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Solute carrier family (SLC)

StructureProduct infoAvailabilityQuantity / Price
BRC1023
Product IDBRC1023
Product classBioreference compound
CAS number700-06-1
MW147.2
Synonyms
NSC 525801; Indinol; I3C;
Transport conditionsNormal

Indole-3-carbinol

Indole-3-carbinol is a cell growth inhibitor that reversibly suppresses incorporation of [3H]thymidine in cells. It has been shown to have anti-cancer effects, at least in part through inhibition of NF-κB and Akt signaling pathways. Indole-3-carbinol displays the ability to inhibit endogenous retinoblastoma protein phosphorylation. Mechanistic studies suggest that in vitro this compound inhibits cell adhesion, migration, and invasion.

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BRC0470
Product IDBRC0470
Product classBioreference compound
CAS number3440-28-6
MW193.2
Synonyms
NSC 192714, CS 443
Transport conditionsNormal

Betamipron

Betamipron is a chemical compound which is used together with panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.

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BRC0814
Product IDBRC0814
Product classBioreference compound
CAS number15687-27-1
MW206.3
Synonyms
NSC 256857; U-18753;
Transport conditionsNormal

Ibuprofen

Ibuprofen is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. It is a non-selective, reversible COX inhibitor (IC50 for human recombinant COX-1 and COX-2 are 2.6 and 1.53 µM, respectively).

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BRC0180
Product IDBRC0180
Product classBioreference compound
CAS number364-98-7
MW230.7
Synonyms
Eudemine, Hyperstat, Sch-6783, SRG-95213, Proglycem
Transport conditionsNormal

Diazoxide

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

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BRC0244
Product IDBRC0244
Product classBioreference compound
CAS number57-66-9
MW285.4
Synonyms
Benemid, Proben, NSC 18786
Transport conditionsNormal

Probenecid

Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. Probenecid may also reduce plasma binding of urate and inhibit renal secretion of uric acid at subtherapeutic concentrations.

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BRC0651
Product IDBRC0651
Product classBioreference compound
CAS number58-94-6
MW295.7
Synonyms
Diutrid, Flumen, Minzil, NSC 25693, Alurene, Chlorosal
Transport conditionsNormal

Chlorothiazide

Chlorothiazide is an inhibitor of carbonic anhydrase (IC50 = 0.06 µM). This compound has been shown to block reabsorption of sodium and chloride ions.

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BRC0370
Product IDBRC0370
Product classBioreference compound
CAS number58-93-5
MW297.7
Synonyms
HCTZ, NSC 53477, SU 5879
Transport conditionsNormal

Hydrochlorothiazide

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. Hydrochlorothiazide results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium.

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BRC0729
Product IDBRC0729
Product classBioreference compound
CAS number58-54-8
MW303.1
Synonyms
Hydromedin, MK 595, Mingit, NSC 624008, NSC 85791, Otacril, Reomax, Taladren, Uregit
Transport conditionsNormal

Ethacrynic acid

Ethacrynic acid is a compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules.

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BRC0381
Product IDBRC0381
Product classBioreference compound
CAS number54-31-9
MW330.7
Synonyms
Frusemide
Transport conditionsNormal

Furosemide

Furosemide is an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Ki = ~10 µM for each). It is commonly used as a loop diuretic, blocking NKCC2 action on the apical membrane of the thick ascending limb of Henle epithelial cells. Furosemide also acts as an antagonist of GABAA receptors and as an inhibitor of carbonic anhydrase and organic anion transporter.

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BRC0732
Product IDBRC0732
Product classBioreference compound
CAS number135-09-1
MW331.3
Synonyms
Leodrine, Metflorylthiazidine, NSC 44627, NaClex
Transport conditionsNormal

Hydroflumethiazide

Hydroflumethiazide is a anti-hypertensive and a diuretic. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0916
Product IDBRC0916
Product classBioreference compound
CAS number518-45-6
MW332.3
Synonyms
Japan Yellow 201, Resorcinolphthalein, Solvent Yellow 94, Yellow fluorescein, CI 45350:1
Transport conditionsNormal

Fluorescein

Fluorescein is a phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma.

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BRC0846
Product IDBRC0846
Product classBioreference compound
CAS number56211-40-6
MW348.4
Synonyms
AC4464, BM02.015, JDL 464
Transport conditionsNormal

Torasemide

Torasemide is a loop diuretic. It inhibits the Na+/K+/2Cl- carrier system.

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BRC0666
Product IDBRC0666
Product classBioreference compound
CAS number69-53-4
MW349.4
Synonyms
AY-6108; Bayer 5427; BRL-1341; NSC-528986; P-50; WY 5103; ABPC;
Transport conditionsNormal

Ampicillin

Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. It acts by interfering directly with the biosynthesis of peptidoglycan, which constitutes the major component of the bacterial cell wall, leading to structural instability and death of bacteria.

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BRC0050
Product IDBRC0050
Product classBioreference compound
CAS number135-07-9
MW360.2
Synonyms
Enduron, Aquatensen, Duretic, Methyclothiazid, Enduronum,
Transport conditionsNormal

Methyclothiazide

Methyclothiazide, a diuretic-antihypertensive agent, is a member of the benzothiadiazine (thiazide) class of drugs. Methyclothiazide has a per mg natriuretic activity approximately 100 times that of the prototype thiazide, chlorothiazide. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic/natriuretic effects. Like other benzothiadiazines, methyclothiazide also has antihypertensive properties, and may be used for this purpose either alone or to enhance the antihypertensive action of other drugs.

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BRC0056
Product IDBRC0056
Product classBioreference compound
CAS number28395-03-1
MW364.4
Synonyms
Bumex, Fordiuran, Burinex, Lunetoron,
Transport conditionsNormal

Bumetanide

Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide interferes with renal cAMP and/or inhibits the sodium-potassium ATPase pump. Bumetanide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis.

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BRC0406
Product IDBRC0406
Product classBioreference compound
CAS number113-98-4
MW372.5
Synonyms
Penicillin G, Bicillin C-R
Transport conditionsNormal

Benzylpenicillin potassium

Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.

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BRC0819
Product IDBRC0819
Product classBioreference compound
CAS number133-67-5
MW380.6
Synonyms
NSC 61560
Transport conditionsNormal

Trichlormethiazide

Trichloromethiazide is a thiazide diuretic, inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0813
Product IDBRC0813
Product classBioreference compound
CAS number73-48-3
MW421.4
Synonyms
BE 724-A, FT 81
Transport conditionsNormal

Bendroflumethiazide

Bendroflumethiazide is a thiazide diuretic, inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0733
Product IDBRC0733
Product classBioreference compound
CAS number91-33-8
MW431.9
Synonyms
Freeuril, HyDrine, Lemazide, P 1393, Pfizer 1393, Proaqua
Transport conditionsNormal

Benzthiazide

Benzthiazide is used to treat hypertension and edema. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0384
Product IDBRC0384
Product classBioreference compound
CAS number64485-93-4
MW477.4
Synonyms
Cephotaxime, Sym-methoxyimino Cephalosporin, Claforan
Transport conditionsNormal

Cefotaxime sodium

Cefotaxime is a third generation intravenous cephalosporin antibiotic. It has broad spectrum activity against Gram positive and Gram negative bacteria. It does not have activity against Pseudomonas aeruginosa. Cefotaxime works by inhibiting bacterial cell wall biosynthesis.

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BRC0851
Product IDBRC0851
Product classBioreference compound
CAS number81103-11-9
MW748.0
Synonyms
A-56268, ABBOTT-56268, TE-031
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Clarithromycin

Clarithromycin is a macrolide antibiotic whose spectrum of activity includes many gram-positive and gram-negative aerobic bacteria, many anaerobic bacteria, some mycobacteria, and some other organisms.

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BRC0856
Product IDBRC0856
Product classBioreference compound
CAS number13292-46-1
MW823.0
Synonyms
BA-41166/E, L-5103 LEPETIT, NIH-10782, NSC-113926
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Rifampicin

Rifampin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium.

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