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Diuretics

StructureProduct infoAvailabilityQuantity / Price
BRC1067
Product IDBRC1067
Product classBioreference compound
CAS number652-67-5
MW146.1
Synonyms
NSC 40725; Polysorb; AT 101; Dianhydro-D-glucitol;
Transport conditionsNormal

Isosorbide

Isosorbide is a heterocyclic compound that is derived from glucose, used as osmotic diuretic to treat hydrocephalus.

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BRC0968
Product IDBRC0968
Product classBioreference compound
CAS number83-67-0
MW180.2
Synonyms
NSC-5039; SC-15090; Diurobromine;
Transport conditionsNormal

Theobromine

Theobromine is a purine alkaloid that is an adenosine receptor antagonist, weak PDE (phosphodiesterase) inhibitor. It is a diuretic and smooth-muscle relaxant.

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BRC0837
Product IDBRC0837
Product classBioreference compound
CAS number69-65-8
MW182.2
Synonyms
E-421; INS-421; Fraxinine;
Transport conditionsNormal

Mannitol

Mannitol is an osmotic diuretic. It elevates blood plasma osmolality, resulting in an enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma.

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BRC0192
Product IDBRC0192
Product classBioreference compound
CAS number59-66-5
MW222.2
Synonyms
Defiltran, Diacarb, Diamox, Diluran, Glaupax
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Acetazolamide

Acetazolamide is a potent carbonic anhydrase inhibitor, effective in the control of fluid secretion, in the treatment of certain convulsive disorders and in the promotion of diuresis in instances of abnormal fluid retention.

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BRC0994
Product IDBRC0994
Product classBioreference compound
CAS number554-57-4
MW236.3
Synonyms
L-584601; VVP-808;
Transport conditionsNormal

Methazolamide

Methazolamide is a potent inhibitor of carbonic anhydrase. Used as a diuretic and in the treatment of glaucoma.

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BRC0054
Product IDBRC0054
Product classBioreference compound
CAS number396-01-0
MW253.3
Synonyms
Dyrenium, Dytac, Triamteren
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Triamterene

Triamterene, a relatively weak, potassium-sparing diuretic and antihypertensive, is used in the management of hypokalemia.

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BRC0017
Product IDBRC0017
Product classBioreference compound
CAS number17440-83-4
MW302.1
Synonyms
Amipramidin, Amipramidine, Midamor
Transport conditionsNormal

Amiloride hydrochloride dihydrate

Amiloride, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. This promotes the loss of sodium and water from the body, but without depleting potassium.

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BRC0729
Product IDBRC0729
Product classBioreference compound
CAS number58-54-8
MW303.1
Synonyms
Hydromedin, MK 595, Mingit, NSC 624008, NSC 85791, Otacril, Reomax, Taladren, Uregit
Transport conditionsNormal

Ethacrynic acid

Ethacrynic acid is a compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules.

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BRC1065
Product IDBRC1065
Product classBioreference compound
CAS number654-62-6
MW319.3
Synonyms
2,4-Disulfamoyl-5-trifluoromethylaniline; 5-Trifluoromethyl-2,4-disulfamoylaniline;
Transport conditionsNormal

NSC 44625

NSC 44625 is a carbonic anhydrase inhibitor. It is potential anti-tumor and antiglaucoma drug. Metabolite of hydroflumethazide, a diuretic.

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BRC0381
Product IDBRC0381
Product classBioreference compound
CAS number54-31-9
MW330.7
Synonyms
Frusemide
Transport conditionsNormal

Furosemide

Furosemide is an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Ki = ~10 µM for each). It is commonly used as a loop diuretic, blocking NKCC2 action on the apical membrane of the thick ascending limb of Henle epithelial cells. Furosemide also acts as an antagonist of GABAA receptors and as an inhibitor of carbonic anhydrase and organic anion transporter.

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BRC0732
Product IDBRC0732
Product classBioreference compound
CAS number135-09-1
MW331.3
Synonyms
Leodrine, Metflorylthiazidine, NSC 44627, NaClex
Transport conditionsNormal

Hydroflumethiazide

Hydroflumethiazide is a anti-hypertensive and a diuretic. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0048
Product IDBRC0048
Product classBioreference compound
CAS number976-71-6
MW340.5
Synonyms
Phanurane, Aldadiene, Luvion, Aldadiene,
Transport conditionsNormal

Canrenone

Mineralocorticoid receptor antagonist. Active metabolite of spironolactone. A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects.

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BRC0846
Product IDBRC0846
Product classBioreference compound
CAS number56211-40-6
MW348.4
Synonyms
AC4464, BM02.015, JDL 464
Transport conditionsNormal

Torasemide

Torasemide is a loop diuretic. It inhibits the Na+/K+/2Cl- carrier system.

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BRC0050
Product IDBRC0050
Product classBioreference compound
CAS number135-07-9
MW360.2
Synonyms
Enduron, Aquatensen, Duretic, Methyclothiazid, Enduronum,
Transport conditionsNormal

Methyclothiazide

Methyclothiazide, a diuretic-antihypertensive agent, is a member of the benzothiadiazine (thiazide) class of drugs. Methyclothiazide has a per mg natriuretic activity approximately 100 times that of the prototype thiazide, chlorothiazide. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic/natriuretic effects. Like other benzothiadiazines, methyclothiazide also has antihypertensive properties, and may be used for this purpose either alone or to enhance the antihypertensive action of other drugs.

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BRC0056
Product IDBRC0056
Product classBioreference compound
CAS number28395-03-1
MW364.4
Synonyms
Bumex, Fordiuran, Burinex, Lunetoron,
Transport conditionsNormal

Bumetanide

Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide interferes with renal cAMP and/or inhibits the sodium-potassium ATPase pump. Bumetanide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis.

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BRC0867
Product IDBRC0867
Product classBioreference compound
CAS number26807-65-8
MW365.8
Synonyms
RHC 2555, S 1520, SE 1520, USV 2555
Transport conditionsNormal

Indapamide

Indapamide is an antihypertensive agent that reduces intracellular calcium levels.

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BRC0819
Product IDBRC0819
Product classBioreference compound
CAS number133-67-5
MW380.6
Synonyms
NSC 61560
Transport conditionsNormal

Trichlormethiazide

Trichloromethiazide is a thiazide diuretic, inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0072
Product IDBRC0072
Product classBioreference compound
CAS number52-01-7
MW416.6
Synonyms
Aldactone, Verospiron, Spiroctan
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Spironolactone

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM. Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics.

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BRC0754
Product IDBRC0754
Product classBioreference compound
CAS number602293-00-5
MW419.5
Synonyms
Transport conditionsNormal

N-(3-Acetylphenyl)-9-amino-2,3-dihydro-1,4-dioxino[2,3-g]thieno[2,3-b]quinoline-8-carboxamide

The compound is a novel disruptor of the PKCε/RACK2 protein-protein interaction.

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BRC0813
Product IDBRC0813
Product classBioreference compound
CAS number73-48-3
MW421.4
Synonyms
BE 724-A, FT 81
Transport conditionsNormal

Bendroflumethiazide

Bendroflumethiazide is a thiazide diuretic, inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0733
Product IDBRC0733
Product classBioreference compound
CAS number91-33-8
MW431.9
Synonyms
Freeuril, HyDrine, Lemazide, P 1393, Pfizer 1393, Proaqua
Transport conditionsNormal

Benzthiazide

Benzthiazide is used to treat hypertension and edema. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0100
Product IDBRC0100
Product classBioreference compound
CAS number150683-30-0
MW449.0
Synonyms
OPC-41061; Samsca;
Transport conditionsNormal

Tolvaptan

Tolvaptan is a selective and competitive arginine vasopressin receptor 2 antagonist.

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BRC0850
Product IDBRC0850
Product classBioreference compound
CAS number82586-55-8
MW475.0
Synonyms
C09AA06
Transport conditionsNormal

Quinapril hydrochloride

Quinapril hydrochloride is a prodrug, angiotensin-converting enzyme (ACE) inhibitor. It is metabolized to quinaprilat (quinapril diacid) following oral administration. Quinaprilat is a competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).

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