafax, Effexor, Efexor, Wy 45030
Transport conditionsNormal

Venlafaxine hydrochloride

Venlafaxine potentiates the neurotransmitter activity in the central nervous system. Furthermore, venlafaxine and its metabolite, O-desmethylvenlafaxine (ODV) potently inhibit the reuptake of serotonin and norepinephrine and weakly inhibit dopamine reuptake.

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BRC0391
Product IDBRC0391
Product classBioreference compound
CAS number1229-29-4
MW315.8
Synonyms
Adapin, Aponal, Curatin, Doxepine, Quitaxon, Sinequan
Transport conditionsNormal

Doxepin hydrochloride

Doxepin, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema. Doxepin has substantial anticholinergic and sedative effects. The E (trans)-isomer is more active as a serotonin reuptake inhibitor while the Z-isomer acts as a sedative.

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BRC0044
Product IDBRC0044
Product classBioreference compound
CAS number113-52-0
MW316.9
Synonyms
Antideprin, Melipramine, Imidobenzyle, Berkomine, Melipramin
Transport conditionsNormal

Imipramine hydrochloride

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use.

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BRC0096
Product IDBRC0096
Product classBioreference compound
CAS number58-46-8
MW317.4
Synonyms
Nitoman, Rubigen,
Transport conditionsNormal

Tetrabenazine

A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. Tetrabenazine is a reversible human vesicular monoamine transporter type 2 inhibitor (Ki = 100 nM). It acts within the basal ganglia and promotes depletion of monoamine neurotransmitters serotonin, norepinephrine, and dopamine from stores. It also decreases uptake into synaptic vesicles.

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BRC0048
Product IDBRC0048
Product classBioreference compound
CAS number976-71-6
MW340.5
Synonyms
Phanurane, Aldadiene, Luvion, Aldadiene,
Transport conditionsNormal

Canrenone

Mineralocorticoid receptor antagonist. Active metabolite of spironolactone. A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects.

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BRC0266
Product IDBRC0266
Product classBioreference compound
CAS number1443980-00-4
MW341.2
Synonyms
Anarel, Hylorel
Transport conditionsNormal

Guanadrel hydroiodide

Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter. Guanadrel slowly displaces norepinephrine from its storage in nerve endings and thereby blocks the release of norepinephrine normally produced by nerve stimulation.

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BRC0037
Product IDBRC0037
Product classBioreference compound
CAS number79559-97-0
MW342.7
Synonyms
Zoloft, (+)-Sertraline, CP 51974
Transport conditionsNormal

Sertraline hydrochloride

Sertraline, an antidepressant drug similar to citalopram, fluoxetine, and paroxetine, is of the selective serotonin reuptake inhibitor (SSRI) type. Sertraline has one active metabolite and, like the other SSRIs, have less sedative, anticholinergic, and cardiovascular effects than the tricyclic antidepressant drugs because it does not have clinically important anticholinergic, antihistamine, or adrenergic blocking activity.

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BRC0838
Product IDBRC0838
Product classBioreference compound
CAS number56296-78-7
MW345.8
Synonyms
Lilly 103472; Lilly 110 140; Prozac;
Transport conditionsNormal

Fluoxetine Hydrochloride

Fluoxetine hydrochloride is the first-in-class antidepressant, selective serotonin-reuptake inhibitor. It displays a selectivity for the serotonin transporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3,600 nM). It is used in the clinical treatment of major depression as well as other psychiatric disorders.

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BRC0409
Product IDBRC0409
Product classBioreference compound
CAS number78246-49-8
MW365.8
Synonyms
BRL-29060A, FG-7051, Aropax, Brisdelle, Paxil, Pexeva, Sereupin, Seroxat,
Transport conditionsNormal

Paroxetine hydrochloride

Paroxetine, an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) type, has no active metabolites and has the highest specificity for serotonin receptors of all the SSRIs.

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BRC0730
Product IDBRC0730
Product classBioreference compound
CAS number52-86-8
MW375.9
Synonyms
MCN-JR-1625; NSC-170973; NSC-615296; R-1625; Dozic; Einalon S; Eukystol;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Haloperidol

Haloperidol is butyrophenone antipsychotic, D2, D3, and D4 dopamine receptor antagonist. It is used primarily to treat schizophrenia and other psychoses.

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BRC0229
Product IDBRC0229
Product classBioreference compound
CAS number57-96-5
MW404.5
Synonyms
Anturane, (+/-)-Sulfinpyrazone, Sulfoxyphenylpyrazolidine
Transport conditionsNormal

Sulfinpyrazone

A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

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BRC0198
Product IDBRC0198
Product classBioreference compound
CAS number59729-32-7
MW405.3
Synonyms
Nitalapram, Celexa, Cipram, Lu 10-171
Transport conditionsNormal

Citalopram hydrobromide

Citalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety.

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BRC0134
Product IDBRC0134
Product classBioreference compound
CAS number25332-39-2
MW408.3
Synonyms
Beneficat, Desirel, Trialodine, Sideril, AF-1161, KB-831
Transport conditionsNormal

Trazodone hydrochloride

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents.

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BRC0108
Product IDBRC0108
Product classBioreference compound
CAS number145821-59-6
MW412.0
Synonyms
Gabitril, NO050328, NO328, TGB
Transport conditionsNormal

Tiagabine hydrochloride

Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.

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BRC0033
Product IDBRC0033
Product classBioreference compound
CAS number61718-82-9
MW434.4
Synonyms
Fluvoxamina, Dumirox, Faverin, Fevarin, Floxyfral, Maveral, MK-264
Transport conditionsNormal

Fluvoxamine maleate

Fluvoxamine, an aralkylketone-derivative agent, is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) that differs structurally from other SSRIs. It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety.

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BRC0410
Product IDBRC0410
Product classBioreference compound
CAS number152-11-4
MW491.1
Synonyms
NSC 272366, NSC 657799, Bosoptin, Calan, Covera-HS, Isoptin, Verelan, Verisop, Vermin, Verogalid, Vertab, Vetrimil, Zolvera
Transport conditionsNormal

Verapamil hydrochloride

Verapamil is an L-type calcium channel blocker that also has antiarrythmic activity. The R-enantiomer is more effective at reducing blood pressure compared to the S-enantiomer. However, the S-enantiomer is 20 times more potent than the R-enantiomer at prolonging the PR interval in treating arrhythmias.

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BRC0579
Product IDBRC0579
Product classBioreference compound
CAS number1049771-07-4
MW546.5
Synonyms
Transport conditionsNormal

TCMDC-124020

The compound is an inhibitor of Plasmodium falciparum 3D7 in whole red blood cells.

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