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BRC1001
Product IDBRC1001
Product classBioreference compound
CAS number504-24-5
MW94.1
Synonyms
EL-970; NSC-15041; N07XX07; Avitrol; Dalfampridine;
Transport conditionsNormal

Dalfampridine

Dalfampridine is a non-selective blocker of voltage-dependent K+-channels. Used to help multiple sclerosis patients walk.

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BRC0970
Product IDBRC0970
Product classBioreference compound
CAS number59-67-6
MW123.1
Synonyms
Nicotinic Acid; Vitamin B3; NSC-169454;
Transport conditionsNormal

Niacin

Niacin is a major chemical component of coenzymes NAD+ and NADP+ (a major electron acceptor molecule in biological oxidations). It also acts to reduce LDL cholesterol, triglycerides, and HDL cholesterol.

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BRC0982
Product IDBRC0982
Product classBioreference compound
CAS number5638-76-6
MW136.2
Synonyms
Transport conditionsNormal

Betahistine

Betahistine is an antivertigo drug, a histamine analog, and H1 receptor agonist. It serves as a vasodilator and is most commonly used to treat the symptoms of vertigo. Betahistine also has a strong affinity as an antagonist for histamine H3 receptors.

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BRC0189
Product IDBRC0189
Product classBioreference compound
CAS number60142-96-3
MW171.2
Synonyms
Gabapentin GR, Neurontin, Aclonium
Transport conditionsNormal

Gabapentin

Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters.

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BRC0996
Product IDBRC0996
Product classBioreference compound
CAS number31828-71-4
MW179.3
Synonyms
Kö 1173;
Transport conditionsNormal

Mexiletine

Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Use-dependent sodium channel blocker.

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BRC0936
Product IDBRC0936
Product classBioreference compound
CAS number50-78-2
MW180.2
Synonyms
BAY1019036; NSC-27223; NSC-406186; ASA; Aspirin;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Acetylsalicylic acid

Acetylsalicylic acid is an anti-inflammatory and antipyretic agent and acts as the inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. It also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.

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BRC0251
Product IDBRC0251
Product classBioreference compound
CAS number75448-53-2
MW180.2
Synonyms
Elixophyllin, Respbid, Theo-dur, Theolair, Uniphyl
Transport conditionsNormal

Theophylline

Theophylline, an xanthine derivative chemically similar to caffeine and theobromine, is used to treat asthma and bronchospasm. Theophylline has two distinct actions in the airways of patients with reversible (asthmatic) obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).

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BRC0968
Product IDBRC0968
Product classBioreference compound
CAS number83-67-0
MW180.2
Synonyms
NSC-5039; SC-15090; Diurobromine;
Transport conditionsNormal

Theobromine

Theobromine is a purine alkaloid that is an adenosine receptor antagonist, weak PDE (phosphodiesterase) inhibitor. It is a diuretic and smooth-muscle relaxant.

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BRC0837
Product IDBRC0837
Product classBioreference compound
CAS number69-65-8
MW182.2
Synonyms
E-421; INS-421; Fraxinine;
Transport conditionsNormal

Mannitol

Mannitol is an osmotic diuretic. It elevates blood plasma osmolality, resulting in an enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma.

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BRC0390
Product IDBRC0390
Product classBioreference compound
CAS number55-65-2
MW198.3
Synonyms
Ismedine, Ismelin
Transport conditionsNormal

Guanethidine

Guanethidine works by decreasing the heart rate and relaxing the blood vessels so that blood can flow more easily through the body, thereby reducing these risks. It is a postganglionic sympathetic nerve terminal blocker that prevents the release of norepinephrine from nerve terminals.

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BRC0365
Product IDBRC0365
Product classBioreference compound
CAS number15421-84-8
MW205.3
Synonyms
Rocornal, Trapymin, Avantrin, Trapymine
Transport conditionsNormal

Trapidil

Trapidil interrupts the autocrine loop at the PDGF and PDGF-receptor level.Trapidil has proved to possess a significant antiproliferative activity. Trapidil is an anti-platelet drug active against various aggregating agents, such as collagen, ADP, arachidonic acid, PAF and calcium ionophore.

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BRC0972
Product IDBRC0972
Product classBioreference compound
CAS number835-31-4
MW210.3
Synonyms
Antan; Rhinazine; Imidin;
Transport conditionsNormal

Naphazoline

Naphazoline is sympathomimetic adrenergic alpha-agonist. It is used to induce systemic vasoconstriction, thereby decreasing nasal congestion and inducing constriction around the conjunctiva.

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BRC0212
Product IDBRC0212
Product classBioreference compound
CAS number882-09-7
MW214.6
Synonyms
Clofibrin
Transport conditionsNormal

Clofibric acid

Clofibric acid is a compound that reduces cholesterol levels in blood through diminishing the activity of NADPH.

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BRC0890
Product IDBRC0890
Product classBioreference compound
CAS number62571-86-2
MW217.3
Synonyms
C09AA01, SA-333, SQ-14225
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause health damage. For more information go to www.P65Warnings.ca.gov.

Captopril

Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS).

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BRC0192
Product IDBRC0192
Product classBioreference compound
CAS number59-66-5
MW222.2
Synonyms
Defiltran, Diacarb, Diamox, Diluran, Glaupax
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Acetazolamide

Acetazolamide is a potent carbonic anhydrase inhibitor, effective in the control of fluid secretion, in the treatment of certain convulsive disorders and in the promotion of diuresis in instances of abnormal fluid retention.

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BRC0910
Product IDBRC0910
Product classBioreference compound
CAS number66-23-9
MW226.1
Synonyms
Transport conditionsNormal

Acetylcholine Bromide

Acetylcholine bromide is endogenous neurotransmitter. Acts at nicotinic and muscarinic acetylcholine receptors.

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BRC0180
Product IDBRC0180
Product classBioreference compound
CAS number364-98-7
MW230.7
Synonyms
Eudemine, Hyperstat, Sch-6783, SRG-95213, Proglycem
Transport conditionsNormal

Diazoxide

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

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BRC0967
Product IDBRC0967
Product classBioreference compound
CAS number137-58-6
MW234.3
Synonyms
ALGRX-3268; LSM-3165; NSC-40030;
Transport conditionsNormal

Lidocaine

Lidocaine is an anaesthetic agent and class Ib antiarrhythmic agent. It is a selective inverse peripheral histamine H1-receptor agonist. This compound is known to block voltage-gated sodium channels in the inactivated state.

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BRC0994
Product IDBRC0994
Product classBioreference compound
CAS number554-57-4
MW236.3
Synonyms
L-584601; VVP-808;
Transport conditionsNormal

Methazolamide

Methazolamide is a potent inhibitor of carbonic anhydrase. Used as a diuretic and in the treatment of glaucoma.

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BRC0337
Product IDBRC0337
Product classBioreference compound
CAS number522-48-5
MW236.7
Synonyms
Visine
Transport conditionsNormal

Tetryzoline hydrochloride

Tetrahydrozoline hydrochloride is an alpha agonist which causes constriction of conjunctival blood vessels.

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BRC0373
Product IDBRC0373
Product classBioreference compound
CAS number61-16-5
MW247.7
Synonyms
NRL001, Mexan
Transport conditionsNormal

Methoxamine hydrochloride

Methoxamine is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Methoxamine acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.

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BRC0903
Product IDBRC0903
Product classBioreference compound
CAS number847163-28-4
MW249.3
Synonyms
CID 664510
Transport conditionsNormal

ML351

ML351 is selective inhibitor of 12/15-lipoxygenase. It was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.

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BRC0974
Product IDBRC0974
Product classBioreference compound
CAS number57-41-0
MW252.3
Synonyms
NSC-8722;
Transport conditionsNormal
Restrictions Included in California Proposition 65 list  WARNING! This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

Phenytoin

Phenytoin is an antiepileptic drug. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.

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BRC0824
Product IDBRC0824
Product classBioreference compound
CAS number28721-07-5
MW252.3
Synonyms
GP 47680; KIN-493; SPN-804;
Transport conditionsNormal

Oxcarbazepine

Oxcarbazepine is a sodium channel protein inhibitor. It is structurally a derivative of carbamazepine.

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BRC0422
Product IDBRC0422
Product classBioreference compound
CAS number55142-85-3
MW263.8
Synonyms
Ticlid
Transport conditionsNormal

Ticlopidine

Ticlopidine is a prodrug that is metabolised to an as yet undetermined metabolite that acts as a platelet aggregation inhibitor. Inhibition of platelet aggregation causes a prolongation of bleeding time. In its prodrug form, ticlopidine has no significant in vitro activity at the concentrations attained in vivo.

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BRC0949
Product IDBRC0949
Product classBioreference compound
CAS number6673-35-4
MW266.3
Synonyms
Transport conditionsNormal

Practolol

Practolol is a beta-adrenergic receptor antagonist that has been used in the emergency treatment of cardiac arrhythmias.

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BRC1005
Product IDBRC1005
Product classBioreference compound
CAS number5011-34-7
MW266.3
Synonyms
40045;
Transport conditionsNormal

Trimetazidine

Trimetazidine is an anti-ischemic metabolic agent. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC50 = 75 nM). This, in turn, stimulates glucose oxidation.

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BRC0889
Product IDBRC0889
Product classBioreference compound
CAS number4205-91-8
MW266.6
Synonyms
ST 155, ST 155-BS
Transport conditionsNormal

Clonidine hydrochloride

Clonidine is an hypotensive agent, centrally-acting α2-adrenergic agonist.

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BRC0828
Product IDBRC0828
Product classBioreference compound
CAS number58-61-7
MW267.2
Synonyms
SR-96225; USAF CB-10; Ado;
Transport conditionsNormal

Adenosine

Adenosine is an endogenous nucleoside. It activates purine receptors, as well as relax vascular smooth muscles through the reduction in calcium uptake by inhibition of slow inward calcium current and activation of adenylate cyclase in smooth muscle cells.

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BRC0632
Product IDBRC0632
Product classBioreference compound
CAS number23113-43-1
MW267.5
Synonyms
NSC 68982, Wy 8678
Transport conditionsNormal

Guanabenz hydrochloride

Guanabenz is a centrally acting α-2 adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand, indicated for treatment of hypertension.

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BRC0942
Product IDBRC0942
Product classBioreference compound
CAS number614-39-1
MW271.8
Synonyms
NSC-27461; Biocoryl;
Transport conditionsNormal

Procainamide hydrochloride

Procainamide hydrochloride is a potent blocker of sodium channels. It demonstrates antiarrhythmic effects correlated with blockade of the Na+ channels. Procainamide hydrochloride is DNA methyltransferase inhibitor.

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BRC0675
Product IDBRC0675
Product classBioreference compound
CAS number14556-46-8
MW271.8
Synonyms
Transport conditionsNormal

Bupranolol

Bupranolol is a competitive, nonselective beta-blocker without intrinsic sympathomimetic activity. It competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation.

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BRC0273
Product IDBRC0273
Product classBioreference compound
CAS number29110-48-3
MW282.6
Synonyms
Estulic, Guanfacina, Guanfacinum, Estulic, SPD 503
Transport conditionsNormal

Guanfacine hydrochloride

Guanfacine selectively stimulates central alpha(2)-adrenergic receptors, resulting in inhibition of sympathetic vasomotor centers, which contributes predominantly to the hypotensive effects of the drug.

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BRC0387
Product IDBRC0387
Product classBioreference compound
CAS number105462-24-6
MW283.1
Synonyms
NE-58095, Actonel, Atelvia, Benet, Risedronic Acid
Transport conditionsNormal

Risedronate

Risedronate is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism and is indicated for the treatment and prevention of osteoporosis in postmenopausal women.

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BRC0350
Product IDBRC0350
Product classBioreference compound
CAS number59803-98-4
MW292.1
Synonyms
UK 14,304
Transport conditionsNormal

Brimonidine

Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2).

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BRC0655
Product IDBRC0655
Product classBioreference compound
CAS number58579-51-4
MW292.5
Synonyms
BL-4162A, Xagrid
Transport conditionsNormal

Anagrelide hydrochloride

Anagrelide hydrochloride is a potent PDE3 (type III phosphodiesterase) inhibitor (IC50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.

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BRC0651
Product IDBRC0651
Product classBioreference compound
CAS number58-94-6
MW295.7
Synonyms
Diutrid, Flumen, Minzil, NSC 25693, Alurene, Chlorosal
Transport conditionsNormal

Chlorothiazide

Chlorothiazide is an inhibitor of carbonic anhydrase (IC50 = 0.06 µM). This compound has been shown to block reabsorption of sodium and chloride ions.

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BRC0428
Product IDBRC0428
Product classBioreference compound
CAS number318-98-9
MW295.8
Synonyms
AY-64043, ICI-45520, NCS-91523, Angilol, Bedranol SR, Cardinol, Ciplar, Deralin, Dociton, Duranol, HEMANGEOL, Inderal, Inderal LA, Indobloc, INNOPRAN, Innopran XL, Prophylux, Sumial
Transport conditionsNormal

Propranolol hydrochloride

Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.

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BRC0370
Product IDBRC0370
Product classBioreference compound
CAS number58-93-5
MW297.7
Synonyms
HCTZ, NSC 53477, SU 5879
Transport conditionsNormal

Hydrochlorothiazide

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. Hydrochlorothiazide results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium.

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BRC0017
Product IDBRC0017
Product classBioreference compound
CAS number17440-83-4
MW302.1
Synonyms
Amipramidin, Amipramidine, Midamor
Transport conditionsNormal

Amiloride hydrochloride dihydrate

Amiloride, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. This promotes the loss of sodium and water from the body, but without depleting potassium.

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BRC0729
Product IDBRC0729
Product classBioreference compound
CAS number58-54-8
MW303.1
Synonyms
Hydromedin, MK 595, Mingit, NSC 624008, NSC 85791, Otacril, Reomax, Taladren, Uregit
Transport conditionsNormal

Ethacrynic acid

Ethacrynic acid is a compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules.

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BRC0357
Product IDBRC0357
Product classBioreference compound
CAS number1052540-65-4
MW303.1
Synonyms
Isocaramidine, Bonipress, Declinax, Tendor
Transport conditionsNormal

Debrisoquin

Debrisoquin is an adrenergic neuron-blocking drug similar in effects to guanethidine. It is a substrate for a polymorphic cytochrome P-450 enzyme.

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BRC0892
Product IDBRC0892
Product classBioreference compound
CAS number2863-34-5
MW305.2
Synonyms
Transport conditionsNormal

Bethanidine iodide

Bethanidine iodide is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission.

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BRC0992
Product IDBRC0992
Product classBioreference compound
CAS number42200-33-9
MW309.4
Synonyms
Corgard; Solgol;
Transport conditionsNormal

Nadolol

Nadolol is a nonselective beta-adrenergic receptor antagonist with a long half-life. Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension.

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BRC0573
Product IDBRC0573
Product classBioreference compound
CAS number1434927-54-4
MW315.4
Synonyms
Transport conditionsNormal

C10D

C10D is novel lipoprotein lipase (LPL) agonist rescues the enzyme from inhibition by angiopoietin-like 4 (ANGPTL4).

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BRC0825
Product IDBRC0825
Product classBioreference compound
CAS number56-54-2
MW324.4
Synonyms
CIN-QUIN; Conchinin; Conquinine; Pitayine;
Transport conditionsNormal

Quinidine

Quinidine is an optical isomer of quinine, antiarrhythmic. It dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.

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BRC0696
Product IDBRC0696
Product classBioreference compound
CAS number332939-46-5
MW326.8
Synonyms
Transport conditionsNormal

N-[(5-Chloro-8-hydroxyquinolin-7-yl)(phenyl)methyl]acetamide

The compound is inhibitor of HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction (IC50 = 3 µM).

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BRC0381
Product IDBRC0381
Product classBioreference compound
CAS number54-31-9
MW330.7
Synonyms
Frusemide
Transport conditionsNormal

Furosemide

Furosemide is an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Ki = ~10 µM for each). It is commonly used as a loop diuretic, blocking NKCC2 action on the apical membrane of the thick ascending limb of Henle epithelial cells. Furosemide also acts as an antagonist of GABAA receptors and as an inhibitor of carbonic anhydrase and organic anion transporter.

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BRC0732
Product IDBRC0732
Product classBioreference compound
CAS number135-09-1
MW331.3
Synonyms
Leodrine, Metflorylthiazidine, NSC 44627, NaClex
Transport conditionsNormal

Hydroflumethiazide

Hydroflumethiazide is a anti-hypertensive and a diuretic. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys.

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BRC0822
Product IDBRC0822
Product classBioreference compound
CAS number3737-09-5
MW339.5
Synonyms
H 3292, SC 7031, Searle 703
Transport conditionsNormal

Disopyramide

Disopyramide is a class I anti-arrhythmic agent and a sodium channel blocker with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.

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